2-Methyl-6-ethoxypyrazine

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  • Identifiers

    CAS number
    53163-97-6

    Molecular formula
    C7H10N2O

    SMILES
    CCOC1=NC(=CN=C1)C

  • Odor profile

    Fragrance
    Nutty 72.18%
    Roasted 70.56%
    Earthy 52.36%
    Hazelnut 48.74%
    Cocoa 40.34%
    Potato 38.92%
    Musty 36.97%
    Coffee 35.64%
    Green 35.18%
    Burnt 34.48%

     

    Flavor
    Nutty 35.84%
    Sweet 35.39%
    Earthy 34.27%
    Roasted 33.55%
    Musty 30.91%
    Coffee 30.7%
    Cocoa 29.51%
    Potato 29.34%
    Fruity 27.66%
    Bitter 27.05%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    4.87 (weak acid)

    Molecular weight
    138.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 191.00 to 193.00 °C. @ 760.00 mm Hg

    Flash point

    • 86.1 ˚C est.

  • Synonyms

    • 2-Ethoxy-6-methylpyrazine
    • 53163-97-6
    • Pyrazine, 2-ethoxy-6-methyl-
    • 2-METHYL-6-ETHOXYPYRAZINE
    • Pyrazine, 6-ethoxy-2-methyl
    • D47RK4A68R
    • EINECS 258-402-9
    • DTXSID8068832
    • 2-ethoxy-6-methyl-pyrazine
    • UNII-D47RK4A68R
    • SCHEMBL2214251
    • DTXCID9041368
    • CHEBI:193650
    • AKOS006285944
    • FEMA NO. 3569,-6-ETHOXY
    • DS-6061
    • FEMA NO. 3569, -6-ETHOXY
    • CS-0186630
    • NS00032666
    • C75488
    • Q27276081
    • 258-402-9

  • Applications

    2-Methyl-6-ethoxypyrazine (CAS 53163-97-6) is a pyrazine odorant with green, earthy notes, typically used as a fragrance ingredient and odorant in perfumery to impart green, herbaceous character to formulations. It is evaluated and may be used as a flavor/aroma component for foods and beverages, contributing green and peppery notes in savory products. In cosmetics and personal care, it may be used as a fragrance ingredient. In household products and cleaning formulations, it can provide fresh, green notes in air fresheners and cleaners. Additionally, 2-Methyl-6-ethoxypyrazine is sometimes employed as an intermediate in the synthesis of more complex pyrazine odorants for industrial fragrance/flavor supply chains.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 219.25
    methanol 375.87
    isopropanol 120.72
    water 4.62
    ethyl acetate 88.21
    n-propanol 150.94
    acetone 119.64
    n-butanol 121.75
    acetonitrile 160.52
    DMF 300.79
    toluene 65.85
    isobutanol 109.52
    1,4-dioxane 179.19
    methyl acetate 99.63
    THF 232.14
    2-butanone 88.13
    n-pentanol 101.43
    sec-butanol 108.72
    n-hexane 15.57
    ethylene glycol 111.25
    NMP 282.17
    cyclohexane 43.74
    DMSO 366.83
    n-butyl acetate 79.77
    n-octanol 67.69
    chloroform 498.73
    n-propyl acetate 55.76
    acetic acid 379.49
    dichloromethane 546.07
    cyclohexanone 178.48
    propylene glycol 97.4
    isopropyl acetate 42.0
    DMAc 253.14
    2-ethoxyethanol 143.99
    isopentanol 84.36
    n-heptane 21.24
    ethyl formate 123.46
    1,2-dichloroethane 220.14
    n-hexanol 110.38
    2-methoxyethanol 261.56
    isobutyl acetate 39.2
    tetrachloromethane 79.65
    n-pentyl acetate 55.54
    transcutol 248.99
    n-heptanol 53.92
    ethylbenzene 43.45
    MIBK 39.13
    2-propoxyethanol 166.85
    tert-butanol 114.39
    MTBE 60.94
    2-butoxyethanol 87.71
    propionic acid 172.21
    o-xylene 55.6
    formic acid 165.92
    diethyl ether 71.53
    m-xylene 43.37
    p-xylene 66.3
    chlorobenzene 138.67
    dimethyl carbonate 52.8
    n-octane 9.59
    formamide 155.99
    cyclopentanone 185.86
    2-pentanone 62.06
    anisole 80.84
    cyclopentyl methyl ether 96.7
    gamma-butyrolactone 245.6
    1-methoxy-2-propanol 148.89
    pyridine 242.44
    3-pentanone 59.86
    furfural 317.91
    n-dodecane 10.73
    diethylene glycol 154.92
    diisopropyl ether 20.22
    tert-amyl alcohol 98.26
    acetylacetone 75.43
    n-hexadecane 12.01
    acetophenone 86.36
    methyl propionate 92.21
    isopentyl acetate 66.57
    trichloroethylene 415.89
    n-nonanol 58.09
    cyclohexanol 120.98
    benzyl alcohol 99.08
    2-ethylhexanol 71.81
    isooctanol 41.07
    dipropyl ether 59.23
    1,2-dichlorobenzene 136.33
    ethyl lactate 63.23
    propylene carbonate 153.25
    n-methylformamide 186.1
    2-pentanol 63.77
    n-pentane 18.07
    1-propoxy-2-propanol 104.07
    1-methoxy-2-propyl acetate 78.44
    2-(2-methoxypropoxy) propanol 98.36
    mesitylene 28.55
    ε-caprolactone 160.95
    p-cymene 45.8
    epichlorohydrin 251.39
    1,1,1-trichloroethane 178.69
    2-aminoethanol 143.59
    morpholine-4-carbaldehyde 232.38
    sulfolane 332.13
    2,2,4-trimethylpentane 12.2
    2-methyltetrahydrofuran 152.61
    n-hexyl acetate 89.59
    isooctane 6.61
    2-(2-butoxyethoxy)ethanol 121.43
    sec-butyl acetate 35.37
    tert-butyl acetate 42.05
    decalin 20.07
    glycerin 143.44
    diglyme 194.14
    acrylic acid 180.73
    isopropyl myristate 40.93
    n-butyric acid 176.07
    acetyl acetate 72.79
    di(2-ethylhexyl) phthalate 61.86
    ethyl propionate 56.76
    nitromethane 275.91
    1,2-diethoxyethane 78.99
    benzonitrile 149.39
    trioctyl phosphate 44.09
    1-bromopropane 121.71
    gamma-valerolactone 228.55
    n-decanol 46.76
    triethyl phosphate 54.34
    4-methyl-2-pentanol 34.55
    propionitrile 136.83
    vinylene carbonate 196.99
    1,1,2-trichlorotrifluoroethane 254.13
    DMS 75.92
    cumene 37.63
    2-octanol 38.12
    2-hexanone 54.47
    octyl acetate 58.68
    limonene 63.65
    1,2-dimethoxyethane 199.68
    ethyl orthosilicate 47.77
    tributyl phosphate 52.65
    diacetone alcohol 65.07
    N,N-dimethylaniline 74.18
    acrylonitrile 186.66
    aniline 102.35
    1,3-propanediol 152.36
    bromobenzene 145.43
    dibromomethane 333.66
    1,1,2,2-tetrachloroethane 326.24
    2-methyl-cyclohexyl acetate 70.75
    tetrabutyl urea 70.04
    diisobutyl methanol 35.91
    2-phenylethanol 99.64
    styrene 58.3
    dioctyl adipate 75.17
    dimethyl sulfate 97.56
    ethyl butyrate 72.93
    methyl lactate 83.57
    butyl lactate 66.91
    diethyl carbonate 69.64
    propanediol butyl ether 98.64
    triethyl orthoformate 62.61
    p-tert-butyltoluene 40.67
    methyl 4-tert-butylbenzoate 91.26
    morpholine 204.84
    tert-butylamine 78.05
    n-dodecanol 39.2
    dimethoxymethane 148.83
    ethylene carbonate 137.13
    cyrene 103.04
    2-ethoxyethyl acetate 71.51
    2-ethylhexyl acetate 56.99
    1,2,4-trichlorobenzene 155.45
    4-methylpyridine 177.69
    dibutyl ether 58.86
    2,6-dimethyl-4-heptanol 35.91
    DEF 127.32
    dimethyl isosorbide 146.63
    tetrachloroethylene 234.97
    eugenol 96.61
    triacetin 91.08
    span 80 104.67
    1,4-butanediol 90.05
    1,1-dichloroethane 178.43
    2-methyl-1-pentanol 84.07
    methyl formate 152.09
    2-methyl-1-butanol 90.04
    n-decane 14.87
    butyronitrile 139.2
    3,7-dimethyl-1-octanol 60.54
    1-chlorooctane 46.15
    1-chlorotetradecane 25.09
    n-nonane 14.27
    undecane 12.23
    tert-butylcyclohexane 15.92
    cyclooctane 12.29
    cyclopentanol 155.32
    tetrahydropyran 158.11
    tert-amyl methyl ether 55.63
    2,5,8-trioxanonane 156.42
    1-hexene 45.46
    2-isopropoxyethanol 85.8
    2,2,2-trifluoroethanol 105.72
    methyl butyrate 81.02

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction