2-Isopropoxyethyl salicylate

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  • Identifiers

    CAS number
    79915-74-5

    Molecular formula
    C12H16O4

    SMILES
    CC(C)OCCOC(=O)C1=CC=CC=C1O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 78.43%
    Floral 73.62%
    Herbal 58.5%
    Balsamic 58.17%
    Green 45.0%
    Vanilla 30.88%
    Spicy 30.64%
    Aromatic 30.56%
    Fruity 29.59%
    Woody 27.95%

     

    Flavor
    Floral 55.6%
    Sweet 50.2%
    Fruity 48.36%
    Bitter 39.89%
    Herbal 33.18%
    Woody 32.81%
    Powdery 28.21%
    Mild 27.18%
    Spicy 26.65%
    Grape 26.49%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.71 (neutral)

    Molecular weight
    224.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very slow

    Boiling point est.
    281°C

    Flash point

    • 150.58 ˚C est.

  • Synonyms

    • 2-Isopropoxyethyl salicylate
    • 79915-74-5
    • 2-propan-2-yloxyethyl 2-hydroxybenzoate
    • EINECS 279-348-2
    • Benzoic acid, 2-hydroxy-, 2-(1-methylethoxy)ethyl ester
    • beta-isopropoxyethyl salicylate
    • isopropoxyethyl salicylate
    • SCHEMBL3505705
    • Benzoic acid,2-hydroxy-, 2-(1-methylethoxy)ethyl ester
    • DTXSID0052546
    • KFBPVHFUHYKWIF-UHFFFAOYSA-N
    • 2-(Propan-2-yloxy)ethyl 2-hydroxybenzoate
    • NS00019687
    • 279-348-2
    • Sakura Salicylate

  • Applications

    2-Isopropoxyethyl salicylate (CAS 79915-74-5) is typically used as a solvent and plasticizer in a range of formulations. In the fragrance and flavor industry, it serves as a solvent carrier for aroma components and can contribute to mild fixation of scents. In cosmetics and personal care, it is commonly employed as a solvent to dissolve and blend fragrance ingredients and other additives. In coatings, inks, and adhesives, it functions as a processing solvent and plasticizer to improve compatibility and processing. In polymers and plastics, it may be used as a plasticizer or processing aid within certain resin systems. It may also be used as an industrial intermediate or solvent in manufacturing processes, depending on the formulation, and its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 178.01
    methanol 220.9
    isopropanol 107.37
    water 0.1
    ethyl acetate 136.16
    n-propanol 123.99
    acetone 311.06
    n-butanol 106.84
    acetonitrile 178.28
    DMF 513.72
    toluene 46.54
    isobutanol 75.73
    1,4-dioxane 226.45
    methyl acetate 150.27
    THF 482.89
    2-butanone 184.86
    n-pentanol 75.43
    sec-butanol 88.1
    n-hexane 3.67
    ethylene glycol 45.24
    NMP 350.05
    cyclohexane 5.94
    DMSO 1199.18
    n-butyl acetate 90.18
    n-octanol 19.89
    chloroform 432.15
    n-propyl acetate 73.26
    acetic acid 195.13
    dichloromethane 458.44
    cyclohexanone 225.32
    propylene glycol 77.45
    isopropyl acetate 69.92
    DMAc 535.61
    2-ethoxyethanol 180.09
    isopentanol 92.1
    n-heptane 1.89
    ethyl formate 78.19
    1,2-dichloroethane 388.8
    n-hexanol 59.49
    2-methoxyethanol 327.48
    isobutyl acetate 45.4
    tetrachloromethane 27.59
    n-pentyl acetate 34.35
    transcutol 564.41
    n-heptanol 20.77
    ethylbenzene 27.65
    MIBK 81.46
    2-propoxyethanol 137.78
    tert-butanol 187.46
    MTBE 99.66
    2-butoxyethanol 61.9
    propionic acid 112.91
    o-xylene 36.09
    formic acid 77.56
    diethyl ether 104.09
    m-xylene 36.45
    p-xylene 34.93
    chlorobenzene 94.0
    dimethyl carbonate 70.88
    n-octane 0.9
    formamide 167.72
    cyclopentanone 324.92
    2-pentanone 139.76
    anisole 87.74
    cyclopentyl methyl ether 145.11
    gamma-butyrolactone 348.58
    1-methoxy-2-propanol 215.07
    pyridine 167.71
    3-pentanone 101.57
    furfural 253.92
    n-dodecane 1.14
    diethylene glycol 144.84
    diisopropyl ether 21.14
    tert-amyl alcohol 125.14
    acetylacetone 187.42
    n-hexadecane 1.35
    acetophenone 90.04
    methyl propionate 124.88
    isopentyl acetate 79.5
    trichloroethylene 589.08
    n-nonanol 19.52
    cyclohexanol 96.04
    benzyl alcohol 81.4
    2-ethylhexanol 33.94
    isooctanol 18.53
    dipropyl ether 35.82
    1,2-dichlorobenzene 93.1
    ethyl lactate 54.17
    propylene carbonate 154.26
    n-methylformamide 178.3
    2-pentanol 58.64
    n-pentane 2.68
    1-propoxy-2-propanol 96.52
    1-methoxy-2-propyl acetate 114.23
    2-(2-methoxypropoxy) propanol 113.29
    mesitylene 21.59
    ε-caprolactone 170.87
    p-cymene 19.41
    epichlorohydrin 470.9
    1,1,1-trichloroethane 205.77
    2-aminoethanol 93.58
    morpholine-4-carbaldehyde 284.5
    sulfolane 511.91
    2,2,4-trimethylpentane 3.86
    2-methyltetrahydrofuran 234.28
    n-hexyl acetate 55.24
    isooctane 2.66
    2-(2-butoxyethoxy)ethanol 131.32
    sec-butyl acetate 50.22
    tert-butyl acetate 96.49
    decalin 5.58
    glycerin 121.07
    diglyme 261.0
    acrylic acid 106.57
    isopropyl myristate 23.91
    n-butyric acid 131.59
    acetyl acetate 88.29
    di(2-ethylhexyl) phthalate 33.29
    ethyl propionate 72.0
    nitromethane 420.97
    1,2-diethoxyethane 112.99
    benzonitrile 87.71
    trioctyl phosphate 21.4
    1-bromopropane 132.51
    gamma-valerolactone 305.67
    n-decanol 14.82
    triethyl phosphate 47.32
    4-methyl-2-pentanol 35.43
    propionitrile 100.79
    vinylene carbonate 124.23
    1,1,2-trichlorotrifluoroethane 296.8
    DMS 81.93
    cumene 20.38
    2-octanol 12.69
    2-hexanone 83.28
    octyl acetate 30.39
    limonene 28.58
    1,2-dimethoxyethane 250.03
    ethyl orthosilicate 40.05
    tributyl phosphate 33.84
    diacetone alcohol 145.65
    N,N-dimethylaniline 60.83
    acrylonitrile 136.83
    aniline 94.29
    1,3-propanediol 146.7
    bromobenzene 97.23
    dibromomethane 287.34
    1,1,2,2-tetrachloroethane 488.53
    2-methyl-cyclohexyl acetate 61.42
    tetrabutyl urea 46.74
    diisobutyl methanol 22.21
    2-phenylethanol 69.03
    styrene 37.23
    dioctyl adipate 48.93
    dimethyl sulfate 163.59
    ethyl butyrate 66.47
    methyl lactate 90.83
    butyl lactate 45.97
    diethyl carbonate 58.69
    propanediol butyl ether 71.49
    triethyl orthoformate 51.35
    p-tert-butyltoluene 19.12
    methyl 4-tert-butylbenzoate 69.78
    morpholine 335.72
    tert-butylamine 79.93
    n-dodecanol 11.37
    dimethoxymethane 230.9
    ethylene carbonate 101.58
    cyrene 110.85
    2-ethoxyethyl acetate 76.35
    2-ethylhexyl acetate 57.99
    1,2,4-trichlorobenzene 123.68
    4-methylpyridine 156.33
    dibutyl ether 29.74
    2,6-dimethyl-4-heptanol 22.21
    DEF 156.91
    dimethyl isosorbide 184.42
    tetrachloroethylene 221.94
    eugenol 70.6
    triacetin 79.15
    span 80 69.66
    1,4-butanediol 54.13
    1,1-dichloroethane 253.59
    2-methyl-1-pentanol 71.46
    methyl formate 120.21
    2-methyl-1-butanol 80.29
    n-decane 1.71
    butyronitrile 99.46
    3,7-dimethyl-1-octanol 29.97
    1-chlorooctane 12.91
    1-chlorotetradecane 5.74
    n-nonane 1.45
    undecane 1.36
    tert-butylcyclohexane 4.88
    cyclooctane 1.81
    cyclopentanol 110.89
    tetrahydropyran 188.88
    tert-amyl methyl ether 74.72
    2,5,8-trioxanonane 199.04
    1-hexene 24.22
    2-isopropoxyethanol 104.13
    2,2,2-trifluoroethanol 70.9
    methyl butyrate 94.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction