2-Hydroxy-5-ethyltetrahydrofuran

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  • Identifiers

    CAS number
    30414-44-9

    Molecular formula
    C6H12O2

    SMILES
    CCC1CCC(O1)O

  • Odor profile

    Fragrance
    Fruity 61.7%
    Green 58.52%
    Ethereal 49.02%
    Fermented 42.11%
    Sweet 37.26%
    Alcoholic 36.99%
    Solvent 29.41%
    Musty 29.11%
    Oily 28.83%
    Nutty 28.3%

     

    Flavor
    Sweet 62.51%
    Caramel 42.34%
    Herbal 32.49%
    Warm 29.65%
    Coconut 26.24%
    Minty 25.48%
    Cauliflower 24.85%
    Oily 24.38%
    Vegetable 23.76%
    Mentholic 22.0%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.0

    pKa est.
    8.5 (weak base)

    Molecular weight
    116.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    181°C

    Flash point

    • 69.39 ˚C est.

  • Synonyms

    • 2-hydroxy-5-ethyltetrahydrofuran
    • 30414-44-9
    • 5-ethyltetrahydro-2-furanol
    • 2-Furanol, 5-ethyltetrahydro-
    • SCHEMBL3007101
    • DTXSID20875631

  • Applications

    2-Hydroxy-5-ethyltetrahydrofuran (CAS 30414-44-9) is a functional cyclic ether-derived diol used primarily as an industrial synthesis intermediate and building block. In polymer and plastic production, it may serve as a reactive diol or precursor for polyurethanes and polyesters or as a handle for introducing functional groups to tailor material properties. In pharmaceuticals and fine chemicals, it may act as a platform for the synthesis of drug intermediates and other functionalized THF derivatives. In coatings, inks, and adhesives, it can function as a polyol component or crosslinking handle to adjust curing behavior and mechanical properties of the binder system. In specialty chemicals, it is viewed as a versatile THF-based unit for converting to various functionalized derivatives, enabling routes to broader industrial intermediates under appropriate regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2197.49
    methanol 3168.13
    isopropanol 1394.26
    water 49.15
    ethyl acetate 391.86
    n-propanol 1353.05
    acetone 642.24
    n-butanol 975.47
    acetonitrile 690.0
    DMF 835.16
    toluene 111.97
    isobutanol 842.05
    1,4-dioxane 806.96
    methyl acetate 375.64
    THF 1082.44
    2-butanone 419.55
    n-pentanol 650.91
    sec-butanol 811.95
    n-hexane 44.07
    ethylene glycol 703.66
    NMP 504.84
    cyclohexane 35.45
    DMSO 1090.76
    n-butyl acetate 251.58
    n-octanol 249.2
    chloroform 1149.85
    n-propyl acetate 198.39
    acetic acid 1064.07
    dichloromethane 997.18
    cyclohexanone 447.12
    propylene glycol 766.18
    isopropyl acetate 235.52
    DMAc 462.02
    2-ethoxyethanol 808.1
    isopentanol 653.49
    n-heptane 31.58
    ethyl formate 353.5
    1,2-dichloroethane 394.18
    n-hexanol 608.7
    2-methoxyethanol 1340.42
    isobutyl acetate 140.4
    tetrachloromethane 185.38
    n-pentyl acetate 179.05
    transcutol 1190.63
    n-heptanol 272.06
    ethylbenzene 57.34
    MIBK 238.43
    2-propoxyethanol 916.85
    tert-butanol 979.2
    MTBE 428.3
    2-butoxyethanol 432.52
    propionic acid 679.51
    o-xylene 80.63
    formic acid 709.74
    diethyl ether 425.32
    m-xylene 99.37
    p-xylene 78.22
    chlorobenzene 215.08
    dimethyl carbonate 105.91
    n-octane 16.84
    formamide 530.8
    cyclopentanone 603.05
    2-pentanone 373.31
    anisole 193.49
    cyclopentyl methyl ether 369.5
    gamma-butyrolactone 690.07
    1-methoxy-2-propanol 933.17
    pyridine 423.48
    3-pentanone 197.41
    furfural 600.24
    n-dodecane 18.32
    diethylene glycol 830.9
    diisopropyl ether 109.8
    tert-amyl alcohol 611.41
    acetylacetone 345.71
    n-hexadecane 19.83
    acetophenone 157.38
    methyl propionate 269.17
    isopentyl acetate 213.93
    trichloroethylene 645.88
    n-nonanol 194.72
    cyclohexanol 377.88
    benzyl alcohol 233.04
    2-ethylhexanol 216.18
    isooctanol 195.94
    dipropyl ether 191.3
    1,2-dichlorobenzene 177.45
    ethyl lactate 146.44
    propylene carbonate 323.78
    n-methylformamide 681.59
    2-pentanol 507.48
    n-pentane 53.27
    1-propoxy-2-propanol 511.12
    1-methoxy-2-propyl acetate 245.83
    2-(2-methoxypropoxy) propanol 278.87
    mesitylene 70.52
    ε-caprolactone 379.7
    p-cymene 58.37
    epichlorohydrin 633.56
    1,1,1-trichloroethane 361.62
    2-aminoethanol 1184.16
    morpholine-4-carbaldehyde 621.73
    sulfolane 620.45
    2,2,4-trimethylpentane 31.66
    2-methyltetrahydrofuran 623.0
    n-hexyl acetate 262.74
    isooctane 31.54
    2-(2-butoxyethoxy)ethanol 423.1
    sec-butyl acetate 130.27
    tert-butyl acetate 230.15
    decalin 23.48
    glycerin 851.75
    diglyme 642.88
    acrylic acid 545.99
    isopropyl myristate 97.34
    n-butyric acid 755.26
    acetyl acetate 232.26
    di(2-ethylhexyl) phthalate 107.94
    ethyl propionate 149.29
    nitromethane 822.57
    1,2-diethoxyethane 300.65
    benzonitrile 279.6
    trioctyl phosphate 86.63
    1-bromopropane 320.86
    gamma-valerolactone 708.64
    n-decanol 140.56
    triethyl phosphate 73.7
    4-methyl-2-pentanol 266.87
    propionitrile 506.62
    vinylene carbonate 310.17
    1,1,2-trichlorotrifluoroethane 514.82
    DMS 142.33
    cumene 54.93
    2-octanol 164.05
    2-hexanone 234.56
    octyl acetate 125.73
    limonene 84.9
    1,2-dimethoxyethane 696.34
    ethyl orthosilicate 75.6
    tributyl phosphate 93.69
    diacetone alcohol 346.29
    N,N-dimethylaniline 124.72
    acrylonitrile 567.26
    aniline 280.98
    1,3-propanediol 1091.62
    bromobenzene 192.87
    dibromomethane 606.2
    1,1,2,2-tetrachloroethane 525.4
    2-methyl-cyclohexyl acetate 121.61
    tetrabutyl urea 107.67
    diisobutyl methanol 121.19
    2-phenylethanol 238.54
    styrene 79.23
    dioctyl adipate 122.87
    dimethyl sulfate 177.26
    ethyl butyrate 147.92
    methyl lactate 230.38
    butyl lactate 164.14
    diethyl carbonate 94.05
    propanediol butyl ether 427.3
    triethyl orthoformate 106.81
    p-tert-butyltoluene 61.11
    methyl 4-tert-butylbenzoate 178.46
    morpholine 890.17
    tert-butylamine 597.65
    n-dodecanol 105.8
    dimethoxymethane 507.92
    ethylene carbonate 253.76
    cyrene 215.28
    2-ethoxyethyl acetate 210.53
    2-ethylhexyl acetate 146.16
    1,2,4-trichlorobenzene 209.04
    4-methylpyridine 387.56
    dibutyl ether 159.89
    2,6-dimethyl-4-heptanol 121.19
    DEF 330.93
    dimethyl isosorbide 333.97
    tetrachloroethylene 380.37
    eugenol 205.37
    triacetin 190.0
    span 80 262.91
    1,4-butanediol 559.89
    1,1-dichloroethane 522.67
    2-methyl-1-pentanol 413.11
    methyl formate 404.82
    2-methyl-1-butanol 586.95
    n-decane 29.19
    butyronitrile 526.8
    3,7-dimethyl-1-octanol 209.29
    1-chlorooctane 107.95
    1-chlorotetradecane 43.06
    n-nonane 27.57
    undecane 22.41
    tert-butylcyclohexane 31.32
    cyclooctane 14.94
    cyclopentanol 584.32
    tetrahydropyran 606.17
    tert-amyl methyl ether 248.46
    2,5,8-trioxanonane 435.28
    1-hexene 171.26
    2-isopropoxyethanol 495.17
    2,2,2-trifluoroethanol 311.25
    methyl butyrate 222.3

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction