2-Hydroxyhexadecyl dihydrogen phosphate

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  • Identifiers

    CAS number
    84753-03-7

    Molecular formula
    C16H35O5P

    SMILES
    CCCCCCCCCCCCCCC(COP(=O)(O)O)O

    Safety labels

  • Odor profile

    Fragrance
    Waxy 51.91%
    Odorless 43.96%
    Fatty 39.85%
    Oily 33.49%
    Citrus 26.54%
    Fresh 25.73%
    Clean 22.03%
    Milky 20.48%
    Balsamic 20.05%
    Sweet 19.3%

     

    Flavor
    Fatty 49.47%
    Waxy 45.07%
    Mild 40.36%
    Odorless 39.26%
    Bland 31.57%
    Oily 27.84%
    Faint 25.91%
    Fat 25.23%
    Bay oil 24.01%
    Slightly waxy 23.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.0

    pKa est.
    8.13 (weak base)

    Molecular weight
    338.42 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    469°C

    Flash point

    • 254.36 ˚C est.

  • Synonyms

    • 2-Hydroxyhexadecyl dihydrogen phosphate
    • 84753-03-7
    • EINECS 283-849-1
    • SCHEMBL10658463
    • RUWOTBASWCAIML-UHFFFAOYSA-N
    • DTXSID601005055
    • NS00013755
    • 84753-03-7

  • Applications

    2-Hydroxyhexadecyl dihydrogen phosphate (CAS 84753-03-7) is commonly used as an anionic surfactant and emulsifier in cosmetics and personal care products to stabilize oil-in-water emulsions, improve foaming, and adjust rheology; it also serves as a wetting and dispersing agent in household cleaners and detergents, aiding soil removal and formulation performance; in coatings and inks it functions as a surfactant and pigment dispersant to enhance wetting and stabilization; in polymers and plastics processing it can act as a processing aid and emulsion stabilizer, promoting compatibility between hydrophobic and hydrophilic components; across industrial manufacturing it is often evaluated as a surfactant additive or emulsifier to improve formulation stability, dispersion, and performance within regulatory and compatibility constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 26.13
    methanol 43.34
    isopropanol 19.94
    water 0.51
    ethyl acetate 9.84
    n-propanol 20.94
    acetone 20.54
    n-butanol 16.35
    acetonitrile 5.3
    DMF 85.25
    toluene 4.74
    isobutanol 14.54
    1,4-dioxane 24.32
    methyl acetate 10.89
    THF 109.31
    2-butanone 16.73
    n-pentanol 18.4
    sec-butanol 17.39
    n-hexane 1.6
    ethylene glycol 8.39
    NMP 122.78
    cyclohexane 3.76
    DMSO 166.93
    n-butyl acetate 19.21
    n-octanol 18.83
    chloroform 23.33
    n-propyl acetate 17.74
    acetic acid 24.04
    dichloromethane 20.53
    cyclohexanone 48.54
    propylene glycol 18.38
    isopropyl acetate 13.36
    DMAc 120.42
    2-ethoxyethanol 53.74
    isopentanol 17.34
    n-heptane 2.41
    ethyl formate 10.56
    1,2-dichloroethane 20.08
    n-hexanol 19.14
    2-methoxyethanol 60.62
    isobutyl acetate 13.46
    tetrachloromethane 6.29
    n-pentyl acetate 28.76
    transcutol 119.48
    n-heptanol 23.34
    ethylbenzene 5.09
    MIBK 18.53
    2-propoxyethanol 54.19
    tert-butanol 35.43
    MTBE 18.03
    2-butoxyethanol 57.0
    propionic acid 19.22
    o-xylene 7.39
    formic acid 17.08
    diethyl ether 8.28
    m-xylene 6.32
    p-xylene 7.15
    chlorobenzene 6.17
    dimethyl carbonate 8.74
    n-octane 1.81
    formamide 30.94
    cyclopentanone 75.65
    2-pentanone 16.99
    anisole 12.14
    cyclopentyl methyl ether 35.55
    gamma-butyrolactone 66.43
    1-methoxy-2-propanol 52.58
    pyridine 18.19
    3-pentanone 13.63
    furfural 49.08
    n-dodecane 1.11
    diethylene glycol 38.07
    diisopropyl ether 5.94
    tert-amyl alcohol 32.01
    acetylacetone 27.98
    n-hexadecane 1.29
    acetophenone 22.35
    methyl propionate 12.51
    isopentyl acetate 22.6
    trichloroethylene 31.96
    n-nonanol 18.67
    cyclohexanol 23.3
    benzyl alcohol 16.2
    2-ethylhexanol 13.78
    isooctanol 20.38
    dipropyl ether 13.3
    1,2-dichlorobenzene 10.26
    ethyl lactate 17.09
    propylene carbonate 31.44
    n-methylformamide 29.79
    2-pentanol 11.74
    n-pentane 1.35
    1-propoxy-2-propanol 45.28
    1-methoxy-2-propyl acetate 28.2
    2-(2-methoxypropoxy) propanol 44.52
    mesitylene 5.96
    ε-caprolactone 44.06
    p-cymene 7.11
    epichlorohydrin 50.26
    1,1,1-trichloroethane 15.42
    2-aminoethanol 24.03
    morpholine-4-carbaldehyde 74.39
    sulfolane 162.27
    2,2,4-trimethylpentane 1.85
    2-methyltetrahydrofuran 43.29
    n-hexyl acetate 28.86
    isooctane 1.27
    2-(2-butoxyethoxy)ethanol 64.87
    sec-butyl acetate 13.51
    tert-butyl acetate 25.9
    decalin 2.61
    glycerin 33.34
    diglyme 96.29
    acrylic acid 15.91
    isopropyl myristate 12.2
    n-butyric acid 26.2
    acetyl acetate 9.56
    di(2-ethylhexyl) phthalate 16.21
    ethyl propionate 12.24
    nitromethane 29.99
    1,2-diethoxyethane 26.8
    benzonitrile 11.42
    trioctyl phosphate 13.65
    1-bromopropane 8.03
    gamma-valerolactone 85.67
    n-decanol 12.81
    triethyl phosphate 14.33
    4-methyl-2-pentanol 11.08
    propionitrile 6.05
    vinylene carbonate 21.04
    1,1,2-trichlorotrifluoroethane 65.29
    DMS 16.99
    cumene 5.74
    2-octanol 15.64
    2-hexanone 19.73
    octyl acetate 16.01
    limonene 10.43
    1,2-dimethoxyethane 57.88
    ethyl orthosilicate 15.72
    tributyl phosphate 14.42
    diacetone alcohol 47.97
    N,N-dimethylaniline 17.59
    acrylonitrile 7.84
    aniline 10.42
    1,3-propanediol 29.84
    bromobenzene 6.05
    dibromomethane 14.31
    1,1,2,2-tetrachloroethane 43.68
    2-methyl-cyclohexyl acetate 25.9
    tetrabutyl urea 25.13
    diisobutyl methanol 11.5
    2-phenylethanol 19.07
    styrene 4.74
    dioctyl adipate 21.58
    dimethyl sulfate 29.28
    ethyl butyrate 16.47
    methyl lactate 19.17
    butyl lactate 34.61
    diethyl carbonate 10.54
    propanediol butyl ether 53.11
    triethyl orthoformate 18.6
    p-tert-butyltoluene 7.86
    methyl 4-tert-butylbenzoate 40.99
    morpholine 44.72
    tert-butylamine 19.22
    n-dodecanol 8.74
    dimethoxymethane 34.42
    ethylene carbonate 18.32
    cyrene 50.58
    2-ethoxyethyl acetate 32.9
    2-ethylhexyl acetate 17.73
    1,2,4-trichlorobenzene 13.55
    4-methylpyridine 15.95
    dibutyl ether 12.44
    2,6-dimethyl-4-heptanol 11.5
    DEF 29.1
    dimethyl isosorbide 80.58
    tetrachloroethylene 30.07
    eugenol 38.79
    triacetin 35.96
    span 80 43.33
    1,4-butanediol 15.65
    1,1-dichloroethane 11.03
    2-methyl-1-pentanol 16.8
    methyl formate 15.57
    2-methyl-1-butanol 15.35
    n-decane 2.2
    butyronitrile 7.39
    3,7-dimethyl-1-octanol 16.91
    1-chlorooctane 8.92
    1-chlorotetradecane 3.28
    n-nonane 2.07
    undecane 1.48
    tert-butylcyclohexane 2.38
    cyclooctane 1.67
    cyclopentanol 39.37
    tetrahydropyran 25.71
    tert-amyl methyl ether 17.89
    2,5,8-trioxanonane 70.46
    1-hexene 4.2
    2-isopropoxyethanol 37.1
    2,2,2-trifluoroethanol 15.11
    methyl butyrate 19.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction