2-Hydroxy-4-methoxy-2'-carboxybenzophenone

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  • Identifiers

    CAS number
    4756-45-0

    Molecular formula
    C15H12O5

    SMILES
    COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2C(=O)O)O

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Sweet 53.32%
    Phenolic 49.54%
    Balsamic 46.89%
    Odorless 42.4%
    Vanilla 36.82%
    Powdery 32.72%
    Aromatic 32.47%
    Bitter 29.4%
    Floral 27.14%
    Spicy 25.71%

     

    Flavor
    Bitter 71.28%
    Odorless 42.78%
    Mild 25.78%
    Faint 24.67%
    Bland 23.33%
    Lovage 21.09%
    Nitrile 20.91%
    Urine 20.76%
    Ethyl benzoate 20.53%
    Sweet-like 20.37%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.0

    pKa est.
    6.69 (neutral)

    Molecular weight
    272.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    430°C

    Flash point

    • 225.7 ˚C est.

  • Synonyms

    • Cyasorb
    • 2-(2-Hydroxy-4-methoxybenzoyl)benzoic acid
    • Benzoic acid, 2-(2-hydroxy-4-methoxybenzoyl)-
    • 2-hydroxy-4-methoxy-2'-carboxybenzophenone
    • EINECS 225-290-8
    • UNII-2A5XYA01F2
    • NSC 79888
    • NSC-79888
    • BRN 2658577
    • 2A5XYA01F2
    • CYASORB UV-207
    • DTXSID8063599
    • 4-10-00-03979 (Beilstein Handbook Reference)
    • 2'-HYDROXY-4'-METHOXY-2-BENZOYLBENZOIC ACID
    • RefChem:87418
    • DTXCID2040577
    • JLZIIHMTTRXXIN-UHFFFAOYSA-N
    • 4756-45-0
    • Cyasorb UV 207
    • 2'-Carboxy-2-hydroxy-4-methoxybenzophenone
    • 2'-Carboxy-2-hydroxy-4-methoxybenzo-phenone
    • Benzoic acid, o-(2-hydroxy-p-anisoyl)-
    • o-(2-Hydroxy-4-methoxybenzoyl)benzoic acid
    • o-(2-Hydroxy-p-anisoyl)benzoic acid
    • BENZOIC ACID, o-(2-HYDROXY-4-METHOXYBENZOYL)-
    • MFCD00020284
    • 2'-Carboxy-2-hydroxy-4-methoxybenzophenone(o-(2-hydroxy-p-anisoyl)benzoic acid)
    • 2/'-Hydroxy-4/'-methoxy-benzophenone-2-carboxylic acid
    • SCHEMBL109604
    • 2-[(2-hydroxy-4-methoxyphenyl)carbonyl]benzoic acid
    • WLN: QVR BVR BQ DO1
    • CHEMBL1939433
    • SCHEMBL29357363
    • SCHEMBL29380442
    • NSC79888
    • AKOS024333028
    • BS-28899
    • 2-(2-Hydroxy-4-methoxybenzoyl)benzoicacid
    • NS00031705
    • ST50546708
    • 2''-Carboxy-2-hydroxy-4-methoxybenzo-phenone
    • 2-(2-hydroxy-4-methoxy-benzoyl)benzoic acid
    • 2-Hydroxy-4-methoxy-benzophenone-2-carboxylic acid
    • Q27254468
    • 4756-45-0

  • Applications

    2-Hydroxy-4-methoxy-2'-carboxybenzophenone (CAS 4756-45-0) is primarily used as a UV absorber and photostabilizer for polymers, plastics, coatings, and inks, helping to improve lightfastness and outdoor durability. In practice, it acts as a UV absorber for polymer matrices, increasing color stability and resistance to UV-induced degradation; the carboxyl group at the 2' position enables it to serve as a reactive intermediate for linking or grafting onto polymer backbones, enhancing adhesion and reducing leaching. It is also considered for use in UV-curable coatings and adhesives to impart UV stability without substantially altering the base material properties. Additionally, it can function as a building block in polymer chemistry, enabling esterification or coupling with other functional groups to integrate UV-protective features into resin systems.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.76
    methanol 12.12
    isopropanol 6.64
    water 0.01
    ethyl acetate 8.96
    n-propanol 11.85
    acetone 14.01
    n-butanol 9.35
    acetonitrile 4.45
    DMF 115.83
    toluene 2.59
    isobutanol 5.16
    1,4-dioxane 20.21
    methyl acetate 13.52
    THF 113.56
    2-butanone 33.66
    n-pentanol 5.53
    sec-butanol 11.97
    n-hexane 0.04
    ethylene glycol 5.02
    NMP 87.46
    cyclohexane 0.07
    DMSO 294.24
    n-butyl acetate 7.36
    n-octanol 1.97
    chloroform 6.58
    n-propyl acetate 6.07
    acetic acid 9.19
    dichloromethane 7.01
    cyclohexanone 27.56
    propylene glycol 6.75
    isopropyl acetate 6.64
    DMAc 197.44
    2-ethoxyethanol 27.51
    isopentanol 7.74
    n-heptane 0.04
    ethyl formate 4.32
    1,2-dichloroethane 10.89
    n-hexanol 5.4
    2-methoxyethanol 63.65
    isobutyl acetate 2.23
    tetrachloromethane 0.59
    n-pentyl acetate 3.78
    transcutol 49.95
    n-heptanol 3.15
    ethylbenzene 1.98
    MIBK 9.37
    2-propoxyethanol 31.09
    tert-butanol 15.18
    MTBE 7.55
    2-butoxyethanol 12.63
    propionic acid 8.05
    o-xylene 2.86
    formic acid 9.24
    diethyl ether 6.55
    m-xylene 1.7
    p-xylene 1.98
    chlorobenzene 2.42
    dimethyl carbonate 12.95
    n-octane 0.03
    formamide 32.84
    cyclopentanone 56.41
    2-pentanone 16.05
    anisole 12.37
    cyclopentyl methyl ether 16.77
    gamma-butyrolactone 43.24
    1-methoxy-2-propanol 41.83
    pyridine 16.97
    3-pentanone 15.42
    furfural 30.16
    n-dodecane 0.06
    diethylene glycol 27.34
    diisopropyl ether 1.28
    tert-amyl alcohol 17.63
    acetylacetone 17.33
    n-hexadecane 0.07
    acetophenone 12.98
    methyl propionate 17.82
    isopentyl acetate 6.8
    trichloroethylene 21.66
    n-nonanol 2.25
    cyclohexanol 8.67
    benzyl alcohol 9.82
    2-ethylhexanol 3.54
    isooctanol 2.73
    dipropyl ether 3.79
    1,2-dichlorobenzene 3.3
    ethyl lactate 8.1
    propylene carbonate 11.24
    n-methylformamide 29.29
    2-pentanol 5.75
    n-pentane 0.03
    1-propoxy-2-propanol 17.91
    1-methoxy-2-propyl acetate 17.49
    2-(2-methoxypropoxy) propanol 20.05
    mesitylene 1.04
    ε-caprolactone 20.91
    p-cymene 1.65
    epichlorohydrin 62.03
    1,1,1-trichloroethane 3.96
    2-aminoethanol 11.61
    morpholine-4-carbaldehyde 51.75
    sulfolane 108.6
    2,2,4-trimethylpentane 0.14
    2-methyltetrahydrofuran 32.22
    n-hexyl acetate 5.67
    isooctane 0.06
    2-(2-butoxyethoxy)ethanol 21.54
    sec-butyl acetate 4.66
    tert-butyl acetate 11.65
    decalin 0.16
    glycerin 21.01
    diglyme 43.9
    acrylic acid 8.93
    isopropyl myristate 2.66
    n-butyric acid 8.11
    acetyl acetate 4.85
    di(2-ethylhexyl) phthalate 4.37
    ethyl propionate 9.03
    nitromethane 28.6
    1,2-diethoxyethane 9.34
    benzonitrile 5.39
    trioctyl phosphate 2.83
    1-bromopropane 3.42
    gamma-valerolactone 50.52
    n-decanol 1.68
    triethyl phosphate 6.81
    4-methyl-2-pentanol 3.47
    propionitrile 7.95
    vinylene carbonate 9.29
    1,1,2-trichlorotrifluoroethane 42.83
    DMS 10.2
    cumene 1.43
    2-octanol 1.78
    2-hexanone 10.06
    octyl acetate 3.53
    limonene 2.34
    1,2-dimethoxyethane 45.68
    ethyl orthosilicate 5.7
    tributyl phosphate 3.58
    diacetone alcohol 27.06
    N,N-dimethylaniline 8.63
    acrylonitrile 12.01
    aniline 9.97
    1,3-propanediol 17.46
    bromobenzene 1.96
    dibromomethane 3.22
    1,1,2,2-tetrachloroethane 19.75
    2-methyl-cyclohexyl acetate 6.65
    tetrabutyl urea 6.6
    diisobutyl methanol 2.37
    2-phenylethanol 9.8
    styrene 2.22
    dioctyl adipate 5.94
    dimethyl sulfate 39.96
    ethyl butyrate 6.86
    methyl lactate 18.54
    butyl lactate 6.26
    diethyl carbonate 5.85
    propanediol butyl ether 9.67
    triethyl orthoformate 6.9
    p-tert-butyltoluene 1.63
    methyl 4-tert-butylbenzoate 12.57
    morpholine 43.19
    tert-butylamine 4.21
    n-dodecanol 1.26
    dimethoxymethane 52.54
    ethylene carbonate 6.9
    cyrene 21.66
    2-ethoxyethyl acetate 8.45
    2-ethylhexyl acetate 5.07
    1,2,4-trichlorobenzene 5.87
    4-methylpyridine 14.77
    dibutyl ether 2.56
    2,6-dimethyl-4-heptanol 2.37
    DEF 28.54
    dimethyl isosorbide 33.36
    tetrachloroethylene 9.1
    eugenol 13.44
    triacetin 9.53
    span 80 10.62
    1,4-butanediol 4.3
    1,1-dichloroethane 4.02
    2-methyl-1-pentanol 6.34
    methyl formate 13.51
    2-methyl-1-butanol 8.78
    n-decane 0.09
    butyronitrile 5.17
    3,7-dimethyl-1-octanol 2.71
    1-chlorooctane 0.85
    1-chlorotetradecane 0.38
    n-nonane 0.06
    undecane 0.07
    tert-butylcyclohexane 0.14
    cyclooctane 0.03
    cyclopentanol 10.43
    tetrahydropyran 15.27
    tert-amyl methyl ether 10.01
    2,5,8-trioxanonane 33.46
    1-hexene 0.5
    2-isopropoxyethanol 13.78
    2,2,2-trifluoroethanol 5.36
    methyl butyrate 10.21

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction