2-Methoxymethyl-6-methylpyridine

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  • Identifiers

    CAS number
    59303-12-7

    Molecular formula
    C8H11NO

    SMILES
    CC1=NC(=CC=C1)COC

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 78.9%
    Earthy 52.26%
    Nutty 47.1%
    Vegetable 42.05%
    Roasted 38.91%
    Musty 33.45%
    Woody 33.17%
    Leafy 32.63%
    Herbal 32.21%
    Fresh 30.28%

     

    Flavor
    Roasted 49.67%
    Nutty 44.09%
    Coffee 42.08%
    Roast 32.13%
    Earthy 31.84%
    Meaty 30.4%
    Chocolate 29.09%
    Cocoa 27.72%
    Oily 27.52%
    Burnt 27.43%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    4.11 (weak acid)

    Molecular weight
    137.18 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    200°C

    Flash point

    • 70.1 ˚C est.

  • Synonyms

    • 2-METHOXYMETHYL-6-METHYLPYRIDINE
    • RefChem:474657
    • 654-650-0
    • 2-(methoxymethyl)-6-methylpyridine
    • 59303-12-7
    • 2-(methoxymethyl)-6-methyl-pyridine
    • MFCD00085469
    • NSC 76084;
    • NSC76084
    • SCHEMBL791993
    • SCHEMBL2939839
    • SCHEMBL9720448
    • DTXSID60291513
    • NSC-76084
    • AKOS024429007
    • BS-53140
    • F74229
    • 59303-12-7

  • Applications

    2-Methoxymethyl-6-methylpyridine is commonly used as a chemical intermediate and building block in the synthesis of heterocyclic pyridine compounds, with applications in pharmaceuticals and agrochemicals. It is also encountered as a fragrance/odorant intermediate in perfumery, where the pyridine framework contributes to scent profiles. In research and development, the compound is used as a starting point to prepare diverse pyridine derivatives and functionally tailored compounds. Additionally, it may be evaluated as a precursor for specialty chemicals and materials, subject to regulatory and formulation constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 780.94
    methanol 1111.43
    isopropanol 345.55
    water 20.4
    ethyl acetate 191.25
    n-propanol 480.97
    acetone 200.76
    n-butanol 391.6
    acetonitrile 392.57
    DMF 509.13
    toluene 157.98
    isobutanol 285.51
    1,4-dioxane 646.88
    methyl acetate 201.04
    THF 446.41
    2-butanone 156.49
    n-pentanol 233.18
    sec-butanol 268.12
    n-hexane 26.6
    ethylene glycol 367.35
    NMP 309.65
    cyclohexane 107.98
    DMSO 492.87
    n-butyl acetate 163.66
    n-octanol 99.6
    chloroform 1080.84
    n-propyl acetate 97.97
    acetic acid 735.59
    dichloromethane 1052.83
    cyclohexanone 295.63
    propylene glycol 268.07
    isopropyl acetate 66.69
    DMAc 292.8
    2-ethoxyethanol 347.35
    isopentanol 204.41
    n-heptane 64.57
    ethyl formate 275.38
    1,2-dichloroethane 400.84
    n-hexanol 312.67
    2-methoxyethanol 697.52
    isobutyl acetate 61.62
    tetrachloromethane 200.55
    n-pentyl acetate 64.21
    transcutol 511.31
    n-heptanol 106.0
    ethylbenzene 68.14
    MIBK 55.39
    2-propoxyethanol 397.55
    tert-butanol 284.62
    MTBE 130.96
    2-butoxyethanol 171.13
    propionic acid 326.59
    o-xylene 99.67
    formic acid 473.27
    diethyl ether 198.61
    m-xylene 86.2
    p-xylene 83.7
    chlorobenzene 228.97
    dimethyl carbonate 72.73
    n-octane 16.56
    formamide 397.13
    cyclopentanone 250.29
    2-pentanone 109.31
    anisole 130.24
    cyclopentyl methyl ether 191.56
    gamma-butyrolactone 322.66
    1-methoxy-2-propanol 314.15
    pyridine 475.1
    3-pentanone 94.5
    furfural 454.85
    n-dodecane 13.92
    diethylene glycol 400.16
    diisopropyl ether 36.22
    tert-amyl alcohol 206.39
    acetylacetone 101.82
    n-hexadecane 15.29
    acetophenone 107.78
    methyl propionate 160.95
    isopentyl acetate 114.46
    trichloroethylene 720.98
    n-nonanol 82.98
    cyclohexanol 303.97
    benzyl alcohol 177.86
    2-ethylhexanol 159.1
    isooctanol 68.39
    dipropyl ether 161.83
    1,2-dichlorobenzene 182.95
    ethyl lactate 83.24
    propylene carbonate 214.67
    n-methylformamide 395.43
    2-pentanol 149.88
    n-pentane 43.52
    1-propoxy-2-propanol 218.24
    1-methoxy-2-propyl acetate 123.21
    2-(2-methoxypropoxy) propanol 136.06
    mesitylene 48.11
    ε-caprolactone 241.64
    p-cymene 68.68
    epichlorohydrin 428.35
    1,1,1-trichloroethane 329.77
    2-aminoethanol 489.86
    morpholine-4-carbaldehyde 393.33
    sulfolane 327.83
    2,2,4-trimethylpentane 20.06
    2-methyltetrahydrofuran 324.56
    n-hexyl acetate 99.45
    isooctane 11.43
    2-(2-butoxyethoxy)ethanol 194.53
    sec-butyl acetate 50.22
    tert-butyl acetate 56.83
    decalin 29.36
    glycerin 337.05
    diglyme 361.88
    acrylic acid 312.05
    isopropyl myristate 45.49
    n-butyric acid 369.16
    acetyl acetate 118.99
    di(2-ethylhexyl) phthalate 64.82
    ethyl propionate 84.93
    nitromethane 551.56
    1,2-diethoxyethane 168.4
    benzonitrile 209.62
    trioctyl phosphate 45.53
    1-bromopropane 258.34
    gamma-valerolactone 369.4
    n-decanol 64.56
    triethyl phosphate 72.11
    4-methyl-2-pentanol 62.42
    propionitrile 280.97
    vinylene carbonate 274.68
    1,1,2-trichlorotrifluoroethane 402.7
    DMS 86.85
    cumene 50.64
    2-octanol 54.34
    2-hexanone 88.23
    octyl acetate 64.75
    limonene 108.75
    1,2-dimethoxyethane 428.28
    ethyl orthosilicate 72.45
    tributyl phosphate 54.1
    diacetone alcohol 97.12
    N,N-dimethylaniline 95.66
    acrylonitrile 321.03
    aniline 246.16
    1,3-propanediol 503.55
    bromobenzene 222.92
    dibromomethane 648.6
    1,1,2,2-tetrachloroethane 520.87
    2-methyl-cyclohexyl acetate 98.41
    tetrabutyl urea 74.14
    diisobutyl methanol 66.23
    2-phenylethanol 164.97
    styrene 92.76
    dioctyl adipate 75.51
    dimethyl sulfate 94.72
    ethyl butyrate 123.97
    methyl lactate 108.13
    butyl lactate 74.03
    diethyl carbonate 102.23
    propanediol butyl ether 140.71
    triethyl orthoformate 102.9
    p-tert-butyltoluene 62.78
    methyl 4-tert-butylbenzoate 91.86
    morpholine 707.22
    tert-butylamine 197.35
    n-dodecanol 53.51
    dimethoxymethane 268.3
    ethylene carbonate 213.76
    cyrene 134.16
    2-ethoxyethyl acetate 97.06
    2-ethylhexyl acetate 96.04
    1,2,4-trichlorobenzene 206.36
    4-methylpyridine 341.41
    dibutyl ether 89.87
    2,6-dimethyl-4-heptanol 66.23
    DEF 194.75
    dimethyl isosorbide 194.94
    tetrachloroethylene 398.88
    eugenol 113.06
    triacetin 97.57
    span 80 134.94
    1,4-butanediol 216.64
    1,1-dichloroethane 391.55
    2-methyl-1-pentanol 154.47
    methyl formate 306.49
    2-methyl-1-butanol 229.31
    n-decane 21.06
    butyronitrile 314.57
    3,7-dimethyl-1-octanol 85.92
    1-chlorooctane 64.46
    1-chlorotetradecane 30.38
    n-nonane 21.26
    undecane 16.3
    tert-butylcyclohexane 23.92
    cyclooctane 28.13
    cyclopentanol 295.58
    tetrahydropyran 470.21
    tert-amyl methyl ether 99.3
    2,5,8-trioxanonane 255.87
    1-hexene 89.45
    2-isopropoxyethanol 171.93
    2,2,2-trifluoroethanol 223.08
    methyl butyrate 126.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction