2-Methoxybenzyl alcohol

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  • Identifiers

    CAS number
    612-16-8

    Molecular formula
    C8H10O2

    SMILES
    COC1=CC=CC=C1CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Sweet 89.0%
    Vanilla 64.6%
    Anisic 60.59%
    Floral 53.14%
    Aromatic 50.7%
    Phenolic 47.91%
    Almond 46.76%
    Fruity 45.38%
    Balsamic 43.65%
    Cherry 39.69%

    Scent© AI

  • Properties

    XLogP3-AA
    1.1

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    240°C

    Flash point est.
    105.89 ˚C

  • Synonyms

    • 2-Methoxybenzyl alcohol
    • 612-16-8
    • (2-Methoxyphenyl)methanol
    • o-Anisyl alcohol
    • Benzenemethanol, 2-methoxy-
    • o-Methoxybenzyl alcohol
    • 2-Methoxybenzenemethanol
    • 2-Methoxybenzylalcohol
    • MFCD00004611
    • 1331-81-3
    • 457NQ8NGCG
    • O-ANISALCOHOL
    • EINECS 210-296-5
    • NSC 66558
    • NSC-66558
    • Benzenemethanol, ar-methoxy-
    • NT090XT6TE
    • (2-Methoxy-phenyl)-methanol
    • Anisyl alcohol (o-,m-,p-)
    • AI3-05521
    • DTXSID4060606
    • BENZYL ALCOHOL, O-METHOXY-
    • oAnisyl alcohol
    • 2Methoxybenzenemethanol
    • 2-methoxy-benzylalcohol
    • 2-Methoxy benzyl alcohol
    • Benzenemethanol, 2methoxy
    • UNII-457NQ8NGCG
    • UNII-NT090XT6TE
    • (2-methoxyphenyl)-methanol
    • SCHEMBL17820
    • (2-Methoxyphenyl)methanol #
    • [2-(methyloxy)phenyl]methanol
    • 2-Methoxybenzyl alcohol, 99%
    • DTXCID3042978
    • DTXSID2047486
    • 1-hydroxymethyl-2-methoxybenzene
    • 1-hydroxymethyl-2-methoxy-benzene
    • NSC66558
    • STR01347
    • AKOS000120315
    • CS-W016501
    • FM49800
    • PS-4450
    • SY019123
    • M1017
    • NS00011986
    • EN300-20605
    • Q15726099
    • F0001-1610
    • Z104479146
    • InChI=1/C8H10O2/c1-10-8-5-3-2-4-7(8)6-9/h2-5,9H,6H2,1H
    • 210-296-5

  • Applications

    2-Methoxybenzyl alcohol (o-anisyl alcohol, CAS 612-16-8) is used mainly as a versatile aromatic intermediate: it can be converted to 2‑methoxybenzyl halides for nucleophilic benzylations, to 2‑methoxybenzyl ethers/esters applied in fragrance creation and odor modulation (e.g., 2‑methoxybenzyl acetate/benzoate for sweet, warm anisic notes), and selectively oxidized to 2‑methoxybenzaldehyde or 2‑methoxybenzoic acid as precursors for fragrances, cosmetic additives, and pharmaceutical scaffolds; the o‑anisylmethyl motif is also leveraged as a building block in medicinal and agrochemical discovery, and the alcohol itself is a common model substrate in catalysis/green-chemistry studies (aromatic alcohol oxidation, C–O hydrogenolysis, selective transformations) owing to its thermal stability, facile functional-group interconversions, and broad reaction compatibility.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1170.32
    methanol 1245.23
    isopropanol 715.98
    water 10.82
    ethyl acetate 735.39
    n-propanol 854.7
    acetone 1116.11
    n-butanol 592.31
    acetonitrile 1278.01
    DMF 1127.03
    toluene 184.59
    isobutanol 469.18
    1,4-dioxane 2615.98
    methyl acetate 855.54
    THF 1962.49
    2-butanone 673.81
    n-pentanol 383.07
    sec-butanol 446.26
    n-hexane 52.71
    ethylene glycol 584.91
    NMP 774.2
    cyclohexane 92.28
    DMSO 2582.41
    n-butyl acetate 314.05
    n-octanol 157.91
    chloroform 1453.88
    n-propyl acetate 419.87
    acetic acid 956.74
    dichloromethane 1673.81
    cyclohexanone 815.01
    propylene glycol 368.62
    isopropyl acetate 308.49
    DMAc 460.38
    2-ethoxyethanol 844.33
    isopentanol 364.92
    n-heptane 50.19
    ethyl formate 614.2
    1,2-dichloroethane 1181.02
    n-hexanol 328.03
    2-methoxyethanol 1370.35
    isobutyl acetate 217.2
    tetrachloromethane 313.48
    n-pentyl acetate 175.27
    transcutol 904.75
    n-heptanol 156.29
    ethylbenzene 99.61
    MIBK 299.13
    2-propoxyethanol 622.91
    tert-butanol 792.5
    MTBE 517.43
    2-butoxyethanol 302.8
    propionic acid 707.21
    o-xylene 112.51
    formic acid 521.67
    diethyl ether 799.54
    m-xylene 126.66
    p-xylene 116.87
    chlorobenzene 345.64
    dimethyl carbonate 282.76
    n-octane 22.75
    formamide 825.9
    cyclopentanone 1181.64
    2-pentanone 556.8
    anisole 311.52
    cyclopentyl methyl ether 638.98
    gamma-butyrolactone 1512.62
    1-methoxy-2-propanol 708.08
    pyridine 755.25
    3-pentanone 385.59
    furfural 912.79
    n-dodecane 19.38
    diethylene glycol 691.24
    diisopropyl ether 160.05
    tert-amyl alcohol 438.7
    acetylacetone 557.14
    n-hexadecane 22.02
    acetophenone 232.94
    methyl propionate 523.45
    isopentyl acetate 225.99
    trichloroethylene 1556.11
    n-nonanol 132.57
    cyclohexanol 423.8
    benzyl alcohol 250.84
    2-ethylhexanol 167.91
    isooctanol 129.71
    dipropyl ether 261.63
    1,2-dichlorobenzene 261.64
    ethyl lactate 193.57
    propylene carbonate 598.45
    n-methylformamide 997.05
    2-pentanol 321.06
    n-pentane 61.18
    1-propoxy-2-propanol 364.11
    1-methoxy-2-propyl acetate 284.3
    2-(2-methoxypropoxy) propanol 232.3
    mesitylene 93.7
    ε-caprolactone 706.4
    p-cymene 71.27
    epichlorohydrin 1806.71
    1,1,1-trichloroethane 893.23
    2-aminoethanol 665.67
    morpholine-4-carbaldehyde 992.68
    sulfolane 1540.21
    2,2,4-trimethylpentane 32.4
    2-methyltetrahydrofuran 1128.33
    n-hexyl acetate 237.42
    isooctane 31.99
    2-(2-butoxyethoxy)ethanol 347.43
    sec-butyl acetate 209.19
    tert-butyl acetate 341.83
    decalin 41.66
    glycerin 536.27
    diglyme 688.61
    acrylic acid 611.61
    isopropyl myristate 106.92
    n-butyric acid 702.76
    acetyl acetate 369.8
    di(2-ethylhexyl) phthalate 86.9
    ethyl propionate 310.92
    nitromethane 1963.13
    1,2-diethoxyethane 350.02
    benzonitrile 316.44
    trioctyl phosphate 84.03
    1-bromopropane 572.27
    gamma-valerolactone 1282.16
    n-decanol 104.86
    triethyl phosphate 116.92
    4-methyl-2-pentanol 159.2
    propionitrile 714.84
    vinylene carbonate 546.28
    1,1,2-trichlorotrifluoroethane 841.04
    DMS 209.84
    cumene 75.01
    2-octanol 109.99
    2-hexanone 359.58
    octyl acetate 135.43
    limonene 110.33
    1,2-dimethoxyethane 1066.15
    ethyl orthosilicate 108.82
    tributyl phosphate 89.58
    diacetone alcohol 396.58
    N,N-dimethylaniline 164.41
    acrylonitrile 859.88
    aniline 327.92
    1,3-propanediol 859.11
    bromobenzene 318.68
    dibromomethane 1079.02
    1,1,2,2-tetrachloroethane 1028.22
    2-methyl-cyclohexyl acetate 156.93
    tetrabutyl urea 114.4
    diisobutyl methanol 109.64
    2-phenylethanol 209.42
    styrene 136.79
    dioctyl adipate 139.85
    dimethyl sulfate 458.82
    ethyl butyrate 241.67
    methyl lactate 278.32
    butyl lactate 135.71
    diethyl carbonate 167.84
    propanediol butyl ether 234.4
    triethyl orthoformate 154.39
    p-tert-butyltoluene 71.78
    methyl 4-tert-butylbenzoate 196.65
    morpholine 2052.4
    tert-butylamine 390.34
    n-dodecanol 86.01
    dimethoxymethane 836.98
    ethylene carbonate 529.59
    cyrene 253.55
    2-ethoxyethyl acetate 249.88
    2-ethylhexyl acetate 170.69
    1,2,4-trichlorobenzene 300.46
    4-methylpyridine 517.01
    dibutyl ether 168.99
    2,6-dimethyl-4-heptanol 109.64
    DEF 509.72
    dimethyl isosorbide 369.25
    tetrachloroethylene 762.25
    eugenol 207.19
    triacetin 198.28
    span 80 194.82
    1,4-butanediol 357.66
    1,1-dichloroethane 1004.22
    2-methyl-1-pentanol 250.3
    methyl formate 826.68
    2-methyl-1-butanol 346.38
    n-decane 30.94
    butyronitrile 615.14
    3,7-dimethyl-1-octanol 132.77
    1-chlorooctane 121.0
    1-chlorotetradecane 52.18
    n-nonane 32.14
    undecane 23.68
    tert-butylcyclohexane 43.61
    cyclooctane 35.21
    cyclopentanol 584.11
    tetrahydropyran 1415.52
    tert-amyl methyl ether 292.27
    2,5,8-trioxanonane 430.6
    1-hexene 165.95
    2-isopropoxyethanol 450.17
    2,2,2-trifluoroethanol 397.96
    methyl butyrate 432.82

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Narcissus (Japan) 1a 8023-75-4 Narcissus tazetta L. (N. poeticus L.), fam. Amarillidaceae 0.3%
Narcissus (Japan) 1b 8023-75-4 Narcissus tazetta L. (N. poeticus L.), fam. Amaryllidaceae 0.36%
Narcissus tazetta (var. chinensis) 8023-75-4 Narcissus tazetta L., var. chinensis, fam. Amaryllidaceae 0.25%