2-Methyl-4-chlorophenoxyacetic Acid

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  • Identifiers

    CAS number
    94-74-6

    Molecular formula
    C9H9ClO3

    SMILES
    CC1=C(C=CC(=C1)Cl)OCC(=O)O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 33.22%
    Phenolic 30.8%
    Odorless 29.57%
    Fatty 29.43%
    Animal 29.2%
    Powdery 28.74%
    Vanilla 28.46%
    Creamy 27.47%
    Musk 25.01%
    Dry 24.99%

     

    Flavor
    Sweet 52.69%
    Mild 37.63%
    Odorless 36.64%
    Powdery 33.34%
    Phenolic 32.64%
    Fruity 28.58%
    Creamy 25.87%
    Sour 24.17%
    Musty 23.34%
    Faint 23.25%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    6.87 (neutral)

    Molecular weight
    200.62 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    306°C

    Melting point expt.

    • 118-119 °C
    • Melting point: 115-117 °C /technical grade MCPA/
    • 113-119 °C

    Flash point

    • 156.16 ˚C est.

    Solubility expt.

    • Solubility: in water 270 g/l, methanol 340 g/l, benzene 1 g/l /2-Methyl-4-chlorophenoxyacetic acid sodium salt/
    • INSOL IN CARBON DISULFIDE; SOLUBILITY (G/100 ML): ETHER 77, ETHANOL 153, N-HEPTANE 0.5, TOLUENE 6.2, XYLENE 4.9
    • SOL IN CARBON TETRACHLORIDE
    • Free acid insol in water but sodium and amine salts are soluble
    • Sol in benzene
    • For more Solubility (Complete) data for 2-METHYL-4-CHLOROPHENOXYACETIC ACID (6 total), please visit the HSDB record page.
    • Solubility in water: none

  • Synonyms

    • MCPA
    • 94-74-6
    • 2-METHYL-4-CHLOROPHENOXYACETIC ACID
    • (4-Chloro-2-methylphenoxy)acetic acid
    • Agroxone
    • 4-Chloro-2-methylphenoxyacetic acid
    • Metaxon
    • Zelan
    • 2-(4-Chloro-2-methylphenoxy)acetic acid
    • Mephanac
    • Emcepan
    • Netazol
    • Rhonox
    • Herbicide M
    • Hedarex M
    • Hedonal M
    • Okultin M
    • Leuna M
    • Bordermaster
    • Hornotuho
    • Linormone
    • Agroxon
    • Chiptox
    • Krezone
    • Raphone
    • Rhomenc
    • Rhomene
    • Trasan
    • Anicon kombi
    • Dicopur-M
    • Anicon M
    • B-Selektonon M
    • Cornox-M
    • Hormotuho
    • Leyspray
    • Shamrox
    • Ustinex
    • 2,4-MCPA
    • Empal
    • Kilsem
    • Acetic acid, (4-chloro-2-methylphenoxy)-
    • Legumex db
    • Phenoxylene plus
    • Seppic mmd
    • Vesakontuho mcpa
    • Hedapur M 52
    • Phenoxylene super
    • Phenoxylene 50
    • Razol dock killer
    • Weedone mcpa ester
    • BH Mcpa
    • Chwastox 30
    • Agritox
    • Vacate
    • 2-Methyl-4-chlorphenoxyessigsaeure
    • Chwastox Extra
    • Acme MCPA Amine 4
    • 2M-4Ch
    • Banvel M
    • Brominal M & plus
    • (4-Chloro-o-toloxy)acetic acid
    • Dikotes
    • Dikotex
    • 2M-4Kh
    • Caswell No. 557C
    • [(4-Chloro-o-tolyl)oxy]acetic acid
    • Kilsem4k-2m
    • Methylchlorophenoxyacetic acid
    • 4-Chloro-o-toloxyacetic acid
    • ((4-Chloro-o-tolyl)oxy)acetic acid
    • 4-Chloro-o-cresoxyacetic acid
    • Cekherbex
    • Chwastox
    • Dicotex
    • Mecaphar
    • (2-Methyl-4-chlorophenoxy)acetic acid
    • Selektonon M
    • Soviet technical herbicide 2M-4C
    • 4K-2M
    • Albar-M
    • Aceticacid, 2-(4-chloro-2-methylphenoxy)-
    • Weedar MCPA
    • Atlas MCPA
    • Agritox 50
    • M 40
    • CHEBI:50099
    • (4-Chloro-o-cresoxy)acetic acid
    • 2-Methyl-4-chlorphenoxyessigsaeure [German]
    • Acetic acid, 2-(4-chloro-2-methylphenoxy)-
    • Kwas 4-chloro-2-metylofenoksyoctowy
    • Dow MCP amine weed killer
    • Kyselina 4-chlor-2-methylfenoxyoctova
    • WLN: QV1OR DG B1
    • Acetic acid, ((4-chloro-o-tolyl)oxy)-
    • 2-(4-chloro-2-methyl-phenoxy)acetic acid
    • Campbell's MCPA 25, 50
    • MLS000054403
    • CHEMBL394657
    • Methyl chlorophenoxy acetic acid
    • DTXSID4024195
    • D888C394VO
    • NSC-2351
    • MCPA 10 microg/mL in Acetonitrile
    • MCPA 100 microg/mL in Acetonitrile
    • Acetic acid, [(4-chloro-o-tolyl)oxy]-
    • SMR000066149
    • Cornox
    • MCPA 2000 microg/mL in Methyl tert-butyl ether
    • DTXCID304195
    • MCPA [BSI:ISO]
    • (((4-chloro-O-tolyl)oxy)acetic) acid
    • {[(4-chloro-O-tolyl)oxy]acetic} acid
    • CAS-94-74-6
    • Acetic acid, (((4-chloro-O-tolyl)oxy)-)
    • Acetic acid, {[(4-chloro-O-tolyl)oxy]-}
    • CCRIS 1022
    • HSDB 1127
    • (4-Chloro-2-methylphenoxy)aceticAcid-13C6
    • NSC 2351
    • 2-METHYL-4-CHLORPHENOXYESSIGSAEURE (GERMAN)
    • EINECS 202-360-6
    • MFCD00004306
    • MCPA [ISO]
    • EPA Pesticide Chemical Code 030501
    • BRN 2051752
    • CornoxM
    • DicopurM
    • UNII-D888C394VO

  • Applications

    2-Methyl-4-chlorophenoxyacetic acid (CAS 94-74-6) is primarily used in agriculture as a selective systemic herbicide to control broadleaf weeds in cereals, pastures, turf and certain horticultural crops. In commercial formulations it is commonly delivered as salts or esters to improve solubility, uptake, and drift characteristics. It also serves as a key intermediate in the synthesis of other phenoxyacetic acid herbicides and related agrochemicals. In formulation development and product lines, it is evaluated for compatibility with adjuvants and tank-mix partners. In research contexts, its auxin-like herbicidal activity is studied to understand mode of action and crop tolerance, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 654.06
    methanol 717.68
    isopropanol 316.6
    water 3.57
    ethyl acetate 263.71
    n-propanol 393.21
    acetone 481.17
    n-butanol 295.21
    acetonitrile 178.83
    DMF 1181.26
    toluene 13.06
    isobutanol 222.49
    1,4-dioxane 552.38
    methyl acetate 307.74
    THF 1017.38
    2-butanone 324.5
    n-pentanol 222.6
    sec-butanol 234.25
    n-hexane 1.85
    ethylene glycol 141.53
    NMP 521.52
    cyclohexane 1.89
    DMSO 648.21
    n-butyl acetate 167.63
    n-octanol 82.86
    chloroform 30.21
    n-propyl acetate 178.12
    acetic acid 238.0
    dichloromethane 94.19
    cyclohexanone 231.67
    propylene glycol 122.31
    isopropyl acetate 140.62
    DMAc 717.61
    2-ethoxyethanol 613.25
    isopentanol 200.81
    n-heptane 8.28
    ethyl formate 182.09
    1,2-dichloroethane 85.25
    n-hexanol 129.7
    2-methoxyethanol 909.34
    isobutyl acetate 98.8
    tetrachloromethane 1.2
    n-pentyl acetate 94.87
    transcutol 717.43
    n-heptanol 73.56
    ethylbenzene 16.45
    MIBK 139.75
    2-propoxyethanol 329.94
    tert-butanol 343.56
    MTBE 228.75
    2-butoxyethanol 168.55
    propionic acid 129.05
    o-xylene 18.04
    formic acid 217.65
    diethyl ether 188.88
    m-xylene 19.71
    p-xylene 24.11
    chlorobenzene 24.88
    dimethyl carbonate 130.79
    n-octane 4.52
    formamide 464.32
    cyclopentanone 404.56
    2-pentanone 280.23
    anisole 120.24
    cyclopentyl methyl ether 210.97
    gamma-butyrolactone 483.05
    1-methoxy-2-propanol 491.87
    pyridine 114.9
    3-pentanone 152.56
    furfural 316.19
    n-dodecane 5.47
    diethylene glycol 299.05
    diisopropyl ether 41.95
    tert-amyl alcohol 255.16
    acetylacetone 258.27
    n-hexadecane 5.94
    acetophenone 115.52
    methyl propionate 234.96
    isopentyl acetate 143.52
    trichloroethylene 112.85
    n-nonanol 75.52
    cyclohexanol 107.61
    benzyl alcohol 108.61
    2-ethylhexanol 77.59
    isooctanol 62.62
    dipropyl ether 108.09
    1,2-dichlorobenzene 29.34
    ethyl lactate 97.56
    propylene carbonate 206.8
    n-methylformamide 513.83
    2-pentanol 153.88
    n-pentane 2.26
    1-propoxy-2-propanol 208.21
    1-methoxy-2-propyl acetate 208.61
    2-(2-methoxypropoxy) propanol 177.38
    mesitylene 16.58
    ε-caprolactone 236.01
    p-cymene 28.81
    epichlorohydrin 564.19
    1,1,1-trichloroethane 26.72
    2-aminoethanol 261.29
    morpholine-4-carbaldehyde 646.91
    sulfolane 393.18
    2,2,4-trimethylpentane 3.92
    2-methyltetrahydrofuran 443.9
    n-hexyl acetate 119.59
    isooctane 3.39
    2-(2-butoxyethoxy)ethanol 243.79
    sec-butyl acetate 106.02
    tert-butyl acetate 159.36
    decalin 4.06
    glycerin 170.09
    diglyme 456.31
    acrylic acid 103.85
    isopropyl myristate 60.94
    n-butyric acid 167.47
    acetyl acetate 114.42
    di(2-ethylhexyl) phthalate 57.27
    ethyl propionate 141.91
    nitromethane 508.83
    1,2-diethoxyethane 285.35
    benzonitrile 75.76
    trioctyl phosphate 44.55
    1-bromopropane 36.88
    gamma-valerolactone 563.84
    n-decanol 63.03
    triethyl phosphate 67.63
    4-methyl-2-pentanol 74.54
    propionitrile 135.78
    vinylene carbonate 153.41
    1,1,2-trichlorotrifluoroethane 178.11
    DMS 113.35
    cumene 18.8
    2-octanol 55.45
    2-hexanone 177.41
    octyl acetate 80.53
    limonene 42.23
    1,2-dimethoxyethane 713.43
    ethyl orthosilicate 64.87
    tributyl phosphate 53.98
    diacetone alcohol 227.48
    N,N-dimethylaniline 87.64
    acrylonitrile 141.62
    aniline 50.06
    1,3-propanediol 361.36
    bromobenzene 18.65
    dibromomethane 37.8
    1,1,2,2-tetrachloroethane 74.15
    2-methyl-cyclohexyl acetate 102.26
    tetrabutyl urea 89.5
    diisobutyl methanol 51.18
    2-phenylethanol 98.0
    styrene 18.35
    dioctyl adipate 94.52
    dimethyl sulfate 180.21
    ethyl butyrate 140.88
    methyl lactate 129.17
    butyl lactate 87.87
    diethyl carbonate 92.76
    propanediol butyl ether 152.79
    triethyl orthoformate 102.42
    p-tert-butyltoluene 29.31
    methyl 4-tert-butylbenzoate 117.16
    morpholine 721.13
    tert-butylamine 123.36
    n-dodecanol 50.71
    dimethoxymethane 678.87
    ethylene carbonate 138.54
    cyrene 192.18
    2-ethoxyethyl acetate 160.29
    2-ethylhexyl acetate 106.24
    1,2,4-trichlorobenzene 42.98
    4-methylpyridine 119.55
    dibutyl ether 96.61
    2,6-dimethyl-4-heptanol 51.18
    DEF 333.63
    dimethyl isosorbide 313.2
    tetrachloroethylene 28.67
    eugenol 119.29
    triacetin 132.42
    span 80 114.4
    1,4-butanediol 182.36
    1,1-dichloroethane 48.22
    2-methyl-1-pentanol 144.77
    methyl formate 381.46
    2-methyl-1-butanol 190.4
    n-decane 7.92
    butyronitrile 140.53
    3,7-dimethyl-1-octanol 77.46
    1-chlorooctane 34.22
    1-chlorotetradecane 16.97
    n-nonane 6.71
    undecane 6.6
    tert-butylcyclohexane 5.14
    cyclooctane 1.49
    cyclopentanol 183.86
    tetrahydropyran 277.28
    tert-amyl methyl ether 169.09
    2,5,8-trioxanonane 335.44
    1-hexene 15.66
    2-isopropoxyethanol 302.76
    2,2,2-trifluoroethanol 83.22
    methyl butyrate 189.39

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction