2-Methoxy-6-methylacetophenone

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  • Identifiers

    CAS number
    6161-64-4

    Molecular formula
    C10H12O2

    SMILES
    CC1=C(C(=CC=C1)OC)C(=O)C

    Safety labels

  • Odor profile

    Fragrance
    Sweet 82.4%
    Floral 65.57%
    Powdery 51.59%
    Woody 51.48%
    Phenolic 51.26%
    Vanilla 46.35%
    Hay 44.33%
    Hawthorn 43.36%
    Herbal 42.87%
    Spicy 42.75%

     

    Flavor
    Sweet 70.18%
    Woody 60.28%
    Floral 48.5%
    Powdery 38.86%
    Tobacco 38.09%
    Spicy 37.92%
    Herbal 35.88%
    Phenolic 35.85%
    Spice 34.99%
    Minty 33.44%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.9

    pKa est.
    7.45 (neutral)

    Molecular weight
    164.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    247°C

    Flash point

    • 99.31 ˚C est.

  • Synonyms

    • 6161-64-4
    • 2-Methoxy-6-methylacetophenone
    • DTXSID80423899
    • RefChem:262677
    • DTXCID40374737
    • WCOFWOOVCLIIFJ-UHFFFAOYSA-N
    • 1-(2-methoxy-6-methylphenyl)ethanone
    • MFCD22068670
    • 1-(2-methoxy-6-methylphenyl)ethan-1-one
    • SCHEMBL8261359
    • AKOS022176753
    • EL-0725
    • 1-(2-methoxy-6-methyl-phenyl)ethanone
    • SY120038
    • CS-0153637
    • C75893
    • EN300-1844704
    • F363187
    • Q67879580
    • 6161-64-4

  • Applications

    2-Methoxy-6-methylacetophenone is commonly used as a fragrance ingredient and a synthetic intermediate in aroma chemistry; it can serve as an odorant and a building block for the synthesis of more complex fragrance molecules. In cosmetics and personal care formulations, it may be used as a fragrance component; in household and cleaning products it can act as a fragrance additive. In industrial manufacturing, it is employed as an intermediate for the synthesis of other aroma chemicals and fine chemicals, and may be used as a pharmaceutical intermediate in synthetic routes; it can also serve as a building block for polymers/plastics and for coatings/inks formulations, subject to regulatory constraints and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 705.7
    methanol 855.11
    isopropanol 520.1
    water 5.86
    ethyl acetate 1030.58
    n-propanol 602.91
    acetone 1383.86
    n-butanol 538.86
    acetonitrile 1406.85
    DMF 1533.45
    toluene 527.07
    isobutanol 405.31
    1,4-dioxane 2353.42
    methyl acetate 1001.25
    THF 2687.41
    2-butanone 867.57
    n-pentanol 357.72
    sec-butanol 451.45
    n-hexane 174.39
    ethylene glycol 334.95
    NMP 1206.61
    cyclohexane 285.79
    DMSO 1520.11
    n-butyl acetate 392.52
    n-octanol 248.08
    chloroform 2201.77
    n-propyl acetate 451.53
    acetic acid 739.91
    dichloromethane 2338.7
    cyclohexanone 1335.64
    propylene glycol 240.75
    isopropyl acetate 513.95
    DMAc 740.51
    2-ethoxyethanol 656.23
    isopentanol 376.91
    n-heptane 92.48
    ethyl formate 662.04
    1,2-dichloroethane 1754.73
    n-hexanol 430.6
    2-methoxyethanol 1284.8
    isobutyl acetate 266.78
    tetrachloromethane 462.33
    n-pentyl acetate 281.77
    transcutol 731.02
    n-heptanol 191.77
    ethylbenzene 294.13
    MIBK 449.09
    2-propoxyethanol 769.8
    tert-butanol 586.86
    MTBE 603.13
    2-butoxyethanol 312.21
    propionic acid 592.95
    o-xylene 292.73
    formic acid 291.72
    diethyl ether 1151.33
    m-xylene 399.78
    p-xylene 313.18
    chlorobenzene 653.32
    dimethyl carbonate 475.85
    n-octane 52.44
    formamide 481.71
    cyclopentanone 1732.07
    2-pentanone 851.77
    anisole 543.36
    cyclopentyl methyl ether 1290.76
    gamma-butyrolactone 1903.64
    1-methoxy-2-propanol 855.54
    pyridine 1048.26
    3-pentanone 693.1
    furfural 1099.24
    n-dodecane 43.5
    diethylene glycol 718.1
    diisopropyl ether 291.44
    tert-amyl alcohol 441.92
    acetylacetone 941.71
    n-hexadecane 51.39
    acetophenone 384.49
    methyl propionate 890.9
    isopentyl acetate 311.59
    trichloroethylene 2248.03
    n-nonanol 199.56
    cyclohexanol 684.95
    benzyl alcohol 349.38
    2-ethylhexanol 243.72
    isooctanol 152.15
    dipropyl ether 358.5
    1,2-dichlorobenzene 521.11
    ethyl lactate 238.99
    propylene carbonate 770.17
    n-methylformamide 884.61
    2-pentanol 390.43
    n-pentane 147.0
    1-propoxy-2-propanol 392.52
    1-methoxy-2-propyl acetate 419.69
    2-(2-methoxypropoxy) propanol 249.06
    mesitylene 259.82
    ε-caprolactone 996.13
    p-cymene 131.6
    epichlorohydrin 2167.64
    1,1,1-trichloroethane 1403.66
    2-aminoethanol 388.1
    morpholine-4-carbaldehyde 1195.86
    sulfolane 1786.76
    2,2,4-trimethylpentane 62.88
    2-methyltetrahydrofuran 1600.01
    n-hexyl acetate 455.94
    isooctane 57.01
    2-(2-butoxyethoxy)ethanol 345.9
    sec-butyl acetate 293.17
    tert-butyl acetate 530.17
    decalin 124.43
    glycerin 388.99
    diglyme 732.77
    acrylic acid 529.97
    isopropyl myristate 177.29
    n-butyric acid 662.71
    acetyl acetate 591.35
    di(2-ethylhexyl) phthalate 136.27
    ethyl propionate 506.54
    nitromethane 1646.31
    1,2-diethoxyethane 379.48
    benzonitrile 480.53
    trioctyl phosphate 122.12
    1-bromopropane 887.38
    gamma-valerolactone 1585.76
    n-decanol 150.86
    triethyl phosphate 174.33
    4-methyl-2-pentanol 204.91
    propionitrile 844.9
    vinylene carbonate 728.02
    1,1,2-trichlorotrifluoroethane 875.53
    DMS 408.26
    cumene 182.05
    2-octanol 165.52
    2-hexanone 458.98
    octyl acetate 222.71
    limonene 209.35
    1,2-dimethoxyethane 1167.36
    ethyl orthosilicate 165.37
    tributyl phosphate 137.77
    diacetone alcohol 517.6
    N,N-dimethylaniline 322.87
    acrylonitrile 976.42
    aniline 519.47
    1,3-propanediol 581.84
    bromobenzene 726.75
    dibromomethane 1578.13
    1,1,2,2-tetrachloroethane 1537.91
    2-methyl-cyclohexyl acetate 240.58
    tetrabutyl urea 174.05
    diisobutyl methanol 138.58
    2-phenylethanol 323.83
    styrene 353.71
    dioctyl adipate 219.04
    dimethyl sulfate 730.84
    ethyl butyrate 309.57
    methyl lactate 365.88
    butyl lactate 171.06
    diethyl carbonate 227.24
    propanediol butyl ether 256.04
    triethyl orthoformate 209.81
    p-tert-butyltoluene 143.05
    methyl 4-tert-butylbenzoate 297.29
    morpholine 2031.89
    tert-butylamine 355.51
    n-dodecanol 119.2
    dimethoxymethane 1441.63
    ethylene carbonate 681.86
    cyrene 308.59
    2-ethoxyethyl acetate 357.73
    2-ethylhexyl acetate 261.12
    1,2,4-trichlorobenzene 542.8
    4-methylpyridine 939.41
    dibutyl ether 291.84
    2,6-dimethyl-4-heptanol 138.58
    DEF 884.12
    dimethyl isosorbide 474.61
    tetrachloroethylene 1107.38
    eugenol 290.32
    triacetin 302.71
    span 80 223.43
    1,4-butanediol 247.79
    1,1-dichloroethane 1407.03
    2-methyl-1-pentanol 269.82
    methyl formate 874.2
    2-methyl-1-butanol 367.66
    n-decane 71.55
    butyronitrile 787.64
    3,7-dimethyl-1-octanol 185.13
    1-chlorooctane 243.48
    1-chlorotetradecane 101.42
    n-nonane 76.38
    undecane 55.2
    tert-butylcyclohexane 106.19
    cyclooctane 119.86
    cyclopentanol 757.79
    tetrahydropyran 1888.9
    tert-amyl methyl ether 479.38
    2,5,8-trioxanonane 435.54
    1-hexene 387.59
    2-isopropoxyethanol 401.94
    2,2,2-trifluoroethanol 339.14
    methyl butyrate 588.63

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction