2-Methoxy-6-methylpyrazine

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  • Identifiers

    CAS number
    2882-21-5

    Molecular formula
    C6H8N2O

    SMILES
    CC1=CN=CC(=N1)OC

  • Odor profile

    Fragrance
    Nutty 75.94%
    Roasted 71.0%
    Earthy 57.96%
    Hazelnut 53.76%
    Cocoa 45.88%
    Potato 44.98%
    Musty 43.89%
    Green 42.66%
    Coffee 39.01%
    Chocolate 38.36%

     

    Flavor
    Nutty 45.5%
    Roasted 43.02%
    Cocoa 39.32%
    Coffee 39.12%
    Potato 36.59%
    Musty 34.7%
    Earthy 34.18%
    Burnt 31.18%
    Hazelnut 28.55%
    Roast 28.02%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    4.42 (weak acid)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 170.00 to 171.00 °C. @ 760.00 mm Hg

    Flash point

    • 81.36 ˚C est.

  • Synonyms

    • 2-Methoxy-6-methylpyrazine
    • 2882-21-5
    • Pyrazine, 2-methoxy-6-methyl-
    • 2-Methyl-6-methoxypyrazine
    • 5-Methoxy-3-methylpyrazine
    • EINECS 220-737-3
    • 18565KT6V3
    • Pyrazine, 2-methyl-6-methoxy
    • DTXSID30878916
    • FEMA NO. 3183, 2-METHYL-6-METHOXY
    • FEMA NO. 3280, 2-METHYL-6-METHOXY-
    • UNII-18565KT6V3
    • MFCD00053108
    • 6-methyl-2-methoxypyrazine
    • CHEMBL93500
    • SCHEMBL231933
    • MYDVJLOKNIAHPH-UHFFFAOYSA-
    • CHEBI:180376
    • MYDVJLOKNIAHPH-UHFFFAOYSA-N
    • DTXCID501016944
    • AKOS006229873
    • BS-49504
    • CS-0311527
    • NS00049406
    • E78059
    • Q27251975
    • InChI=1/C6H8N2O/c1-5-3-7-4-6(8-5)9-2/h3-4H,1-2H3
    • 220-737-3

  • Applications

    2-Methoxy-6-methylpyrazine (CAS 2882-21-5) is used primarily as an aroma and flavor ingredient in fragrance and flavor formulations. In perfumery and cosmetics/personal care, it contributes roasted and nutty notes as an odorant or fragrance component; in food processing and flavor formulation, it is evaluated for its pyrazine notes within controlled dosage ranges; in household products such as air fresheners and cleaners, it can be used to impart or modulate scent; in industrial manufacturing, it serves as an intermediate for the synthesis of other pyrazine-derived aroma chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 154.95
    methanol 234.46
    isopropanol 121.64
    water 12.97
    ethyl acetate 159.93
    n-propanol 128.3
    acetone 244.5
    n-butanol 98.82
    acetonitrile 208.05
    DMF 402.01
    toluene 50.67
    isobutanol 107.15
    1,4-dioxane 245.59
    methyl acetate 163.3
    THF 283.77
    2-butanone 159.1
    n-pentanol 78.35
    sec-butanol 111.7
    n-hexane 8.98
    ethylene glycol 110.04
    NMP 334.64
    cyclohexane 12.68
    DMSO 478.07
    n-butyl acetate 74.53
    n-octanol 46.03
    chloroform 321.97
    n-propyl acetate 68.74
    acetic acid 317.38
    dichloromethane 366.95
    cyclohexanone 203.84
    propylene glycol 95.83
    isopropyl acetate 70.71
    DMAc 320.33
    2-ethoxyethanol 159.82
    isopentanol 77.66
    n-heptane 10.32
    ethyl formate 143.55
    1,2-dichloroethane 196.56
    n-hexanol 73.96
    2-methoxyethanol 294.94
    isobutyl acetate 43.11
    tetrachloromethane 59.1
    n-pentyl acetate 49.33
    transcutol 205.65
    n-heptanol 41.36
    ethylbenzene 30.3
    MIBK 60.31
    2-propoxyethanol 144.14
    tert-butanol 140.79
    MTBE 97.17
    2-butoxyethanol 83.62
    propionic acid 175.65
    o-xylene 48.71
    formic acid 178.43
    diethyl ether 94.37
    m-xylene 43.23
    p-xylene 46.51
    chlorobenzene 101.44
    dimethyl carbonate 68.73
    n-octane 5.33
    formamide 163.35
    cyclopentanone 261.99
    2-pentanone 110.47
    anisole 73.47
    cyclopentyl methyl ether 122.36
    gamma-butyrolactone 324.17
    1-methoxy-2-propanol 182.49
    pyridine 169.88
    3-pentanone 100.67
    furfural 323.65
    n-dodecane 5.44
    diethylene glycol 151.69
    diisopropyl ether 24.71
    tert-amyl alcohol 123.97
    acetylacetone 137.49
    n-hexadecane 6.11
    acetophenone 79.47
    methyl propionate 146.47
    isopentyl acetate 65.01
    trichloroethylene 385.49
    n-nonanol 40.0
    cyclohexanol 100.43
    benzyl alcohol 79.2
    2-ethylhexanol 49.29
    isooctanol 37.05
    dipropyl ether 50.9
    1,2-dichlorobenzene 106.97
    ethyl lactate 63.28
    propylene carbonate 165.51
    n-methylformamide 220.1
    2-pentanol 70.5
    n-pentane 9.41
    1-propoxy-2-propanol 96.09
    1-methoxy-2-propyl acetate 81.32
    2-(2-methoxypropoxy) propanol 80.85
    mesitylene 28.61
    ε-caprolactone 168.56
    p-cymene 30.83
    epichlorohydrin 309.96
    1,1,1-trichloroethane 176.17
    2-aminoethanol 130.18
    morpholine-4-carbaldehyde 293.19
    sulfolane 414.3
    2,2,4-trimethylpentane 10.08
    2-methyltetrahydrofuran 208.51
    n-hexyl acetate 70.48
    isooctane 5.87
    2-(2-butoxyethoxy)ethanol 100.75
    sec-butyl acetate 42.21
    tert-butyl acetate 66.13
    decalin 10.45
    glycerin 164.01
    diglyme 180.9
    acrylic acid 185.48
    isopropyl myristate 29.5
    n-butyric acid 177.97
    acetyl acetate 98.44
    di(2-ethylhexyl) phthalate 40.31
    ethyl propionate 68.84
    nitromethane 428.13
    1,2-diethoxyethane 68.37
    benzonitrile 106.08
    trioctyl phosphate 30.73
    1-bromopropane 104.61
    gamma-valerolactone 307.54
    n-decanol 31.4
    triethyl phosphate 43.55
    4-methyl-2-pentanol 40.17
    propionitrile 135.3
    vinylene carbonate 168.97
    1,1,2-trichlorotrifluoroethane 263.09
    DMS 69.91
    cumene 27.95
    2-octanol 33.31
    2-hexanone 69.64
    octyl acetate 41.37
    limonene 41.51
    1,2-dimethoxyethane 199.83
    ethyl orthosilicate 39.0
    tributyl phosphate 36.05
    diacetone alcohol 96.55
    N,N-dimethylaniline 62.76
    acrylonitrile 193.38
    aniline 92.46
    1,3-propanediol 150.81
    bromobenzene 95.37
    dibromomethane 220.61
    1,1,2,2-tetrachloroethane 292.28
    2-methyl-cyclohexyl acetate 53.71
    tetrabutyl urea 46.45
    diisobutyl methanol 31.43
    2-phenylethanol 72.37
    styrene 35.17
    dioctyl adipate 46.26
    dimethyl sulfate 138.05
    ethyl butyrate 63.45
    methyl lactate 96.26
    butyl lactate 55.22
    diethyl carbonate 50.1
    propanediol butyl ether 85.54
    triethyl orthoformate 48.09
    p-tert-butyltoluene 29.1
    methyl 4-tert-butylbenzoate 73.89
    morpholine 236.61
    tert-butylamine 75.24
    n-dodecanol 25.19
    dimethoxymethane 174.73
    ethylene carbonate 129.61
    cyrene 102.22
    2-ethoxyethyl acetate 68.35
    2-ethylhexyl acetate 52.78
    1,2,4-trichlorobenzene 132.07
    4-methylpyridine 158.92
    dibutyl ether 42.1
    2,6-dimethyl-4-heptanol 31.43
    DEF 171.23
    dimethyl isosorbide 118.9
    tetrachloroethylene 199.22
    eugenol 83.58
    triacetin 74.33
    span 80 68.24
    1,4-butanediol 78.95
    1,1-dichloroethane 191.83
    2-methyl-1-pentanol 67.21
    methyl formate 203.01
    2-methyl-1-butanol 88.0
    n-decane 8.28
    butyronitrile 127.13
    3,7-dimethyl-1-octanol 44.93
    1-chlorooctane 30.55
    1-chlorotetradecane 14.25
    n-nonane 7.9
    undecane 6.53
    tert-butylcyclohexane 10.9
    cyclooctane 5.56
    cyclopentanol 137.04
    tetrahydropyran 157.22
    tert-amyl methyl ether 82.06
    2,5,8-trioxanonane 124.72
    1-hexene 30.49
    2-isopropoxyethanol 98.12
    2,2,2-trifluoroethanol 136.78
    methyl butyrate 94.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction