2-Methyl-5-ethoxypyrazine

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  • Identifiers

    CAS number
    67845-34-5

    Molecular formula
    C7H10N2O

    SMILES
    CCOC1=NC=C(N=C1)C

  • Odor profile

    Fragrance
    Nutty 78.11%
    Roasted 74.41%
    Earthy 57.43%
    Hazelnut 53.81%
    Cocoa 44.73%
    Potato 43.58%
    Musty 41.38%
    Coffee 38.81%
    Chocolate 37.82%
    Almond 37.21%

     

    Flavor
    Sweet 53.48%
    Nutty 43.38%
    Earthy 35.97%
    Coffee 34.73%
    Musty 33.07%
    Cocoa 32.71%
    Roasted 32.15%
    Potato 31.54%
    Caramel 31.29%
    Chocolate 28.78%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    4.31 (weak acid)

    Molecular weight
    138.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point

    • 189.00 to 191.00 °C. @ 760.00 mm Hg

    Flash point

    • 93.81 ˚C est.

  • Synonyms

    • 2-Ethoxy-5-methylpyrazine
    • 67845-34-5
    • 2-Methyl-5-ethoxypyrazine
    • 5-Ethoxy-2-methylpyrazine
    • Pyrazine, 2-ethoxy-5-methyl-
    • Pyrazine, 5-ethoxy-2-methyl
    • 8TD8256VKE
    • EINECS 267-309-2
    • DTXSID2070687
    • FEMA NO. 3569, 5-ETHOXY
    • UNII-8TD8256VKE
    • PYRAZINE,2-ETHOXY-5-METHYL-
    • 2-Ethoxy-5-methyl-Pyrazine
    • SCHEMBL7941732
    • DTXCID6045111
    • CHEBI:193649
    • AKOS006272102
    • NS00036219
    • Q27270989
    • 267-309-2

  • Applications

    2-Methyl-5-ethoxypyrazine (CAS 67845-34-5) is primarily used as an aroma compound in perfumery and flavor formulations, contributing green, earthy, and peppery notes; in cosmetics and personal care it can serve as a fragrance ingredient; in household products, such as air fresheners and cleaners, it can be employed to impart a pleasant scent; in industrial manufacturing it may be evaluated as an odorant or as an intermediate in chemical synthesis.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 176.68
    methanol 287.46
    isopropanol 93.79
    water 5.64
    ethyl acetate 71.16
    n-propanol 116.34
    acetone 69.03
    n-butanol 118.3
    acetonitrile 76.84
    DMF 199.82
    toluene 74.49
    isobutanol 88.1
    1,4-dioxane 162.43
    methyl acetate 70.32
    THF 155.69
    2-butanone 62.91
    n-pentanol 80.78
    sec-butanol 83.76
    n-hexane 10.15
    ethylene glycol 78.68
    NMP 151.88
    cyclohexane 27.37
    DMSO 218.89
    n-butyl acetate 54.44
    n-octanol 33.17
    chloroform 379.17
    n-propyl acetate 36.41
    acetic acid 252.67
    dichloromethane 334.19
    cyclohexanone 126.0
    propylene glycol 66.41
    isopropyl acetate 35.46
    DMAc 231.54
    2-ethoxyethanol 120.27
    isopentanol 89.03
    n-heptane 8.63
    ethyl formate 85.48
    1,2-dichloroethane 154.37
    n-hexanol 74.66
    2-methoxyethanol 219.77
    isobutyl acetate 26.96
    tetrachloromethane 66.95
    n-pentyl acetate 33.38
    transcutol 217.09
    n-heptanol 33.18
    ethylbenzene 34.25
    MIBK 29.58
    2-propoxyethanol 113.87
    tert-butanol 103.35
    MTBE 67.26
    2-butoxyethanol 64.81
    propionic acid 102.6
    o-xylene 51.4
    formic acid 166.59
    diethyl ether 61.26
    m-xylene 40.98
    p-xylene 49.2
    chlorobenzene 110.49
    dimethyl carbonate 34.77
    n-octane 4.14
    formamide 139.45
    cyclopentanone 104.46
    2-pentanone 43.85
    anisole 63.22
    cyclopentyl methyl ether 63.89
    gamma-butyrolactone 129.41
    1-methoxy-2-propanol 111.28
    pyridine 200.11
    3-pentanone 44.79
    furfural 207.56
    n-dodecane 4.46
    diethylene glycol 119.87
    diisopropyl ether 15.82
    tert-amyl alcohol 95.03
    acetylacetone 52.16
    n-hexadecane 4.97
    acetophenone 61.01
    methyl propionate 59.76
    isopentyl acetate 51.79
    trichloroethylene 306.87
    n-nonanol 31.13
    cyclohexanol 103.86
    benzyl alcohol 82.01
    2-ethylhexanol 45.98
    isooctanol 26.54
    dipropyl ether 33.15
    1,2-dichlorobenzene 100.02
    ethyl lactate 37.38
    propylene carbonate 92.71
    n-methylformamide 116.71
    2-pentanol 54.98
    n-pentane 12.15
    1-propoxy-2-propanol 68.83
    1-methoxy-2-propyl acetate 49.95
    2-(2-methoxypropoxy) propanol 70.85
    mesitylene 26.31
    ε-caprolactone 107.86
    p-cymene 26.68
    epichlorohydrin 163.19
    1,1,1-trichloroethane 137.78
    2-aminoethanol 110.68
    morpholine-4-carbaldehyde 163.04
    sulfolane 163.49
    2,2,4-trimethylpentane 9.14
    2-methyltetrahydrofuran 112.79
    n-hexyl acetate 47.19
    isooctane 4.25
    2-(2-butoxyethoxy)ethanol 88.7
    sec-butyl acetate 25.87
    tert-butyl acetate 33.04
    decalin 12.96
    glycerin 101.56
    diglyme 142.94
    acrylic acid 112.66
    isopropyl myristate 22.97
    n-butyric acid 133.89
    acetyl acetate 60.7
    di(2-ethylhexyl) phthalate 37.3
    ethyl propionate 35.45
    nitromethane 181.67
    1,2-diethoxyethane 64.35
    benzonitrile 100.87
    trioctyl phosphate 22.7
    1-bromopropane 94.69
    gamma-valerolactone 155.1
    n-decanol 24.47
    triethyl phosphate 33.64
    4-methyl-2-pentanol 31.48
    propionitrile 82.54
    vinylene carbonate 111.81
    1,1,2-trichlorotrifluoroethane 188.58
    DMS 47.25
    cumene 26.12
    2-octanol 22.21
    2-hexanone 37.08
    octyl acetate 30.33
    limonene 36.45
    1,2-dimethoxyethane 149.96
    ethyl orthosilicate 32.4
    tributyl phosphate 28.56
    diacetone alcohol 47.54
    N,N-dimethylaniline 52.76
    acrylonitrile 109.86
    aniline 113.92
    1,3-propanediol 139.8
    bromobenzene 110.33
    dibromomethane 207.79
    1,1,2,2-tetrachloroethane 249.0
    2-methyl-cyclohexyl acetate 44.57
    tetrabutyl urea 38.72
    diisobutyl methanol 24.72
    2-phenylethanol 72.7
    styrene 48.81
    dioctyl adipate 40.75
    dimethyl sulfate 62.23
    ethyl butyrate 41.42
    methyl lactate 53.89
    butyl lactate 35.41
    diethyl carbonate 38.05
    propanediol butyl ether 59.66
    triethyl orthoformate 38.84
    p-tert-butyltoluene 25.18
    methyl 4-tert-butylbenzoate 51.31
    morpholine 181.37
    tert-butylamine 69.54
    n-dodecanol 19.91
    dimethoxymethane 88.71
    ethylene carbonate 88.05
    cyrene 66.89
    2-ethoxyethyl acetate 47.38
    2-ethylhexyl acetate 42.21
    1,2,4-trichlorobenzene 118.37
    4-methylpyridine 154.64
    dibutyl ether 34.11
    2,6-dimethyl-4-heptanol 24.72
    DEF 91.55
    dimethyl isosorbide 96.48
    tetrachloroethylene 200.23
    eugenol 65.78
    triacetin 50.47
    span 80 62.39
    1,4-butanediol 62.09
    1,1-dichloroethane 141.42
    2-methyl-1-pentanol 75.31
    methyl formate 88.22
    2-methyl-1-butanol 91.88
    n-decane 6.1
    butyronitrile 94.26
    3,7-dimethyl-1-octanol 36.71
    1-chlorooctane 22.4
    1-chlorotetradecane 11.95
    n-nonane 5.57
    undecane 5.07
    tert-butylcyclohexane 9.96
    cyclooctane 7.84
    cyclopentanol 96.64
    tetrahydropyran 130.88
    tert-amyl methyl ether 56.65
    2,5,8-trioxanonane 116.02
    1-hexene 33.44
    2-isopropoxyethanol 66.28
    2,2,2-trifluoroethanol 84.15
    methyl butyrate 50.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction