2-Isopropyl-5-methylpyrazine

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  • Identifiers

    CAS number
    13925-05-8

    Molecular formula
    C8H12N2

    SMILES
    CC1=CN=C(C=N1)C(C)C

  • Odor profile

    Green 76.79%
    Nutty 75.57%
    Earthy 67.31%
    Roasted 65.56%
    Cocoa 52.26%
    Vegetable 51.11%
    Potato 50.15%
    Musty 48.82%
    Coffee 46.78%
    Hazelnut 45.92%

    Scent© AI

  • Properties

    XLogP3-AA
    1.3

    Molecular weight
    136.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point

    • 190.00 °C. @ 760.00 mm Hg

    Flash point est.
    78.26 ˚C

    Solubility expt.

    • soluble in water, soluble in oils, organic solvents
    • miscible at room temperature (in ethanol)

  • Synonyms

    • 2-Isopropyl-5-methylpyrazine
    • 13925-05-8
    • 2-Methyl-5-(1-methylethyl)pyrazine
    • Pyrazine, 2-methyl-5-(1-methylethyl)-
    • 2-methyl-5-propan-2-ylpyrazine
    • 2-Methyl-5-isopropylpyrazine
    • 2-methyl-5-isopropyl pyrazine
    • 5-Isopropyl-2-methylpyrazine
    • FEMA No. 3554
    • Pyrazine, 2-isopropyl-5-methyl-
    • 2-methyl-5-(propan-2-yl)pyrazine
    • UNII-818RIW504V
    • 818RIW504V
    • 2-isopropyl-5-methyl-pyrazine
    • DTXSID7065677
    • FEMA 3554
    • 2-Methyl-5-(1-methylethyl)-Pyrazine
    • 2-Methyl-5-(1-methylethyl)pyrazine, 9CI
    • 5-ISOPROPYL-2-METHYLPYRAZINE [FHFI]
    • 2-Methyl-5-i-propylpyrazin
    • SCHEMBL179362
    • DTXCID5034513
    • CHEBI:193643
    • AKOS006326657
    • AS-59519
    • DB-116848
    • CS-0059950
    • NS00124338
    • W18369
    • Q27269228

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 195.87
    methanol 187.42
    isopropanol 128.73
    water 1.69
    ethyl acetate 101.76
    n-propanol 155.75
    acetone 141.19
    n-butanol 162.37
    acetonitrile 174.49
    DMF 183.11
    toluene 116.23
    isobutanol 136.39
    1,4-dioxane 252.04
    methyl acetate 116.77
    THF 381.88
    2-butanone 149.39
    n-pentanol 121.01
    sec-butanol 142.79
    n-hexane 34.81
    ethylene glycol 30.5
    NMP 239.54
    cyclohexane 71.05
    DMSO 171.6
    n-butyl acetate 214.93
    n-octanol 89.26
    chloroform 892.99
    n-propyl acetate 93.86
    acetic acid 246.68
    dichloromethane 703.38
    cyclohexanone 293.82
    propylene glycol 53.15
    isopropyl acetate 62.92
    DMAc 168.78
    2-ethoxyethanol 105.84
    isopentanol 132.22
    n-heptane 43.96
    ethyl formate 155.87
    1,2-dichloroethane 254.67
    n-hexanol 203.9
    2-methoxyethanol 166.49
    isobutyl acetate 70.57
    tetrachloromethane 170.91
    n-pentyl acetate 100.7
    transcutol 277.65
    n-heptanol 96.25
    ethylbenzene 70.4
    MIBK 68.28
    2-propoxyethanol 179.6
    tert-butanol 140.22
    MTBE 102.02
    2-butoxyethanol 119.54
    propionic acid 142.1
    o-xylene 81.69
    formic acid 74.02
    diethyl ether 92.76
    m-xylene 73.79
    p-xylene 121.21
    chlorobenzene 209.32
    dimethyl carbonate 39.01
    n-octane 16.45
    formamide 83.96
    cyclopentanone 293.84
    2-pentanone 100.28
    anisole 100.68
    cyclopentyl methyl ether 150.33
    gamma-butyrolactone 320.14
    1-methoxy-2-propanol 112.36
    pyridine 327.14
    3-pentanone 82.08
    furfural 361.76
    n-dodecane 14.38
    diethylene glycol 100.46
    diisopropyl ether 33.48
    tert-amyl alcohol 144.45
    acetylacetone 96.07
    n-hexadecane 15.92
    acetophenone 104.57
    methyl propionate 80.5
    isopentyl acetate 170.82
    trichloroethylene 558.43
    n-nonanol 75.5
    cyclohexanol 153.38
    benzyl alcohol 107.29
    2-ethylhexanol 135.55
    isooctanol 72.69
    dipropyl ether 112.94
    1,2-dichlorobenzene 191.26
    ethyl lactate 53.1
    propylene carbonate 248.11
    n-methylformamide 114.88
    2-pentanol 93.74
    n-pentane 32.04
    1-propoxy-2-propanol 149.66
    1-methoxy-2-propyl acetate 116.44
    2-(2-methoxypropoxy) propanol 101.83
    mesitylene 48.04
    ε-caprolactone 222.09
    p-cymene 78.86
    epichlorohydrin 293.23
    1,1,1-trichloroethane 316.77
    2-aminoethanol 73.44
    morpholine-4-carbaldehyde 205.22
    sulfolane 299.33
    2,2,4-trimethylpentane 22.14
    2-methyltetrahydrofuran 274.87
    n-hexyl acetate 133.59
    isooctane 13.12
    2-(2-butoxyethoxy)ethanol 128.34
    sec-butyl acetate 58.89
    tert-butyl acetate 67.95
    decalin 29.52
    glycerin 61.84
    diglyme 211.08
    acrylic acid 132.1
    isopropyl myristate 57.11
    n-butyric acid 219.67
    acetyl acetate 85.28
    di(2-ethylhexyl) phthalate 75.25
    ethyl propionate 67.99
    nitromethane 224.3
    1,2-diethoxyethane 121.56
    benzonitrile 207.44
    trioctyl phosphate 52.68
    1-bromopropane 196.56
    gamma-valerolactone 298.85
    n-decanol 57.89
    triethyl phosphate 68.13
    4-methyl-2-pentanol 57.41
    propionitrile 160.36
    vinylene carbonate 239.65
    1,1,2-trichlorotrifluoroethane 228.87
    DMS 80.93
    cumene 57.73
    2-octanol 65.45
    2-hexanone 105.83
    octyl acetate 76.89
    limonene 108.1
    1,2-dimethoxyethane 177.07
    ethyl orthosilicate 67.99
    tributyl phosphate 64.28
    diacetone alcohol 84.2
    N,N-dimethylaniline 83.55
    acrylonitrile 181.03
    aniline 143.44
    1,3-propanediol 111.51
    bromobenzene 224.93
    dibromomethane 494.67
    1,1,2,2-tetrachloroethane 447.37
    2-methyl-cyclohexyl acetate 118.77
    tetrabutyl urea 77.22
    diisobutyl methanol 63.97
    2-phenylethanol 142.19
    styrene 87.74
    dioctyl adipate 90.58
    dimethyl sulfate 60.97
    ethyl butyrate 127.24
    methyl lactate 53.8
    butyl lactate 87.67
    diethyl carbonate 95.52
    propanediol butyl ether 98.87
    triethyl orthoformate 96.88
    p-tert-butyltoluene 69.97
    methyl 4-tert-butylbenzoate 102.84
    morpholine 263.45
    tert-butylamine 109.91
    n-dodecanol 47.52
    dimethoxymethane 89.65
    ethylene carbonate 186.33
    cyrene 108.47
    2-ethoxyethyl acetate 103.57
    2-ethylhexyl acetate 148.13
    1,2,4-trichlorobenzene 214.95
    4-methylpyridine 269.31
    dibutyl ether 101.46
    2,6-dimethyl-4-heptanol 63.97
    DEF 118.34
    dimethyl isosorbide 187.35
    tetrachloroethylene 316.33
    eugenol 104.9
    triacetin 100.03
    span 80 114.07
    1,4-butanediol 51.35
    1,1-dichloroethane 294.37
    2-methyl-1-pentanol 114.41
    methyl formate 103.95
    2-methyl-1-butanol 134.99
    n-decane 21.91
    butyronitrile 213.84
    3,7-dimethyl-1-octanol 81.02
    1-chlorooctane 73.15
    1-chlorotetradecane 31.42
    n-nonane 21.83
    undecane 17.02
    tert-butylcyclohexane 27.31
    cyclooctane 21.04
    cyclopentanol 175.15
    tetrahydropyran 262.55
    tert-amyl methyl ether 83.91
    2,5,8-trioxanonane 154.63
    1-hexene 94.91
    2-isopropoxyethanol 75.02
    2,2,2-trifluoroethanol 78.35
    methyl butyrate 113.32

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction