2-Hydroxy-5-methylacetophenone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    1450-72-2

    Molecular formula
    C9H10O2

    SMILES
    CC1=CC(=C(C=C1)O)C(=O)C

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • DB5: 1316.0

  • Odor profile

    Sweet 89.55%
    Floral 64.49%
    Phenolic 64.17%
    Herbal 58.35%
    Hawthorn 54.33%
    Cherry 53.0%
    Hay 52.65%
    Coumarinic 50.11%
    Vanilla 47.79%
    Almond 46.33%

    Scent© AI

  • Properties

    XLogP3-AA
    2.3

    Molecular weight
    150.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 50 °C

    Boiling point

    • 210.00 °C. @ 760.00 mm Hg

    Flash point est.
    115.39 ˚C

    Solubility expt.

    • Practically insoluble or insoluble in water
    • Soluble (in ethanol)

  • Synonyms

    • 1450-72-2
    • 1-(2-Hydroxy-5-methylphenyl)ethanone
    • 2'-Hydroxy-5'-methylacetophenone
    • 2-Hydroxy-5-methylacetophenone
    • Ethanone, 1-(2-hydroxy-5-methylphenyl)-
    • o-Acetyl-p-cresol
    • 2-ACETYL-4-METHYLPHENOL
    • 1-(2-Hydroxy-5-Methylphenyl)Ethan-1-One
    • 1-Hydroxy-2-acetyl-4-methylbenzene
    • MFCD00002380
    • Acetophenone, 2'-hydroxy-5'-methyl-
    • 1-(2-Hydroxy-5-methyl-phenyl)-ethanone
    • 11661U1ZEN
    • EINECS 215-915-2
    • NSC-26458
    • NSC-63363
    • DTXSID9061702
    • FEMA NO. 4594
    • NSC 26458
    • NSC 63363
    • 5'-METHYL-2'-HYDROXYACETOPHENONE
    • UNII-11661U1ZEN
    • NSC63363
    • 2-Acetyl-p-cresol
    • NCIOpen2_000252
    • SCHEMBL471440
    • CHEMBL4444601
    • DTXCID0034720
    • Methyl 6-hydroxy-m-tolyl ketone
    • CHEBI:179659
    • 2'-hydroxy-5'-methyl-acetophenone
    • ALBB-019497
    • NSC26458
    • STK727255
    • Acetophenone, 2"-hydroxy-5"-methyl-
    • AKOS000266093
    • FH33098
    • HY-W100681
    • SDCCGMLS-0065880.P001
    • 1-(2-Hydroxy-5-methylphenyl)-Ethanone
    • 2'-Hydroxy-5'-methylacetophenone, 98%
    • 1-(2-Hydroxy-5-methylphenyl)ethanone #
    • BP-12459
    • PD171706
    • SY048474
    • DB-011374
    • 1-(2-Hydroxy-5-methylphenyl)ethanone, 9CI
    • CS-0153323
    • H0790
    • NS00021663
    • EN300-18588
    • 5D-073
    • 1-(2-HYDROXY-5-METHYLPHENYL)-1-ETHANONE
    • Q27251292
    • Z85923114
    • 2 inverted exclamation mark -Hydroxy-5 inverted exclamation mark -methylacetophenone
    • 215-915-2

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 628.66
    methanol 703.91
    isopropanol 531.53
    water 2.72
    ethyl acetate 506.58
    n-propanol 527.3
    acetone 970.27
    n-butanol 441.24
    acetonitrile 548.57
    DMF 1150.64
    toluene 104.73
    isobutanol 354.1
    1,4-dioxane 1034.51
    methyl acetate 561.78
    THF 2061.91
    2-butanone 648.57
    n-pentanol 283.06
    sec-butanol 428.82
    n-hexane 44.59
    ethylene glycol 193.37
    NMP 457.15
    cyclohexane 21.61
    DMSO 1064.49
    n-butyl acetate 179.27
    n-octanol 188.39
    chloroform 412.92
    n-propyl acetate 204.69
    acetic acid 206.71
    dichloromethane 422.73
    cyclohexanone 461.73
    propylene glycol 214.0
    isopropyl acetate 225.75
    DMAc 502.64
    2-ethoxyethanol 419.03
    isopentanol 295.21
    n-heptane 25.69
    ethyl formate 288.02
    1,2-dichloroethane 369.14
    n-hexanol 356.83
    2-methoxyethanol 787.64
    isobutyl acetate 126.12
    tetrachloromethane 62.27
    n-pentyl acetate 134.85
    transcutol 380.5
    n-heptanol 168.49
    ethylbenzene 87.49
    MIBK 262.56
    2-propoxyethanol 536.36
    tert-butanol 537.48
    MTBE 402.27
    2-butoxyethanol 245.28
    propionic acid 272.62
    o-xylene 76.2
    formic acid 98.07
    diethyl ether 481.35
    m-xylene 103.87
    p-xylene 99.4
    chlorobenzene 129.87
    dimethyl carbonate 187.93
    n-octane 17.55
    formamide 181.72
    cyclopentanone 872.35
    2-pentanone 519.01
    anisole 236.88
    cyclopentyl methyl ether 488.92
    gamma-butyrolactone 809.42
    1-methoxy-2-propanol 621.76
    pyridine 271.54
    3-pentanone 318.65
    furfural 368.21
    n-dodecane 17.93
    diethylene glycol 416.0
    diisopropyl ether 111.89
    tert-amyl alcohol 396.4
    acetylacetone 441.22
    n-hexadecane 19.8
    acetophenone 147.11
    methyl propionate 431.03
    isopentyl acetate 149.54
    trichloroethylene 427.01
    n-nonanol 149.39
    cyclohexanol 265.31
    benzyl alcohol 158.46
    2-ethylhexanol 149.54
    isooctanol 123.8
    dipropyl ether 161.78
    1,2-dichlorobenzene 110.38
    ethyl lactate 119.03
    propylene carbonate 274.26
    n-methylformamide 520.35
    2-pentanol 300.69
    n-pentane 32.0
    1-propoxy-2-propanol 283.99
    1-methoxy-2-propyl acetate 209.32
    2-(2-methoxypropoxy) propanol 157.09
    mesitylene 66.77
    ε-caprolactone 334.66
    p-cymene 47.79
    epichlorohydrin 863.11
    1,1,1-trichloroethane 280.23
    2-aminoethanol 288.84
    morpholine-4-carbaldehyde 525.34
    sulfolane 704.1
    2,2,4-trimethylpentane 20.17
    2-methyltetrahydrofuran 810.5
    n-hexyl acetate 219.58
    isooctane 21.5
    2-(2-butoxyethoxy)ethanol 233.21
    sec-butyl acetate 128.06
    tert-butyl acetate 239.28
    decalin 24.13
    glycerin 255.49
    diglyme 412.21
    acrylic acid 193.88
    isopropyl myristate 83.0
    n-butyric acid 310.55
    acetyl acetate 183.28
    di(2-ethylhexyl) phthalate 63.05
    ethyl propionate 198.5
    nitromethane 580.42
    1,2-diethoxyethane 181.96
    benzonitrile 151.76
    trioctyl phosphate 65.52
    1-bromopropane 254.31
    gamma-valerolactone 700.07
    n-decanol 115.79
    triethyl phosphate 66.18
    4-methyl-2-pentanol 158.76
    propionitrile 374.91
    vinylene carbonate 216.09
    1,1,2-trichlorotrifluoroethane 303.96
    DMS 157.83
    cumene 65.6
    2-octanol 135.98
    2-hexanone 274.49
    octyl acetate 112.77
    limonene 71.61
    1,2-dimethoxyethane 621.51
    ethyl orthosilicate 63.15
    tributyl phosphate 66.81
    diacetone alcohol 319.87
    N,N-dimethylaniline 143.04
    acrylonitrile 403.63
    aniline 154.4
    1,3-propanediol 416.71
    bromobenzene 119.08
    dibromomethane 288.24
    1,1,2,2-tetrachloroethane 343.98
    2-methyl-cyclohexyl acetate 102.47
    tetrabutyl urea 89.91
    diisobutyl methanol 85.58
    2-phenylethanol 171.1
    styrene 97.47
    dioctyl adipate 93.43
    dimethyl sulfate 293.3
    ethyl butyrate 121.29
    methyl lactate 205.71
    butyl lactate 99.49
    diethyl carbonate 80.79
    propanediol butyl ether 209.56
    triethyl orthoformate 78.86
    p-tert-butyltoluene 53.45
    methyl 4-tert-butylbenzoate 145.4
    morpholine 976.2
    tert-butylamine 276.2
    n-dodecanol 87.14
    dimethoxymethane 743.07
    ethylene carbonate 194.77
    cyrene 164.13
    2-ethoxyethyl acetate 162.41
    2-ethylhexyl acetate 109.34
    1,2,4-trichlorobenzene 121.79
    4-methylpyridine 288.89
    dibutyl ether 141.26
    2,6-dimethyl-4-heptanol 85.58
    DEF 370.69
    dimethyl isosorbide 240.52
    tetrachloroethylene 194.67
    eugenol 153.07
    triacetin 126.82
    span 80 141.45
    1,4-butanediol 177.98
    1,1-dichloroethane 373.8
    2-methyl-1-pentanol 198.61
    methyl formate 435.84
    2-methyl-1-butanol 282.61
    n-decane 28.53
    butyronitrile 376.92
    3,7-dimethyl-1-octanol 134.81
    1-chlorooctane 109.43
    1-chlorotetradecane 42.87
    n-nonane 28.17
    undecane 22.29
    tert-butylcyclohexane 31.87
    cyclooctane 11.52
    cyclopentanol 398.86
    tetrahydropyran 758.7
    tert-amyl methyl ether 262.93
    2,5,8-trioxanonane 250.95
    1-hexene 163.18
    2-isopropoxyethanol 279.57
    2,2,2-trifluoroethanol 104.23
    methyl butyrate 251.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artemisia waltonii (China) Artemisia waltonii J.R. Drumm. ex Pamp., fam. Asteraceae (Compositae) 0.87%