2-Methoxy-5-methylpyrazine

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  • Identifiers

    CAS number
    2882-22-6

    Molecular formula
    C6H8N2O

    SMILES
    CC1=CN=C(C=N1)OC

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Nutty 80.95%
    Roasted 73.84%
    Earthy 63.59%
    Hazelnut 57.91%
    Cocoa 50.65%
    Potato 50.27%
    Musty 48.52%
    Green 43.01%
    Chocolate 42.85%
    Coffee 41.69%

    Scent© AI

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    4.0 (weak acid)

    Molecular weight
    124.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point

    • 167.00 to 168.00 °C. @ 760.00 mm Hg

    Flash point est.
    86.11 ˚C

  • Synonyms

    • 2-Methoxy-5-methylpyrazine
    • 2882-22-6
    • Pyrazine, 2-methoxy-5-methyl-
    • 6-Methoxy-3-methylpyrazine
    • Pyrazine, 2-methyl-5-methoxy
    • LJ792258CD
    • EINECS 220-738-9
    • DTXSID0062684
    • FEMA NO. 3183, 2-METHYL-5-METHOXY-
    • FEMA NO. 3280, 2-METHYL-5-METHOXY-
    • Pyrazine,2-methoxy-5-methyl-
    • UNII-LJ792258CD
    • 2-Methoxy-5-methylpyrazin
    • SCHEMBL46319
    • 2-Methoxy-5-methyl-Pyrazine
    • DTXCID3037882
    • CHEBI:180377
    • AKOS006281032
    • AT23462
    • NS00028560
    • Q27283024
    • 220-738-9

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 121.28
    methanol 170.08
    isopropanol 73.14
    water 11.16
    ethyl acetate 37.78
    n-propanol 89.45
    acetone 37.16
    n-butanol 75.17
    acetonitrile 77.23
    DMF 128.66
    toluene 44.12
    isobutanol 62.46
    1,4-dioxane 148.07
    methyl acetate 53.24
    THF 106.56
    2-butanone 40.05
    n-pentanol 53.53
    sec-butanol 63.46
    n-hexane 2.41
    ethylene glycol 63.04
    NMP 85.43
    cyclohexane 11.83
    DMSO 159.56
    n-butyl acetate 23.4
    n-octanol 19.23
    chloroform 182.71
    n-propyl acetate 17.98
    acetic acid 158.36
    dichloromethane 215.42
    cyclohexanone 66.42
    propylene glycol 50.9
    isopropyl acetate 13.96
    DMAc 137.67
    2-ethoxyethanol 97.11
    isopentanol 52.17
    n-heptane 5.17
    ethyl formate 82.51
    1,2-dichloroethane 81.39
    n-hexanol 41.76
    2-methoxyethanol 194.47
    isobutyl acetate 11.52
    tetrachloromethane 36.95
    n-pentyl acetate 15.84
    transcutol 115.24
    n-heptanol 22.57
    ethylbenzene 17.96
    MIBK 12.73
    2-propoxyethanol 69.95
    tert-butanol 71.28
    MTBE 31.74
    2-butoxyethanol 43.68
    propionic acid 72.03
    o-xylene 35.26
    formic acid 172.92
    diethyl ether 28.16
    m-xylene 21.78
    p-xylene 30.78
    chlorobenzene 54.12
    dimethyl carbonate 20.01
    n-octane 2.13
    formamide 170.52
    cyclopentanone 59.39
    2-pentanone 22.65
    anisole 35.21
    cyclopentyl methyl ether 36.39
    gamma-butyrolactone 82.5
    1-methoxy-2-propanol 83.44
    pyridine 169.19
    3-pentanone 19.65
    furfural 165.5
    n-dodecane 2.11
    diethylene glycol 74.9
    diisopropyl ether 5.77
    tert-amyl alcohol 61.94
    acetylacetone 24.75
    n-hexadecane 2.38
    acetophenone 32.68
    methyl propionate 34.75
    isopentyl acetate 20.71
    trichloroethylene 161.88
    n-nonanol 18.08
    cyclohexanol 66.15
    benzyl alcohol 51.71
    2-ethylhexanol 25.42
    isooctanol 17.45
    dipropyl ether 20.51
    1,2-dichlorobenzene 47.89
    ethyl lactate 18.65
    propylene carbonate 55.39
    n-methylformamide 110.59
    2-pentanol 31.69
    n-pentane 4.23
    1-propoxy-2-propanol 39.44
    1-methoxy-2-propyl acetate 23.32
    2-(2-methoxypropoxy) propanol 40.1
    mesitylene 11.94
    ε-caprolactone 61.59
    p-cymene 16.12
    epichlorohydrin 108.0
    1,1,1-trichloroethane 68.15
    2-aminoethanol 102.91
    morpholine-4-carbaldehyde 118.11
    sulfolane 87.95
    2,2,4-trimethylpentane 3.32
    2-methyltetrahydrofuran 87.19
    n-hexyl acetate 20.84
    isooctane 1.38
    2-(2-butoxyethoxy)ethanol 54.08
    sec-butyl acetate 10.5
    tert-butyl acetate 12.69
    decalin 4.77
    glycerin 81.67
    diglyme 94.06
    acrylic acid 78.21
    isopropyl myristate 10.14
    n-butyric acid 86.36
    acetyl acetate 26.55
    di(2-ethylhexyl) phthalate 17.94
    ethyl propionate 17.11
    nitromethane 147.77
    1,2-diethoxyethane 31.67
    benzonitrile 63.93
    trioctyl phosphate 11.28
    1-bromopropane 46.86
    gamma-valerolactone 104.99
    n-decanol 14.02
    triethyl phosphate 18.81
    4-methyl-2-pentanol 15.59
    propionitrile 64.88
    vinylene carbonate 71.34
    1,1,2-trichlorotrifluoroethane 128.63
    DMS 18.7
    cumene 13.78
    2-octanol 13.04
    2-hexanone 17.34
    octyl acetate 14.54
    limonene 20.73
    1,2-dimethoxyethane 108.46
    ethyl orthosilicate 18.45
    tributyl phosphate 12.68
    diacetone alcohol 27.52
    N,N-dimethylaniline 30.09
    acrylonitrile 89.56
    aniline 81.03
    1,3-propanediol 116.44
    bromobenzene 50.91
    dibromomethane 120.74
    1,1,2,2-tetrachloroethane 119.88
    2-methyl-cyclohexyl acetate 22.43
    tetrabutyl urea 18.61
    diisobutyl methanol 13.56
    2-phenylethanol 43.66
    styrene 23.37
    dioctyl adipate 19.02
    dimethyl sulfate 33.2
    ethyl butyrate 22.78
    methyl lactate 32.61
    butyl lactate 17.91
    diethyl carbonate 21.74
    propanediol butyl ether 32.33
    triethyl orthoformate 21.86
    p-tert-butyltoluene 14.24
    methyl 4-tert-butylbenzoate 32.0
    morpholine 182.45
    tert-butylamine 43.12
    n-dodecanol 11.37
    dimethoxymethane 61.19
    ethylene carbonate 52.95
    cyrene 40.33
    2-ethoxyethyl acetate 24.03
    2-ethylhexyl acetate 16.56
    1,2,4-trichlorobenzene 62.2
    4-methylpyridine 119.41
    dibutyl ether 16.43
    2,6-dimethyl-4-heptanol 13.56
    DEF 51.91
    dimethyl isosorbide 55.32
    tetrachloroethylene 94.02
    eugenol 38.21
    triacetin 23.6
    span 80 34.82
    1,4-butanediol 45.72
    1,1-dichloroethane 70.73
    2-methyl-1-pentanol 43.96
    methyl formate 80.78
    2-methyl-1-butanol 55.96
    n-decane 3.15
    butyronitrile 71.48
    3,7-dimethyl-1-octanol 18.76
    1-chlorooctane 10.95
    1-chlorotetradecane 5.49
    n-nonane 2.73
    undecane 2.49
    tert-butylcyclohexane 3.5
    cyclooctane 3.19
    cyclopentanol 70.79
    tetrahydropyran 92.63
    tert-amyl methyl ether 27.54
    2,5,8-trioxanonane 75.86
    1-hexene 10.9
    2-isopropoxyethanol 44.54
    2,2,2-trifluoroethanol 59.51
    methyl butyrate 28.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction