2'-Hydroxyflavanone

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  • Identifiers

    CAS number
    17348-76-4

    Molecular formula
    C15H12O3

    SMILES
    C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3O

    Safety labels

  • Odor profile

    Fragrance
    Sweet 74.52%
    Phenolic 59.62%
    Spicy 50.76%
    Coumarinic 47.67%
    Vanilla 40.32%
    Herbal 39.78%
    Coconut 38.69%
    Hay 35.23%
    Medicinal 34.08%
    Aromatic 33.55%

     

    Flavor
    Bitter 87.48%
    Herbal 29.35%
    Tonka 28.17%
    Sweet 27.54%
    Coconut 21.81%
    Balsam 21.34%
    Lovage 21.2%
    Naphthalic 20.01%
    Moth ball 19.62%
    Naphthelene 19.35%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    9.39 (weak base)

    Molecular weight
    240.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    431°C

    Flash point

    • 191.93 ˚C est.

  • Synonyms

    • 2'-Hydroxyflavanone
    • 17348-76-4
    • 2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
    • 2'-Hydroxy-Flavanone
    • 2'-OH flavanone
    • RefChem:80374
    • 2-(2-Hydroxyphenyl)chroman-4-one
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2-hydroxyphenyl)-
    • MFCD00017702
    • CHEMBL75897
    • 2-(2-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
    • 2 inverted exclamation marka-Hydroxyflavanone
    • ST059080
    • 2''-Hydroxyflavanone
    • Chroman-4-one, 2-(2-hydroxyphenyl)-
    • 2''-hydroxy-flavanone
    • SCHEMBL128288
    • orb1299325
    • SCHEMBL29661236
    • 2-(2-Hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
    • DTXSID60938395
    • BDBM50051340
    • NSC814528
    • AKOS015856273
    • EBC-617344
    • FH67228
    • NSC-814528
    • AS-69876
    • PD119842
    • SY116950
    • DB-043945
    • HY-134556
    • 2 inverted exclamation mark -Hydroxyflavanone
    • CS-0145355
    • H1024
    • T71923
    • 17348-76-4

  • Applications

    2'-Hydroxyflavanone (CAS 17348-76-4) is primarily used as an intermediate in the synthesis of flavonoid-derived compounds for pharmaceutical and agrochemical manufacturing; it is also employed as a building block for fragrance and flavor precursors in the perfumery and flavor industries. In cosmetics and personal care, it serves as a synthetic intermediate for aroma-related ingredients and related specialty compounds. In polymer and coatings applications, the compound is explored as an antioxidant/stabilizer additive and as a precursor for chromophoric compounds used in dyes and pigments for coatings and inks. Additionally, it can serve as a starting material in dye/pigment synthesis and may be evaluated for use in adhesives and advanced polymer systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.57
    methanol 14.09
    isopropanol 8.01
    water 0.12
    ethyl acetate 51.98
    n-propanol 8.29
    acetone 78.15
    n-butanol 8.59
    acetonitrile 58.9
    DMF 174.92
    toluene 23.48
    isobutanol 7.67
    1,4-dioxane 192.21
    methyl acetate 73.0
    THF 227.02
    2-butanone 70.21
    n-pentanol 11.15
    sec-butanol 8.06
    n-hexane 0.31
    ethylene glycol 10.26
    NMP 111.92
    cyclohexane 0.95
    DMSO 314.03
    n-butyl acetate 42.87
    n-octanol 8.38
    chloroform 85.52
    n-propyl acetate 45.73
    acetic acid 49.72
    dichloromethane 87.99
    cyclohexanone 106.54
    propylene glycol 9.78
    isopropyl acetate 39.18
    DMAc 227.57
    2-ethoxyethanol 47.15
    isopentanol 13.8
    n-heptane 1.05
    ethyl formate 35.24
    1,2-dichloroethane 88.74
    n-hexanol 12.91
    2-methoxyethanol 71.99
    isobutyl acetate 30.84
    tetrachloromethane 4.47
    n-pentyl acetate 23.17
    transcutol 504.18
    n-heptanol 8.79
    ethylbenzene 12.02
    MIBK 38.83
    2-propoxyethanol 59.1
    tert-butanol 22.58
    MTBE 23.44
    2-butoxyethanol 33.78
    propionic acid 28.96
    o-xylene 15.99
    formic acid 21.44
    diethyl ether 25.37
    m-xylene 14.62
    p-xylene 16.84
    chlorobenzene 35.89
    dimethyl carbonate 67.16
    n-octane 0.5
    formamide 67.41
    cyclopentanone 137.07
    2-pentanone 45.36
    anisole 53.22
    cyclopentyl methyl ether 50.08
    gamma-butyrolactone 164.87
    1-methoxy-2-propanol 60.15
    pyridine 91.43
    3-pentanone 51.35
    furfural 145.56
    n-dodecane 0.97
    diethylene glycol 69.3
    diisopropyl ether 9.89
    tert-amyl alcohol 15.53
    acetylacetone 116.91
    n-hexadecane 1.19
    acetophenone 56.46
    methyl propionate 51.96
    isopentyl acetate 42.11
    trichloroethylene 172.03
    n-nonanol 9.91
    cyclohexanol 18.25
    benzyl alcohol 37.66
    2-ethylhexanol 13.48
    isooctanol 9.69
    dipropyl ether 23.71
    1,2-dichlorobenzene 36.7
    ethyl lactate 33.62
    propylene carbonate 76.7
    n-methylformamide 60.6
    2-pentanol 8.19
    n-pentane 0.25
    1-propoxy-2-propanol 42.76
    1-methoxy-2-propyl acetate 71.93
    2-(2-methoxypropoxy) propanol 72.09
    mesitylene 10.58
    ε-caprolactone 82.3
    p-cymene 11.8
    epichlorohydrin 190.89
    1,1,1-trichloroethane 41.1
    2-aminoethanol 13.08
    morpholine-4-carbaldehyde 192.48
    sulfolane 198.63
    2,2,4-trimethylpentane 0.9
    2-methyltetrahydrofuran 65.95
    n-hexyl acetate 33.99
    isooctane 0.82
    2-(2-butoxyethoxy)ethanol 88.74
    sec-butyl acetate 34.05
    tert-butyl acetate 49.26
    decalin 1.81
    glycerin 33.01
    diglyme 221.54
    acrylic acid 40.88
    isopropyl myristate 19.87
    n-butyric acid 33.57
    acetyl acetate 58.86
    di(2-ethylhexyl) phthalate 21.56
    ethyl propionate 44.39
    nitromethane 197.83
    1,2-diethoxyethane 97.63
    benzonitrile 52.35
    trioctyl phosphate 14.35
    1-bromopropane 16.72
    gamma-valerolactone 185.27
    n-decanol 8.62
    triethyl phosphate 32.48
    4-methyl-2-pentanol 9.69
    propionitrile 40.23
    vinylene carbonate 83.13
    1,1,2-trichlorotrifluoroethane 115.25
    DMS 71.83
    cumene 9.42
    2-octanol 5.81
    2-hexanone 44.12
    octyl acetate 21.21
    limonene 14.84
    1,2-dimethoxyethane 137.68
    ethyl orthosilicate 28.35
    tributyl phosphate 21.94
    diacetone alcohol 61.54
    N,N-dimethylaniline 31.68
    acrylonitrile 72.35
    aniline 36.02
    1,3-propanediol 22.97
    bromobenzene 33.29
    dibromomethane 37.76
    1,1,2,2-tetrachloroethane 114.58
    2-methyl-cyclohexyl acetate 37.33
    tetrabutyl urea 29.84
    diisobutyl methanol 12.17
    2-phenylethanol 33.81
    styrene 16.87
    dioctyl adipate 36.47
    dimethyl sulfate 111.91
    ethyl butyrate 40.28
    methyl lactate 47.63
    butyl lactate 28.26
    diethyl carbonate 36.85
    propanediol butyl ether 34.16
    triethyl orthoformate 38.25
    p-tert-butyltoluene 11.03
    methyl 4-tert-butylbenzoate 48.02
    morpholine 129.67
    tert-butylamine 9.8
    n-dodecanol 7.42
    dimethoxymethane 125.96
    ethylene carbonate 69.42
    cyrene 66.85
    2-ethoxyethyl acetate 57.71
    2-ethylhexyl acetate 33.63
    1,2,4-trichlorobenzene 50.05
    4-methylpyridine 65.88
    dibutyl ether 22.32
    2,6-dimethyl-4-heptanol 12.17
    DEF 68.39
    dimethyl isosorbide 119.62
    tetrachloroethylene 57.74
    eugenol 46.62
    triacetin 76.12
    span 80 42.26
    1,4-butanediol 11.21
    1,1-dichloroethane 42.16
    2-methyl-1-pentanol 14.74
    methyl formate 64.68
    2-methyl-1-butanol 10.39
    n-decane 1.3
    butyronitrile 24.77
    3,7-dimethyl-1-octanol 13.59
    1-chlorooctane 6.84
    1-chlorotetradecane 4.16
    n-nonane 0.95
    undecane 1.13
    tert-butylcyclohexane 1.63
    cyclooctane 0.54
    cyclopentanol 19.51
    tetrahydropyran 71.67
    tert-amyl methyl ether 20.08
    2,5,8-trioxanonane 155.52
    1-hexene 2.46
    2-isopropoxyethanol 38.26
    2,2,2-trifluoroethanol 32.9
    methyl butyrate 51.18

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction