2-(Methoxymethyl)pyridine

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  • Identifiers

    CAS number
    23579-92-2

    Molecular formula
    C7H9NO

    SMILES
    COCC1=CC=CC=N1

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 77.16%
    Earthy 53.95%
    Nutty 50.43%
    Roasted 39.48%
    Vegetable 38.16%
    Almond 37.06%
    Fresh 34.22%
    Musty 32.87%
    Burnt 32.06%
    Sweet 30.44%

     

    Flavor
    Nutty 46.13%
    Roasted 44.97%
    Coffee 42.39%
    Green 36.61%
    Vegetable 31.46%
    Earthy 30.99%
    Bitter 30.39%
    Oily 29.74%
    Fatty 29.16%
    Chocolate 28.35%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.6

    pKa est.
    3.78 (weak acid)

    Molecular weight
    123.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    193°C

    Flash point

    • 62.34 ˚C est.

  • Synonyms

    • 2-(methoxymethyl)pyridine
    • 23579-92-2
    • Pyridine, 2-(methoxymethyl)-
    • DTXSID90291485
    • RefChem:254272
    • DTXCID40242629
    • 607-248-4
    • MFCD00030825
    • Pyridine, methoxymethyl-
    • 2-methoxymethylpyridine
    • NSC75841
    • 2-(CH3OCH2)-pyridine
    • SCHEMBL303388
    • SCHEMBL754866
    • SCHEMBL1555045
    • SCHEMBL1923725
    • SCHEMBL2066976
    • SCHEMBL3343033
    • SCHEMBL3391020
    • SCHEMBL3391021
    • SCHEMBL4593515
    • SCHEMBL4593517
    • SCHEMBL5285310
    • SCHEMBL10205402
    • SCHEMBL29424113
    • NSC 75841
    • NSC-75841
    • AKOS006345688
    • DS-0793
    • PS-3671
    • SY009122
    • DB-046187
    • CS-0150187
    • NS00124630
    • F077656
    • 23579-92-2

  • Applications

    2-(Methoxymethyl)pyridine (CAS 23579-92-2) is mainly used as a building block in organic synthesis, providing a pyridyl-methyl scaffold for constructing diverse heterocyclic compounds in pharmaceutical and agrochemical development. It is commonly evaluated as an intermediate for generating pyridine-based derivatives to populate medicinal-chemistry libraries and to enable lead optimization, while also serving as a platform for preparing pyridine-containing materials and ligands for transition-metal catalysis in industrial settings. Additionally, it can function as a versatile starting material in polymer and materials chemistry to access pyridine-functionalized monomers and coordination systems, and in research as a reusable scaffold for multi-step synthetic sequences.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 448.65
    methanol 480.0
    isopropanol 239.18
    water 27.85
    ethyl acetate 133.85
    n-propanol 302.33
    acetone 175.18
    n-butanol 204.98
    acetonitrile 348.17
    DMF 527.51
    toluene 80.95
    isobutanol 196.21
    1,4-dioxane 356.39
    methyl acetate 175.47
    THF 272.46
    2-butanone 140.63
    n-pentanol 124.25
    sec-butanol 191.78
    n-hexane 10.77
    ethylene glycol 295.11
    NMP 374.67
    cyclohexane 46.84
    DMSO 664.32
    n-butyl acetate 113.18
    n-octanol 70.61
    chloroform 919.73
    n-propyl acetate 87.87
    acetic acid 743.52
    dichloromethane 954.97
    cyclohexanone 259.89
    propylene glycol 219.96
    isopropyl acetate 50.94
    DMAc 316.75
    2-ethoxyethanol 240.64
    isopentanol 119.43
    n-heptane 33.54
    ethyl formate 207.11
    1,2-dichloroethane 379.27
    n-hexanol 164.63
    2-methoxyethanol 474.42
    isobutyl acetate 51.08
    tetrachloromethane 158.54
    n-pentyl acetate 50.88
    transcutol 404.84
    n-heptanol 78.28
    ethylbenzene 41.16
    MIBK 45.17
    2-propoxyethanol 236.55
    tert-butanol 215.71
    MTBE 77.05
    2-butoxyethanol 135.62
    propionic acid 366.66
    o-xylene 73.63
    formic acid 408.92
    diethyl ether 88.53
    m-xylene 56.62
    p-xylene 58.8
    chlorobenzene 183.13
    dimethyl carbonate 69.15
    n-octane 9.95
    formamide 425.69
    cyclopentanone 253.95
    2-pentanone 81.96
    anisole 99.35
    cyclopentyl methyl ether 128.22
    gamma-butyrolactone 353.93
    1-methoxy-2-propanol 252.59
    pyridine 396.74
    3-pentanone 75.06
    furfural 483.76
    n-dodecane 9.1
    diethylene glycol 285.31
    diisopropyl ether 21.09
    tert-amyl alcohol 165.73
    acetylacetone 95.36
    n-hexadecane 9.84
    acetophenone 105.16
    methyl propionate 136.81
    isopentyl acetate 80.88
    trichloroethylene 724.33
    n-nonanol 59.99
    cyclohexanol 201.55
    benzyl alcohol 139.98
    2-ethylhexanol 99.04
    isooctanol 59.8
    dipropyl ether 98.24
    1,2-dichlorobenzene 169.28
    ethyl lactate 85.2
    propylene carbonate 217.92
    n-methylformamide 427.16
    2-pentanol 94.59
    n-pentane 16.2
    1-propoxy-2-propanol 169.74
    1-methoxy-2-propyl acetate 90.49
    2-(2-methoxypropoxy) propanol 116.02
    mesitylene 36.03
    ε-caprolactone 208.29
    p-cymene 52.43
    epichlorohydrin 370.35
    1,1,1-trichloroethane 312.45
    2-aminoethanol 371.39
    morpholine-4-carbaldehyde 382.65
    sulfolane 436.28
    2,2,4-trimethylpentane 12.27
    2-methyltetrahydrofuran 208.71
    n-hexyl acetate 76.91
    isooctane 7.78
    2-(2-butoxyethoxy)ethanol 154.03
    sec-butyl acetate 41.59
    tert-butyl acetate 48.54
    decalin 17.44
    glycerin 331.07
    diglyme 312.16
    acrylic acid 388.25
    isopropyl myristate 33.96
    n-butyric acid 328.91
    acetyl acetate 87.22
    di(2-ethylhexyl) phthalate 52.14
    ethyl propionate 73.97
    nitromethane 677.41
    1,2-diethoxyethane 98.06
    benzonitrile 207.01
    trioctyl phosphate 37.46
    1-bromopropane 172.08
    gamma-valerolactone 342.87
    n-decanol 47.19
    triethyl phosphate 63.7
    4-methyl-2-pentanol 43.36
    propionitrile 247.72
    vinylene carbonate 261.63
    1,1,2-trichlorotrifluoroethane 439.67
    DMS 72.81
    cumene 36.48
    2-octanol 41.28
    2-hexanone 67.1
    octyl acetate 50.17
    limonene 78.96
    1,2-dimethoxyethane 281.92
    ethyl orthosilicate 60.07
    tributyl phosphate 43.44
    diacetone alcohol 95.65
    N,N-dimethylaniline 82.25
    acrylonitrile 363.3
    aniline 190.09
    1,3-propanediol 342.87
    bromobenzene 173.93
    dibromomethane 580.97
    1,1,2,2-tetrachloroethane 539.72
    2-methyl-cyclohexyl acetate 75.09
    tetrabutyl urea 64.68
    diisobutyl methanol 49.11
    2-phenylethanol 122.21
    styrene 57.71
    dioctyl adipate 64.07
    dimethyl sulfate 126.87
    ethyl butyrate 106.08
    methyl lactate 122.25
    butyl lactate 69.98
    diethyl carbonate 88.42
    propanediol butyl ether 123.46
    triethyl orthoformate 80.5
    p-tert-butyltoluene 47.65
    methyl 4-tert-butylbenzoate 97.45
    morpholine 399.29
    tert-butylamine 127.56
    n-dodecanol 39.63
    dimethoxymethane 184.22
    ethylene carbonate 193.85
    cyrene 128.71
    2-ethoxyethyl acetate 72.11
    2-ethylhexyl acetate 63.18
    1,2,4-trichlorobenzene 203.09
    4-methylpyridine 249.98
    dibutyl ether 55.85
    2,6-dimethyl-4-heptanol 49.11
    DEF 175.95
    dimethyl isosorbide 168.39
    tetrachloroethylene 420.6
    eugenol 106.84
    triacetin 92.72
    span 80 111.32
    1,4-butanediol 156.0
    1,1-dichloroethane 326.33
    2-methyl-1-pentanol 86.76
    methyl formate 306.4
    2-methyl-1-butanol 144.28
    n-decane 12.97
    butyronitrile 218.58
    3,7-dimethyl-1-octanol 64.37
    1-chlorooctane 45.83
    1-chlorotetradecane 21.64
    n-nonane 13.18
    undecane 10.47
    tert-butylcyclohexane 14.98
    cyclooctane 13.04
    cyclopentanol 236.3
    tetrahydropyran 237.95
    tert-amyl methyl ether 63.42
    2,5,8-trioxanonane 218.46
    1-hexene 38.86
    2-isopropoxyethanol 136.33
    2,2,2-trifluoroethanol 265.17
    methyl butyrate 113.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction