2'-Hydroxy-4',5'-dimethoxyacetophenone

Overview IFRA Botanical Request a quote

  • Identifiers

    CAS number
    20628-06-2

    Molecular formula
    C10H12O4

    SMILES
    CC(=O)C1=CC(=C(C=C1O)OC)OC

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • Carbowax: 2654.0

  • Odor profile

    Sweet 85.77%
    Vanilla 75.8%
    Balsamic 59.06%
    Spicy 57.65%
    Floral 55.62%
    Phenolic 55.57%
    Powdery 53.3%
    Woody 53.12%
    Creamy 46.74%
    Clove 42.19%

    Scent© AI

  • Properties

    XLogP3-AA
    1.7

    Molecular weight
    196.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    315°C

    Flash point est.
    131.58 ˚C

  • Synonyms

    • 20628-06-2
    • 1-(2-hydroxy-4,5-dimethoxyphenyl)ethanone
    • 2'-Hydroxy-4',5'-dimethoxyacetophenone
    • 4',5'-Dimethoxy-2'-hydroxyacetophenone
    • 1-(2-Hydroxy-4,5-dimethoxyphenyl)ethan-1-one
    • Ethanone, 1-(2-hydroxy-4,5-dimethoxyphenyl)-
    • 2-hydroxy-4,5-dimethoxyacetophenone
    • 4,5-Dimethoxy-2-hydroxyacetophenone
    • MFCD00017241
    • MLS000549622
    • SCHEMBL3661837
    • CHEMBL1338374
    • KEQHBVWVKYHDCS-UHFFFAOYSA-
    • DTXSID40351684
    • HMS2314C08
    • STK130409
    • AKOS001745587
    • FD71265
    • AS-66206
    • BP-13100
    • SMR000113656
    • DB-045312
    • CS-0077084
    • H1206
    • 1-(2-Hydroxy-4,5-dimethoxy-phenyl)-ethanone
    • T72056
    • AO-080/41904565
    • SR-01000539951
    • SR-01000539951-1
    • Q63409261
    • 626-316-4
    • InChI=1/C10H12O4/c1-6(11)7-4-9(13-2)10(14-3)5-8(7)12/h4-5,12H,1-3H3

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 44.98
    methanol 73.04
    isopropanol 32.44
    water 1.1
    ethyl acetate 94.4
    n-propanol 34.59
    acetone 157.33
    n-butanol 29.08
    acetonitrile 118.23
    DMF 381.94
    toluene 15.76
    isobutanol 23.54
    1,4-dioxane 206.65
    methyl acetate 127.83
    THF 340.12
    2-butanone 90.56
    n-pentanol 25.96
    sec-butanol 26.97
    n-hexane 2.71
    ethylene glycol 64.16
    NMP 275.76
    cyclohexane 5.18
    DMSO 489.03
    n-butyl acetate 51.89
    n-octanol 19.28
    chloroform 128.21
    n-propyl acetate 64.3
    acetic acid 113.79
    dichloromethane 182.22
    cyclohexanone 140.1
    propylene glycol 27.69
    isopropyl acetate 47.97
    DMAc 277.51
    2-ethoxyethanol 99.08
    isopentanol 28.47
    n-heptane 3.65
    ethyl formate 94.07
    1,2-dichloroethane 139.98
    n-hexanol 30.02
    2-methoxyethanol 197.67
    isobutyl acetate 36.04
    tetrachloromethane 24.98
    n-pentyl acetate 29.22
    transcutol 101.78
    n-heptanol 17.34
    ethylbenzene 19.71
    MIBK 41.72
    2-propoxyethanol 86.53
    tert-butanol 78.66
    MTBE 47.36
    2-butoxyethanol 42.14
    propionic acid 67.82
    o-xylene 22.75
    formic acid 77.94
    diethyl ether 47.65
    m-xylene 18.4
    p-xylene 26.19
    chlorobenzene 40.83
    dimethyl carbonate 78.65
    n-octane 1.97
    formamide 164.99
    cyclopentanone 236.91
    2-pentanone 68.16
    anisole 64.87
    cyclopentyl methyl ether 91.52
    gamma-butyrolactone 340.19
    1-methoxy-2-propanol 98.88
    pyridine 84.27
    3-pentanone 59.54
    furfural 240.5
    n-dodecane 2.18
    diethylene glycol 117.35
    diisopropyl ether 14.55
    tert-amyl alcohol 51.44
    acetylacetone 117.51
    n-hexadecane 2.53
    acetophenone 72.3
    methyl propionate 98.85
    isopentyl acetate 44.61
    trichloroethylene 199.2
    n-nonanol 18.69
    cyclohexanol 45.37
    benzyl alcohol 48.41
    2-ethylhexanol 24.19
    isooctanol 16.09
    dipropyl ether 31.03
    1,2-dichlorobenzene 54.99
    ethyl lactate 45.98
    propylene carbonate 130.23
    n-methylformamide 180.74
    2-pentanol 20.05
    n-pentane 2.1
    1-propoxy-2-propanol 50.17
    1-methoxy-2-propyl acetate 66.54
    2-(2-methoxypropoxy) propanol 51.08
    mesitylene 14.47
    ε-caprolactone 125.03
    p-cymene 17.16
    epichlorohydrin 299.97
    1,1,1-trichloroethane 95.4
    2-aminoethanol 51.27
    morpholine-4-carbaldehyde 244.8
    sulfolane 358.15
    2,2,4-trimethylpentane 2.69
    2-methyltetrahydrofuran 151.26
    n-hexyl acetate 41.86
    isooctane 1.88
    2-(2-butoxyethoxy)ethanol 54.21
    sec-butyl acetate 39.38
    tert-butyl acetate 61.79
    decalin 5.52
    glycerin 72.42
    diglyme 126.95
    acrylic acid 79.22
    isopropyl myristate 20.06
    n-butyric acid 66.3
    acetyl acetate 74.28
    di(2-ethylhexyl) phthalate 23.93
    ethyl propionate 62.64
    nitromethane 315.34
    1,2-diethoxyethane 41.81
    benzonitrile 57.76
    trioctyl phosphate 18.35
    1-bromopropane 40.23
    gamma-valerolactone 252.81
    n-decanol 14.95
    triethyl phosphate 42.69
    4-methyl-2-pentanol 16.42
    propionitrile 66.37
    vinylene carbonate 124.78
    1,1,2-trichlorotrifluoroethane 179.94
    DMS 64.66
    cumene 17.55
    2-octanol 13.39
    2-hexanone 54.71
    octyl acetate 25.28
    limonene 23.94
    1,2-dimethoxyethane 193.62
    ethyl orthosilicate 35.86
    tributyl phosphate 22.82
    diacetone alcohol 78.97
    N,N-dimethylaniline 49.85
    acrylonitrile 100.97
    aniline 40.85
    1,3-propanediol 70.85
    bromobenzene 37.68
    dibromomethane 99.73
    1,1,2,2-tetrachloroethane 148.55
    2-methyl-cyclohexyl acetate 48.35
    tetrabutyl urea 32.51
    diisobutyl methanol 17.03
    2-phenylethanol 44.99
    styrene 21.62
    dioctyl adipate 35.45
    dimethyl sulfate 160.82
    ethyl butyrate 51.28
    methyl lactate 66.85
    butyl lactate 25.81
    diethyl carbonate 47.0
    propanediol butyl ether 34.4
    triethyl orthoformate 40.85
    p-tert-butyltoluene 16.71
    methyl 4-tert-butylbenzoate 53.13
    morpholine 194.12
    tert-butylamine 34.51
    n-dodecanol 12.34
    dimethoxymethane 198.52
    ethylene carbonate 102.67
    cyrene 84.32
    2-ethoxyethyl acetate 47.63
    2-ethylhexyl acetate 37.72
    1,2,4-trichlorobenzene 66.06
    4-methylpyridine 82.51
    dibutyl ether 21.66
    2,6-dimethyl-4-heptanol 17.03
    DEF 109.15
    dimethyl isosorbide 114.35
    tetrachloroethylene 103.05
    eugenol 50.1
    triacetin 54.69
    span 80 35.35
    1,4-butanediol 27.97
    1,1-dichloroethane 84.13
    2-methyl-1-pentanol 26.24
    methyl formate 190.4
    2-methyl-1-butanol 24.52
    n-decane 3.41
    butyronitrile 55.27
    3,7-dimethyl-1-octanol 20.15
    1-chlorooctane 15.0
    1-chlorotetradecane 7.18
    n-nonane 3.1
    undecane 2.66
    tert-butylcyclohexane 4.96
    cyclooctane 2.09
    cyclopentanol 65.86
    tetrahydropyran 105.91
    tert-amyl methyl ether 40.7
    2,5,8-trioxanonane 91.94
    1-hexene 11.32
    2-isopropoxyethanol 60.31
    2,2,2-trifluoroethanol 82.22
    methyl butyrate 84.75

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Artemisia variabilis (Italy) Artemisia variabilis Ten., fam. Asteraceae (Compositae) 0.1%
Artemisia campestris, ssp. glutinosa (Italy) Artemisia campestris L. ssp. glutinosa (Ten.) Briq. et Cavill., Asteraceae 0.4%