2-Hydroxy-5-methoxybenzaldehyde

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  • Identifiers

    CAS number
    672-13-9

    Molecular formula
    C8H8O3

    SMILES
    COC1=CC(=C(C=C1)O)C=O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 89.04%
    Vanilla 73.03%
    Phenolic 58.67%
    Spicy 54.94%
    Almond 44.36%
    Aromatic 41.99%
    Powdery 41.24%
    Anisic 39.1%
    Smoky 38.34%
    Creamy 37.24%

     

    Flavor
    Bitter 57.76%
    Sweet 42.92%
    Vanilla 42.01%
    Phenolic 32.29%
    Woody 31.87%
    Spicy 31.69%
    Creamy 29.09%
    Almond 28.83%
    Powdery 27.64%
    Cinnamon 25.33%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    7.75 (neutral)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    247°C

    Flash point

    • 126.08 ˚C est.

  • Synonyms

    • 2-Hydroxy-5-methoxybenzaldehyde
    • 672-13-9
    • 5-Methoxysalicylaldehyde
    • m-Anisaldehyde, 6-hydroxy-
    • Benzaldehyde, 2-hydroxy-5-methoxy-
    • 2-Formyl-4-methoxyphenol
    • GYT2Q9UR3W
    • NSC-30116
    • CHEBI:137359
    • DTXSID40217478
    • RefChem:87441
    • DTXCID40139969
    • 211-589-0
    • 6-Hydroxy-m-anisaldehyde
    • Salicylaldehyde, 5-methoxy-
    • MFCD00003332
    • 2-hydroxy-5-methoxy-benzaldehyde
    • 5-Methoxy-2-hydroxybenzaldehyde
    • 2-hydroxy-5-methoxy benzaldehyde
    • EINECS 211-589-0
    • NSC 30116
    • BRN 1100532
    • AI3-19305
    • NSC30116
    • Entacapone Impurity 26
    • Entacapone Impurity 64
    • 5-methoxy-salicylaldehyde
    • UNII-GYT2Q9UR3W
    • 4-methoxy-2-formylphenol
    • WLN: VHR BQ EO1
    • SCHEMBL120412
    • 3-methoxy-6-hydroxybenzaldehyde
    • CHEMBL3660371
    • SCHEMBL18770386
    • SCHEMBL29559365
    • 2-hydroxy-5-methoxybenzal dehyde
    • 5-methoxy-2-hydroxy-benzaldehyde
    • BDBM111039
    • BB_SC-09407
    • BBL027434
    • CL8287
    • SBB063767
    • STL374089
    • AKOS000112554
    • 2-Hydroxy-5-methoxybenzaldehyde, 98%
    • CS-W001206
    • EBC-439049
    • FH04958
    • GS-6684
    • 2-Hydroxy-5-methoxybenzaldehyde (NIST)
    • NCGC00665637-01
    • PD193523
    • H0881
    • NS00036099
    • ST50824321
    • EN300-17188
    • 672H139
    • F209088
    • US8614253, .3-70
    • Q15634035
    • Z56899054
    • F2113-0146
    • 2-Formyl-4-methoxyphenol;2-hydroxy-5-methoxy-benzaldehyd;6-hydroxy-m-anisaldehyd
    • InChI=1/C8H8O3/c1-11-7-2-3-8(10)6(4-7)5-9/h2-5,10H,1H
    • 672-13-9

  • Applications

    2-Hydroxy-5-methoxybenzaldehyde (CAS 672-13-9) is used primarily as an intermediate and aroma-active building block across several industries. In fragrance and flavor applications, it serves as a precursor or active component for aroma compounds and fragrance ingredients used in perfumery and flavor formulations. In cosmetics and personal care, it can function as a fragrance ingredient or an intermediate contributing to scent profiles. In household products, it is employed as an odorant additive to impart or stabilize fragrance in cleaners and detergents. In coatings, inks and polymers, it can act as a synthetic building block for fragrance-related additives or as a precursor for further derivatization toward specialty polymers and coatings. In pharmaceuticals, it is evaluated as a synthetic intermediate for complex organic molecules or scaffolds in drug development, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 100.28
    methanol 122.7
    isopropanol 70.97
    water 3.78
    ethyl acetate 131.05
    n-propanol 77.94
    acetone 232.98
    n-butanol 48.82
    acetonitrile 242.17
    DMF 328.4
    toluene 17.87
    isobutanol 49.27
    1,4-dioxane 262.39
    methyl acetate 271.8
    THF 354.03
    2-butanone 177.76
    n-pentanol 36.46
    sec-butanol 52.91
    n-hexane 0.92
    ethylene glycol 78.29
    NMP 234.93
    cyclohexane 3.16
    DMSO 553.89
    n-butyl acetate 45.21
    n-octanol 25.47
    chloroform 109.94
    n-propyl acetate 72.16
    acetic acid 145.83
    dichloromethane 275.67
    cyclohexanone 143.31
    propylene glycol 48.86
    isopropyl acetate 53.63
    DMAc 333.15
    2-ethoxyethanol 124.58
    isopentanol 41.94
    n-heptane 4.1
    ethyl formate 145.97
    1,2-dichloroethane 156.47
    n-hexanol 35.38
    2-methoxyethanol 217.09
    isobutyl acetate 34.36
    tetrachloromethane 18.17
    n-pentyl acetate 29.44
    transcutol 180.3
    n-heptanol 23.46
    ethylbenzene 15.79
    MIBK 47.3
    2-propoxyethanol 90.71
    tert-butanol 128.64
    MTBE 62.67
    2-butoxyethanol 56.77
    propionic acid 105.83
    o-xylene 21.98
    formic acid 104.28
    diethyl ether 48.66
    m-xylene 17.84
    p-xylene 24.93
    chlorobenzene 41.2
    dimethyl carbonate 81.18
    n-octane 2.03
    formamide 309.09
    cyclopentanone 264.44
    2-pentanone 79.6
    anisole 77.42
    cyclopentyl methyl ether 77.35
    gamma-butyrolactone 390.02
    1-methoxy-2-propanol 104.09
    pyridine 143.34
    3-pentanone 69.19
    furfural 259.6
    n-dodecane 2.69
    diethylene glycol 100.22
    diisopropyl ether 13.08
    tert-amyl alcohol 80.43
    acetylacetone 123.47
    n-hexadecane 2.97
    acetophenone 79.57
    methyl propionate 125.86
    isopentyl acetate 41.01
    trichloroethylene 245.98
    n-nonanol 24.24
    cyclohexanol 41.58
    benzyl alcohol 57.66
    2-ethylhexanol 26.13
    isooctanol 21.69
    dipropyl ether 30.64
    1,2-dichlorobenzene 47.14
    ethyl lactate 41.81
    propylene carbonate 149.25
    n-methylformamide 243.0
    2-pentanol 27.01
    n-pentane 1.3
    1-propoxy-2-propanol 53.66
    1-methoxy-2-propyl acetate 67.71
    2-(2-methoxypropoxy) propanol 65.05
    mesitylene 12.78
    ε-caprolactone 126.64
    p-cymene 17.14
    epichlorohydrin 420.07
    1,1,1-trichloroethane 103.47
    2-aminoethanol 95.14
    morpholine-4-carbaldehyde 261.15
    sulfolane 362.36
    2,2,4-trimethylpentane 2.07
    2-methyltetrahydrofuran 172.8
    n-hexyl acetate 43.59
    isooctane 1.63
    2-(2-butoxyethoxy)ethanol 79.11
    sec-butyl acetate 38.9
    tert-butyl acetate 62.33
    decalin 3.3
    glycerin 88.66
    diglyme 180.56
    acrylic acid 104.27
    isopropyl myristate 22.44
    n-butyric acid 80.2
    acetyl acetate 90.81
    di(2-ethylhexyl) phthalate 26.29
    ethyl propionate 60.31
    nitromethane 490.9
    1,2-diethoxyethane 64.02
    benzonitrile 74.01
    trioctyl phosphate 19.56
    1-bromopropane 42.89
    gamma-valerolactone 282.85
    n-decanol 20.48
    triethyl phosphate 36.7
    4-methyl-2-pentanol 19.45
    propionitrile 125.93
    vinylene carbonate 136.08
    1,1,2-trichlorotrifluoroethane 175.96
    DMS 62.98
    cumene 14.71
    2-octanol 15.25
    2-hexanone 61.14
    octyl acetate 29.31
    limonene 23.1
    1,2-dimethoxyethane 219.02
    ethyl orthosilicate 30.86
    tributyl phosphate 23.15
    diacetone alcohol 86.56
    N,N-dimethylaniline 51.27
    acrylonitrile 195.39
    aniline 47.99
    1,3-propanediol 102.84
    bromobenzene 35.77
    dibromomethane 103.15
    1,1,2,2-tetrachloroethane 131.09
    2-methyl-cyclohexyl acetate 44.71
    tetrabutyl urea 34.73
    diisobutyl methanol 19.49
    2-phenylethanol 48.54
    styrene 20.0
    dioctyl adipate 40.74
    dimethyl sulfate 138.89
    ethyl butyrate 52.02
    methyl lactate 61.15
    butyl lactate 26.02
    diethyl carbonate 49.02
    propanediol butyl ether 42.56
    triethyl orthoformate 36.47
    p-tert-butyltoluene 16.33
    methyl 4-tert-butylbenzoate 59.01
    morpholine 243.62
    tert-butylamine 51.82
    n-dodecanol 17.17
    dimethoxymethane 172.1
    ethylene carbonate 111.07
    cyrene 94.53
    2-ethoxyethyl acetate 56.61
    2-ethylhexyl acetate 30.6
    1,2,4-trichlorobenzene 61.92
    4-methylpyridine 103.12
    dibutyl ether 26.17
    2,6-dimethyl-4-heptanol 19.49
    DEF 112.48
    dimethyl isosorbide 137.93
    tetrachloroethylene 78.45
    eugenol 58.39
    triacetin 64.97
    span 80 44.31
    1,4-butanediol 42.95
    1,1-dichloroethane 105.79
    2-methyl-1-pentanol 34.33
    methyl formate 239.52
    2-methyl-1-butanol 39.78
    n-decane 3.7
    butyronitrile 81.73
    3,7-dimethyl-1-octanol 26.32
    1-chlorooctane 14.97
    1-chlorotetradecane 7.91
    n-nonane 3.11
    undecane 3.09
    tert-butylcyclohexane 3.34
    cyclooctane 1.41
    cyclopentanol 78.61
    tetrahydropyran 112.04
    tert-amyl methyl ether 44.72
    2,5,8-trioxanonane 133.59
    1-hexene 6.2
    2-isopropoxyethanol 75.99
    2,2,2-trifluoroethanol 95.35
    methyl butyrate 87.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction