2-Methoxy-3,5-dimethylpyrazine

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  • Identifiers

    CAS number
    92508-08-2

    Molecular formula
    C7H10N2O

    SMILES
    CC1=CN=C(C(=N1)C)OC

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Nutty 60.4%
    Roasted 59.0%
    Earthy 57.96%
    Hazelnut 47.56%
    Cocoa 41.21%
    Musty 41.05%
    Burnt 38.93%
    Chocolate 37.59%
    Potato 36.91%
    Coffee 36.55%

     

    Flavor
    Roasted 53.3%
    Nutty 47.08%
    Earthy 44.08%
    Cocoa 43.12%
    Coffee 42.81%
    Potato 41.87%
    Burnt 41.05%
    Musty 40.2%
    Roast 36.09%
    Hazelnut 36.04%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    4.05 (weak acid)

    Molecular weight
    138.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    223°C

    Flash point

    • 83.39 ˚C est.

  • Synonyms

    • 2-methoxy-3,5-dimethylpyrazine
    • 92508-08-2
    • 2-Methoxy-3,5-dimethylpyrimidine
    • DTXSID30423905
    • Pyrazine, 2-methoxy-3,5-dimethyl-
    • MFCD00126946
    • SCHEMBL1487932
    • DTXCID50374743
    • BXKLSVWRSUPMBO-UHFFFAOYSA-N
    • CHEBI:193651
    • AKOS016004800
    • CS-W018976
    • 2-Methoxy-3,5-dimethylpyrimidine, 9CI
    • DS-14642
    • DB-347198
    • EN300-3445817
    • 809-795-6

  • Applications

    2-Methoxy-3,5-dimethylpyrazine is an aroma-active pyrazine derivative commonly evaluated for use as a fragrance ingredient in perfumery and as a flavoring component in food and beverages, contributing roasted, nutty, and coffee-like notes. It is often used as an intermediate in the synthesis of other pyrazine-based aroma compounds in industrial chemical manufacturing. In cosmetics and personal care, it may serve as a fragrance ingredient or scent additive. In household products such as air fresheners and cleaners, it can contribute to the product scent. In industrial contexts, it may function as an intermediate for preparing aroma compounds and related materials across flavor/fragrance and related sectors.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 801.04
    methanol 1376.89
    isopropanol 465.83
    water 21.39
    ethyl acetate 376.29
    n-propanol 606.14
    acetone 405.22
    n-butanol 553.17
    acetonitrile 682.3
    DMF 490.73
    toluene 281.76
    isobutanol 407.08
    1,4-dioxane 750.01
    methyl acetate 385.19
    THF 878.0
    2-butanone 385.34
    n-pentanol 429.55
    sec-butanol 467.3
    n-hexane 83.54
    ethylene glycol 214.15
    NMP 383.39
    cyclohexane 173.88
    DMSO 476.98
    n-butyl acetate 324.08
    n-octanol 159.79
    chloroform 1339.42
    n-propyl acetate 243.08
    acetic acid 753.7
    dichloromethane 1583.32
    cyclohexanone 471.68
    propylene glycol 159.44
    isopropyl acetate 168.37
    DMAc 367.17
    2-ethoxyethanol 568.05
    isopentanol 372.52
    n-heptane 98.34
    ethyl formate 530.0
    1,2-dichloroethane 630.98
    n-hexanol 350.96
    2-methoxyethanol 842.38
    isobutyl acetate 136.79
    tetrachloromethane 343.23
    n-pentyl acetate 170.9
    transcutol 538.03
    n-heptanol 168.77
    ethylbenzene 158.49
    MIBK 147.97
    2-propoxyethanol 475.9
    tert-butanol 418.78
    MTBE 336.65
    2-butoxyethanol 255.54
    propionic acid 350.39
    o-xylene 174.06
    formic acid 625.33
    diethyl ether 519.36
    m-xylene 154.99
    p-xylene 224.02
    chlorobenzene 345.6
    dimethyl carbonate 138.56
    n-octane 37.45
    formamide 654.48
    cyclopentanone 443.71
    2-pentanone 281.69
    anisole 255.74
    cyclopentyl methyl ether 354.94
    gamma-butyrolactone 542.12
    1-methoxy-2-propanol 382.0
    pyridine 717.4
    3-pentanone 236.88
    furfural 629.16
    n-dodecane 27.71
    diethylene glycol 335.96
    diisopropyl ether 109.61
    tert-amyl alcohol 378.42
    acetylacetone 211.15
    n-hexadecane 30.53
    acetophenone 209.49
    methyl propionate 289.32
    isopentyl acetate 236.45
    trichloroethylene 997.27
    n-nonanol 137.88
    cyclohexanol 392.11
    benzyl alcohol 270.38
    2-ethylhexanol 212.34
    isooctanol 124.4
    dipropyl ether 281.31
    1,2-dichlorobenzene 281.09
    ethyl lactate 118.86
    propylene carbonate 340.84
    n-methylformamide 544.89
    2-pentanol 293.82
    n-pentane 104.98
    1-propoxy-2-propanol 268.16
    1-methoxy-2-propyl acetate 186.63
    2-(2-methoxypropoxy) propanol 162.39
    mesitylene 93.77
    ε-caprolactone 402.87
    p-cymene 122.19
    epichlorohydrin 715.76
    1,1,1-trichloroethane 545.7
    2-aminoethanol 365.61
    morpholine-4-carbaldehyde 430.76
    sulfolane 448.93
    2,2,4-trimethylpentane 49.71
    2-methyltetrahydrofuran 706.9
    n-hexyl acetate 206.29
    isooctane 26.32
    2-(2-butoxyethoxy)ethanol 235.19
    sec-butyl acetate 139.1
    tert-butyl acetate 147.29
    decalin 59.76
    glycerin 211.56
    diglyme 456.22
    acrylic acid 319.9
    isopropyl myristate 87.53
    n-butyric acid 500.54
    acetyl acetate 220.38
    di(2-ethylhexyl) phthalate 92.86
    ethyl propionate 218.89
    nitromethane 740.65
    1,2-diethoxyethane 323.33
    benzonitrile 401.87
    trioctyl phosphate 73.65
    1-bromopropane 509.59
    gamma-valerolactone 556.16
    n-decanol 103.7
    triethyl phosphate 119.08
    4-methyl-2-pentanol 132.47
    propionitrile 557.47
    vinylene carbonate 391.49
    1,1,2-trichlorotrifluoroethane 430.98
    DMS 131.5
    cumene 113.14
    2-octanol 116.13
    2-hexanone 236.5
    octyl acetate 117.22
    limonene 164.64
    1,2-dimethoxyethane 783.06
    ethyl orthosilicate 124.79
    tributyl phosphate 94.17
    diacetone alcohol 168.61
    N,N-dimethylaniline 174.22
    acrylonitrile 590.75
    aniline 314.14
    1,3-propanediol 511.54
    bromobenzene 356.25
    dibromomethane 990.2
    1,1,2,2-tetrachloroethane 668.3
    2-methyl-cyclohexyl acetate 164.49
    tetrabutyl urea 113.76
    diisobutyl methanol 106.92
    2-phenylethanol 232.9
    styrene 197.77
    dioctyl adipate 121.88
    dimethyl sulfate 139.92
    ethyl butyrate 278.45
    methyl lactate 122.6
    butyl lactate 115.6
    diethyl carbonate 203.07
    propanediol butyl ether 159.71
    triethyl orthoformate 190.05
    p-tert-butyltoluene 103.54
    methyl 4-tert-butylbenzoate 149.99
    morpholine 814.09
    tert-butylamine 302.97
    n-dodecanol 82.27
    dimethoxymethane 446.43
    ethylene carbonate 331.44
    cyrene 166.96
    2-ethoxyethyl acetate 197.22
    2-ethylhexyl acetate 199.69
    1,2,4-trichlorobenzene 289.7
    4-methylpyridine 559.51
    dibutyl ether 198.8
    2,6-dimethyl-4-heptanol 106.92
    DEF 345.37
    dimethyl isosorbide 262.78
    tetrachloroethylene 543.4
    eugenol 168.86
    triacetin 148.24
    span 80 141.31
    1,4-butanediol 260.62
    1,1-dichloroethane 618.03
    2-methyl-1-pentanol 339.03
    methyl formate 497.12
    2-methyl-1-butanol 381.18
    n-decane 43.13
    butyronitrile 642.48
    3,7-dimethyl-1-octanol 138.33
    1-chlorooctane 119.64
    1-chlorotetradecane 52.53
    n-nonane 44.12
    undecane 33.16
    tert-butylcyclohexane 50.66
    cyclooctane 54.81
    cyclopentanol 452.63
    tetrahydropyran 749.82
    tert-amyl methyl ether 263.89
    2,5,8-trioxanonane 299.27
    1-hexene 212.38
    2-isopropoxyethanol 298.9
    2,2,2-trifluoroethanol 268.59
    methyl butyrate 304.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction