2-Methoxypropanal

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  • Identifiers

    CAS number
    6142-38-7

    Molecular formula
    C4H8O2

    SMILES
    CC(C=O)OC

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Ethereal 70.06%
    Fruity 65.82%
    Green 55.54%
    Pungent 50.37%
    Nutty 45.74%
    Alcoholic 44.48%
    Sweet 44.47%
    Fresh 41.99%
    Fermented 39.75%
    Sharp 39.68%

     

    Flavor
    Pungent 54.26%
    Ethereal 47.19%
    Nutty 45.64%
    Green 41.2%
    Musty 39.89%
    Sweet 38.37%
    Earthy 35.54%
    Cocoa 33.98%
    Fruity 33.49%
    Ether 33.38%

     

    Odor impact est.
    High

  • Properties

    pKa est.
    5.92 (weak acid)

    Molecular weight
    88.11 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    96°C

    Flash point

    • 13.08 ˚C est.

  • Synonyms

    • 2-Methoxypropanal
    • 2-Methoxypropionaldehyde
    • 2-Methoxypropional
    • Propanal, 2-methoxy-
    • Propionaldehyde, 2-methoxy-
    • BRN 1699103
    • DTXSID40976977
    • 4-01-00-03967 (Beilstein Handbook Reference)
    • RefChem:87942
    • DTXCID801404342
    • 863-585-9
    • 6142-38-7
    • Methoxypropanal
    • SCHEMBL57048
    • SCHEMBL414176
    • SCHEMBL748666
    • GAA14238
    • CS-0437758
    • EN300-223023
    • 6142-38-7

  • Applications

    2-Methoxypropanal (CAS 6142-38-7) is primarily used as a reactive aldehyde intermediate in organic synthesis for fragrance and flavor chemistry, serving as a building block toward more complex aroma compounds and specialty materials. In perfumery and cosmetics, it is commonly evaluated as a scent precursor and can be further derivatized to longer-chain aldehydes. It may also be encountered in household products as an odorant component within formulated fragrances and cleaners. In industrial manufacturing, it serves as a versatile intermediate for polymer and resin chemistries, coatings and inks, and adhesive formulations, enabling functionalization and crosslinking. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 161.54
    methanol 267.74
    isopropanol 87.62
    water 51.66
    ethyl acetate 66.33
    n-propanol 103.24
    acetone 85.23
    n-butanol 86.43
    acetonitrile 166.48
    DMF 188.64
    toluene 14.42
    isobutanol 70.6
    1,4-dioxane 166.66
    methyl acetate 111.48
    THF 118.21
    2-butanone 72.14
    n-pentanol 40.0
    sec-butanol 86.93
    n-hexane 3.4
    ethylene glycol 129.63
    NMP 180.53
    cyclohexane 9.82
    DMSO 215.18
    n-butyl acetate 28.28
    n-octanol 20.97
    chloroform 186.68
    n-propyl acetate 23.63
    acetic acid 403.91
    dichloromethane 193.3
    cyclohexanone 96.22
    propylene glycol 104.36
    isopropyl acetate 23.28
    DMAc 179.63
    2-ethoxyethanol 114.31
    isopentanol 57.91
    n-heptane 4.5
    ethyl formate 72.3
    1,2-dichloroethane 91.45
    n-hexanol 36.9
    2-methoxyethanol 226.93
    isobutyl acetate 13.21
    tetrachloromethane 48.05
    n-pentyl acetate 18.83
    transcutol 247.91
    n-heptanol 19.41
    ethylbenzene 8.62
    MIBK 18.0
    2-propoxyethanol 79.39
    tert-butanol 110.29
    MTBE 44.45
    2-butoxyethanol 47.53
    propionic acid 185.15
    o-xylene 19.69
    formic acid 376.37
    diethyl ether 36.96
    m-xylene 11.31
    p-xylene 15.31
    chlorobenzene 36.56
    dimethyl carbonate 21.11
    n-octane 1.93
    formamide 350.8
    cyclopentanone 102.47
    2-pentanone 34.73
    anisole 33.32
    cyclopentyl methyl ether 41.16
    gamma-butyrolactone 158.87
    1-methoxy-2-propanol 102.87
    pyridine 128.39
    3-pentanone 34.27
    furfural 213.27
    n-dodecane 1.83
    diethylene glycol 119.88
    diisopropyl ether 7.62
    tert-amyl alcohol 101.32
    acetylacetone 51.01
    n-hexadecane 1.95
    acetophenone 36.82
    methyl propionate 52.44
    isopentyl acetate 25.5
    trichloroethylene 198.51
    n-nonanol 18.44
    cyclohexanol 79.07
    benzyl alcohol 44.4
    2-ethylhexanol 24.47
    isooctanol 16.46
    dipropyl ether 17.0
    1,2-dichlorobenzene 45.5
    ethyl lactate 27.21
    propylene carbonate 73.41
    n-methylformamide 159.65
    2-pentanol 40.11
    n-pentane 4.45
    1-propoxy-2-propanol 49.48
    1-methoxy-2-propyl acetate 34.36
    2-(2-methoxypropoxy) propanol 67.46
    mesitylene 8.66
    ε-caprolactone 97.19
    p-cymene 11.34
    epichlorohydrin 141.9
    1,1,1-trichloroethane 93.44
    2-aminoethanol 165.28
    morpholine-4-carbaldehyde 194.05
    sulfolane 171.57
    2,2,4-trimethylpentane 4.34
    2-methyltetrahydrofuran 102.04
    n-hexyl acetate 30.53
    isooctane 1.79
    2-(2-butoxyethoxy)ethanol 75.98
    sec-butyl acetate 14.99
    tert-butyl acetate 25.09
    decalin 4.41
    glycerin 164.63
    diglyme 133.31
    acrylic acid 196.19
    isopropyl myristate 12.31
    n-butyric acid 137.51
    acetyl acetate 51.97
    di(2-ethylhexyl) phthalate 20.38
    ethyl propionate 25.12
    nitromethane 431.1
    1,2-diethoxyethane 43.4
    benzonitrile 52.54
    trioctyl phosphate 11.97
    1-bromopropane 35.8
    gamma-valerolactone 174.54
    n-decanol 13.49
    triethyl phosphate 22.03
    4-methyl-2-pentanol 18.56
    propionitrile 82.92
    vinylene carbonate 82.74
    1,1,2-trichlorotrifluoroethane 205.57
    DMS 34.91
    cumene 9.63
    2-octanol 12.24
    2-hexanone 21.18
    octyl acetate 17.45
    limonene 18.36
    1,2-dimethoxyethane 110.85
    ethyl orthosilicate 20.16
    tributyl phosphate 16.68
    diacetone alcohol 51.99
    N,N-dimethylaniline 26.81
    acrylonitrile 131.5
    aniline 59.14
    1,3-propanediol 159.62
    bromobenzene 28.16
    dibromomethane 105.14
    1,1,2,2-tetrachloroethane 141.6
    2-methyl-cyclohexyl acetate 27.22
    tetrabutyl urea 21.07
    diisobutyl methanol 13.76
    2-phenylethanol 35.84
    styrene 11.84
    dioctyl adipate 26.89
    dimethyl sulfate 47.23
    ethyl butyrate 27.54
    methyl lactate 49.64
    butyl lactate 24.89
    diethyl carbonate 24.3
    propanediol butyl ether 50.0
    triethyl orthoformate 23.38
    p-tert-butyltoluene 10.65
    methyl 4-tert-butylbenzoate 39.03
    morpholine 194.2
    tert-butylamine 58.7
    n-dodecanol 10.59
    dimethoxymethane 55.37
    ethylene carbonate 57.94
    cyrene 62.97
    2-ethoxyethyl acetate 35.39
    2-ethylhexyl acetate 20.08
    1,2,4-trichlorobenzene 64.15
    4-methylpyridine 76.98
    dibutyl ether 16.74
    2,6-dimethyl-4-heptanol 13.76
    DEF 72.41
    dimethyl isosorbide 84.86
    tetrachloroethylene 136.35
    eugenol 45.18
    triacetin 47.37
    span 80 51.96
    1,4-butanediol 59.38
    1,1-dichloroethane 79.53
    2-methyl-1-pentanol 39.33
    methyl formate 104.04
    2-methyl-1-butanol 68.62
    n-decane 2.84
    butyronitrile 63.18
    3,7-dimethyl-1-octanol 22.67
    1-chlorooctane 10.66
    1-chlorotetradecane 4.82
    n-nonane 2.67
    undecane 2.17
    tert-butylcyclohexane 4.19
    cyclooctane 2.82
    cyclopentanol 87.76
    tetrahydropyran 87.77
    tert-amyl methyl ether 37.99
    2,5,8-trioxanonane 105.89
    1-hexene 10.12
    2-isopropoxyethanol 57.95
    2,2,2-trifluoroethanol 189.93
    methyl butyrate 37.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction