2-Methyl-2-oxazoline

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  • Identifiers

    CAS number
    1120-64-5

    Molecular formula
    C4H7NO

    SMILES
    CC1=NCCO1

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Nutty 66.04%
    Roasted 53.41%
    Sweet 47.31%
    Meaty 45.59%
    Vegetable 45.03%
    Green 44.17%
    Musty 42.94%
    Herbal 36.77%
    Cocoa 34.1%
    Burnt 33.24%

     

    Flavor
    Nutty 43.48%
    Green 42.18%
    Caramel 35.89%
    Vegetable 35.2%
    Potato 28.63%
    Earthy 27.37%
    Roasted 26.58%
    Musty 25.64%
    Fruity 25.15%
    Sweet 20.88%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    -0.2

    pKa est.
    7.31 (neutral)

    Molecular weight
    85.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    122°C

    Flash point

    • 25.07 ˚C est.

  • Synonyms

    • 2-Methyl-2-oxazoline
    • 1120-64-5
    • 2-Methyl-4,5-dihydro-1,3-oxazole
    • CHEBI:53614
    • DTXSID40870845
    • RefChem:475175
    • DTXCID90818530
    • 214-316-3
    • 2-methyl-4,5-dihydrooxazole
    • 2-Methyloxazoline
    • Oxazole, 4,5-dihydro-2-methyl-
    • MFCD00005298
    • 2-Methyl-2-oxazolin
    • 2-methyl-1,3-oxazoline
    • 26375-28-0
    • Oxazole, 4,5-dihydro-2-methyl-, homopolymer
    • 2-Oxazoline, 2-methyl-
    • methyl oxazoline
    • 2-methyl-oxazoline
    • NSC43141
    • EINECS 214-316-3
    • SCHEMBL30176
    • SCHEMBL434650
    • 2-Methyl-2-oxazoline, 98%
    • SCHEMBL1207040
    • SCHEMBL1207041
    • SCHEMBL2545656
    • SCHEMBL6842624
    • SCHEMBL13721069
    • 2-Oxazoline, Delta, 2-methyl-
    • NSC 43141
    • NSC-43141
    • SBB071039
    • AKOS015915305
    • 2-Methyl-4,5-dihydro-1,3-oxazole #
    • DB-041037
    • CS-0128804
    • M0857
    • NS00044493
    • EN300-172226
    • F16112
    • Q27124115
    • InChI=1/C4H7NO/c1-4-5-2-3-6-4/h2-3H2,1H
    • 1120-64-5

  • Applications

    2-Methyl-2-oxazoline (CAS 1120-64-5) is the monomer used to synthesize poly(2-oxazoline)s (POx) by cationic ring-opening polymerization, yielding well-defined polymers with tunable properties. In real-world terms, POx derived from this monomer are employed in biomedical applications and medical-device coatings and drug-delivery polymers; in cosmetics and personal care as thickening and conditioning polymers; in coatings and adhesives, particularly waterborne formulations; in electronics and sensors as surface-modifying or dielectric polymers; and as a versatile building block in industrial polymer manufacturing to tailor materials for specialty coatings, adhesives, and plastics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 875.75
    methanol 1634.07
    isopropanol 557.66
    water 216.41
    ethyl acetate 371.43
    n-propanol 512.67
    acetone 801.07
    n-butanol 344.39
    acetonitrile 973.24
    DMF 1734.33
    toluene 235.14
    isobutanol 339.73
    1,4-dioxane 709.58
    methyl acetate 506.83
    THF 654.13
    2-butanone 451.96
    n-pentanol 176.62
    sec-butanol 362.91
    n-hexane 17.09
    ethylene glycol 512.84
    NMP 1037.67
    cyclohexane 32.42
    DMSO 1283.76
    n-butyl acetate 47.1
    n-octanol 56.54
    chloroform 1482.19
    n-propyl acetate 74.0
    acetic acid 939.77
    dichloromethane 1421.47
    cyclohexanone 349.56
    propylene glycol 473.04
    isopropyl acetate 137.2
    DMAc 1376.62
    2-ethoxyethanol 428.85
    isopentanol 211.22
    n-heptane 10.04
    ethyl formate 323.02
    1,2-dichloroethane 565.23
    n-hexanol 80.06
    2-methoxyethanol 1157.73
    isobutyl acetate 39.97
    tetrachloromethane 247.19
    n-pentyl acetate 53.73
    transcutol 479.64
    n-heptanol 49.67
    ethylbenzene 55.42
    MIBK 97.95
    2-propoxyethanol 221.72
    tert-butanol 389.71
    MTBE 207.36
    2-butoxyethanol 125.68
    propionic acid 522.48
    o-xylene 128.4
    formic acid 1024.34
    diethyl ether 291.31
    m-xylene 100.82
    p-xylene 77.34
    chlorobenzene 306.24
    dimethyl carbonate 192.87
    n-octane 4.65
    formamide 1390.3
    cyclopentanone 541.2
    2-pentanone 256.62
    anisole 201.86
    cyclopentyl methyl ether 245.52
    gamma-butyrolactone 609.2
    1-methoxy-2-propanol 626.54
    pyridine 812.08
    3-pentanone 223.73
    furfural 818.47
    n-dodecane 4.78
    diethylene glycol 272.23
    diisopropyl ether 43.32
    tert-amyl alcohol 292.96
    acetylacetone 303.23
    n-hexadecane 5.28
    acetophenone 161.1
    methyl propionate 380.21
    isopentyl acetate 39.68
    trichloroethylene 1121.34
    n-nonanol 49.89
    cyclohexanol 246.31
    benzyl alcohol 239.52
    2-ethylhexanol 36.86
    isooctanol 37.78
    dipropyl ether 48.33
    1,2-dichlorobenzene 231.8
    ethyl lactate 73.66
    propylene carbonate 225.17
    n-methylformamide 1214.15
    2-pentanol 173.96
    n-pentane 30.16
    1-propoxy-2-propanol 120.42
    1-methoxy-2-propyl acetate 97.79
    2-(2-methoxypropoxy) propanol 112.01
    mesitylene 44.77
    ε-caprolactone 288.42
    p-cymene 25.87
    epichlorohydrin 737.43
    1,1,1-trichloroethane 559.13
    2-aminoethanol 711.71
    morpholine-4-carbaldehyde 960.4
    sulfolane 561.36
    2,2,4-trimethylpentane 11.51
    2-methyltetrahydrofuran 426.21
    n-hexyl acetate 81.86
    isooctane 5.52
    2-(2-butoxyethoxy)ethanol 149.54
    sec-butyl acetate 50.26
    tert-butyl acetate 96.23
    decalin 11.58
    glycerin 609.04
    diglyme 312.65
    acrylic acid 589.17
    isopropyl myristate 28.74
    n-butyric acid 414.41
    acetyl acetate 204.6
    di(2-ethylhexyl) phthalate 40.71
    ethyl propionate 93.7
    nitromethane 1597.47
    1,2-diethoxyethane 108.44
    benzonitrile 269.12
    trioctyl phosphate 21.94
    1-bromopropane 283.03
    gamma-valerolactone 765.02
    n-decanol 33.52
    triethyl phosphate 31.26
    4-methyl-2-pentanol 66.15
    propionitrile 465.16
    vinylene carbonate 278.88
    1,1,2-trichlorotrifluoroethane 690.62
    DMS 99.68
    cumene 33.62
    2-octanol 33.62
    2-hexanone 87.85
    octyl acetate 42.0
    limonene 38.59
    1,2-dimethoxyethane 436.9
    ethyl orthosilicate 29.02
    tributyl phosphate 27.98
    diacetone alcohol 168.3
    N,N-dimethylaniline 129.22
    acrylonitrile 717.85
    aniline 457.06
    1,3-propanediol 605.46
    bromobenzene 274.47
    dibromomethane 723.04
    1,1,2,2-tetrachloroethane 758.58
    2-methyl-cyclohexyl acetate 38.56
    tetrabutyl urea 44.46
    diisobutyl methanol 22.44
    2-phenylethanol 113.95
    styrene 98.43
    dioctyl adipate 47.44
    dimethyl sulfate 319.6
    ethyl butyrate 48.26
    methyl lactate 251.8
    butyl lactate 53.98
    diethyl carbonate 35.03
    propanediol butyl ether 120.31
    triethyl orthoformate 37.45
    p-tert-butyltoluene 25.69
    methyl 4-tert-butylbenzoate 101.18
    morpholine 902.51
    tert-butylamine 226.39
    n-dodecanol 23.88
    dimethoxymethane 611.98
    ethylene carbonate 198.85
    cyrene 133.24
    2-ethoxyethyl acetate 106.82
    2-ethylhexyl acetate 30.38
    1,2,4-trichlorobenzene 318.58
    4-methylpyridine 635.38
    dibutyl ether 46.04
    2,6-dimethyl-4-heptanol 22.44
    DEF 439.22
    dimethyl isosorbide 145.65
    tetrachloroethylene 547.97
    eugenol 112.33
    triacetin 105.6
    span 80 95.71
    1,4-butanediol 209.6
    1,1-dichloroethane 732.66
    2-methyl-1-pentanol 123.67
    methyl formate 664.55
    2-methyl-1-butanol 241.48
    n-decane 8.04
    butyronitrile 337.01
    3,7-dimethyl-1-octanol 44.97
    1-chlorooctane 31.51
    1-chlorotetradecane 12.84
    n-nonane 7.6
    undecane 5.88
    tert-butylcyclohexane 9.78
    cyclooctane 8.87
    cyclopentanol 337.43
    tetrahydropyran 390.86
    tert-amyl methyl ether 146.45
    2,5,8-trioxanonane 216.06
    1-hexene 54.81
    2-isopropoxyethanol 191.29
    2,2,2-trifluoroethanol 458.57
    methyl butyrate 122.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction