2-Hydroxyethyl hexadecanoate

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  • Identifiers

    CAS number
    4219-49-2

    Molecular formula
    C18H36O3

    SMILES
    CCCCCCCCCCCCCCCC(=O)OCCO

    Safety labels

  • Odor profile

    Fragrance
    Waxy 72.31%
    Fatty 68.89%
    Oily 50.24%
    Odorless 36.41%
    Creamy 31.27%
    Sweet 28.7%
    Buttery 24.09%
    Dairy 23.93%
    Milky 21.7%
    Soapy 21.44%

     

    Flavor
    Waxy 72.78%
    Fatty 54.47%
    Oily 51.4%
    Soapy 45.99%
    Mild 44.93%
    Coconut 40.6%
    Creamy 39.58%
    Sweet 39.23%
    Fat 35.48%
    Fruity 34.82%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.8

    pKa est.
    7.18 (neutral)

    Molecular weight
    300.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    380°C

    Flash point

    • 177.33 ˚C est.

  • Synonyms

    • 2-Hydroxyethyl palmitate
    • Glycol palmitate
    • 4219-49-2
    • 2-Hydroxyethyl hexadecanoate
    • Ethylene glycol monopalmitate
    • Palmitoylglycol
    • Hexadecanoic acid, 2-hydroxyethyl ester
    • Glycol monopalmitate
    • PALMITIC ACID, 2-HYDROXYETHYL ESTER
    • Lanol P
    • NSC 406556
    • EINECS 224-160-8
    • BRN 1789719
    • T80A3T38WE
    • AI3-03503
    • NSC-406556
    • CHEBI:136809
    • DTXSID10863345
    • RefChem:473432
    • Hexadecanoic acid, 2-hydroxyethyl ester (9CI)
    • GLYCOL PALMITATE [INCI]
    • DTXCID60811977
    • 224-160-8
    • 618-403-0
    • 1-monopalmitoylethylene glycol
    • MFCD01709442
    • 9004-94-8
    • UNII-T80A3T38WE
    • mono-C16-EG
    • SCHEMBL406849
    • ethylene glycol monohexadecanoate
    • NSC406556
    • AKOS027321382
    • AS-58105
    • CS-0160236
    • NS00013717
    • D82526
    • Q27289787
    • 4219-49-2

  • Applications

    2-Hydroxyethyl hexadecanoate is a fatty ester used as an emollient and conditioning agent in cosmetic and personal-care formulations; it serves as a lubricant and processing aid in polymer and plastic systems; it is used as a wax-like additive to improve texture, gloss, and slip in coatings and printing inks; and it can act as a chemical intermediate in industrial manufacturing, enabling the synthesis of other fatty ester derivatives or surfactants.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 38.01
    methanol 56.6
    isopropanol 59.27
    water 0.02
    ethyl acetate 273.69
    n-propanol 58.45
    acetone 158.24
    n-butanol 72.21
    acetonitrile 70.2
    DMF 305.22
    toluene 78.1
    isobutanol 65.27
    1,4-dioxane 247.45
    methyl acetate 160.73
    THF 690.95
    2-butanone 224.84
    n-pentanol 64.85
    sec-butanol 74.61
    n-hexane 20.16
    ethylene glycol 4.3
    NMP 623.01
    cyclohexane 104.08
    DMSO 534.86
    n-butyl acetate 343.71
    n-octanol 76.33
    chloroform 564.29
    n-propyl acetate 397.61
    acetic acid 86.51
    dichloromethane 628.52
    cyclohexanone 747.62
    propylene glycol 14.17
    isopropyl acetate 281.76
    DMAc 496.64
    2-ethoxyethanol 169.39
    isopentanol 110.67
    n-heptane 24.27
    ethyl formate 122.08
    1,2-dichloroethane 495.6
    n-hexanol 64.54
    2-methoxyethanol 165.73
    isobutyl acetate 251.99
    tetrachloromethane 137.34
    n-pentyl acetate 449.61
    transcutol 876.71
    n-heptanol 68.35
    ethylbenzene 70.71
    MIBK 294.37
    2-propoxyethanol 167.04
    tert-butanol 146.91
    MTBE 215.6
    2-butoxyethanol 207.27
    propionic acid 91.62
    o-xylene 85.22
    formic acid 16.3
    diethyl ether 148.43
    m-xylene 73.4
    p-xylene 107.02
    chlorobenzene 159.79
    dimethyl carbonate 58.8
    n-octane 12.3
    formamide 40.83
    cyclopentanone 704.98
    2-pentanone 277.02
    anisole 172.07
    cyclopentyl methyl ether 365.59
    gamma-butyrolactone 622.97
    1-methoxy-2-propanol 191.42
    pyridine 279.32
    3-pentanone 214.63
    furfural 447.2
    n-dodecane 7.28
    diethylene glycol 66.34
    diisopropyl ether 83.53
    tert-amyl alcohol 152.14
    acetylacetone 373.34
    n-hexadecane 9.1
    acetophenone 250.63
    methyl propionate 183.11
    isopentyl acetate 331.29
    trichloroethylene 754.23
    n-nonanol 77.41
    cyclohexanol 181.28
    benzyl alcohol 106.48
    2-ethylhexanol 86.69
    isooctanol 82.2
    dipropyl ether 193.67
    1,2-dichlorobenzene 228.81
    ethyl lactate 120.69
    propylene carbonate 353.29
    n-methylformamide 95.78
    2-pentanol 68.51
    n-pentane 12.96
    1-propoxy-2-propanol 201.87
    1-methoxy-2-propyl acetate 290.44
    2-(2-methoxypropoxy) propanol 188.24
    mesitylene 66.11
    ε-caprolactone 600.81
    p-cymene 68.62
    epichlorohydrin 645.08
    1,1,1-trichloroethane 504.22
    2-aminoethanol 19.08
    morpholine-4-carbaldehyde 457.94
    sulfolane 1095.32
    2,2,4-trimethylpentane 17.52
    2-methyltetrahydrofuran 480.68
    n-hexyl acetate 370.39
    isooctane 11.06
    2-(2-butoxyethoxy)ethanol 265.01
    sec-butyl acetate 291.97
    tert-butyl acetate 403.99
    decalin 39.62
    glycerin 29.47
    diglyme 642.77
    acrylic acid 60.0
    isopropyl myristate 114.51
    n-butyric acid 241.01
    acetyl acetate 179.72
    di(2-ethylhexyl) phthalate 85.89
    ethyl propionate 310.96
    nitromethane 251.91
    1,2-diethoxyethane 368.04
    benzonitrile 164.69
    trioctyl phosphate 69.95
    1-bromopropane 251.2
    gamma-valerolactone 879.43
    n-decanol 48.36
    triethyl phosphate 157.32
    4-methyl-2-pentanol 66.3
    propionitrile 90.13
    vinylene carbonate 249.49
    1,1,2-trichlorotrifluoroethane 424.71
    DMS 181.86
    cumene 59.5
    2-octanol 71.11
    2-hexanone 302.45
    octyl acetate 137.32
    limonene 132.46
    1,2-dimethoxyethane 489.32
    ethyl orthosilicate 155.95
    tributyl phosphate 102.54
    diacetone alcohol 335.05
    N,N-dimethylaniline 127.62
    acrylonitrile 99.61
    aniline 88.41
    1,3-propanediol 48.92
    bromobenzene 197.63
    dibromomethane 404.19
    1,1,2,2-tetrachloroethane 795.28
    2-methyl-cyclohexyl acetate 260.76
    tetrabutyl urea 157.6
    diisobutyl methanol 74.54
    2-phenylethanol 100.41
    styrene 85.16
    dioctyl adipate 199.48
    dimethyl sulfate 165.89
    ethyl butyrate 333.33
    methyl lactate 80.76
    butyl lactate 241.94
    diethyl carbonate 172.99
    propanediol butyl ether 157.89
    triethyl orthoformate 247.06
    p-tert-butyltoluene 64.77
    methyl 4-tert-butylbenzoate 259.45
    morpholine 376.41
    tert-butylamine 94.21
    n-dodecanol 33.86
    dimethoxymethane 179.9
    ethylene carbonate 244.96
    cyrene 208.48
    2-ethoxyethyl acetate 420.72
    2-ethylhexyl acetate 278.16
    1,2,4-trichlorobenzene 271.1
    4-methylpyridine 271.56
    dibutyl ether 230.14
    2,6-dimethyl-4-heptanol 74.54
    DEF 386.94
    dimethyl isosorbide 434.74
    tetrachloroethylene 494.76
    eugenol 195.88
    triacetin 373.91
    span 80 180.99
    1,4-butanediol 22.58
    1,1-dichloroethane 356.46
    2-methyl-1-pentanol 92.04
    methyl formate 66.95
    2-methyl-1-butanol 90.3
    n-decane 17.42
    butyronitrile 125.6
    3,7-dimethyl-1-octanol 91.47
    1-chlorooctane 99.81
    1-chlorotetradecane 28.08
    n-nonane 17.07
    undecane 10.32
    tert-butylcyclohexane 28.37
    cyclooctane 22.51
    cyclopentanol 174.88
    tetrahydropyran 412.45
    tert-amyl methyl ether 193.61
    2,5,8-trioxanonane 362.02
    1-hexene 62.15
    2-isopropoxyethanol 159.09
    2,2,2-trifluoroethanol 46.82
    methyl butyrate 465.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction