2-Hydroxyacetophenone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    582-24-1

    Molecular formula
    C8H8O2

    SMILES
    C1=CC=C(C=C1)C(=O)CO

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 74.14%
    Honey 48.91%
    Spicy 48.52%
    Balsamic 48.25%
    Caramellic 44.94%
    Almond 44.28%
    Green 43.36%
    Creamy 41.78%
    Floral 41.14%
    Vanilla 41.11%

     

    Flavor
    Sweet 69.28%
    Balsam 48.77%
    Honey 36.82%
    Balsamic 35.91%
    Almond 35.33%
    Creamy 33.32%
    Faint 31.74%
    Powdery 31.65%
    Hawthorn 27.87%
    Caramel 26.61%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.1

    pKa est.
    7.16 (neutral)

    Molecular weight
    136.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    247°C

    Flash point

    • 127.87 ˚C est.

  • Synonyms

    • 2-Hydroxyacetophenone
    • 582-24-1
    • 2-Hydroxy-1-phenylethanone
    • Phenacyl alcohol
    • Benzoylcarbinol
    • Glycolophenone
    • Ethanone, 2-hydroxy-1-phenyl-
    • alpha-Hydroxyacetophenone
    • 2-Hydroxy-1-phenylethan-1-one
    • Methanol, benzoyl-
    • Acetophenone, 2-hydroxy-
    • (Hydroxyacetyl)benzene
    • omega-Hydroxyacetophenone
    • Hydroxymethyl phenyl ketone
    • .alpha.-Hydroxyacetophenone
    • .omega.-Hydroxyacetophenone
    • 1-Phenyl-2-hydroxyethanone
    • MFCD00041829
    • 2-hydroxy-1-phenyl-ethanone
    • 2-Phenyl-2-oxoethanol
    • NSC 171232
    • DQ1N9R01IA
    • Acetophenone, .alpha.-hydroxy-
    • NSC-171232
    • UNII-DQ1N9R01IA
    • benzoylmethanol
    • hydroxy-acetophenone
    • 2-hydroxyacetophenon
    • a-hydroxyacetophenone
    • EINECS 209-480-8
    • ?-Hydroxyacetophenone
    • 2-hydroxy acetophenone
    • 2-hydroxy-acetophenone
    • 2-hydroxyaceto-phenone
    • AI3-15121
    • alpha-hydroxy acetophenone
    • SCHEMBL44898
    • 2-Hydroxyacetophenone, 98%
    • 2-Hydroxy-1-phenylethanone #
    • DTXSID7060388
    • CHEBI:28341
    • NSC171232
    • AKOS009157007
    • CS-W002198
    • HY-W002198
    • AC-13228
    • SY014756
    • DB-021198
    • H0347
    • NS00022418
    • EN300-62495
    • C07189
    • Q27103649
    • Z906206792
    • InChI=1/C8H8O2/c9-6-8(10)7-4-2-1-3-5-7/h1-5,9H,6H

  • Applications

    2-Hydroxyacetophenone (CAS 582-24-1) is primarily used as an intermediate in organic synthesis, serving as a building block for more complex aryl compounds; in the fragrance and cosmetics industries it is used as a fragrance intermediate or precursor to odor-active molecules; in pharmaceutical synthesis it provides a route to various drug-like intermediates; in the dyes and coatings sector it acts as a precursor for pigments and functional aromatic compounds used in paints and coatings; in polymer and plastics chemistry it can serve as a functional aryl building block for specialty polymers and resin systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 255.84
    methanol 349.28
    isopropanol 156.34
    water 22.64
    ethyl acetate 104.41
    n-propanol 170.47
    acetone 225.26
    n-butanol 109.08
    acetonitrile 216.11
    DMF 892.39
    toluene 32.37
    isobutanol 102.95
    1,4-dioxane 321.12
    methyl acetate 158.45
    THF 241.77
    2-butanone 155.74
    n-pentanol 81.72
    sec-butanol 108.93
    n-hexane 5.15
    ethylene glycol 244.89
    NMP 495.53
    cyclohexane 11.67
    DMSO 1022.58
    n-butyl acetate 79.65
    n-octanol 87.25
    chloroform 292.19
    n-propyl acetate 91.05
    acetic acid 234.92
    dichloromethane 430.06
    cyclohexanone 210.76
    propylene glycol 114.8
    isopropyl acetate 56.73
    DMAc 496.13
    2-ethoxyethanol 209.29
    isopentanol 73.96
    n-heptane 13.87
    ethyl formate 151.44
    1,2-dichloroethane 300.3
    n-hexanol 90.61
    2-methoxyethanol 350.79
    isobutyl acetate 49.28
    tetrachloromethane 40.24
    n-pentyl acetate 65.99
    transcutol 466.42
    n-heptanol 75.38
    ethylbenzene 35.39
    MIBK 66.03
    2-propoxyethanol 179.09
    tert-butanol 144.39
    MTBE 70.45
    2-butoxyethanol 138.82
    propionic acid 180.22
    o-xylene 45.55
    formic acid 179.79
    diethyl ether 76.4
    m-xylene 37.87
    p-xylene 42.04
    chlorobenzene 87.64
    dimethyl carbonate 96.78
    n-octane 8.37
    formamide 411.85
    cyclopentanone 279.98
    2-pentanone 100.16
    anisole 102.03
    cyclopentyl methyl ether 89.54
    gamma-butyrolactone 368.78
    1-methoxy-2-propanol 207.99
    pyridine 186.02
    3-pentanone 83.12
    furfural 316.46
    n-dodecane 8.81
    diethylene glycol 224.61
    diisopropyl ether 22.96
    tert-amyl alcohol 103.48
    acetylacetone 140.59
    n-hexadecane 9.72
    acetophenone 109.7
    methyl propionate 119.09
    isopentyl acetate 66.1
    trichloroethylene 443.79
    n-nonanol 76.36
    cyclohexanol 89.23
    benzyl alcohol 98.62
    2-ethylhexanol 60.69
    isooctanol 60.82
    dipropyl ether 68.77
    1,2-dichlorobenzene 104.43
    ethyl lactate 85.48
    propylene carbonate 193.75
    n-methylformamide 449.26
    2-pentanol 60.7
    n-pentane 6.64
    1-propoxy-2-propanol 132.58
    1-methoxy-2-propyl acetate 95.5
    2-(2-methoxypropoxy) propanol 134.18
    mesitylene 31.5
    ε-caprolactone 173.01
    p-cymene 36.91
    epichlorohydrin 345.53
    1,1,1-trichloroethane 139.15
    2-aminoethanol 242.59
    morpholine-4-carbaldehyde 390.0
    sulfolane 535.99
    2,2,4-trimethylpentane 6.33
    2-methyltetrahydrofuran 148.69
    n-hexyl acetate 98.32
    isooctane 5.86
    2-(2-butoxyethoxy)ethanol 183.97
    sec-butyl acetate 47.17
    tert-butyl acetate 68.76
    decalin 9.92
    glycerin 202.67
    diglyme 378.62
    acrylic acid 183.82
    isopropyl myristate 49.16
    n-butyric acid 156.74
    acetyl acetate 73.08
    di(2-ethylhexyl) phthalate 49.78
    ethyl propionate 77.34
    nitromethane 484.76
    1,2-diethoxyethane 118.19
    benzonitrile 119.09
    trioctyl phosphate 45.54
    1-bromopropane 89.44
    gamma-valerolactone 329.08
    n-decanol 62.51
    triethyl phosphate 52.48
    4-methyl-2-pentanol 37.98
    propionitrile 143.48
    vinylene carbonate 182.46
    1,1,2-trichlorotrifluoroethane 274.89
    DMS 88.14
    cumene 32.09
    2-octanol 51.53
    2-hexanone 83.13
    octyl acetate 65.7
    limonene 50.82
    1,2-dimethoxyethane 295.52
    ethyl orthosilicate 47.28
    tributyl phosphate 45.98
    diacetone alcohol 133.19
    N,N-dimethylaniline 88.21
    acrylonitrile 238.25
    aniline 78.41
    1,3-propanediol 220.16
    bromobenzene 77.06
    dibromomethane 229.84
    1,1,2,2-tetrachloroethane 317.67
    2-methyl-cyclohexyl acetate 62.65
    tetrabutyl urea 78.02
    diisobutyl methanol 44.51
    2-phenylethanol 90.9
    styrene 44.4
    dioctyl adipate 76.83
    dimethyl sulfate 191.28
    ethyl butyrate 82.56
    methyl lactate 132.73
    butyl lactate 74.02
    diethyl carbonate 65.27
    propanediol butyl ether 134.45
    triethyl orthoformate 61.23
    p-tert-butyltoluene 33.67
    methyl 4-tert-butylbenzoate 125.0
    morpholine 291.41
    tert-butylamine 74.37
    n-dodecanol 49.88
    dimethoxymethane 244.44
    ethylene carbonate 143.69
    cyrene 141.78
    2-ethoxyethyl acetate 90.72
    2-ethylhexyl acetate 48.57
    1,2,4-trichlorobenzene 114.88
    4-methylpyridine 132.03
    dibutyl ether 65.26
    2,6-dimethyl-4-heptanol 44.51
    DEF 202.07
    dimethyl isosorbide 191.39
    tetrachloroethylene 218.21
    eugenol 123.78
    triacetin 113.04
    span 80 112.47
    1,4-butanediol 113.23
    1,1-dichloroethane 185.2
    2-methyl-1-pentanol 60.78
    methyl formate 302.84
    2-methyl-1-butanol 74.62
    n-decane 13.21
    butyronitrile 108.59
    3,7-dimethyl-1-octanol 65.22
    1-chlorooctane 52.29
    1-chlorotetradecane 22.76
    n-nonane 12.6
    undecane 10.64
    tert-butylcyclohexane 9.24
    cyclooctane 5.49
    cyclopentanol 121.15
    tetrahydropyran 150.51
    tert-amyl methyl ether 57.8
    2,5,8-trioxanonane 266.61
    1-hexene 21.27
    2-isopropoxyethanol 130.15
    2,2,2-trifluoroethanol 133.57
    methyl butyrate 116.23

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction