2-Methoxy-1,3-dioxolane

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  • Identifiers

    CAS number
    19693-75-5

    Molecular formula
    C4H8O3

    SMILES
    COC1OCCO1

    Safety labels

    Flammable
    Flammable

  • Odor profile

    Fragrance
    Ethereal 67.33%
    Fruity 49.7%
    Sweet 44.06%
    Alcoholic 37.06%
    Green 35.97%
    Fresh 30.31%
    Fermented 29.71%
    Rummy 27.96%
    Solvent 27.2%
    Pungent 25.63%

     

    Flavor
    Sweet 55.27%
    Vegetable 39.08%
    Green 39.01%
    Bitter 32.24%
    Nutty 31.3%
    Earthy 30.84%
    Caramel 27.74%
    Musty 27.61%
    Fatty 25.43%
    Oily 23.99%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    -0.2

    pKa est.
    5.98 (weak acid)

    Molecular weight
    104.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    128°C

    Flash point

    • 31.66 ˚C est.

  • Synonyms

    • 2-METHOXY-1,3-DIOXOLANE
    • 1,3-Dioxolane, 2-methoxy-
    • EINECS 243-229-3
    • VRAYTNFBRROPJU-UHFFFAOYSA-
    • DTXSID80173362
    • RefChem:87794
    • DTXCID8095853
    • 243-229-3
    • InChI=1/C4H8O3/c1-5-4-6-2-3-7-4/h4H,2-3H2,1H3
    • VRAYTNFBRROPJU-UHFFFAOYSA-N
    • 19693-75-5
    • MFCD00003208
    • SRV8DHN55D
    • SCHEMBL669092
    • SCHEMBL4912273
    • SCHEMBL28650675
    • 2-Methoxy-1,3-dioxolane, 99%
    • 1,3-Dioxolan-2-yl methyl ether #
    • AKOS015852556
    • AS-78330
    • SY051549
    • DB-044944
    • M0816
    • NS00048264
    • D78408
    • EN300-187585
    • 19693-75-5

  • Applications

    Chemical name: 2-Methoxy-1,3-dioxolane; CAS 19693-75-5. In practical use, it may serve as an acetal protecting group for carbonyl compounds (aldehydes and ketones) in organic synthesis, enabling selective transformations by guarding carbonyl functionality; it may function as a specialty solvent or co-solvent for moisture-sensitive or polar reactions; it may act as a processing solvent or additive in coatings and inks, as well as polymer formulations; it may serve as an intermediate in pharmaceutical and fine chemical synthesis; and it may be employed in cleaning formulations as a solvent or formulation diluent.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4986.6
    methanol 7592.7
    isopropanol 3235.96
    water 1103.21
    ethyl acetate 2031.85
    n-propanol 2961.13
    acetone 3415.47
    n-butanol 2348.12
    acetonitrile 5057.71
    DMF 4248.37
    toluene 688.61
    isobutanol 2049.97
    1,4-dioxane 2469.06
    methyl acetate 2099.95
    THF 3099.87
    2-butanone 1884.36
    n-pentanol 1446.31
    sec-butanol 2239.71
    n-hexane 209.81
    ethylene glycol 1966.41
    NMP 2207.03
    cyclohexane 359.57
    DMSO 4203.85
    n-butyl acetate 678.17
    n-octanol 442.24
    chloroform 5581.91
    n-propyl acetate 938.66
    acetic acid 10773.62
    dichloromethane 6001.33
    cyclohexanone 1554.79
    propylene glycol 1495.75
    isopropyl acetate 1047.01
    DMAc 2465.6
    2-ethoxyethanol 2791.42
    isopentanol 1600.25
    n-heptane 166.53
    ethyl formate 1935.1
    1,2-dichloroethane 2460.37
    n-hexanol 725.67
    2-methoxyethanol 4928.58
    isobutyl acetate 478.95
    tetrachloromethane 1402.73
    n-pentyl acetate 434.32
    transcutol 2084.88
    n-heptanol 396.29
    ethylbenzene 269.41
    MIBK 737.34
    2-propoxyethanol 1532.32
    tert-butanol 3032.35
    MTBE 1649.93
    2-butoxyethanol 859.57
    propionic acid 2952.38
    o-xylene 399.09
    formic acid 8330.27
    diethyl ether 2007.86
    m-xylene 426.74
    p-xylene 382.63
    chlorobenzene 935.24
    dimethyl carbonate 808.13
    n-octane 75.22
    formamide 7127.11
    cyclopentanone 2017.34
    2-pentanone 1495.0
    anisole 711.08
    cyclopentyl methyl ether 1444.57
    gamma-butyrolactone 2453.33
    1-methoxy-2-propanol 2735.58
    pyridine 2418.78
    3-pentanone 1062.45
    furfural 2396.37
    n-dodecane 57.71
    diethylene glycol 1527.46
    diisopropyl ether 525.58
    tert-amyl alcohol 2133.16
    acetylacetone 1434.69
    n-hexadecane 61.43
    acetophenone 606.39
    methyl propionate 1489.26
    isopentyl acetate 524.61
    trichloroethylene 4478.34
    n-nonanol 359.15
    cyclohexanol 1544.23
    benzyl alcohol 812.86
    2-ethylhexanol 402.8
    isooctanol 331.77
    dipropyl ether 653.01
    1,2-dichlorobenzene 743.46
    ethyl lactate 453.18
    propylene carbonate 1209.43
    n-methylformamide 3906.7
    2-pentanol 1497.31
    n-pentane 341.25
    1-propoxy-2-propanol 971.68
    1-methoxy-2-propyl acetate 590.77
    2-(2-methoxypropoxy) propanol 497.43
    mesitylene 290.45
    ε-caprolactone 1295.03
    p-cymene 202.4
    epichlorohydrin 2788.75
    1,1,1-trichloroethane 2443.13
    2-aminoethanol 2758.7
    morpholine-4-carbaldehyde 2261.74
    sulfolane 1945.81
    2,2,4-trimethylpentane 163.0
    2-methyltetrahydrofuran 2368.47
    n-hexyl acetate 536.71
    isooctane 114.64
    2-(2-butoxyethoxy)ethanol 693.81
    sec-butyl acetate 558.36
    tert-butyl acetate 839.71
    decalin 120.68
    glycerin 2149.02
    diglyme 1475.66
    acrylic acid 3013.76
    isopropyl myristate 205.1
    n-butyric acid 3233.3
    acetyl acetate 1423.69
    di(2-ethylhexyl) phthalate 200.43
    ethyl propionate 789.05
    nitromethane 8125.27
    1,2-diethoxyethane 847.82
    benzonitrile 1025.94
    trioctyl phosphate 156.53
    1-bromopropane 1507.18
    gamma-valerolactone 2355.18
    n-decanol 249.85
    triethyl phosphate 263.52
    4-methyl-2-pentanol 655.18
    propionitrile 2258.8
    vinylene carbonate 1281.96
    1,1,2-trichlorotrifluoroethane 2730.31
    DMS 387.59
    cumene 206.16
    2-octanol 295.9
    2-hexanone 769.91
    octyl acetate 280.35
    limonene 303.5
    1,2-dimethoxyethane 2690.82
    ethyl orthosilicate 273.03
    tributyl phosphate 198.67
    diacetone alcohol 1001.87
    N,N-dimethylaniline 483.51
    acrylonitrile 2768.74
    aniline 1351.06
    1,3-propanediol 3184.43
    bromobenzene 890.59
    dibromomethane 3454.64
    1,1,2,2-tetrachloroethane 2839.39
    2-methyl-cyclohexyl acetate 319.01
    tetrabutyl urea 263.84
    diisobutyl methanol 278.88
    2-phenylethanol 487.59
    styrene 403.99
    dioctyl adipate 275.88
    dimethyl sulfate 957.81
    ethyl butyrate 613.18
    methyl lactate 797.96
    butyl lactate 324.62
    diethyl carbonate 410.01
    propanediol butyl ether 614.15
    triethyl orthoformate 403.59
    p-tert-butyltoluene 197.83
    methyl 4-tert-butylbenzoate 466.64
    morpholine 3248.32
    tert-butylamine 1821.19
    n-dodecanol 191.95
    dimethoxymethane 2408.83
    ethylene carbonate 1106.9
    cyrene 504.13
    2-ethoxyethyl acetate 549.75
    2-ethylhexyl acetate 376.89
    1,2,4-trichlorobenzene 829.34
    4-methylpyridine 1785.95
    dibutyl ether 433.68
    2,6-dimethyl-4-heptanol 278.88
    DEF 1833.43
    dimethyl isosorbide 681.57
    tetrachloroethylene 2520.63
    eugenol 450.74
    triacetin 459.33
    span 80 379.61
    1,4-butanediol 1363.44
    1,1-dichloroethane 3063.02
    2-methyl-1-pentanol 995.35
    methyl formate 2837.21
    2-methyl-1-butanol 1648.16
    n-decane 96.8
    butyronitrile 2278.87
    3,7-dimethyl-1-octanol 416.16
    1-chlorooctane 266.08
    1-chlorotetradecane 109.23
    n-nonane 101.2
    undecane 70.28
    tert-butylcyclohexane 114.44
    cyclooctane 128.4
    cyclopentanol 1855.93
    tetrahydropyran 2116.68
    tert-amyl methyl ether 1136.13
    2,5,8-trioxanonane 869.07
    1-hexene 553.05
    2-isopropoxyethanol 1515.45
    2,2,2-trifluoroethanol 3588.29
    methyl butyrate 1074.25

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction