2-Methyl-5-hydroxypyridine

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  • Identifiers

    CAS number
    1121-78-4

    Molecular formula
    C6H7NO

    SMILES
    CC1=NC=C(C=C1)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Roasted 54.22%
    Nutty 51.86%
    Phenolic 46.2%
    Burnt 44.83%
    Musty 39.69%
    Smoky 38.52%
    Meaty 37.08%
    Animal 36.56%
    Sweet 34.52%
    Coffee 33.77%

     

    Flavor
    Nutty 47.01%
    Phenolic 45.66%
    Musty 36.7%
    Bitter 35.75%
    Coffee 34.8%
    Medicinal 34.45%
    Medical 31.8%
    Roasted 31.74%
    Cocoa 30.69%
    Almond 29.79%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    8.5 (weak base)

    Molecular weight
    109.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    212°C

    Flash point

    • 97.78 ˚C est.

  • Synonyms

    • 5-Hydroxy-2-methylpyridine
    • 1121-78-4
    • 6-Methylpyridin-3-ol
    • 2-Methyl-5-hydroxypyridine
    • 3-HYDROXY-6-METHYLPYRIDINE
    • 6-Methyl-3-pyridinol
    • 3-Pyridinol, 6-methyl-
    • 6-Methyl-3-hydroxypyridine
    • 5-Hydroxy-2-picoline
    • 2-methyl-5-pyridinol
    • UKE16JP1JR
    • EINECS 214-337-8
    • NSC 27963
    • BRN 0107077
    • DTXSID4051580
    • NSC-27963
    • 3-PYRIDOL, 6-METHYL-
    • DTXCID8030132
    • DHLUJPLHLZJUBW-UHFFFAOYSA-
    • 5-21-02-00139 (Beilstein Handbook Reference)
    • HYDROXY-6-METHYLPYRIDINE, 3-
    • RefChem:475705
    • InChI=1/C6H7NO/c1-5-2-3-6(8)4-7-5/h2-4,8H,1H3
    • MFCD00006339
    • 2-methyl-5-hydroxy-pyridine
    • 2-methyl-5-hydroxy pyridine
    • UNII-UKE16JP1JR
    • 6-Methyl-3-hydroxypyridine; 6-Methyl-3-pyridinol; NSC 27963
    • 5-hydroxypicoline
    • 6-Methyl-3-pyridol; 2-Methyl-5-hydroxypyridine; 2-Methyl-5-pyridinol; 3-Hydroxy-6-methylpyridine; 5-Hydroxy-2-methylpyridine; 5-Hydroxy-2-picoline
    • 6-Methyl-pyridin-3-ol
    • 6-methyl-pyridine-3-ol
    • 2-methyl-5hydroxypyridine
    • 5-hydroxy-2-methylpridine
    • 3-hydroxy-6-methyl-pyridine
    • 5-hydroxy-2-methyl pyridine
    • 5-hydroxy-2-methyl-pyridine
    • 6-methyl-3-hydroxy-pyridine
    • SCHEMBL104940
    • SCHEMBL324219
    • CHEMBL134979
    • orb3023372
    • SCHEMBL1238565
    • SCHEMBL2302892
    • SCHEMBL6476090
    • SCHEMBL17335777
    • SCHEMBL30146727
    • 5-Hydroxy-2-methylpyridine, 99%
    • NSC27963
    • STR03888
    • Tox21_304013
    • CL0058
    • SBB004349
    • AKOS007930884
    • AC-5086
    • CS-W004681
    • FH35512
    • PB30543
    • NCGC00357226-01
    • BP-10108
    • SY007644
    • CAS-1121-78-4
    • H0763
    • NS00023606
    • ST51044688
    • EN300-55469
    • AC-907/25014124
    • F076959
    • Q27291117
    • F0001-0268
    • Z838078132
    • 1121-78-4

  • Applications

    2-Methyl-5-hydroxypyridine (CAS number: 1121-78-4) is primarily used as an organic synthesis intermediate and platform for constructing functional pyridine derivatives. It is commonly employed to prepare functionalized pyridine ligands and chelating agents for transition-metal catalysis and coordination chemistry. The compound serves as a precursor in the synthesis of pharmaceutical and agrochemical intermediates and as a starting material in polymer and materials chemistry where pyridine scaffolds provide advantages. It may also be used to furnish dyes or pigment precursors and related functional materials, supporting research into electronic or coating applications, illustrating its versatility as a heteroaromatic building block.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 135.44
    methanol 161.01
    isopropanol 95.06
    water 15.87
    ethyl acetate 47.47
    n-propanol 108.47
    acetone 69.58
    n-butanol 76.14
    acetonitrile 28.99
    DMF 272.55
    toluene 8.09
    isobutanol 73.79
    1,4-dioxane 66.46
    methyl acetate 61.84
    THF 181.42
    2-butanone 68.44
    n-pentanol 51.16
    sec-butanol 74.23
    n-hexane 1.25
    ethylene glycol 72.1
    NMP 115.99
    cyclohexane 0.7
    DMSO 211.63
    n-butyl acetate 34.69
    n-octanol 28.18
    chloroform 47.08
    n-propyl acetate 22.84
    acetic acid 52.16
    dichloromethane 39.26
    cyclohexanone 59.38
    propylene glycol 83.05
    isopropyl acetate 23.01
    DMAc 219.4
    2-ethoxyethanol 97.61
    isopentanol 57.78
    n-heptane 2.28
    ethyl formate 71.44
    1,2-dichloroethane 26.14
    n-hexanol 68.05
    2-methoxyethanol 204.71
    isobutyl acetate 15.83
    tetrachloromethane 12.94
    n-pentyl acetate 22.57
    transcutol 96.47
    n-heptanol 36.59
    ethylbenzene 7.89
    MIBK 30.31
    2-propoxyethanol 128.82
    tert-butanol 87.72
    MTBE 35.91
    2-butoxyethanol 75.0
    propionic acid 71.01
    o-xylene 9.96
    formic acid 82.18
    diethyl ether 15.9
    m-xylene 11.07
    p-xylene 11.58
    chlorobenzene 17.08
    dimethyl carbonate 31.15
    n-octane 1.25
    formamide 91.48
    cyclopentanone 112.89
    2-pentanone 43.91
    anisole 29.72
    cyclopentyl methyl ether 42.12
    gamma-butyrolactone 121.56
    1-methoxy-2-propanol 141.04
    pyridine 44.41
    3-pentanone 24.03
    furfural 116.88
    n-dodecane 1.33
    diethylene glycol 123.82
    diisopropyl ether 5.79
    tert-amyl alcohol 72.8
    acetylacetone 42.96
    n-hexadecane 1.46
    acetophenone 29.98
    methyl propionate 54.46
    isopentyl acetate 30.69
    trichloroethylene 52.08
    n-nonanol 23.1
    cyclohexanol 33.02
    benzyl alcohol 36.97
    2-ethylhexanol 31.42
    isooctanol 27.46
    dipropyl ether 17.83
    1,2-dichlorobenzene 20.25
    ethyl lactate 27.41
    propylene carbonate 57.51
    n-methylformamide 162.89
    2-pentanol 35.97
    n-pentane 1.07
    1-propoxy-2-propanol 78.63
    1-methoxy-2-propyl acetate 45.04
    2-(2-methoxypropoxy) propanol 53.54
    mesitylene 7.17
    ε-caprolactone 55.5
    p-cymene 10.47
    epichlorohydrin 119.92
    1,1,1-trichloroethane 29.85
    2-aminoethanol 130.4
    morpholine-4-carbaldehyde 138.81
    sulfolane 117.63
    2,2,4-trimethylpentane 1.76
    2-methyltetrahydrofuran 82.3
    n-hexyl acetate 29.93
    isooctane 1.52
    2-(2-butoxyethoxy)ethanol 66.74
    sec-butyl acetate 13.73
    tert-butyl acetate 24.74
    decalin 1.49
    glycerin 126.87
    diglyme 110.39
    acrylic acid 56.27
    isopropyl myristate 11.18
    n-butyric acid 81.55
    acetyl acetate 20.37
    di(2-ethylhexyl) phthalate 17.59
    ethyl propionate 23.15
    nitromethane 97.3
    1,2-diethoxyethane 25.57
    benzonitrile 32.55
    trioctyl phosphate 14.52
    1-bromopropane 15.14
    gamma-valerolactone 138.43
    n-decanol 17.26
    triethyl phosphate 15.62
    4-methyl-2-pentanol 24.89
    propionitrile 41.8
    vinylene carbonate 55.8
    1,1,2-trichlorotrifluoroethane 99.61
    DMS 22.97
    cumene 8.74
    2-octanol 21.29
    2-hexanone 27.98
    octyl acetate 16.56
    limonene 12.07
    1,2-dimethoxyethane 112.95
    ethyl orthosilicate 15.32
    tributyl phosphate 14.6
    diacetone alcohol 57.65
    N,N-dimethylaniline 26.68
    acrylonitrile 58.87
    aniline 29.38
    1,3-propanediol 129.26
    bromobenzene 12.96
    dibromomethane 21.77
    1,1,2,2-tetrachloroethane 48.29
    2-methyl-cyclohexyl acetate 20.44
    tetrabutyl urea 21.78
    diisobutyl methanol 17.67
    2-phenylethanol 44.51
    styrene 7.97
    dioctyl adipate 16.58
    dimethyl sulfate 61.54
    ethyl butyrate 21.94
    methyl lactate 55.76
    butyl lactate 30.04
    diethyl carbonate 16.03
    propanediol butyl ether 61.07
    triethyl orthoformate 18.5
    p-tert-butyltoluene 10.65
    methyl 4-tert-butylbenzoate 36.95
    morpholine 100.63
    tert-butylamine 36.46
    n-dodecanol 12.79
    dimethoxymethane 103.04
    ethylene carbonate 43.7
    cyrene 49.97
    2-ethoxyethyl acetate 31.94
    2-ethylhexyl acetate 22.42
    1,2,4-trichlorobenzene 23.58
    4-methylpyridine 54.66
    dibutyl ether 13.55
    2,6-dimethyl-4-heptanol 17.67
    DEF 66.91
    dimethyl isosorbide 70.53
    tetrachloroethylene 33.46
    eugenol 46.14
    triacetin 23.7
    span 80 40.61
    1,4-butanediol 57.29
    1,1-dichloroethane 31.49
    2-methyl-1-pentanol 42.86
    methyl formate 114.22
    2-methyl-1-butanol 60.16
    n-decane 1.97
    butyronitrile 44.65
    3,7-dimethyl-1-octanol 25.22
    1-chlorooctane 9.55
    1-chlorotetradecane 4.14
    n-nonane 1.78
    undecane 1.58
    tert-butylcyclohexane 2.32
    cyclooctane 0.49
    cyclopentanol 60.15
    tetrahydropyran 41.45
    tert-amyl methyl ether 26.91
    2,5,8-trioxanonane 79.5
    1-hexene 6.02
    2-isopropoxyethanol 58.82
    2,2,2-trifluoroethanol 38.47
    methyl butyrate 36.4

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction