2-Methoxy-5-methylphenol

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  • Identifiers

    CAS number
    1195-09-1

    Molecular formula
    C8H10O2

    SMILES
    CC1=CC(=C(C=C1)OC)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 85.1%
    Sweet 77.1%
    Smoky 71.93%
    Spicy 71.89%
    Woody 70.38%
    Vanilla 66.81%
    Medicinal 58.77%
    Clove 52.07%
    Powdery 44.0%
    Burnt 43.09%

     

    Flavor
    Phenolic 77.94%
    Woody 62.17%
    Smoky 61.26%
    Medicinal 57.67%
    Spice 57.33%
    Sweet 56.22%
    Clove 54.42%
    Bacon 53.67%
    Vanilla 52.74%
    Smoke 50.84%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.1

    pKa est.
    9.12 (weak base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    221°C

    Flash point

    • 93.75 ˚C est.

  • Synonyms

    • 2-Methoxy-5-methylphenol
    • 1195-09-1
    • Isocreosol
    • 5-Methylguaiacol
    • Phenol, 2-methoxy-5-methyl-
    • 6-Methoxy-m-cresol
    • 2-Hydroxy-4-methylanisole
    • m-CRESOL, 6-METHOXY-
    • Isocreosole
    • 3-hydroxy-4-methoxytoluene
    • 2-methoxy-5-methyl-phenol
    • EINECS 214-791-7
    • UNII-AV5V76OU33
    • BRN 1817644
    • AV5V76OU33
    • 5-methyl-2-methoxyphenol
    • MFCD00040901
    • IFNDEOYXGHGERA-UHFFFAOYSA-
    • DTXSID70152469
    • 4-06-00-05879 (Beilstein Handbook Reference)
    • 3-HYDROXY-4-METHOXY-1-METHYLBENZENE
    • m-Creosol
    • 4-methyl-2-hydroxy anisole
    • ghl.PD_Mitscher_leg0.527
    • Phenol,2-methoxy-5-methyl-
    • SCHEMBL218637
    • DTXCID6074960
    • CHEBI:194904
    • CL8467
    • 2-methoxy-5-methylphenol, AldrichCPR
    • AKOS009158076
    • CS-W016494
    • BP-11158
    • SY037881
    • TS-01781
    • DB-021278
    • H0624
    • NS00021557
    • EN300-177729
    • Q10303982

  • Applications

    2-Methoxy-5-methylphenol is used as an odorant and fixed fragrance ingredient in perfumery and as a fragrance component in cosmetics and personal care formulations. In industrial manufacturing, it serves as a chemical intermediate for the synthesis of specialty phenolic compounds and resins and as a precursor for coatings and inks formulations. In polymer technology, it can be evaluated as an antioxidant additive or stabilizer for select polymer systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1178.14
    methanol 1624.18
    isopropanol 651.97
    water 5.23
    ethyl acetate 485.59
    n-propanol 730.06
    acetone 427.4
    n-butanol 599.09
    acetonitrile 1125.25
    DMF 521.06
    toluene 96.22
    isobutanol 365.33
    1,4-dioxane 1533.01
    methyl acetate 476.17
    THF 1071.39
    2-butanone 331.29
    n-pentanol 374.42
    sec-butanol 464.74
    n-hexane 26.24
    ethylene glycol 315.95
    NMP 173.15
    cyclohexane 71.01
    DMSO 634.1
    n-butyl acetate 243.13
    n-octanol 161.66
    chloroform 675.97
    n-propyl acetate 241.4
    acetic acid 813.19
    dichloromethane 719.44
    cyclohexanone 310.68
    propylene glycol 293.54
    isopropyl acetate 145.91
    DMAc 208.77
    2-ethoxyethanol 655.32
    isopentanol 313.33
    n-heptane 50.18
    ethyl formate 474.55
    1,2-dichloroethane 364.23
    n-hexanol 381.28
    2-methoxyethanol 1217.93
    isobutyl acetate 108.54
    tetrachloromethane 115.71
    n-pentyl acetate 115.24
    transcutol 856.58
    n-heptanol 152.49
    ethylbenzene 63.24
    MIBK 127.64
    2-propoxyethanol 553.86
    tert-butanol 723.17
    MTBE 317.37
    2-butoxyethanol 264.66
    propionic acid 395.1
    o-xylene 60.98
    formic acid 492.09
    diethyl ether 484.87
    m-xylene 64.43
    p-xylene 75.08
    chlorobenzene 139.39
    dimethyl carbonate 111.16
    n-octane 19.14
    formamide 858.13
    cyclopentanone 314.75
    2-pentanone 247.55
    anisole 193.52
    cyclopentyl methyl ether 246.75
    gamma-butyrolactone 451.1
    1-methoxy-2-propanol 617.74
    pyridine 454.09
    3-pentanone 152.5
    furfural 448.82
    n-dodecane 15.94
    diethylene glycol 490.8
    diisopropyl ether 73.51
    tert-amyl alcohol 400.92
    acetylacetone 212.11
    n-hexadecane 17.5
    acetophenone 130.74
    methyl propionate 259.28
    isopentyl acetate 157.16
    trichloroethylene 515.95
    n-nonanol 137.88
    cyclohexanol 293.08
    benzyl alcohol 194.63
    2-ethylhexanol 172.25
    isooctanol 112.89
    dipropyl ether 220.24
    1,2-dichlorobenzene 111.53
    ethyl lactate 113.06
    propylene carbonate 255.23
    n-methylformamide 620.03
    2-pentanol 284.05
    n-pentane 38.99
    1-propoxy-2-propanol 320.63
    1-methoxy-2-propyl acetate 175.33
    2-(2-methoxypropoxy) propanol 194.99
    mesitylene 42.23
    ε-caprolactone 279.36
    p-cymene 54.48
    epichlorohydrin 652.85
    1,1,1-trichloroethane 298.82
    2-aminoethanol 533.02
    morpholine-4-carbaldehyde 436.13
    sulfolane 316.99
    2,2,4-trimethylpentane 17.76
    2-methyltetrahydrofuran 530.86
    n-hexyl acetate 171.88
    isooctane 16.14
    2-(2-butoxyethoxy)ethanol 335.23
    sec-butyl acetate 109.23
    tert-butyl acetate 154.81
    decalin 24.45
    glycerin 366.06
    diglyme 627.81
    acrylic acid 310.35
    isopropyl myristate 75.66
    n-butyric acid 520.74
    acetyl acetate 202.38
    di(2-ethylhexyl) phthalate 65.49
    ethyl propionate 172.28
    nitromethane 1059.35
    1,2-diethoxyethane 297.71
    benzonitrile 208.93
    trioctyl phosphate 55.62
    1-bromopropane 232.05
    gamma-valerolactone 496.35
    n-decanol 106.54
    triethyl phosphate 79.36
    4-methyl-2-pentanol 116.02
    propionitrile 529.34
    vinylene carbonate 274.06
    1,1,2-trichlorotrifluoroethane 346.78
    DMS 107.56
    cumene 48.48
    2-octanol 98.03
    2-hexanone 193.33
    octyl acetate 98.11
    limonene 80.46
    1,2-dimethoxyethane 923.68
    ethyl orthosilicate 80.6
    tributyl phosphate 63.78
    diacetone alcohol 219.52
    N,N-dimethylaniline 100.86
    acrylonitrile 538.65
    aniline 200.97
    1,3-propanediol 742.55
    bromobenzene 119.98
    dibromomethane 440.79
    1,1,2,2-tetrachloroethane 362.18
    2-methyl-cyclohexyl acetate 109.5
    tetrabutyl urea 77.62
    diisobutyl methanol 90.2
    2-phenylethanol 176.18
    styrene 83.13
    dioctyl adipate 105.61
    dimethyl sulfate 107.09
    ethyl butyrate 193.59
    methyl lactate 139.58
    butyl lactate 96.0
    diethyl carbonate 145.8
    propanediol butyl ether 195.04
    triethyl orthoformate 127.29
    p-tert-butyltoluene 53.09
    methyl 4-tert-butylbenzoate 116.9
    morpholine 1409.0
    tert-butylamine 390.88
    n-dodecanol 83.35
    dimethoxymethane 532.27
    ethylene carbonate 252.72
    cyrene 155.07
    2-ethoxyethyl acetate 165.91
    2-ethylhexyl acetate 117.39
    1,2,4-trichlorobenzene 122.26
    4-methylpyridine 274.68
    dibutyl ether 158.24
    2,6-dimethyl-4-heptanol 90.2
    DEF 235.11
    dimethyl isosorbide 270.1
    tetrachloroethylene 256.07
    eugenol 143.38
    triacetin 139.85
    span 80 161.19
    1,4-butanediol 253.49
    1,1-dichloroethane 341.04
    2-methyl-1-pentanol 231.7
    methyl formate 482.4
    2-methyl-1-butanol 286.84
    n-decane 26.99
    butyronitrile 497.27
    3,7-dimethyl-1-octanol 122.81
    1-chlorooctane 88.45
    1-chlorotetradecane 36.53
    n-nonane 27.24
    undecane 19.89
    tert-butylcyclohexane 22.45
    cyclooctane 21.54
    cyclopentanol 309.5
    tetrahydropyran 839.74
    tert-amyl methyl ether 175.31
    2,5,8-trioxanonane 403.78
    1-hexene 91.9
    2-isopropoxyethanol 335.4
    2,2,2-trifluoroethanol 217.75
    methyl butyrate 234.58

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction