2-Methoxyphenylacetone

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  • Identifiers

    CAS number
    5211-62-1

    Molecular formula
    C10H12O2

    SMILES
    CC(=O)CC1=CC=CC=C1OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 75.93%
    Sweet 75.48%
    Floral 49.6%
    Spicy 45.89%
    Vanilla 45.3%
    Woody 44.35%
    Caramellic 42.77%
    Balsamic 41.83%
    Berry 38.12%
    Green 36.64%

     

    Flavor
    Sweet 87.82%
    Fruity 65.77%
    Spicy 58.76%
    Floral 43.9%
    Balsam 39.58%
    Powdery 37.63%
    Woody 35.22%
    Vanilla 34.1%
    Cherry 33.35%
    Raspberry 32.29%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    7.27 (neutral)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    251°C

    Flash point

    • 107.89 ˚C est.

  • Synonyms

    • 2-Methoxyphenylacetone
    • 1-(2-methoxyphenyl)propan-2-one
    • (2-methoxyphenyl)acetone
    • o-Methoxy phenyl acetone
    • 1-(2-Methoxyphenyl)-2-propanone
    • 2-Propanone, 1-(2-methoxyphenyl)-
    • UNII-C38517JK47
    • EINECS 226-008-6
    • C38517JK47
    • (O-METHOXYPHENYL)ACETONE
    • DTXSID20200121
    • RefChem:87941
    • DTXCID20122612
    • 226-008-6
    • GMBFNZCPZFVKAT-UHFFFAOYSA-N
    • 5211-62-1
    • MFCD00008770
    • 2-Methoxybenzyl methyl ketone
    • 1-(2-Methoxyphenyl)acetone
    • o-Anisylacetone
    • 2-Acetonylanisole
    • o-Methoxyphenylaceton
    • 2-methoxyphenyl acetone
    • SCHEMBL266821
    • 1-(2-Methoxyphenyl)acetone #
    • orb3023256
    • SCHEMBL2768673
    • SCHEMBL28078108
    • SCHEMBL28145584
    • SCHEMBL29737506
    • 1-(2-methoxyphenyl)-propan-2-one
    • BB_NC-02173
    • 1-(2'-Methoxyphenyl)-2-propanone
    • BBL027726
    • STL372960
    • AKOS000120868
    • AC-5624
    • CS-W017906
    • FM71068
    • 31116-84-4
    • PD151335
    • VS-08584
    • DB-021306
    • M0794
    • NS00032425
    • ST50407446
    • EN300-20819
    • N11926
    • F238890
    • Q27275136
    • 5211-62-1

  • Applications

    2-Methoxyphenylacetone (CAS 5211-62-1) is primarily used as an intermediate in organic synthesis, providing a building block for substituted arylacetone derivatives used in pharmaceutical and specialty chemicals; in the cosmetics and personal care sector, it is considered a fragrance intermediate; in polymers and plastics, it participates in the synthesis of aryl ketone derivatives for resins and materials; in coatings and inks, it can serve as a precursor for functional coating systems and formulations; its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 522.95
    methanol 764.25
    isopropanol 330.84
    water 8.6
    ethyl acetate 338.48
    n-propanol 331.14
    acetone 408.31
    n-butanol 274.79
    acetonitrile 590.38
    DMF 580.06
    toluene 193.6
    isobutanol 227.31
    1,4-dioxane 853.07
    methyl acetate 424.47
    THF 595.98
    2-butanone 317.84
    n-pentanol 189.87
    sec-butanol 243.26
    n-hexane 26.27
    ethylene glycol 265.26
    NMP 434.24
    cyclohexane 73.9
    DMSO 626.29
    n-butyl acetate 185.94
    n-octanol 118.96
    chloroform 1153.02
    n-propyl acetate 180.33
    acetic acid 396.0
    dichloromethane 1380.14
    cyclohexanone 410.97
    propylene glycol 189.47
    isopropyl acetate 135.1
    DMAc 550.66
    2-ethoxyethanol 365.96
    isopentanol 184.16
    n-heptane 40.24
    ethyl formate 316.98
    1,2-dichloroethane 604.25
    n-hexanol 211.64
    2-methoxyethanol 583.09
    isobutyl acetate 108.99
    tetrachloromethane 162.75
    n-pentyl acetate 99.89
    transcutol 600.52
    n-heptanol 92.54
    ethylbenzene 127.06
    MIBK 123.62
    2-propoxyethanol 343.01
    tert-butanol 367.73
    MTBE 219.51
    2-butoxyethanol 165.99
    propionic acid 286.12
    o-xylene 144.66
    formic acid 204.2
    diethyl ether 284.54
    m-xylene 130.97
    p-xylene 149.75
    chlorobenzene 254.84
    dimethyl carbonate 147.23
    n-octane 17.69
    formamide 289.17
    cyclopentanone 393.51
    2-pentanone 215.55
    anisole 277.25
    cyclopentyl methyl ether 248.26
    gamma-butyrolactone 495.57
    1-methoxy-2-propanol 321.55
    pyridine 438.4
    3-pentanone 199.03
    furfural 480.35
    n-dodecane 18.92
    diethylene glycol 359.91
    diisopropyl ether 63.14
    tert-amyl alcohol 252.67
    acetylacetone 245.17
    n-hexadecane 20.94
    acetophenone 227.67
    methyl propionate 271.22
    isopentyl acetate 143.86
    trichloroethylene 958.51
    n-nonanol 102.76
    cyclohexanol 243.87
    benzyl alcohol 218.33
    2-ethylhexanol 126.17
    isooctanol 75.55
    dipropyl ether 169.94
    1,2-dichlorobenzene 239.88
    ethyl lactate 125.28
    propylene carbonate 295.03
    n-methylformamide 355.43
    2-pentanol 143.81
    n-pentane 31.18
    1-propoxy-2-propanol 198.97
    1-methoxy-2-propyl acetate 186.33
    2-(2-methoxypropoxy) propanol 190.51
    mesitylene 76.97
    ε-caprolactone 334.72
    p-cymene 83.93
    epichlorohydrin 653.38
    1,1,1-trichloroethane 490.92
    2-aminoethanol 313.08
    morpholine-4-carbaldehyde 557.1
    sulfolane 489.89
    2,2,4-trimethylpentane 17.4
    2-methyltetrahydrofuran 414.73
    n-hexyl acetate 173.65
    isooctane 11.93
    2-(2-butoxyethoxy)ethanol 241.77
    sec-butyl acetate 112.27
    tert-butyl acetate 136.24
    decalin 33.99
    glycerin 259.33
    diglyme 466.97
    acrylic acid 270.21
    isopropyl myristate 88.68
    n-butyric acid 280.33
    acetyl acetate 216.77
    di(2-ethylhexyl) phthalate 87.91
    ethyl propionate 175.12
    nitromethane 597.44
    1,2-diethoxyethane 231.65
    benzonitrile 261.22
    trioctyl phosphate 64.47
    1-bromopropane 326.72
    gamma-valerolactone 503.24
    n-decanol 84.19
    triethyl phosphate 105.53
    4-methyl-2-pentanol 76.75
    propionitrile 344.27
    vinylene carbonate 331.05
    1,1,2-trichlorotrifluoroethane 390.08
    DMS 178.86
    cumene 88.56
    2-octanol 66.17
    2-hexanone 175.28
    octyl acetate 113.02
    limonene 115.09
    1,2-dimethoxyethane 591.08
    ethyl orthosilicate 96.49
    tributyl phosphate 80.37
    diacetone alcohol 176.5
    N,N-dimethylaniline 183.32
    acrylonitrile 396.74
    aniline 223.84
    1,3-propanediol 345.59
    bromobenzene 264.97
    dibromomethane 782.71
    1,1,2,2-tetrachloroethane 658.34
    2-methyl-cyclohexyl acetate 144.87
    tetrabutyl urea 111.89
    diisobutyl methanol 74.0
    2-phenylethanol 185.77
    styrene 157.26
    dioctyl adipate 131.31
    dimethyl sulfate 206.31
    ethyl butyrate 187.06
    methyl lactate 148.52
    butyl lactate 96.11
    diethyl carbonate 159.75
    propanediol butyl ether 160.42
    triethyl orthoformate 123.95
    p-tert-butyltoluene 77.37
    methyl 4-tert-butylbenzoate 171.28
    morpholine 738.28
    tert-butylamine 213.96
    n-dodecanol 71.09
    dimethoxymethane 388.87
    ethylene carbonate 269.99
    cyrene 197.69
    2-ethoxyethyl acetate 161.97
    2-ethylhexyl acetate 116.11
    1,2,4-trichlorobenzene 268.38
    4-methylpyridine 399.35
    dibutyl ether 130.83
    2,6-dimethyl-4-heptanol 74.0
    DEF 290.66
    dimethyl isosorbide 286.6
    tetrachloroethylene 431.71
    eugenol 179.52
    triacetin 193.03
    span 80 152.42
    1,4-butanediol 171.69
    1,1-dichloroethane 551.51
    2-methyl-1-pentanol 153.74
    methyl formate 335.99
    2-methyl-1-butanol 192.24
    n-decane 28.31
    butyronitrile 311.49
    3,7-dimethyl-1-octanol 106.53
    1-chlorooctane 91.61
    1-chlorotetradecane 46.14
    n-nonane 28.5
    undecane 22.45
    tert-butylcyclohexane 30.7
    cyclooctane 22.35
    cyclopentanol 242.05
    tetrahydropyran 534.42
    tert-amyl methyl ether 160.53
    2,5,8-trioxanonane 351.46
    1-hexene 96.72
    2-isopropoxyethanol 227.06
    2,2,2-trifluoroethanol 176.78
    methyl butyrate 238.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction