2-Methoxythiazole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    14542-13-3

    Molecular formula
    C4H5NOS

    SMILES
    COC1=NC=CS1

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Nutty 57.65%
    Green 51.91%
    Vegetable 50.97%
    Roasted 46.17%
    Sulfurous 43.93%
    Meaty 43.18%
    Burnt 39.3%
    Coffee 37.32%
    Earthy 36.19%
    Sweet 34.17%

     

    Flavor
    Nutty 67.05%
    Green 58.16%
    Sweet 42.13%
    Earthy 38.83%
    Vegetable 38.09%
    Coffee 36.61%
    Roasted 32.25%
    Cocoa 26.59%
    Potato 25.99%
    Musty 25.47%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    6.37 (neutral)

    Molecular weight
    115.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    166°C

    Flash point

    • 56.26 ˚C est.

  • Synonyms

    • 2-Methoxythiazole
    • 14542-13-3
    • Thiazole, 2-methoxy-
    • 2-Methoxy-1,3-thiazole
    • DTXSID60341744
    • MFCD01631143
    • 2-Methoxy-1,3-thiazole #
    • SCHEMBL303744
    • DTXCID20292824
    • 2-Methoxy-1,3-thiazole, 97%
    • BBL037422
    • STL414555
    • AKOS006223670
    • AB09330
    • CS-W005816
    • AS-50080
    • DB-021309
    • M1753
    • EN300-174552
    • O10826
    • 623-710-8

  • Applications

    2-Methoxythiazole (CAS 14542-13-3) is primarily viewed as a versatile intermediate for the synthesis of heterocyclic thiazole compounds, serving as a building block for derivatives in pharmaceutical and agrochemical R&D. In organic synthesis, it is commonly employed as an intermediate to introduce a 2-methoxy thiazole moiety, enabling diverse synthetic sequences. In materials science, it functions as a precursor for thiazole-containing polymers and functional materials with potential applications in coatings, adhesives, and organic electronic platforms. In the field of colorants, it can be converted into thiazole-containing dyes or pigment precursors for coatings and inks. Applications are typically considered within pharmaceutical, agrochemical, polymer/materials, and colorant spaces, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 232.32
    methanol 359.95
    isopropanol 164.19
    water 12.12
    ethyl acetate 266.74
    n-propanol 180.64
    acetone 450.81
    n-butanol 177.2
    acetonitrile 368.34
    DMF 723.29
    toluene 158.54
    isobutanol 138.52
    1,4-dioxane 462.5
    methyl acetate 273.0
    THF 626.95
    2-butanone 306.53
    n-pentanol 162.4
    sec-butanol 145.84
    n-hexane 23.62
    ethylene glycol 105.01
    NMP 583.98
    cyclohexane 42.17
    DMSO 740.71
    n-butyl acetate 159.65
    n-octanol 63.97
    chloroform 624.39
    n-propyl acetate 187.33
    acetic acid 417.85
    dichloromethane 722.04
    cyclohexanone 360.77
    propylene glycol 74.94
    isopropyl acetate 161.52
    DMAc 482.54
    2-ethoxyethanol 412.16
    isopentanol 160.51
    n-heptane 28.89
    ethyl formate 249.17
    1,2-dichloroethane 399.51
    n-hexanol 107.94
    2-methoxyethanol 545.92
    isobutyl acetate 117.9
    tetrachloromethane 161.03
    n-pentyl acetate 116.69
    transcutol 559.95
    n-heptanol 66.55
    ethylbenzene 78.79
    MIBK 169.96
    2-propoxyethanol 258.91
    tert-butanol 238.82
    MTBE 221.09
    2-butoxyethanol 159.05
    propionic acid 165.81
    o-xylene 103.75
    formic acid 299.0
    diethyl ether 263.49
    m-xylene 105.58
    p-xylene 113.69
    chlorobenzene 237.32
    dimethyl carbonate 149.57
    n-octane 13.0
    formamide 424.89
    cyclopentanone 475.23
    2-pentanone 264.29
    anisole 232.34
    cyclopentyl methyl ether 264.72
    gamma-butyrolactone 487.48
    1-methoxy-2-propanol 321.34
    pyridine 433.51
    3-pentanone 205.13
    furfural 624.15
    n-dodecane 11.01
    diethylene glycol 236.81
    diisopropyl ether 92.6
    tert-amyl alcohol 187.98
    acetylacetone 336.58
    n-hexadecane 12.54
    acetophenone 217.44
    methyl propionate 205.49
    isopentyl acetate 145.06
    trichloroethylene 785.07
    n-nonanol 62.52
    cyclohexanol 164.2
    benzyl alcohol 178.52
    2-ethylhexanol 84.99
    isooctanol 61.83
    dipropyl ether 142.91
    1,2-dichlorobenzene 213.15
    ethyl lactate 95.58
    propylene carbonate 242.27
    n-methylformamide 398.36
    2-pentanol 121.27
    n-pentane 32.25
    1-propoxy-2-propanol 169.29
    1-methoxy-2-propyl acetate 173.68
    2-(2-methoxypropoxy) propanol 166.99
    mesitylene 79.67
    ε-caprolactone 277.1
    p-cymene 61.25
    epichlorohydrin 611.93
    1,1,1-trichloroethane 385.36
    2-aminoethanol 158.92
    morpholine-4-carbaldehyde 639.41
    sulfolane 535.88
    2,2,4-trimethylpentane 22.44
    2-methyltetrahydrofuran 422.54
    n-hexyl acetate 125.76
    isooctane 17.16
    2-(2-butoxyethoxy)ethanol 219.41
    sec-butyl acetate 118.83
    tert-butyl acetate 183.6
    decalin 25.65
    glycerin 152.84
    diglyme 473.6
    acrylic acid 195.22
    isopropyl myristate 69.51
    n-butyric acid 228.68
    acetyl acetate 192.17
    di(2-ethylhexyl) phthalate 69.86
    ethyl propionate 159.93
    nitromethane 741.75
    1,2-diethoxyethane 252.81
    benzonitrile 259.99
    trioctyl phosphate 49.75
    1-bromopropane 197.64
    gamma-valerolactone 621.88
    n-decanol 50.48
    triethyl phosphate 88.51
    4-methyl-2-pentanol 79.73
    propionitrile 236.17
    vinylene carbonate 257.36
    1,1,2-trichlorotrifluoroethane 393.78
    DMS 124.04
    cumene 62.94
    2-octanol 51.42
    2-hexanone 190.52
    octyl acetate 80.05
    limonene 85.41
    1,2-dimethoxyethane 580.69
    ethyl orthosilicate 88.39
    tributyl phosphate 64.33
    diacetone alcohol 204.87
    N,N-dimethylaniline 171.21
    acrylonitrile 314.99
    aniline 208.28
    1,3-propanediol 228.54
    bromobenzene 239.48
    dibromomethane 395.12
    1,1,2,2-tetrachloroethane 450.16
    2-methyl-cyclohexyl acetate 121.73
    tetrabutyl urea 92.64
    diisobutyl methanol 65.69
    2-phenylethanol 131.3
    styrene 116.92
    dioctyl adipate 99.34
    dimethyl sulfate 235.29
    ethyl butyrate 161.64
    methyl lactate 122.48
    butyl lactate 86.29
    diethyl carbonate 114.91
    propanediol butyl ether 123.25
    triethyl orthoformate 123.63
    p-tert-butyltoluene 60.86
    methyl 4-tert-butylbenzoate 159.9
    morpholine 487.32
    tert-butylamine 146.44
    n-dodecanol 42.23
    dimethoxymethane 479.3
    ethylene carbonate 207.55
    cyrene 211.7
    2-ethoxyethyl acetate 173.62
    2-ethylhexyl acetate 121.17
    1,2,4-trichlorobenzene 244.44
    4-methylpyridine 392.84
    dibutyl ether 110.06
    2,6-dimethyl-4-heptanol 65.69
    DEF 340.48
    dimethyl isosorbide 283.56
    tetrachloroethylene 334.12
    eugenol 167.54
    triacetin 154.79
    span 80 122.27
    1,4-butanediol 125.12
    1,1-dichloroethane 365.55
    2-methyl-1-pentanol 140.48
    methyl formate 350.27
    2-methyl-1-butanol 145.32
    n-decane 17.27
    butyronitrile 258.72
    3,7-dimethyl-1-octanol 77.4
    1-chlorooctane 55.01
    1-chlorotetradecane 28.44
    n-nonane 16.46
    undecane 13.27
    tert-butylcyclohexane 25.16
    cyclooctane 19.0
    cyclopentanol 192.03
    tetrahydropyran 329.79
    tert-amyl methyl ether 180.91
    2,5,8-trioxanonane 333.74
    1-hexene 72.86
    2-isopropoxyethanol 250.55
    2,2,2-trifluoroethanol 203.8
    methyl butyrate 210.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction