2-Methyl-4-(1-methylethyl)thiazole

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  • Identifiers

    CAS number
    32272-52-9

    Molecular formula
    C7H11NS

    SMILES
    CC1=NC(=CS1)C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Green 92.78%
    Vegetable 71.65%
    Nutty 60.12%
    Earthy 54.29%
    Meaty 50.1%
    Sulfurous 49.29%
    Roasted 47.26%
    Tropical 46.69%
    Fruity 43.39%
    Tomato 40.2%

     

    Flavor
    Green 71.78%
    Earthy 52.7%
    Vegetable 46.34%
    Roasted 41.88%
    Nutty 41.63%
    Earth 36.73%
    Pepper 33.83%
    Tomato 32.33%
    Raw 31.15%
    Hazelnut 31.07%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    5.79 (weak acid)

    Molecular weight
    141.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    171°C

    Flash point

    • 55.27 ˚C est.

  • Synonyms

    • 4-Isopropyl-2-methylthiazole
    • 32272-52-9
    • 2-methyl-4-(propan-2-yl)-1,3-thiazole
    • Thiazole, 4-isopropyl-2-methyl-
    • Thiazole, 2-methyl-4-(1-methylethyl)-
    • 2-Methyl-4-(1-methylethyl)thiazole
    • 4-Isopropyl-2-methyl-Thiazole
    • 2-Methyl-4-(1-methylethyl)-Thiazole
    • 2-Methyl-4-(1-methylethyl)thiazole, 9CI
    • RefChem:88114
    • SRTOJEUVLKLAGK-UHFFFAOYSA-N
    • 2-methyl-4-propan-2-yl-1,3-thiazole
    • 4-Isopropyl-2-methyl-1,3-thiazole
    • SCHEMBL179318
    • SCHEMBL2264899
    • DTXSID001377240
    • HBA27252
    • 4-(1-Methylethyl)-2-methylthiazole
    • AKOS006282511
    • DA-20634
    • CS-0057980
    • EN300-1659555
    • Z1152201834
    • 32272-52-9

  • Applications

    2-Methyl-4-(1-methylethyl)thiazole (CAS 32272-52-9) is primarily used as an aroma and flavor ingredient in the fragrance, flavor, cosmetics/personal care, and household products sectors, contributing roasty and meat-like notes in formulations. It may also be employed as a fragrance component in cosmetics and personal care products to impart or enhance scent. In industrial manufacturing, the compound can serve as an intermediate or building block for synthesizing other thiazole-based compounds used in pharmaceuticals, agrochemicals, or materials. In coatings/inks and polymers, it can function as a fragrance-release component or as a chemical intermediate within formulation chemistries. Applications are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 132.54
    methanol 149.57
    isopropanol 140.96
    water 1.02
    ethyl acetate 232.59
    n-propanol 152.75
    acetone 348.54
    n-butanol 181.28
    acetonitrile 154.27
    DMF 414.26
    toluene 268.45
    isobutanol 161.41
    1,4-dioxane 448.1
    methyl acetate 259.68
    THF 658.43
    2-butanone 335.16
    n-pentanol 164.33
    sec-butanol 174.61
    n-hexane 100.11
    ethylene glycol 52.6
    NMP 550.14
    cyclohexane 95.84
    DMSO 319.45
    n-butyl acetate 306.98
    n-octanol 210.77
    chloroform 799.94
    n-propyl acetate 201.73
    acetic acid 116.65
    dichloromethane 640.59
    cyclohexanone 534.92
    propylene glycol 81.78
    isopropyl acetate 203.37
    DMAc 449.72
    2-ethoxyethanol 199.16
    isopentanol 192.92
    n-heptane 85.97
    ethyl formate 147.6
    1,2-dichloroethane 399.88
    n-hexanol 270.66
    2-methoxyethanol 244.63
    isobutyl acetate 196.34
    tetrachloromethane 210.88
    n-pentyl acetate 245.9
    transcutol 454.95
    n-heptanol 177.91
    ethylbenzene 185.22
    MIBK 251.19
    2-propoxyethanol 352.03
    tert-butanol 214.4
    MTBE 313.75
    2-butoxyethanol 243.36
    propionic acid 148.22
    o-xylene 213.18
    formic acid 30.37
    diethyl ether 249.51
    m-xylene 229.03
    p-xylene 245.31
    chlorobenzene 359.77
    dimethyl carbonate 139.88
    n-octane 51.94
    formamide 38.83
    cyclopentanone 624.68
    2-pentanone 303.34
    anisole 293.12
    cyclopentyl methyl ether 388.75
    gamma-butyrolactone 538.53
    1-methoxy-2-propanol 256.32
    pyridine 328.04
    3-pentanone 277.26
    furfural 489.15
    n-dodecane 47.34
    diethylene glycol 225.5
    diisopropyl ether 140.91
    tert-amyl alcohol 223.14
    acetylacetone 345.57
    n-hexadecane 54.03
    acetophenone 287.65
    methyl propionate 234.07
    isopentyl acetate 310.61
    trichloroethylene 735.24
    n-nonanol 174.46
    cyclohexanol 232.85
    benzyl alcohol 207.15
    2-ethylhexanol 215.2
    isooctanol 154.34
    dipropyl ether 236.15
    1,2-dichlorobenzene 354.94
    ethyl lactate 134.45
    propylene carbonate 356.66
    n-methylformamide 130.57
    2-pentanol 162.11
    n-pentane 73.09
    1-propoxy-2-propanol 294.92
    1-methoxy-2-propyl acetate 309.36
    2-(2-methoxypropoxy) propanol 232.47
    mesitylene 173.79
    ε-caprolactone 432.96
    p-cymene 159.66
    epichlorohydrin 551.85
    1,1,1-trichloroethane 534.15
    2-aminoethanol 80.28
    morpholine-4-carbaldehyde 493.79
    sulfolane 707.32
    2,2,4-trimethylpentane 64.02
    2-methyltetrahydrofuran 497.82
    n-hexyl acetate 357.73
    isooctane 53.26
    2-(2-butoxyethoxy)ethanol 283.8
    sec-butyl acetate 182.93
    tert-butyl acetate 267.92
    decalin 88.44
    glycerin 118.18
    diglyme 449.86
    acrylic acid 136.18
    isopropyl myristate 173.12
    n-butyric acid 202.21
    acetyl acetate 183.58
    di(2-ethylhexyl) phthalate 161.9
    ethyl propionate 191.16
    nitromethane 208.14
    1,2-diethoxyethane 267.43
    benzonitrile 292.72
    trioctyl phosphate 125.39
    1-bromopropane 306.09
    gamma-valerolactone 596.87
    n-decanol 136.53
    triethyl phosphate 139.25
    4-methyl-2-pentanol 130.92
    propionitrile 179.65
    vinylene carbonate 319.96
    1,1,2-trichlorotrifluoroethane 341.91
    DMS 265.14
    cumene 156.97
    2-octanol 160.4
    2-hexanone 274.14
    octyl acetate 202.25
    limonene 223.31
    1,2-dimethoxyethane 379.17
    ethyl orthosilicate 138.86
    tributyl phosphate 143.92
    diacetone alcohol 268.12
    N,N-dimethylaniline 239.92
    acrylonitrile 196.14
    aniline 221.32
    1,3-propanediol 121.16
    bromobenzene 418.93
    dibromomethane 490.34
    1,1,2,2-tetrachloroethane 630.5
    2-methyl-cyclohexyl acetate 240.64
    tetrabutyl urea 185.31
    diisobutyl methanol 141.56
    2-phenylethanol 251.04
    styrene 212.37
    dioctyl adipate 198.89
    dimethyl sulfate 243.26
    ethyl butyrate 217.38
    methyl lactate 148.75
    butyl lactate 189.01
    diethyl carbonate 157.28
    propanediol butyl ether 226.19
    triethyl orthoformate 174.67
    p-tert-butyltoluene 169.77
    methyl 4-tert-butylbenzoate 280.13
    morpholine 367.12
    tert-butylamine 165.84
    n-dodecanol 116.53
    dimethoxymethane 292.65
    ethylene carbonate 255.39
    cyrene 263.87
    2-ethoxyethyl acetate 276.18
    2-ethylhexyl acetate 275.59
    1,2,4-trichlorobenzene 429.07
    4-methylpyridine 415.26
    dibutyl ether 240.15
    2,6-dimethyl-4-heptanol 141.56
    DEF 305.87
    dimethyl isosorbide 402.08
    tetrachloroethylene 419.54
    eugenol 260.27
    triacetin 278.46
    span 80 243.23
    1,4-butanediol 82.89
    1,1-dichloroethane 446.22
    2-methyl-1-pentanol 187.2
    methyl formate 139.47
    2-methyl-1-butanol 191.77
    n-decane 70.34
    butyronitrile 204.7
    3,7-dimethyl-1-octanol 188.27
    1-chlorooctane 209.75
    1-chlorotetradecane 101.24
    n-nonane 74.14
    undecane 56.06
    tert-butylcyclohexane 92.93
    cyclooctane 59.21
    cyclopentanol 244.7
    tetrahydropyran 395.69
    tert-amyl methyl ether 280.68
    2,5,8-trioxanonane 330.27
    1-hexene 195.94
    2-isopropoxyethanol 188.08
    2,2,2-trifluoroethanol 71.96
    methyl butyrate 244.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction