2-Hydroxypropyl propionate

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  • Identifiers

    CAS number
    54541-19-4

    Molecular formula
    C6H12O3

    SMILES
    CCC(=O)OCC(C)O

  • Odor profile

    Fragrance
    Fruity 87.33%
    Ethereal 47.84%
    Buttery 47.13%
    Caramellic 46.27%
    Sweet 36.34%
    Winey 35.7%
    Milky 29.29%
    Creamy 27.61%
    Fermented 26.43%
    Oily 26.36%

     

    Flavor
    Fruity 82.26%
    Sweet 54.71%
    Bitter 44.03%
    Tropical 41.18%
    Fruit 39.3%
    Creamy 36.27%
    Pineapple 36.08%
    Green 33.99%
    Grape 32.36%
    Buttery 31.18%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    8.3 (weak base)

    Molecular weight
    132.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    180°C

    Flash point

    • 81.31 ˚C est.

  • Synonyms

    • 2-Hydroxypropyl propionate
    • 54541-19-4
    • 25496-75-7
    • Propane-1,2-diol, monopropionate
    • propane-1,2-diol,monopropionate
    • EINECS 247-039-1
    • EINECS 259-208-7
    • 2-Hydroxypropyl propanoatato
    • 6VU4SH5Y9K
    • SCHEMBL444679
    • 1,2-Propanediol, 1-propanoate
    • DTXSID80948390
    • Propylene glycol 1-monopropionate
    • AAMWEWAFFUFOJV-UHFFFAOYSA-N
    • DB-314095
    • NS00050412

  • Applications

    2-Hydroxypropyl propionate (CAS 54541-19-4) is a glycol ester that serves as a versatile solvent and processing aid. It is commonly used as a co-solvent in coatings, inks, and adhesive formulations; as a plasticizer to improve flexibility of various polymers and resins; as a humectant and solvent in cosmetics and personal care products; as an ingredient in cleaning formulations and household products; and as an intermediate in chemical synthesis to prepare related esters or functional additives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 907.57
    methanol 1611.53
    isopropanol 614.75
    water 103.56
    ethyl acetate 127.65
    n-propanol 546.1
    acetone 356.35
    n-butanol 457.94
    acetonitrile 342.63
    DMF 769.72
    toluene 54.31
    isobutanol 350.33
    1,4-dioxane 533.98
    methyl acetate 205.73
    THF 436.8
    2-butanone 241.86
    n-pentanol 331.03
    sec-butanol 429.67
    n-hexane 26.22
    ethylene glycol 405.31
    NMP 488.17
    cyclohexane 36.65
    DMSO 871.36
    n-butyl acetate 131.92
    n-octanol 158.53
    chloroform 327.96
    n-propyl acetate 111.23
    acetic acid 680.96
    dichloromethane 420.21
    cyclohexanone 282.25
    propylene glycol 372.79
    isopropyl acetate 75.62
    DMAc 660.31
    2-ethoxyethanol 520.61
    isopentanol 322.15
    n-heptane 23.1
    ethyl formate 269.58
    1,2-dichloroethane 226.17
    n-hexanol 233.97
    2-methoxyethanol 844.87
    isobutyl acetate 70.32
    tetrachloromethane 47.5
    n-pentyl acetate 94.59
    transcutol 603.26
    n-heptanol 128.49
    ethylbenzene 56.86
    MIBK 100.64
    2-propoxyethanol 365.48
    tert-butanol 609.3
    MTBE 248.11
    2-butoxyethanol 242.24
    propionic acid 346.5
    o-xylene 66.17
    formic acid 592.17
    diethyl ether 172.18
    m-xylene 45.42
    p-xylene 86.1
    chlorobenzene 92.52
    dimethyl carbonate 61.8
    n-octane 12.77
    formamide 521.08
    cyclopentanone 290.12
    2-pentanone 152.09
    anisole 148.1
    cyclopentyl methyl ether 145.09
    gamma-butyrolactone 342.7
    1-methoxy-2-propanol 453.41
    pyridine 247.02
    3-pentanone 107.21
    furfural 427.36
    n-dodecane 13.33
    diethylene glycol 384.45
    diisopropyl ether 41.17
    tert-amyl alcohol 450.01
    acetylacetone 140.94
    n-hexadecane 13.84
    acetophenone 151.58
    methyl propionate 123.98
    isopentyl acetate 125.17
    trichloroethylene 322.6
    n-nonanol 125.84
    cyclohexanol 261.59
    benzyl alcohol 196.13
    2-ethylhexanol 136.08
    isooctanol 101.09
    dipropyl ether 96.45
    1,2-dichlorobenzene 94.07
    ethyl lactate 99.7
    propylene carbonate 197.62
    n-methylformamide 472.13
    2-pentanol 233.8
    n-pentane 30.12
    1-propoxy-2-propanol 233.07
    1-methoxy-2-propyl acetate 113.34
    2-(2-methoxypropoxy) propanol 225.95
    mesitylene 35.36
    ε-caprolactone 262.0
    p-cymene 46.97
    epichlorohydrin 358.46
    1,1,1-trichloroethane 122.35
    2-aminoethanol 546.65
    morpholine-4-carbaldehyde 554.77
    sulfolane 420.33
    2,2,4-trimethylpentane 20.19
    2-methyltetrahydrofuran 316.58
    n-hexyl acetate 147.13
    isooctane 12.14
    2-(2-butoxyethoxy)ethanol 274.06
    sec-butyl acetate 65.99
    tert-butyl acetate 88.71
    decalin 21.8
    glycerin 464.76
    diglyme 461.78
    acrylic acid 318.52
    isopropyl myristate 63.6
    n-butyric acid 339.1
    acetyl acetate 83.9
    di(2-ethylhexyl) phthalate 86.82
    ethyl propionate 88.74
    nitromethane 563.37
    1,2-diethoxyethane 178.47
    benzonitrile 194.12
    trioctyl phosphate 67.34
    1-bromopropane 135.68
    gamma-valerolactone 433.43
    n-decanol 94.77
    triethyl phosphate 68.77
    4-methyl-2-pentanol 120.31
    propionitrile 236.75
    vinylene carbonate 221.16
    1,1,2-trichlorotrifluoroethane 356.95
    DMS 90.49
    cumene 49.05
    2-octanol 92.96
    2-hexanone 150.83
    octyl acetate 87.92
    limonene 71.08
    1,2-dimethoxyethane 662.74
    ethyl orthosilicate 66.48
    tributyl phosphate 76.54
    diacetone alcohol 175.05
    N,N-dimethylaniline 130.31
    acrylonitrile 299.36
    aniline 132.67
    1,3-propanediol 609.82
    bromobenzene 73.51
    dibromomethane 243.7
    1,1,2,2-tetrachloroethane 275.58
    2-methyl-cyclohexyl acetate 102.07
    tetrabutyl urea 109.79
    diisobutyl methanol 73.79
    2-phenylethanol 140.14
    styrene 70.72
    dioctyl adipate 109.34
    dimethyl sulfate 114.61
    ethyl butyrate 107.47
    methyl lactate 128.74
    butyl lactate 110.72
    diethyl carbonate 79.75
    propanediol butyl ether 245.83
    triethyl orthoformate 83.9
    p-tert-butyltoluene 44.52
    methyl 4-tert-butylbenzoate 139.83
    morpholine 561.62
    tert-butylamine 368.82
    n-dodecanol 74.84
    dimethoxymethane 297.09
    ethylene carbonate 169.79
    cyrene 196.5
    2-ethoxyethyl acetate 120.79
    2-ethylhexyl acetate 91.77
    1,2,4-trichlorobenzene 116.75
    4-methylpyridine 252.47
    dibutyl ether 106.25
    2,6-dimethyl-4-heptanol 73.79
    DEF 279.19
    dimethyl isosorbide 244.03
    tetrachloroethylene 189.8
    eugenol 162.42
    triacetin 140.14
    span 80 183.85
    1,4-butanediol 328.04
    1,1-dichloroethane 183.12
    2-methyl-1-pentanol 265.37
    methyl formate 331.4
    2-methyl-1-butanol 305.44
    n-decane 19.06
    butyronitrile 283.78
    3,7-dimethyl-1-octanol 134.04
    1-chlorooctane 63.35
    1-chlorotetradecane 29.85
    n-nonane 18.48
    undecane 15.38
    tert-butylcyclohexane 21.84
    cyclooctane 12.91
    cyclopentanol 322.29
    tetrahydropyran 326.25
    tert-amyl methyl ether 181.54
    2,5,8-trioxanonane 359.62
    1-hexene 91.74
    2-isopropoxyethanol 286.1
    2,2,2-trifluoroethanol 206.37
    methyl butyrate 166.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction