(2-Methyl-1,3-dioxolan-4-yl)methanol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    3773-93-1

    Molecular formula
    C5H10O3

    SMILES
    CC1OCC(O1)CO

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 89.45%
    Green 68.07%
    Ethereal 62.32%
    Fermented 38.87%
    Alcoholic 33.24%
    Sweet 33.03%
    Buttery 30.91%
    Fresh 28.55%
    Winey 27.83%
    Rummy 24.25%

     

    Flavor
    Sweet 51.29%
    Caramel 43.19%
    Vegetable 42.76%
    Bitter 33.39%
    Fatty 31.48%
    Oily 31.33%
    Musty 29.24%
    Nutty 28.8%
    Roasted 27.18%
    Cauliflower 26.58%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.4

    pKa est.
    7.07 (neutral)

    Molecular weight
    118.13 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    196°C

    Flash point

    • 78.52 ˚C est.

  • Synonyms

    • (2-methyl-1,3-dioxolan-4-yl)methanol
    • 3773-93-1
    • 4-hydroxymethyl-2-methyl-1,3-dioxolane
    • DTXSID60958770
    • 2-Methyl-1,3-dioxolane-4-methanol
    • NSC26598
    • 1,3-Dioxolane-4-methanol, 2-methyl-
    • SCHEMBL343862
    • DTXCID40972651
    • NSC 26598
    • NSC-26598
    • NS00127142
    • F87646
    • EN300-1703369
    • 821-391-1

  • Applications

    For the compound (2-Methyl-1,3-dioxolan-4-yl)methanol (CAS 3773-93-1), common applications include serving as a protecting-group building block in organic synthesis (the 1,3-dioxolane ring acts as a robust acetal protecting group for carbonyls and hydroxyls in carbohydrate and polyol chemistry); functioning as an intermediate in pharmaceutical and agrochemical synthesis, enabling selective transformations with the masked diol-like handle; after deprotection, providing a primary alcohol functionality for downstream coupling; serving as a precursor for polymers and specialty materials (for example as a protected diol-derived building block in polyester or polyurethane chemistries once deprotected); and, in fragrance or flavor research, being evaluated as a possible synthesis intermediate for certain fragrance formulations, depending on formulation constraints and regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 925.49
    methanol 1689.41
    isopropanol 580.9
    water 859.23
    ethyl acetate 178.74
    n-propanol 532.45
    acetone 441.97
    n-butanol 362.86
    acetonitrile 516.66
    DMF 1263.69
    toluene 38.58
    isobutanol 326.11
    1,4-dioxane 400.67
    methyl acetate 246.18
    THF 419.73
    2-butanone 207.7
    n-pentanol 185.97
    sec-butanol 325.48
    n-hexane 6.43
    ethylene glycol 852.32
    NMP 539.98
    cyclohexane 9.66
    DMSO 1300.29
    n-butyl acetate 50.24
    n-octanol 66.82
    chloroform 436.84
    n-propyl acetate 61.06
    acetic acid 1036.08
    dichloromethane 508.71
    cyclohexanone 197.66
    propylene glycol 626.69
    isopropyl acetate 85.91
    DMAc 712.03
    2-ethoxyethanol 497.24
    isopentanol 226.02
    n-heptane 7.87
    ethyl formate 244.1
    1,2-dichloroethane 228.18
    n-hexanol 115.14
    2-methoxyethanol 1112.6
    isobutyl acetate 38.63
    tetrachloromethane 82.87
    n-pentyl acetate 44.95
    transcutol 393.51
    n-heptanol 62.01
    ethylbenzene 17.48
    MIBK 87.19
    2-propoxyethanol 290.12
    tert-butanol 452.72
    MTBE 134.99
    2-butoxyethanol 150.06
    propionic acid 440.49
    o-xylene 36.37
    formic acid 1503.54
    diethyl ether 131.74
    m-xylene 37.06
    p-xylene 25.93
    chlorobenzene 77.55
    dimethyl carbonate 94.47
    n-octane 4.02
    formamide 1073.76
    cyclopentanone 309.97
    2-pentanone 154.89
    anisole 82.91
    cyclopentyl methyl ether 136.63
    gamma-butyrolactone 400.85
    1-methoxy-2-propanol 588.26
    pyridine 211.7
    3-pentanone 96.27
    furfural 457.92
    n-dodecane 4.69
    diethylene glycol 453.38
    diisopropyl ether 30.66
    tert-amyl alcohol 271.8
    acetylacetone 182.53
    n-hexadecane 5.06
    acetophenone 81.8
    methyl propionate 168.92
    isopentyl acetate 44.12
    trichloroethylene 359.06
    n-nonanol 55.45
    cyclohexanol 182.3
    benzyl alcohol 123.92
    2-ethylhexanol 49.36
    isooctanol 48.83
    dipropyl ether 44.58
    1,2-dichlorobenzene 78.59
    ethyl lactate 88.91
    propylene carbonate 174.3
    n-methylformamide 856.2
    2-pentanol 169.24
    n-pentane 10.94
    1-propoxy-2-propanol 153.86
    1-methoxy-2-propyl acetate 86.84
    2-(2-methoxypropoxy) propanol 126.84
    mesitylene 26.13
    ε-caprolactone 175.82
    p-cymene 20.98
    epichlorohydrin 386.04
    1,1,1-trichloroethane 167.49
    2-aminoethanol 915.76
    morpholine-4-carbaldehyde 578.99
    sulfolane 444.13
    2,2,4-trimethylpentane 8.41
    2-methyltetrahydrofuran 226.43
    n-hexyl acetate 66.44
    isooctane 6.58
    2-(2-butoxyethoxy)ethanol 154.59
    sec-butyl acetate 40.47
    tert-butyl acetate 78.29
    decalin 6.61
    glycerin 859.71
    diglyme 289.07
    acrylic acid 477.79
    isopropyl myristate 29.65
    n-butyric acid 370.99
    acetyl acetate 118.27
    di(2-ethylhexyl) phthalate 41.92
    ethyl propionate 62.25
    nitromethane 1073.51
    1,2-diethoxyethane 75.92
    benzonitrile 120.36
    trioctyl phosphate 31.38
    1-bromopropane 106.98
    gamma-valerolactone 462.57
    n-decanol 40.62
    triethyl phosphate 38.69
    4-methyl-2-pentanol 85.26
    propionitrile 248.29
    vinylene carbonate 190.42
    1,1,2-trichlorotrifluoroethane 441.93
    DMS 60.34
    cumene 18.82
    2-octanol 40.31
    2-hexanone 67.97
    octyl acetate 40.33
    limonene 29.31
    1,2-dimethoxyethane 435.17
    ethyl orthosilicate 35.12
    tributyl phosphate 33.82
    diacetone alcohol 166.57
    N,N-dimethylaniline 66.11
    acrylonitrile 366.36
    aniline 145.8
    1,3-propanediol 752.88
    bromobenzene 60.8
    dibromomethane 249.33
    1,1,2,2-tetrachloroethane 261.74
    2-methyl-cyclohexyl acetate 41.25
    tetrabutyl urea 49.3
    diisobutyl methanol 34.99
    2-phenylethanol 80.97
    styrene 24.04
    dioctyl adipate 48.13
    dimethyl sulfate 204.72
    ethyl butyrate 48.2
    methyl lactate 204.01
    butyl lactate 56.36
    diethyl carbonate 37.64
    propanediol butyl ether 143.05
    triethyl orthoformate 41.64
    p-tert-butyltoluene 21.96
    methyl 4-tert-butylbenzoate 86.98
    morpholine 466.74
    tert-butylamine 214.96
    n-dodecanol 31.56
    dimethoxymethane 401.54
    ethylene carbonate 141.3
    cyrene 141.21
    2-ethoxyethyl acetate 66.3
    2-ethylhexyl acetate 32.54
    1,2,4-trichlorobenzene 94.34
    4-methylpyridine 188.48
    dibutyl ether 35.7
    2,6-dimethyl-4-heptanol 34.99
    DEF 244.32
    dimethyl isosorbide 153.76
    tetrachloroethylene 192.91
    eugenol 104.83
    triacetin 79.35
    span 80 100.03
    1,4-butanediol 343.42
    1,1-dichloroethane 228.33
    2-methyl-1-pentanol 125.35
    methyl formate 540.67
    2-methyl-1-butanol 229.65
    n-decane 7.12
    butyronitrile 241.37
    3,7-dimethyl-1-octanol 57.52
    1-chlorooctane 27.84
    1-chlorotetradecane 12.98
    n-nonane 6.55
    undecane 5.48
    tert-butylcyclohexane 7.3
    cyclooctane 4.62
    cyclopentanol 275.76
    tetrahydropyran 177.4
    tert-amyl methyl ether 99.39
    2,5,8-trioxanonane 218.06
    1-hexene 24.59
    2-isopropoxyethanol 231.81
    2,2,2-trifluoroethanol 498.21
    methyl butyrate 92.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction