(+-)-2-Hydroxyisovaleric acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    4026-18-0

    Molecular formula
    C5H10O3

    SMILES
    CC(C)C(C(=O)O)O

    Safety labels

    Irritant
    Irritant

  • Properties

    XLogP3-AA
    0.5

    Molecular weight
    118.13 g/mol

    Solubility expt.

    • 350 mg/mL

  • Synonyms

    • 2-Hydroxy-3-methylbutyric acid
    • 2-Hydroxy-3-methylbutanoic acid
    • 4026-18-0
    • 2-Hydroxyisovaleric acid
    • Butanoic acid, 2-hydroxy-3-methyl-
    • 3-Methyl-2-hydroxybutyric acid
    • 02X1W97FWN
    • NSC-227884
    • CHEBI:60645
    • DTXSID10863305
    • RefChem:473463
    • DTXCID20203834
    • (+-)-2-HYDROXYISOVALERIC ACID
    • 223-697-5
    • 600-37-3
    • alpha-hydroxyisovaleric acid
    • 2-Oxyisovaleric acid
    • DL-2-Hydroxyisovaleric acid
    • MFCD00004242
    • DL-2-Hydroxy-3-methylbutanoic acid
    • 2-Hydroxyisopentanoic acid
    • 2-Oxyisovalerate
    • D-Valic acid
    • L-Valic acid
    • 2-Hydroxyisovalerate
    • (+/-)-2-HYDROXYISOVALERIC ACID
    • A-hydroxyisovalerate
    • 2-Hydroxyisopentanoate
    • alpha-hydroxyisovalerate
    • DL-a-hydroxyisovalerate
    • DL-2-Hydroxyisovalerate
    • DL-alpha-hydroxyisovalerate
    • 3-Methyl-2-hydroxybutyrate
    • DL-2-Hydroxy-3-methylbutanoate
    • NSC 227884
    • UNII-02X1W97FWN
    • 2-Hydroxy-3-methyl butyric acid
    • 2-hydroxy-3-methyl-butanoic acid
    • EINECS 209-994-2
    • EINECS 223-697-5
    • (1)-2-Hydroxy-3-methylbutyric acid
    • NSC227884
    • (+/-)-2-Hydroxy-3-methylbutyric acid
    • A-hydroxyisovaleric acid
    • D-a-Hydroxyisovaleric acid
    • L-a-Hydroxyisovaleric acid
    • DL-a-hydroxyisovaleric acid
    • SCHEMBL43434
    • (RS)-2-hydroxyisovaleric acid
    • 2-Hydroxy-3-methylbutanoicacid
    • DL-alpha-hydroxyisovaleric acid
    • orb1301934
    • SCHEMBL4831104
    • CHEMBL1162479
    • SCHEMBL27323652
    • SCHEMBL28239302
    • NGEWQZIDQIYUNV-UHFFFAOYSA-
    • 2-Hydroxy-3-methylbutanoic acid #
    • LMFA01050478
    • MSK158249
    • s6098
    • .ALPHA.-HYDROXYISOVALERIC ACID
    • AKOS000278106
    • AKOS016182980
    • 2-Hydroxy-3-methylbutyric acid, 99%
    • AB88448
    • CS-W008150
    • FH09748
    • HY-W008150
    • DL-.ALPHA.-HYDROXYISOVALERIC ACID
    • AS-12349
    • PD099517
    • SY107317
    • (+/-)-2-HYDROXYISOPENTANOIC ACID
    • Butanoic acid,2-hydroxy-3-methyl-,(2R)-
    • BUTYRIC ACID, 2-HYDROXY-3-METHYL-
    • DB-021168
    • DB-293121
    • NS00014672
    • ST50758692
    • (+/-)-.ALPHA.-HYDROXYISOVALERIC ACID
    • EN300-115018
    • F19720
    • 026H180
    • F336693
    • Q27104874
    • InChI=1/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)
    • 4026-18-0

  • Applications

    (+-)-2-Hydroxyisovaleric acid, CAS 4026-18-0, is an aliphatic hydroxycarboxylic acid that exists as a racemic mixture and offers reactive functionality for downstream synthesis; in practice, its applications commonly include: serving as a building block and intermediate for fragrance and flavor compounds via ester formation; used in cosmetics and personal care as an intermediate for fragrance derivatives; explored as a building block for specialty polyesters and other polymeric materials; employed as an industrial intermediate for the synthesis of esters, lactones, and related derivatives; and may be used as an intermediate in pharmaceutical synthesis.

    gpt-5-nano

1 3

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction