(2-Hydroxyphenyl)acetic acid

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  • Identifiers

    CAS number
    614-75-5

    Molecular formula
    C8H8O3

    SMILES
    C1=CC=C(C(=C1)CC(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Phenolic 61.35%
    Balsamic 40.18%
    Odorless 38.3%
    Sweet 37.95%
    Vanilla 36.96%
    Nutty 28.79%
    Creamy 28.74%
    Animal 28.7%
    Burnt 28.56%
    Honey 28.43%

     

    Flavor
    Phenolic 50.23%
    Mild 50.1%
    Odorless 46.3%
    Sour 42.43%
    Sweet 42.27%
    Nutty 33.97%
    Faint 31.91%
    Balsamic 27.92%
    Honey 26.45%
    Musty 26.17%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    7.43 (neutral)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    307°C

    Melting point expt.

    • 145 - 147 °C

    Flash point

    • 169.93 ˚C est.

    Solubility expt.

    • 44 mg/mL

  • Synonyms

    • 2-Hydroxyphenylacetic acid
    • 614-75-5
    • (2-Hydroxyphenyl)acetic acid
    • 2-Hydroxybenzeneacetic acid
    • Benzeneacetic acid, 2-hydroxy-
    • (o-Hydroxyphenyl)acetic acid
    • Acetic acid, (o-hydroxyphenyl)-
    • UK3R9Q59AV
    • DTXSID1060633
    • NSC-62000
    • CHEBI:28478
    • o-hydroxyphenyl acetic acid
    • alpha-hydroxy phenylacetic acid
    • RefChem:905769
    • DTXCID3043025
    • 210-393-2
    • (2R)-2-oxidanyl-2-phenyl-ethanoic acid
    • 2-(2-hydroxyphenyl)acetic acid
    • O-HYDROXYPHENYLACETIC ACID
    • MFCD00004323
    • ortho-Hydroxyphenylacetic acid
    • 2-HPAA
    • o-Hydroxy phenylacetic acid
    • CHEMBL240714
    • (2-HYDROXYPHENYL)-ACETIC ACID
    • 2-Hydroxyphenylaceticacid
    • UNII-UK3R9Q59AV
    • 2-hydroxy phenylacetic acid
    • Hydroxyphenylacetate
    • OHP
    • EINECS 210-393-2
    • NSC 62000
    • 2-Hydroxybenzeneacetate
    • Olopatadine Impurity 34
    • (o-hydroxyphenyl)-Acetate
    • bmse000715
    • 2'-hydroxyphenylacetic acid
    • 2-hydroxy-phenylacetic acid
    • 2-hydroxy-benzeneacetic acid
    • SCHEMBL72309
    • 2-(Hydroxyphenyl)acetic acid
    • (o-hydroxyphenyl)-Acetic acid
    • Acetic acid, 2-hydroxyphenyl-
    • orb1301903
    • SCHEMBL1450954
    • SCHEMBL6762396
    • SCHEMBL6762399
    • SCHEMBL6966215
    • SCHEMBL8573806
    • SCHEMBL9580151
    • (2-hydroxy-phenyl)-acetic acid
    • SCHEMBL30449014
    • BDBM16426
    • NSC62000
    • HYDROXYPHENYLACETIC ACID, O-
    • EBC-04102
    • s6154
    • SBB057742
    • STL301502
    • AKOS004909470
    • AC-2695
    • CS-W016306
    • FH24476
    • FS-2587
    • HY-W015590
    • BP-13099
    • PD099467
    • DB-013545
    • H0340
    • NS00014664
    • ST50824315
    • EN300-50865
    • C05852
    • 2-Hydroxyphenylacetic acid, ReagentPlus(R), 99%
    • 614H755
    • F044950
    • Q27103728
    • 7C10F5F6-7BF6-48EE-85EE-22D3FA4D62B1
    • Z608061328
    • 2-Hydroxyphenylacetic acid, Vetec(TM) reagent grade, 98%
    • InChI=1/C8H8O3/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4,9H,5H2,(H,10,11
    • 614-75-5

  • Applications

    (2-Hydroxyphenyl)acetic acid (CAS number: 614-75-5) is a versatile building block used as an intermediate in the synthesis of pharmaceutical and agrochemical compounds; it also serves as a precursor for fragrance and flavor materials, enabling the production of odor-active derivatives. In cosmetics and personal care, it is employed as a component in fragrance chemistry and as a handle for further functionalization; in household products it contributes as a fragrance ingredient in cleaners and detergents. In polymer and plastics development, it provides a convenient aromatic building block for functionalized monomers and additives, while in coatings and inks it can serve as a basis for specialty chemicals used in formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 412.32
    methanol 571.61
    isopropanol 332.61
    water 30.26
    ethyl acetate 111.63
    n-propanol 306.37
    acetone 321.2
    n-butanol 236.11
    acetonitrile 152.55
    DMF 1024.14
    toluene 13.61
    isobutanol 179.58
    1,4-dioxane 185.95
    methyl acetate 148.05
    THF 409.19
    2-butanone 228.37
    n-pentanol 136.61
    sec-butanol 206.91
    n-hexane 1.93
    ethylene glycol 244.71
    NMP 207.89
    cyclohexane 1.61
    DMSO 705.92
    n-butyl acetate 41.27
    n-octanol 49.01
    chloroform 10.74
    n-propyl acetate 47.75
    acetic acid 91.59
    dichloromethane 22.86
    cyclohexanone 92.99
    propylene glycol 156.66
    isopropyl acetate 51.99
    DMAc 629.6
    2-ethoxyethanol 290.1
    isopentanol 161.84
    n-heptane 4.23
    ethyl formate 103.16
    1,2-dichloroethane 30.45
    n-hexanol 97.1
    2-methoxyethanol 534.63
    isobutyl acetate 19.28
    tetrachloromethane 4.64
    n-pentyl acetate 26.35
    transcutol 130.73
    n-heptanol 53.08
    ethylbenzene 16.06
    MIBK 75.13
    2-propoxyethanol 198.02
    tert-butanol 363.42
    MTBE 88.71
    2-butoxyethanol 95.55
    propionic acid 87.67
    o-xylene 21.07
    formic acid 128.42
    diethyl ether 82.6
    m-xylene 19.78
    p-xylene 16.95
    chlorobenzene 10.53
    dimethyl carbonate 73.66
    n-octane 2.4
    formamide 294.89
    cyclopentanone 188.58
    2-pentanone 157.18
    anisole 66.98
    cyclopentyl methyl ether 78.07
    gamma-butyrolactone 172.41
    1-methoxy-2-propanol 317.16
    pyridine 54.42
    3-pentanone 81.6
    furfural 110.43
    n-dodecane 2.94
    diethylene glycol 215.28
    diisopropyl ether 17.99
    tert-amyl alcohol 201.96
    acetylacetone 118.28
    n-hexadecane 3.11
    acetophenone 55.92
    methyl propionate 138.17
    isopentyl acetate 35.52
    trichloroethylene 32.11
    n-nonanol 44.01
    cyclohexanol 65.7
    benzyl alcohol 66.03
    2-ethylhexanol 43.98
    isooctanol 38.87
    dipropyl ether 43.33
    1,2-dichlorobenzene 12.57
    ethyl lactate 46.9
    propylene carbonate 66.6
    n-methylformamide 434.01
    2-pentanol 124.36
    n-pentane 2.13
    1-propoxy-2-propanol 108.18
    1-methoxy-2-propyl acetate 65.98
    2-(2-methoxypropoxy) propanol 76.63
    mesitylene 13.87
    ε-caprolactone 75.14
    p-cymene 15.15
    epichlorohydrin 195.99
    1,1,1-trichloroethane 16.9
    2-aminoethanol 313.29
    morpholine-4-carbaldehyde 238.78
    sulfolane 190.33
    2,2,4-trimethylpentane 2.12
    2-methyltetrahydrofuran 147.96
    n-hexyl acetate 38.4
    isooctane 2.14
    2-(2-butoxyethoxy)ethanol 97.92
    sec-butyl acetate 27.54
    tert-butyl acetate 54.93
    decalin 2.59
    glycerin 188.57
    diglyme 168.64
    acrylic acid 65.48
    isopropyl myristate 20.93
    n-butyric acid 97.94
    acetyl acetate 41.52
    di(2-ethylhexyl) phthalate 22.2
    ethyl propionate 58.46
    nitromethane 239.52
    1,2-diethoxyethane 50.0
    benzonitrile 36.15
    trioctyl phosphate 21.92
    1-bromopropane 17.42
    gamma-valerolactone 179.85
    n-decanol 36.99
    triethyl phosphate 24.4
    4-methyl-2-pentanol 57.15
    propionitrile 114.08
    vinylene carbonate 54.74
    1,1,2-trichlorotrifluoroethane 97.19
    DMS 30.77
    cumene 14.64
    2-octanol 30.76
    2-hexanone 67.74
    octyl acetate 30.33
    limonene 20.07
    1,2-dimethoxyethane 305.43
    ethyl orthosilicate 22.1
    tributyl phosphate 20.58
    diacetone alcohol 132.58
    N,N-dimethylaniline 56.52
    acrylonitrile 133.07
    aniline 37.16
    1,3-propanediol 332.4
    bromobenzene 7.12
    dibromomethane 12.03
    1,1,2,2-tetrachloroethane 29.45
    2-methyl-cyclohexyl acetate 30.17
    tetrabutyl urea 41.48
    diisobutyl methanol 28.77
    2-phenylethanol 58.6
    styrene 14.7
    dioctyl adipate 30.15
    dimethyl sulfate 110.03
    ethyl butyrate 43.2
    methyl lactate 92.91
    butyl lactate 30.0
    diethyl carbonate 28.73
    propanediol butyl ether 72.32
    triethyl orthoformate 26.55
    p-tert-butyltoluene 15.0
    methyl 4-tert-butylbenzoate 56.75
    morpholine 237.74
    tert-butylamine 119.73
    n-dodecanol 29.27
    dimethoxymethane 373.32
    ethylene carbonate 48.74
    cyrene 84.37
    2-ethoxyethyl acetate 39.34
    2-ethylhexyl acetate 23.79
    1,2,4-trichlorobenzene 15.36
    4-methylpyridine 64.83
    dibutyl ether 25.96
    2,6-dimethyl-4-heptanol 28.77
    DEF 176.37
    dimethyl isosorbide 102.09
    tetrachloroethylene 18.46
    eugenol 60.64
    triacetin 34.42
    span 80 52.46
    1,4-butanediol 166.01
    1,1-dichloroethane 21.33
    2-methyl-1-pentanol 90.81
    methyl formate 271.3
    2-methyl-1-butanol 147.62
    n-decane 3.99
    butyronitrile 113.4
    3,7-dimethyl-1-octanol 39.53
    1-chlorooctane 14.02
    1-chlorotetradecane 7.51
    n-nonane 3.46
    undecane 3.39
    tert-butylcyclohexane 2.91
    cyclooctane 1.23
    cyclopentanol 107.3
    tetrahydropyran 98.06
    tert-amyl methyl ether 69.6
    2,5,8-trioxanonane 141.79
    1-hexene 11.54
    2-isopropoxyethanol 149.79
    2,2,2-trifluoroethanol 58.43
    methyl butyrate 75.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction