2-Isopropyl-3,5-dimethoxy-6-methylpyrazine

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  • Identifiers

    CAS number
    32021-42-4

    Molecular formula
    C10H16N2O2

    SMILES
    CC1=C(N=C(C(=N1)C(C)C)OC)OC

  • Odor profile

    Earthy 62.35%
    Green 56.64%
    Nutty 46.06%
    Vegetable 37.48%
    Woody 36.64%
    Roasted 34.4%
    Musty 34.35%
    Potato 32.63%
    Cocoa 30.4%
    Burnt 29.73%

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  • Properties

    XLogP3-AA
    2.0

    Molecular weight
    196.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    305°C

    Flash point est.
    107.8 ˚C

  • Synonyms

    • 2-Isopropyl-3,5-dimethoxy-6-methylpyrazine
    • 32021-42-4
    • CHEMBL94620
    • CHEBI:172438
    • DTXSID001240380
    • AKOS006317803
    • 2,6-dimethoxy-3-methyl-5-propan-2-ylpyrazine
    • 2,6-dimethoxy-3-methyl-5-(propan-2-yl)pyrazine
    • 2,6-Dimethoxy-3-methyl-5-(1-methylethyl)pyrazine
    • 2,6-Dimethoxy-3-methyl-5-(1-methylethyl)pyrazine, 9CI

  • Applications

    2-Isopropyl-3,5-dimethoxy-6-methylpyrazine (CAS 32021-42-4) is a pyrazine derivative exhibiting the characteristic alkyl‑methoxypyrazine odor profile; in flavors and fragrances it is applied at trace levels to create or modulate green, herbaceous, bell‑pepper, roasted/nutty, and chocolate/coffee notes in snack seasonings, baked goods, beverages, and protein-based products; in laboratories it serves as a reference standard for GC-MS/GC-O, for SPME optimization and quantitation of methoxypyrazines, for sensory and matrix-interaction studies, and for tracking aroma changes during processing and storage; in R&D it functions as a synthesis building block and odor tracer for quality control, environmental odor source assessment, and studies of aroma release from packaging and polymers.

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 463.43
    methanol 470.52
    isopropanol 401.99
    water 1.7
    ethyl acetate 615.12
    n-propanol 439.98
    acetone 792.77
    n-butanol 415.02
    acetonitrile 534.1
    DMF 920.53
    toluene 338.95
    isobutanol 371.96
    1,4-dioxane 906.39
    methyl acetate 639.47
    THF 1101.28
    2-butanone 610.71
    n-pentanol 300.25
    sec-butanol 443.44
    n-hexane 31.1
    ethylene glycol 181.5
    NMP 693.39
    cyclohexane 113.62
    DMSO 619.28
    n-butyl acetate 368.27
    n-octanol 176.43
    chloroform 2367.91
    n-propyl acetate 319.89
    acetic acid 962.05
    dichloromethane 2156.67
    cyclohexanone 904.96
    propylene glycol 209.8
    isopropyl acetate 316.77
    DMAc 583.15
    2-ethoxyethanol 472.27
    isopentanol 327.92
    n-heptane 35.07
    ethyl formate 633.33
    1,2-dichloroethane 1152.14
    n-hexanol 315.62
    2-methoxyethanol 769.89
    isobutyl acetate 184.8
    tetrachloromethane 474.23
    n-pentyl acetate 292.32
    transcutol 393.29
    n-heptanol 194.61
    ethylbenzene 165.69
    MIBK 232.27
    2-propoxyethanol 440.44
    tert-butanol 426.24
    MTBE 379.01
    2-butoxyethanol 296.08
    propionic acid 552.2
    o-xylene 222.96
    formic acid 304.27
    diethyl ether 408.08
    m-xylene 216.68
    p-xylene 261.85
    chlorobenzene 584.39
    dimethyl carbonate 296.87
    n-octane 23.22
    formamide 384.93
    cyclopentanone 1019.35
    2-pentanone 466.26
    anisole 283.54
    cyclopentyl methyl ether 508.48
    gamma-butyrolactone 1198.77
    1-methoxy-2-propanol 498.28
    pyridine 916.09
    3-pentanone 370.69
    furfural 1073.6
    n-dodecane 20.05
    diethylene glycol 348.67
    diisopropyl ether 108.15
    tert-amyl alcohol 420.2
    acetylacetone 507.86
    n-hexadecane 23.75
    acetophenone 300.47
    methyl propionate 540.73
    isopentyl acetate 299.4
    trichloroethylene 2440.29
    n-nonanol 150.36
    cyclohexanol 544.79
    benzyl alcohol 353.92
    2-ethylhexanol 189.74
    isooctanol 150.25
    dipropyl ether 159.17
    1,2-dichlorobenzene 492.96
    ethyl lactate 186.85
    propylene carbonate 736.22
    n-methylformamide 599.41
    2-pentanol 289.82
    n-pentane 44.5
    1-propoxy-2-propanol 282.5
    1-methoxy-2-propyl acetate 282.67
    2-(2-methoxypropoxy) propanol 160.88
    mesitylene 134.22
    ε-caprolactone 719.17
    p-cymene 128.56
    epichlorohydrin 1272.99
    1,1,1-trichloroethane 1264.11
    2-aminoethanol 266.6
    morpholine-4-carbaldehyde 703.47
    sulfolane 1073.21
    2,2,4-trimethylpentane 35.19
    2-methyltetrahydrofuran 774.91
    n-hexyl acetate 345.54
    isooctane 20.63
    2-(2-butoxyethoxy)ethanol 233.29
    sec-butyl acetate 187.82
    tert-butyl acetate 273.25
    decalin 48.02
    glycerin 273.57
    diglyme 480.12
    acrylic acid 551.01
    isopropyl myristate 106.57
    n-butyric acid 704.97
    acetyl acetate 432.64
    di(2-ethylhexyl) phthalate 127.16
    ethyl propionate 275.46
    nitromethane 1228.21
    1,2-diethoxyethane 232.29
    benzonitrile 487.59
    trioctyl phosphate 107.32
    1-bromopropane 542.67
    gamma-valerolactone 1087.59
    n-decanol 110.65
    triethyl phosphate 132.04
    4-methyl-2-pentanol 138.83
    propionitrile 439.29
    vinylene carbonate 762.21
    1,1,2-trichlorotrifluoroethane 938.92
    DMS 271.61
    cumene 117.1
    2-octanol 154.94
    2-hexanone 284.2
    octyl acetate 159.83
    limonene 167.35
    1,2-dimethoxyethane 619.53
    ethyl orthosilicate 123.82
    tributyl phosphate 116.7
    diacetone alcohol 312.24
    N,N-dimethylaniline 185.76
    acrylonitrile 592.34
    aniline 427.42
    1,3-propanediol 421.86
    bromobenzene 619.63
    dibromomethane 1308.59
    1,1,2,2-tetrachloroethane 1845.16
    2-methyl-cyclohexyl acetate 200.91
    tetrabutyl urea 133.96
    diisobutyl methanol 107.62
    2-phenylethanol 297.73
    styrene 207.46
    dioctyl adipate 152.83
    dimethyl sulfate 395.5
    ethyl butyrate 231.27
    methyl lactate 274.18
    butyl lactate 196.81
    diethyl carbonate 184.55
    propanediol butyl ether 236.95
    triethyl orthoformate 161.18
    p-tert-butyltoluene 120.95
    methyl 4-tert-butylbenzoate 233.27
    morpholine 891.06
    tert-butylamine 243.79
    n-dodecanol 83.66
    dimethoxymethane 616.4
    ethylene carbonate 614.01
    cyrene 252.08
    2-ethoxyethyl acetate 316.45
    2-ethylhexyl acetate 245.11
    1,2,4-trichlorobenzene 593.34
    4-methylpyridine 731.02
    dibutyl ether 137.89
    2,6-dimethyl-4-heptanol 107.62
    DEF 507.17
    dimethyl isosorbide 301.19
    tetrachloroethylene 1353.12
    eugenol 233.85
    triacetin 241.95
    span 80 180.15
    1,4-butanediol 211.62
    1,1-dichloroethane 1150.78
    2-methyl-1-pentanol 264.44
    methyl formate 647.5
    2-methyl-1-butanol 356.0
    n-decane 33.68
    butyronitrile 492.93
    3,7-dimethyl-1-octanol 143.25
    1-chlorooctane 136.36
    1-chlorotetradecane 53.17
    n-nonane 33.09
    undecane 25.25
    tert-butylcyclohexane 40.78
    cyclooctane 34.92
    cyclopentanol 627.67
    tetrahydropyran 832.1
    tert-amyl methyl ether 289.2
    2,5,8-trioxanonane 267.75
    1-hexene 119.94
    2-isopropoxyethanol 299.25
    2,2,2-trifluoroethanol 384.04
    methyl butyrate 404.98

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1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Galbanum 4 9000-24-2 Ferula galbaniflua Boiss. et Buhse, fam. Apiaceae (Umbelliferae) 0.01%