2-Methyl-6-(2-methylpropyl)pyrazine

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  • Identifiers

    CAS number
    32184-48-8

    Molecular formula
    C9H14N2

    SMILES
    CC1=CN=CC(=N1)CC(C)C

    Safety labels

  • Odor profile

    Fragrance
    Green 65.23%
    Fruity 55.52%
    Earthy 46.61%
    Nutty 45.75%
    Woody 38.95%
    Roasted 38.86%
    Vegetable 34.63%
    Burnt 32.78%
    Cocoa 31.75%
    Mint 30.44%

     

    Flavor
    Green 41.29%
    Earthy 40.55%
    Roasted 35.34%
    Musty 33.29%
    Earth 31.15%
    Pepper 29.75%
    Herbal 28.9%
    Cocoa 28.72%
    Burnt 28.36%
    Spice 26.79%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    4.74 (weak acid)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    222°C

    Flash point

    • 85.24 ˚C est.

  • Synonyms

    • 2-Methyl-6-(2-methylpropyl)pyrazine
    • 32184-48-8
    • DTXSID50610294
    • RefChem:263581
    • DTXCID40561049
    • 2-Methyl-6-isobutylpyrazine
    • SCHEMBL1913006
    • SCHEMBL4684655
    • LIRDEXCRJBABIY-UHFFFAOYSA-N
    • Pyrazine, 6-methyl-2-(2-methylpropyl)
    • DB-261326
    • 32184-48-8

  • Applications

    2-Methyl-6-(2-methylpropyl)pyrazine (CAS 32184-48-8) is a pyrazine compound used as an aroma ingredient across several industries, including perfumery/fragrance and flavor, cosmetics/personal care, household products, and cleaning formulations, providing roasted or nutty odor notes. It can also function as an intermediate in the synthesis of other aroma chemicals or as a fixing agent for fragrance notes in certain formulations, depending on local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 193.39
    methanol 287.5
    isopropanol 109.86
    water 1.36
    ethyl acetate 81.52
    n-propanol 147.01
    acetone 128.03
    n-butanol 145.31
    acetonitrile 96.5
    DMF 238.86
    toluene 101.46
    isobutanol 122.1
    1,4-dioxane 220.67
    methyl acetate 81.54
    THF 407.14
    2-butanone 103.34
    n-pentanol 110.59
    sec-butanol 107.12
    n-hexane 38.94
    ethylene glycol 56.52
    NMP 278.86
    cyclohexane 86.14
    DMSO 197.36
    n-butyl acetate 188.46
    n-octanol 86.34
    chloroform 549.01
    n-propyl acetate 71.79
    acetic acid 247.51
    dichloromethane 414.12
    cyclohexanone 274.58
    propylene glycol 79.49
    isopropyl acetate 51.97
    DMAc 165.54
    2-ethoxyethanol 96.05
    isopentanol 114.85
    n-heptane 62.56
    ethyl formate 112.36
    1,2-dichloroethane 183.79
    n-hexanol 258.14
    2-methoxyethanol 178.28
    isobutyl acetate 61.47
    tetrachloromethane 99.49
    n-pentyl acetate 76.54
    transcutol 283.45
    n-heptanol 86.84
    ethylbenzene 55.37
    MIBK 61.12
    2-propoxyethanol 242.16
    tert-butanol 116.82
    MTBE 86.49
    2-butoxyethanol 112.66
    propionic acid 132.24
    o-xylene 68.01
    formic acid 89.04
    diethyl ether 81.53
    m-xylene 71.17
    p-xylene 80.03
    chlorobenzene 158.75
    dimethyl carbonate 43.0
    n-octane 16.4
    formamide 71.25
    cyclopentanone 267.12
    2-pentanone 88.17
    anisole 80.07
    cyclopentyl methyl ether 167.59
    gamma-butyrolactone 281.35
    1-methoxy-2-propanol 117.35
    pyridine 226.48
    3-pentanone 70.35
    furfural 308.25
    n-dodecane 14.16
    diethylene glycol 159.7
    diisopropyl ether 30.21
    tert-amyl alcohol 105.41
    acetylacetone 88.03
    n-hexadecane 15.63
    acetophenone 86.54
    methyl propionate 73.43
    isopentyl acetate 152.09
    trichloroethylene 395.86
    n-nonanol 74.38
    cyclohexanol 171.34
    benzyl alcohol 101.5
    2-ethylhexanol 151.99
    isooctanol 63.2
    dipropyl ether 121.63
    1,2-dichlorobenzene 145.81
    ethyl lactate 52.89
    propylene carbonate 216.54
    n-methylformamide 112.6
    2-pentanol 79.14
    n-pentane 34.29
    1-propoxy-2-propanol 177.81
    1-methoxy-2-propyl acetate 123.97
    2-(2-methoxypropoxy) propanol 118.01
    mesitylene 46.05
    ε-caprolactone 203.74
    p-cymene 75.33
    epichlorohydrin 246.29
    1,1,1-trichloroethane 194.77
    2-aminoethanol 100.37
    morpholine-4-carbaldehyde 235.36
    sulfolane 321.18
    2,2,4-trimethylpentane 20.82
    2-methyltetrahydrofuran 246.4
    n-hexyl acetate 116.66
    isooctane 12.73
    2-(2-butoxyethoxy)ethanol 144.14
    sec-butyl acetate 45.85
    tert-butyl acetate 60.24
    decalin 32.31
    glycerin 94.71
    diglyme 207.76
    acrylic acid 133.83
    isopropyl myristate 55.05
    n-butyric acid 186.68
    acetyl acetate 68.77
    di(2-ethylhexyl) phthalate 82.97
    ethyl propionate 54.25
    nitromethane 175.7
    1,2-diethoxyethane 112.85
    benzonitrile 160.05
    trioctyl phosphate 58.84
    1-bromopropane 142.27
    gamma-valerolactone 299.34
    n-decanol 59.02
    triethyl phosphate 64.03
    4-methyl-2-pentanol 50.4
    propionitrile 98.76
    vinylene carbonate 207.86
    1,1,2-trichlorotrifluoroethane 221.18
    DMS 81.97
    cumene 45.13
    2-octanol 53.83
    2-hexanone 86.01
    octyl acetate 79.52
    limonene 119.93
    1,2-dimethoxyethane 157.9
    ethyl orthosilicate 64.44
    tributyl phosphate 70.04
    diacetone alcohol 82.47
    N,N-dimethylaniline 71.68
    acrylonitrile 109.35
    aniline 120.96
    1,3-propanediol 121.96
    bromobenzene 173.33
    dibromomethane 300.51
    1,1,2,2-tetrachloroethane 329.06
    2-methyl-cyclohexyl acetate 119.61
    tetrabutyl urea 87.66
    diisobutyl methanol 68.35
    2-phenylethanol 147.14
    styrene 66.87
    dioctyl adipate 92.94
    dimethyl sulfate 67.41
    ethyl butyrate 104.13
    methyl lactate 62.21
    butyl lactate 85.64
    diethyl carbonate 81.23
    propanediol butyl ether 118.52
    triethyl orthoformate 87.54
    p-tert-butyltoluene 69.84
    methyl 4-tert-butylbenzoate 97.92
    morpholine 248.11
    tert-butylamine 91.9
    n-dodecanol 49.2
    dimethoxymethane 118.66
    ethylene carbonate 160.58
    cyrene 118.19
    2-ethoxyethyl acetate 88.51
    2-ethylhexyl acetate 132.24
    1,2,4-trichlorobenzene 162.68
    4-methylpyridine 209.8
    dibutyl ether 86.65
    2,6-dimethyl-4-heptanol 68.35
    DEF 112.42
    dimethyl isosorbide 211.08
    tetrachloroethylene 224.71
    eugenol 105.59
    triacetin 100.23
    span 80 139.08
    1,4-butanediol 65.55
    1,1-dichloroethane 173.87
    2-methyl-1-pentanol 99.32
    methyl formate 105.73
    2-methyl-1-butanol 115.33
    n-decane 21.42
    butyronitrile 145.74
    3,7-dimethyl-1-octanol 84.0
    1-chlorooctane 65.85
    1-chlorotetradecane 32.15
    n-nonane 21.23
    undecane 16.75
    tert-butylcyclohexane 27.6
    cyclooctane 27.2
    cyclopentanol 181.99
    tetrahydropyran 246.78
    tert-amyl methyl ether 72.86
    2,5,8-trioxanonane 170.54
    1-hexene 87.41
    2-isopropoxyethanol 72.4
    2,2,2-trifluoroethanol 71.3
    methyl butyrate 85.33

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction