2-Methoxybenzyl ethyl ether

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  • Identifiers

    CAS number
    64988-06-3

    Molecular formula
    C10H14O2

    SMILES
    CCOCC1=CC=CC=C1OC

  • Odor profile

    Fragrance
    Floral 72.82%
    Sweet 71.29%
    Fruity 65.43%
    Anisic 57.27%
    Green 53.98%
    Spicy 47.94%
    Rose 42.54%
    Aromatic 40.24%
    Earthy 37.99%
    Fresh 37.86%

     

    Flavor
    Fruity 72.12%
    Floral 55.75%
    Sweet 54.19%
    Earthy 42.28%
    Rose 42.25%
    Spicy 36.5%
    Pineapple 34.6%
    Chocolate 31.52%
    Green 30.1%
    Wine 29.88%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    6.42 (neutral)

    Molecular weight
    166.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    234°C

    Flash point

    • 86.24 ˚C est.

  • Synonyms

    • o-(Ethoxymethyl)anisole
    • 64988-06-3
    • 1-(ethoxymethyl)-2-methoxybenzene
    • Ethyl o-methoxybenzyl ether
    • Ethyl 2-methoxybenzyl ether
    • o-Methoxybenzyl ethyl ether
    • 2-Methoxybenzyl ethyl ether
    • Ether, ethyl o-methoxybenzyl
    • 1-Ethoxymethyl-2-methoxybenzene
    • Benzene, 1-(ethoxymethyl)-2-methoxy-
    • B4GR6Q7FDH
    • EINECS 265-301-3
    • o-Methoxybenzyl alcohol, ethyl ether
    • BRN 2087623
    • 0-06-00-00893 (Beilstein Handbook Reference)
    • DTXSID5052333
    • ETHER, ETHYL 2-METHOXYBENZYL
    • UNII-B4GR6Q7FDH
    • SCHEMBL585111
    • ortho-methoxybenzyl ethyl ether
    • DTXCID5030905
    • DEYIKSBEIOIJCD-UHFFFAOYSA-N
    • NS00012428
    • 265-301-3

  • Applications

    2-Methoxybenzyl ethyl ether (CAS 64988-06-3) is used as an organic-synthesis intermediate and, as a benzyl ether, can function as a protecting group for alcohols, enabling selective transformations and subsequent deprotection. It may also serve as a fragrance-related intermediate or precursor in perfumery and flavor chemistry, and can be incorporated into cosmetic/personal-care formulations where fragrance components are allowed, subject to regulatory limits. In industrial manufacturing, it can appear as a specialty solvent or solvent-like additive for certain reactions or processing steps, and as an intermediate in the preparation of aromatic compounds used in coatings, inks, and polymers. In pharmaceutical synthesis, it can be encountered as a building block or protecting group in medicinal chemistry, again subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1432.0
    methanol 1401.12
    isopropanol 823.7
    water 3.62
    ethyl acetate 981.15
    n-propanol 1036.85
    acetone 845.52
    n-butanol 907.9
    acetonitrile 1187.34
    DMF 839.9
    toluene 473.22
    isobutanol 685.88
    1,4-dioxane 2315.58
    methyl acetate 902.89
    THF 1259.27
    2-butanone 633.83
    n-pentanol 539.18
    sec-butanol 656.97
    n-hexane 89.78
    ethylene glycol 469.19
    NMP 552.0
    cyclohexane 355.68
    DMSO 1213.57
    n-butyl acetate 542.35
    n-octanol 189.51
    chloroform 4340.73
    n-propyl acetate 477.39
    acetic acid 1487.82
    dichloromethane 4070.34
    cyclohexanone 933.79
    propylene glycol 438.46
    isopropyl acetate 370.65
    DMAc 565.29
    2-ethoxyethanol 941.8
    isopentanol 586.14
    n-heptane 101.31
    ethyl formate 764.8
    1,2-dichloroethane 2209.99
    n-hexanol 575.78
    2-methoxyethanol 1486.3
    isobutyl acetate 273.28
    tetrachloromethane 744.38
    n-pentyl acetate 228.34
    transcutol 1398.27
    n-heptanol 194.23
    ethylbenzene 210.45
    MIBK 231.06
    2-propoxyethanol 784.26
    tert-butanol 1007.7
    MTBE 624.53
    2-butoxyethanol 357.2
    propionic acid 840.2
    o-xylene 242.8
    formic acid 497.5
    diethyl ether 987.02
    m-xylene 232.63
    p-xylene 258.72
    chlorobenzene 798.79
    dimethyl carbonate 261.35
    n-octane 33.16
    formamide 635.68
    cyclopentanone 732.43
    2-pentanone 447.4
    anisole 459.49
    cyclopentyl methyl ether 608.68
    gamma-butyrolactone 1032.48
    1-methoxy-2-propanol 739.92
    pyridine 1465.62
    3-pentanone 394.94
    furfural 1065.07
    n-dodecane 28.49
    diethylene glycol 757.45
    diisopropyl ether 167.82
    tert-amyl alcohol 633.39
    acetylacetone 473.71
    n-hexadecane 32.3
    acetophenone 356.39
    methyl propionate 594.79
    isopentyl acetate 387.56
    trichloroethylene 3501.3
    n-nonanol 165.2
    cyclohexanol 878.03
    benzyl alcohol 446.26
    2-ethylhexanol 291.95
    isooctanol 155.24
    dipropyl ether 396.09
    1,2-dichlorobenzene 636.32
    ethyl lactate 235.02
    propylene carbonate 659.75
    n-methylformamide 631.45
    2-pentanol 439.8
    n-pentane 113.8
    1-propoxy-2-propanol 462.77
    1-methoxy-2-propyl acetate 374.74
    2-(2-methoxypropoxy) propanol 286.83
    mesitylene 148.09
    ε-caprolactone 846.85
    p-cymene 133.44
    epichlorohydrin 1581.37
    1,1,1-trichloroethane 1957.99
    2-aminoethanol 690.69
    morpholine-4-carbaldehyde 889.28
    sulfolane 904.1
    2,2,4-trimethylpentane 53.99
    2-methyltetrahydrofuran 1047.99
    n-hexyl acetate 312.26
    isooctane 38.37
    2-(2-butoxyethoxy)ethanol 423.18
    sec-butyl acetate 264.7
    tert-butyl acetate 326.96
    decalin 95.97
    glycerin 563.23
    diglyme 913.84
    acrylic acid 712.97
    isopropyl myristate 128.96
    n-butyric acid 1055.78
    acetyl acetate 603.14
    di(2-ethylhexyl) phthalate 133.92
    ethyl propionate 369.32
    nitromethane 1541.35
    1,2-diethoxyethane 562.82
    benzonitrile 582.49
    trioctyl phosphate 96.11
    1-bromopropane 1122.15
    gamma-valerolactone 980.56
    n-decanol 123.99
    triethyl phosphate 186.74
    4-methyl-2-pentanol 185.35
    propionitrile 828.35
    vinylene carbonate 752.1
    1,1,2-trichlorotrifluoroethane 1232.32
    DMS 286.26
    cumene 136.03
    2-octanol 121.38
    2-hexanone 357.3
    octyl acetate 164.29
    limonene 218.5
    1,2-dimethoxyethane 1265.34
    ethyl orthosilicate 193.76
    tributyl phosphate 128.63
    diacetone alcohol 350.27
    N,N-dimethylaniline 249.43
    acrylonitrile 916.86
    aniline 681.97
    1,3-propanediol 924.99
    bromobenzene 876.36
    dibromomethane 2432.92
    1,1,2,2-tetrachloroethane 2710.7
    2-methyl-cyclohexyl acetate 250.19
    tetrabutyl urea 155.65
    diisobutyl methanol 153.43
    2-phenylethanol 364.27
    styrene 318.61
    dioctyl adipate 198.82
    dimethyl sulfate 321.55
    ethyl butyrate 406.86
    methyl lactate 279.45
    butyl lactate 185.03
    diethyl carbonate 316.28
    propanediol butyl ether 282.09
    triethyl orthoformate 285.19
    p-tert-butyltoluene 126.62
    methyl 4-tert-butylbenzoate 247.99
    morpholine 2309.38
    tert-butylamine 614.5
    n-dodecanol 102.04
    dimethoxymethane 700.78
    ethylene carbonate 687.21
    cyrene 293.46
    2-ethoxyethyl acetate 342.22
    2-ethylhexyl acetate 302.69
    1,2,4-trichlorobenzene 719.52
    4-methylpyridine 1031.0
    dibutyl ether 266.43
    2,6-dimethyl-4-heptanol 153.43
    DEF 641.99
    dimethyl isosorbide 418.41
    tetrachloroethylene 1862.66
    eugenol 269.35
    triacetin 307.13
    span 80 261.61
    1,4-butanediol 383.37
    1,1-dichloroethane 2028.32
    2-methyl-1-pentanol 410.47
    methyl formate 579.5
    2-methyl-1-butanol 586.19
    n-decane 44.94
    butyronitrile 850.06
    3,7-dimethyl-1-octanol 176.07
    1-chlorooctane 164.05
    1-chlorotetradecane 68.74
    n-nonane 45.14
    undecane 34.36
    tert-butylcyclohexane 74.96
    cyclooctane 86.54
    cyclopentanol 660.6
    tetrahydropyran 1742.57
    tert-amyl methyl ether 367.79
    2,5,8-trioxanonane 568.61
    1-hexene 293.35
    2-isopropoxyethanol 512.83
    2,2,2-trifluoroethanol 481.64
    methyl butyrate 548.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction