2-Methoxymethyl-p-phenylenediamine

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  • Identifiers

    CAS number
    337906-36-2

    Molecular formula
    C8H12N2O

    SMILES
    COCC1=C(C=CC(=C1)N)N

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 44.56%
    Grape 39.12%
    Floral 33.49%
    Fruity 32.04%
    Animal 31.81%
    Cheesy 26.29%
    Meaty 26.22%
    Burnt 25.81%
    Musty 25.24%
    Ripe 23.32%

     

    Flavor
    Fruity 49.17%
    Floral 37.2%
    Bitter 35.79%
    Sweet 35.63%
    Meaty 33.48%
    Mild 31.83%
    Roasted 30.18%
    Coffee 28.95%
    Sulfurous 28.75%
    Powdery 23.74%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.2

    pKa est.
    2.7 (strong acid)

    Molecular weight
    152.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    304°C

    Flash point

    • 155.44 ˚C est.

  • Synonyms

    • 337906-36-2
    • 2-Methoxymethyl-p-phenylenediamine
    • 1,4-Benzenediamine, 2-(methoxymethyl)-
    • 1,4-Diamino-2-(methoxymethyl)benzene
    • 5982W4U40M
    • DTXSID50187451
    • ME-PPD compound
    • RefChem:87934
    • DTXCID60109942
    • 679-526-3
    • 2-(methoxymethyl)benzene-1,4-diamine
    • MFCD20690892
    • UNII-5982W4U40M
    • 2-Methoxymethyl-p-phenylenediamine [INCI]
    • EC 679-526-3
    • SCHEMBL108757
    • SCHEMBL29354986
    • 2-methoxymethyl-1,4-benzenediamine
    • AKOS027250641
    • SB76075
    • DS-18961
    • SY344744
    • CS-0161584
    • NS00010060
    • C74735
    • Q27261675
    • 337906-36-2

  • Applications

    2-Methoxymethyl-p-phenylenediamine (CAS 337906-36-2) is commonly used as an intermediate in the synthesis of colorants and pigments for textiles, leather, and printing inks, and as a precursor for cosmetic and personal care colorants; it is also employed as a curing agent for epoxy resins and related coating systems, adhesives, and electronic encapsulants, and serves as a building block for specialty pigments and colorants in polyurethane and epoxy resin formulations used in coatings and plastics.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 23.22
    methanol 34.16
    isopropanol 10.88
    water 16.94
    ethyl acetate 9.8
    n-propanol 16.55
    acetone 15.6
    n-butanol 11.48
    acetonitrile 23.68
    DMF 91.54
    toluene 3.71
    isobutanol 9.65
    1,4-dioxane 43.95
    methyl acetate 13.38
    THF 57.31
    2-butanone 11.63
    n-pentanol 8.19
    sec-butanol 7.17
    n-hexane 0.14
    ethylene glycol 37.97
    NMP 57.33
    cyclohexane 0.53
    DMSO 150.28
    n-butyl acetate 5.4
    n-octanol 5.76
    chloroform 25.63
    n-propyl acetate 5.25
    acetic acid 79.72
    dichloromethane 22.3
    cyclohexanone 22.89
    propylene glycol 25.98
    isopropyl acetate 3.88
    DMAc 69.5
    2-ethoxyethanol 39.87
    isopentanol 8.26
    n-heptane 0.81
    ethyl formate 22.15
    1,2-dichloroethane 9.54
    n-hexanol 13.81
    2-methoxyethanol 85.11
    isobutyl acetate 3.87
    tetrachloromethane 5.99
    n-pentyl acetate 3.95
    transcutol 29.19
    n-heptanol 8.62
    ethylbenzene 2.0
    MIBK 4.57
    2-propoxyethanol 40.95
    tert-butanol 16.03
    MTBE 4.07
    2-butoxyethanol 21.59
    propionic acid 26.75
    o-xylene 4.18
    formic acid 99.69
    diethyl ether 2.73
    m-xylene 3.83
    p-xylene 2.89
    chlorobenzene 7.85
    dimethyl carbonate 11.79
    n-octane 0.37
    formamide 89.34
    cyclopentanone 42.99
    2-pentanone 6.41
    anisole 9.53
    cyclopentyl methyl ether 12.61
    gamma-butyrolactone 61.07
    1-methoxy-2-propanol 37.89
    pyridine 27.29
    3-pentanone 5.6
    furfural 89.12
    n-dodecane 0.34
    diethylene glycol 64.55
    diisopropyl ether 0.86
    tert-amyl alcohol 9.32
    acetylacetone 13.3
    n-hexadecane 0.38
    acetophenone 12.34
    methyl propionate 12.92
    isopentyl acetate 5.0
    trichloroethylene 30.96
    n-nonanol 5.5
    cyclohexanol 10.21
    benzyl alcohol 16.67
    2-ethylhexanol 6.97
    isooctanol 6.41
    dipropyl ether 4.99
    1,2-dichlorobenzene 9.22
    ethyl lactate 11.38
    propylene carbonate 32.64
    n-methylformamide 64.61
    2-pentanol 3.98
    n-pentane 0.18
    1-propoxy-2-propanol 20.07
    1-methoxy-2-propyl acetate 11.84
    2-(2-methoxypropoxy) propanol 15.9
    mesitylene 2.41
    ε-caprolactone 22.08
    p-cymene 3.32
    epichlorohydrin 48.74
    1,1,1-trichloroethane 10.35
    2-aminoethanol 44.45
    morpholine-4-carbaldehyde 71.66
    sulfolane 81.39
    2,2,4-trimethylpentane 0.29
    2-methyltetrahydrofuran 20.43
    n-hexyl acetate 5.31
    isooctane 0.24
    2-(2-butoxyethoxy)ethanol 21.31
    sec-butyl acetate 2.77
    tert-butyl acetate 5.29
    decalin 0.48
    glycerin 71.73
    diglyme 40.87
    acrylic acid 39.88
    isopropyl myristate 2.3
    n-butyric acid 32.06
    acetyl acetate 10.21
    di(2-ethylhexyl) phthalate 6.34
    ethyl propionate 5.26
    nitromethane 108.16
    1,2-diethoxyethane 5.64
    benzonitrile 14.33
    trioctyl phosphate 4.56
    1-bromopropane 2.92
    gamma-valerolactone 68.23
    n-decanol 4.14
    triethyl phosphate 6.52
    4-methyl-2-pentanol 3.16
    propionitrile 12.47
    vinylene carbonate 34.22
    1,1,2-trichlorotrifluoroethane 78.21
    DMS 6.63
    cumene 2.08
    2-octanol 3.61
    2-hexanone 5.15
    octyl acetate 3.88
    limonene 4.22
    1,2-dimethoxyethane 38.45
    ethyl orthosilicate 5.97
    tributyl phosphate 3.97
    diacetone alcohol 15.78
    N,N-dimethylaniline 7.97
    acrylonitrile 24.0
    aniline 13.61
    1,3-propanediol 44.59
    bromobenzene 6.25
    dibromomethane 9.76
    1,1,2,2-tetrachloroethane 21.82
    2-methyl-cyclohexyl acetate 7.69
    tetrabutyl urea 6.04
    diisobutyl methanol 3.48
    2-phenylethanol 16.34
    styrene 2.25
    dioctyl adipate 5.38
    dimethyl sulfate 28.9
    ethyl butyrate 6.29
    methyl lactate 22.93
    butyl lactate 7.2
    diethyl carbonate 5.61
    propanediol butyl ether 15.94
    triethyl orthoformate 6.06
    p-tert-butyltoluene 3.1
    methyl 4-tert-butylbenzoate 14.5
    morpholine 50.02
    tert-butylamine 5.46
    n-dodecanol 3.14
    dimethoxymethane 30.21
    ethylene carbonate 23.56
    cyrene 31.5
    2-ethoxyethyl acetate 7.44
    2-ethylhexyl acetate 3.77
    1,2,4-trichlorobenzene 12.74
    4-methylpyridine 17.99
    dibutyl ether 2.41
    2,6-dimethyl-4-heptanol 3.48
    DEF 16.12
    dimethyl isosorbide 28.76
    tetrachloroethylene 17.49
    eugenol 16.89
    triacetin 9.7
    span 80 16.12
    1,4-butanediol 20.56
    1,1-dichloroethane 7.2
    2-methyl-1-pentanol 6.65
    methyl formate 52.37
    2-methyl-1-butanol 8.19
    n-decane 0.53
    butyronitrile 11.3
    3,7-dimethyl-1-octanol 4.44
    1-chlorooctane 2.01
    1-chlorotetradecane 0.97
    n-nonane 0.44
    undecane 0.42
    tert-butylcyclohexane 0.45
    cyclooctane 0.32
    cyclopentanol 17.51
    tetrahydropyran 14.15
    tert-amyl methyl ether 3.7
    2,5,8-trioxanonane 32.15
    1-hexene 0.58
    2-isopropoxyethanol 18.6
    2,2,2-trifluoroethanol 50.85
    methyl butyrate 7.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction