2-Hydroxy-4-Methoxybenzaldehyde

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  • Identifiers

    CAS number
    673-22-3

    Molecular formula
    C8H8O3

    SMILES
    COC1=CC(=C(C=C1)C=O)O

    Safety labels

    Irritant
    Irritant

    Retention indicies (RI)

    • Carbowax: 2140.0

  • Odor profile

    Sweet 87.46%
    Vanilla 63.64%
    Phenolic 60.56%
    Spicy 51.59%
    Almond 46.17%
    Aromatic 41.77%
    Bitter 41.12%
    Medicinal 39.51%
    Cherry 37.8%
    Anisic 35.73%

    Scent© AI

  • Properties

    XLogP3-AA
    1.5

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    253°C

    Flash point est.
    121.04 ˚C

    Solubility expt.

    • Slightly soluble
    • Soluble (in ethanol)

  • Synonyms

    • 2-Hydroxy-4-methoxybenzaldehyde
    • 673-22-3
    • 4-Methoxysalicylaldehyde
    • Benzaldehyde, 2-hydroxy-4-methoxy-
    • 4-Methoxysalicyaldehyde
    • o-Hydroxy-p-methoxybenzaldehyde
    • p-Anisaldehyde, 2-hydroxy-
    • Salicylaldehyde, 4-methoxy-
    • 2-Hydroxy-4-methoxy-benzaldehyde
    • 2-Hydroxy-p-anisaldehyde
    • 2-Formyl-5-methoxyphenol
    • MFCD00003327
    • EINECS 211-604-0
    • NSC 155334
    • UNII-2N395P88LW
    • BRN 1072443
    • AI3-38507
    • 4-o-Methylresorcylaldehyde
    • NSC-155334
    • CHEMBL350966
    • 4-methoxy-2-hydroxybenzaldehyde
    • DTXSID1060970
    • FEMA NO. 4435
    • 2N395P88LW
    • 4-08-00-01754 (Beilstein Handbook Reference)
    • 2-hydroxyanisaldehyde
    • 2-hydroxy4methoxybenzaldehyde
    • ghl.PD_Mitscher_leg0.298
    • SCHEMBL133876
    • 2-hydroxy-4methoxybenzaldehyde
    • 2-Hydroxy-4-methoxybenazldehyde
    • 4-methoxy-6-hydroxybenzaldehyde
    • DTXCID9044873
    • 2-hydroxyl-4-methoxybenzaldehyde
    • 4-METHOXY SALICYLAIDEHYDE
    • 2-hydroxy-4-methoxy benzaldehyde
    • 4-methoxy-2-hydroxy-benzaldehyde
    • CHEBI:183274
    • CS-D1182
    • HY-N0445
    • BDBM50139368
    • CL8285
    • NSC155334
    • s5156
    • STL195538
    • AKOS000112553
    • 2-Hydroxy-4-methoxybenzaldehyde, 98%
    • CCG-266224
    • FH11114
    • PS-3237
    • AC-24065
    • BP-11480
    • PD088138
    • SY012932
    • DB-021178
    • H0699
    • NS00022648
    • EN300-24375
    • Q15634116
    • Z188964138
    • 211-604-0

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 93.41
    methanol 127.43
    isopropanol 69.44
    water 1.54
    ethyl acetate 108.99
    n-propanol 67.61
    acetone 236.69
    n-butanol 51.3
    acetonitrile 162.04
    DMF 490.28
    toluene 14.83
    isobutanol 39.54
    1,4-dioxane 204.01
    methyl acetate 176.17
    THF 402.25
    2-butanone 154.74
    n-pentanol 40.27
    sec-butanol 52.66
    n-hexane 1.67
    ethylene glycol 83.09
    NMP 349.5
    cyclohexane 2.62
    DMSO 1085.69
    n-butyl acetate 53.31
    n-octanol 17.72
    chloroform 67.09
    n-propyl acetate 67.73
    acetic acid 126.43
    dichloromethane 96.05
    cyclohexanone 125.17
    propylene glycol 70.59
    isopropyl acetate 50.71
    DMAc 404.35
    2-ethoxyethanol 144.81
    isopentanol 44.65
    n-heptane 2.54
    ethyl formate 89.61
    1,2-dichloroethane 92.42
    n-hexanol 38.76
    2-methoxyethanol 235.77
    isobutyl acetate 30.47
    tetrachloromethane 16.05
    n-pentyl acetate 22.94
    transcutol 317.92
    n-heptanol 16.78
    ethylbenzene 11.02
    MIBK 53.67
    2-propoxyethanol 108.12
    tert-butanol 120.07
    MTBE 58.79
    2-butoxyethanol 49.21
    propionic acid 105.11
    o-xylene 17.54
    formic acid 130.74
    diethyl ether 59.36
    m-xylene 14.31
    p-xylene 14.68
    chlorobenzene 28.13
    dimethyl carbonate 81.47
    n-octane 0.8
    formamide 300.77
    cyclopentanone 247.77
    2-pentanone 94.7
    anisole 65.95
    cyclopentyl methyl ether 86.75
    gamma-butyrolactone 296.23
    1-methoxy-2-propanol 144.65
    pyridine 96.6
    3-pentanone 70.98
    furfural 218.01
    n-dodecane 0.88
    diethylene glycol 132.82
    diisopropyl ether 13.88
    tert-amyl alcohol 80.98
    acetylacetone 149.53
    n-hexadecane 1.02
    acetophenone 66.19
    methyl propionate 117.11
    isopentyl acetate 42.83
    trichloroethylene 152.48
    n-nonanol 16.02
    cyclohexanol 45.89
    benzyl alcohol 46.63
    2-ethylhexanol 24.41
    isooctanol 14.63
    dipropyl ether 29.36
    1,2-dichlorobenzene 33.62
    ethyl lactate 51.86
    propylene carbonate 122.91
    n-methylformamide 268.62
    2-pentanol 31.39
    n-pentane 1.47
    1-propoxy-2-propanol 71.96
    1-methoxy-2-propyl acetate 78.25
    2-(2-methoxypropoxy) propanol 77.66
    mesitylene 11.05
    ε-caprolactone 105.74
    p-cymene 11.88
    epichlorohydrin 284.6
    1,1,1-trichloroethane 67.46
    2-aminoethanol 98.27
    morpholine-4-carbaldehyde 268.3
    sulfolane 427.57
    2,2,4-trimethylpentane 1.96
    2-methyltetrahydrofuran 156.96
    n-hexyl acetate 35.1
    isooctane 1.49
    2-(2-butoxyethoxy)ethanol 88.24
    sec-butyl acetate 36.33
    tert-butyl acetate 66.97
    decalin 2.63
    glycerin 121.05
    diglyme 194.0
    acrylic acid 111.58
    isopropyl myristate 15.67
    n-butyric acid 78.09
    acetyl acetate 68.85
    di(2-ethylhexyl) phthalate 20.2
    ethyl propionate 63.16
    nitromethane 446.62
    1,2-diethoxyethane 57.67
    benzonitrile 51.08
    trioctyl phosphate 15.06
    1-bromopropane 29.35
    gamma-valerolactone 250.33
    n-decanol 12.33
    triethyl phosphate 33.07
    4-methyl-2-pentanol 21.16
    propionitrile 81.46
    vinylene carbonate 98.64
    1,1,2-trichlorotrifluoroethane 191.4
    DMS 56.6
    cumene 10.43
    2-octanol 10.66
    2-hexanone 70.51
    octyl acetate 20.75
    limonene 17.09
    1,2-dimethoxyethane 229.72
    ethyl orthosilicate 26.77
    tributyl phosphate 19.76
    diacetone alcohol 111.45
    N,N-dimethylaniline 42.99
    acrylonitrile 122.38
    aniline 47.01
    1,3-propanediol 106.61
    bromobenzene 21.57
    dibromomethane 50.23
    1,1,2,2-tetrachloroethane 106.56
    2-methyl-cyclohexyl acetate 37.6
    tetrabutyl urea 28.36
    diisobutyl methanol 16.33
    2-phenylethanol 42.38
    styrene 13.61
    dioctyl adipate 30.75
    dimethyl sulfate 180.35
    ethyl butyrate 47.91
    methyl lactate 84.27
    butyl lactate 29.37
    diethyl carbonate 41.88
    propanediol butyl ether 53.67
    triethyl orthoformate 35.86
    p-tert-butyltoluene 11.81
    methyl 4-tert-butylbenzoate 52.06
    morpholine 233.71
    tert-butylamine 45.84
    n-dodecanol 9.34
    dimethoxymethane 192.11
    ethylene carbonate 80.64
    cyrene 88.84
    2-ethoxyethyl acetate 48.73
    2-ethylhexyl acetate 32.1
    1,2,4-trichlorobenzene 46.63
    4-methylpyridine 81.4
    dibutyl ether 18.16
    2,6-dimethyl-4-heptanol 16.33
    DEF 131.49
    dimethyl isosorbide 127.15
    tetrachloroethylene 68.14
    eugenol 50.11
    triacetin 56.24
    span 80 45.65
    1,4-butanediol 45.35
    1,1-dichloroethane 65.71
    2-methyl-1-pentanol 34.77
    methyl formate 208.91
    2-methyl-1-butanol 39.12
    n-decane 1.4
    butyronitrile 60.48
    3,7-dimethyl-1-octanol 20.75
    1-chlorooctane 8.26
    1-chlorotetradecane 3.58
    n-nonane 1.21
    undecane 1.09
    tert-butylcyclohexane 2.7
    cyclooctane 1.15
    cyclopentanol 70.48
    tetrahydropyran 105.86
    tert-amyl methyl ether 44.97
    2,5,8-trioxanonane 137.74
    1-hexene 8.59
    2-isopropoxyethanol 82.24
    2,2,2-trifluoroethanol 79.79
    methyl butyrate 85.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction

Botanical

Name CAS Botanical Proportion
Decalepis hamiltonii root (India) Decalepis hamiltonii (Wight & Arn), fam. Asclepiadaceae 96.0%
Hemidesmus indicus Hemidesmus indicus R.Br., fam. Asclepiadaceae 91.0%