2-(Hydroxymethyl)menthol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    51210-01-6

    Molecular formula
    C11H22O2

    SMILES
    CC1CCC(C(C1CO)O)C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Mint 73.36%
    Herbal 57.59%
    Cooling 56.58%
    Camphoreous 47.39%
    Sweet 38.62%
    Woody 38.26%
    Odorless 33.57%
    Floral 33.18%
    Musty 30.63%
    Pine 30.58%

     

    Flavor
    Sweet 44.73%
    Minty 44.31%
    Herbal 40.65%
    Herb 33.52%
    Fruity 27.51%
    Odorless 24.53%
    Mentholic 24.41%
    Fruit 22.67%
    Mild 22.65%
    Tropical 21.69%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    2.8

    pKa est.
    8.54 (weak base)

    Molecular weight
    186.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    299°C

    Flash point

    • 137.61 ˚C est.

  • Synonyms

    • 2-(Hydroxymethyl)menthol
    • 51210-01-6
    • EINECS 257-059-2
    • SCHEMBL708832
    • DTXSID20965485
    • UCRUTNJGISGZMY-UHFFFAOYSA-N
    • 2-(Hydroxymethyl)-3-methyl-6-(propan-2-yl)cyclohexan-1-ol
    • NS00057664
    • 51210-01-6

  • Applications

    2-(Hydroxymethyl)menthol (CAS 51210-01-6) is primarily used as an intermediate in the synthesis of menthol-related fragrance compounds and can function as an odorant or mint-tinged fragrance ingredient; in cosmetics and personal care, it may be used as a fragrance component with a mint note; in flavor formulations, it may be evaluated for providing a mint-like note; in household products, it is employed as a fragrance additive to impart a fresh aroma; in industrial manufacturing, it serves as a building block or intermediate for the synthesis of fragrance chemicals and related menthol derivatives.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 695.0
    methanol 634.48
    isopropanol 631.68
    water 2.61
    ethyl acetate 170.03
    n-propanol 524.87
    acetone 300.58
    n-butanol 383.38
    acetonitrile 290.08
    DMF 254.82
    toluene 49.96
    isobutanol 338.06
    1,4-dioxane 888.82
    methyl acetate 169.89
    THF 1323.67
    2-butanone 173.41
    n-pentanol 171.72
    sec-butanol 267.6
    n-hexane 11.96
    ethylene glycol 104.31
    NMP 260.08
    cyclohexane 39.19
    DMSO 565.86
    n-butyl acetate 194.48
    n-octanol 106.49
    chloroform 490.08
    n-propyl acetate 114.48
    acetic acid 398.82
    dichloromethane 434.97
    cyclohexanone 421.58
    propylene glycol 168.87
    isopropyl acetate 109.38
    DMAc 112.52
    2-ethoxyethanol 218.69
    isopentanol 261.57
    n-heptane 21.23
    ethyl formate 191.55
    1,2-dichloroethane 241.71
    n-hexanol 303.02
    2-methoxyethanol 550.3
    isobutyl acetate 81.4
    tetrachloromethane 93.3
    n-pentyl acetate 95.37
    transcutol 440.0
    n-heptanol 133.79
    ethylbenzene 30.62
    MIBK 105.51
    2-propoxyethanol 380.53
    tert-butanol 521.35
    MTBE 187.75
    2-butoxyethanol 190.21
    propionic acid 252.46
    o-xylene 44.17
    formic acid 134.88
    diethyl ether 186.45
    m-xylene 48.81
    p-xylene 43.86
    chlorobenzene 112.63
    dimethyl carbonate 38.27
    n-octane 8.45
    formamide 166.73
    cyclopentanone 560.27
    2-pentanone 163.46
    anisole 73.13
    cyclopentyl methyl ether 254.02
    gamma-butyrolactone 662.22
    1-methoxy-2-propanol 338.3
    pyridine 268.86
    3-pentanone 81.45
    furfural 367.46
    n-dodecane 6.34
    diethylene glycol 264.51
    diisopropyl ether 54.85
    tert-amyl alcohol 221.32
    acetylacetone 160.37
    n-hexadecane 7.27
    acetophenone 73.85
    methyl propionate 103.18
    isopentyl acetate 164.43
    trichloroethylene 402.62
    n-nonanol 88.91
    cyclohexanol 274.34
    benzyl alcohol 90.25
    2-ethylhexanol 130.97
    isooctanol 102.72
    dipropyl ether 127.37
    1,2-dichlorobenzene 99.25
    ethyl lactate 60.16
    propylene carbonate 287.39
    n-methylformamide 249.42
    2-pentanol 184.1
    n-pentane 16.1
    1-propoxy-2-propanol 267.38
    1-methoxy-2-propyl acetate 155.8
    2-(2-methoxypropoxy) propanol 117.99
    mesitylene 40.85
    ε-caprolactone 317.1
    p-cymene 43.99
    epichlorohydrin 589.42
    1,1,1-trichloroethane 200.67
    2-aminoethanol 239.19
    morpholine-4-carbaldehyde 302.45
    sulfolane 555.14
    2,2,4-trimethylpentane 11.05
    2-methyltetrahydrofuran 579.98
    n-hexyl acetate 131.46
    isooctane 13.02
    2-(2-butoxyethoxy)ethanol 194.34
    sec-butyl acetate 66.68
    tert-butyl acetate 120.81
    decalin 13.93
    glycerin 201.49
    diglyme 342.1
    acrylic acid 187.75
    isopropyl myristate 45.49
    n-butyric acid 386.13
    acetyl acetate 97.47
    di(2-ethylhexyl) phthalate 55.43
    ethyl propionate 72.43
    nitromethane 513.84
    1,2-diethoxyethane 154.21
    benzonitrile 140.5
    trioctyl phosphate 50.78
    1-bromopropane 129.27
    gamma-valerolactone 608.73
    n-decanol 63.31
    triethyl phosphate 47.49
    4-methyl-2-pentanol 104.52
    propionitrile 204.59
    vinylene carbonate 233.93
    1,1,2-trichlorotrifluoroethane 282.88
    DMS 73.36
    cumene 30.62
    2-octanol 78.36
    2-hexanone 99.05
    octyl acetate 62.12
    limonene 71.69
    1,2-dimethoxyethane 339.26
    ethyl orthosilicate 50.1
    tributyl phosphate 50.53
    diacetone alcohol 170.36
    N,N-dimethylaniline 50.0
    acrylonitrile 212.03
    aniline 117.37
    1,3-propanediol 418.34
    bromobenzene 96.04
    dibromomethane 278.82
    1,1,2,2-tetrachloroethane 297.95
    2-methyl-cyclohexyl acetate 100.41
    tetrabutyl urea 60.36
    diisobutyl methanol 83.53
    2-phenylethanol 125.53
    styrene 33.0
    dioctyl adipate 65.29
    dimethyl sulfate 71.86
    ethyl butyrate 111.94
    methyl lactate 78.64
    butyl lactate 95.22
    diethyl carbonate 63.74
    propanediol butyl ether 160.65
    triethyl orthoformate 82.91
    p-tert-butyltoluene 44.29
    methyl 4-tert-butylbenzoate 100.05
    morpholine 854.71
    tert-butylamine 273.12
    n-dodecanol 45.3
    dimethoxymethane 188.77
    ethylene carbonate 213.0
    cyrene 121.82
    2-ethoxyethyl acetate 114.79
    2-ethylhexyl acetate 114.92
    1,2,4-trichlorobenzene 115.88
    4-methylpyridine 182.54
    dibutyl ether 81.28
    2,6-dimethyl-4-heptanol 83.53
    DEF 134.23
    dimethyl isosorbide 208.89
    tetrachloroethylene 222.22
    eugenol 94.12
    triacetin 97.32
    span 80 134.95
    1,4-butanediol 106.64
    1,1-dichloroethane 230.82
    2-methyl-1-pentanol 113.43
    methyl formate 195.0
    2-methyl-1-butanol 189.96
    n-decane 11.64
    butyronitrile 258.81
    3,7-dimethyl-1-octanol 89.27
    1-chlorooctane 50.4
    1-chlorotetradecane 16.15
    n-nonane 11.36
    undecane 8.26
    tert-butylcyclohexane 13.56
    cyclooctane 12.32
    cyclopentanol 420.98
    tetrahydropyran 669.96
    tert-amyl methyl ether 90.37
    2,5,8-trioxanonane 204.94
    1-hexene 40.14
    2-isopropoxyethanol 144.18
    2,2,2-trifluoroethanol 120.82
    methyl butyrate 112.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction