2-Hydroxy-3-Methoxybenzaldehyde

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  • Identifiers

    CAS number
    148-53-8

    Molecular formula
    C8H8O3

    SMILES
    COC1=CC=CC(=C1O)C=O

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 88.98%
    Vanilla 79.1%
    Spicy 60.21%
    Phenolic 57.28%
    Creamy 45.13%
    Powdery 44.14%
    Smoky 43.23%
    Caramellic 40.46%
    Balsamic 40.02%
    Woody 38.96%

     

    Flavor
    Sweet 82.79%
    Vanilla 63.42%
    Woody 54.43%
    Creamy 46.02%
    Powdery 44.04%
    Spicy 40.87%
    Bitter 40.02%
    Phenolic 39.67%
    Almond 38.64%
    Hawthorn 36.98%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    7.78 (neutral)

    Molecular weight
    152.15 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    261°C

    Flash point

    • 112.23 ˚C est.

  • Synonyms

    • 2-Hydroxy-3-methoxybenzaldehyde
    • 148-53-8
    • 3-Methoxysalicylaldehyde
    • O-VANILLIN
    • 2-Vanillin
    • 6-Formylguaiacol
    • ortho-vanillin
    • 2-Hydroxy-m-anisaldehyde
    • Benzaldehyde, 2-hydroxy-3-methoxy-
    • Orthovanilline
    • o-Vanilline
    • 6-Formyl-2-methoxyphenol
    • 3-Methoxy-2-hydroxybenzaldehyde
    • m-Anisaldehyde, 2-hydroxy-
    • Oxy-2 methoxy-3 benzaldehyde
    • MFCD00003322
    • Ortho vanillin
    • 2-Hydroxy-3-methoxy-benzaldehyde
    • NSC 2150
    • EINECS 205-715-3
    • BRN 0471913
    • CCRIS 8811
    • CHEBI:78339
    • AI3-00076
    • NSC-2150
    • UNII-008LR748FI
    • DTXSID5022011
    • 2-hydroxy-3-methoxy benzaldehyde
    • 008LR748FI
    • 4-08-00-01747 (Beilstein Handbook Reference)
    • 2-HYDROXYL-3-METHOXYBENZALDEHYDE
    • HYDROXY-3-METHOXYBENZALDEHYDE, 2-
    • Ortho-vanillin, 99%
    • US8614253, .3-63
    • Oxy-2 methoxy-3 benzaldehyde [French]
    • oVanilline
    • oVanillin
    • 6Formylguaiacol
    • o-vaniline
    • 0-vanillin
    • 2-hydroxy-3-(methyloxy)benzaldehyde
    • 2Hydroxymanisaldehyde
    • 6Formyl2methoxyphenol
    • o-Vanillin, 99%
    • 3Methoxysalicylaldehyde
    • mAnisaldehyde, 2hydroxy
    • Oxy2 methoxy3 benzaldehyde
    • WLN: VHR BQ CO1
    • 3Methoxy2hydroxybenzaldehyde
    • SCHEMBL16004
    • CHEMBL13859
    • Benzaldehyde, 2hydroxy3methoxy
    • DTXCID902011
    • 2-hydroxy-3 methoxybenzaldehyde
    • mAnisaldehyde, 2hydroxy (8CI)
    • 3-methoxy-2-hydroxy-benzaldehyde
    • NSC2150
    • BDBM111024
    • 3-Methoxysalicylaldehyde;o-Vanillin
    • HY-Y1832
    • BBL009824
    • STK397284
    • AKOS000119724
    • CS-W008876
    • FH11115
    • AC-11135
    • NS-00006
    • 2-Hydroxy-3-methoxybenzaldehyde o-Vanillin
    • DB-042941
    • H0262
    • NS00024863
    • EN300-18431
    • P20004
    • Q309747
    • US8614253, .3-55
    • 2-HYDROXY,3-METHOXY-BENZALDEHYDE (O-VANILLIN)
    • Z57921503
    • 2-HYDROXY,3-METHOXY-BENZALDEHYDE (O-VANILLIN)
    • F2190-0634

  • Applications

    2-Hydroxy-3-Methoxybenzaldehyde, CAS 148-53-8, is primarily used as an aromatic intermediate in fragrance and flavor chemistry, enabling the synthesis of related substituted benzaldehydes and serving as an odorant component in perfumery; it is commonly evaluated as a fragrance ingredient for cosmetics and personal care products, and may be used as a building block in the industrial production of more complex aromatic compounds. Additionally, it can function as a synthesis precursor for aroma substances employed in household cleaners and other consumer goods, and may appear as a reactive intermediate in coatings and inks formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 700.29
    methanol 534.92
    isopropanol 259.66
    water 5.63
    ethyl acetate 475.14
    n-propanol 510.09
    acetone 819.83
    n-butanol 180.65
    acetonitrile 613.76
    DMF 781.19
    toluene 39.23
    isobutanol 152.77
    1,4-dioxane 743.57
    methyl acetate 661.85
    THF 1301.26
    2-butanone 485.51
    n-pentanol 122.61
    sec-butanol 188.46
    n-hexane 6.08
    ethylene glycol 257.4
    NMP 456.48
    cyclohexane 11.56
    DMSO 1777.79
    n-butyl acetate 159.09
    n-octanol 52.99
    chloroform 336.02
    n-propyl acetate 280.84
    acetic acid 479.77
    dichloromethane 644.72
    cyclohexanone 393.13
    propylene glycol 125.12
    isopropyl acetate 181.91
    DMAc 349.23
    2-ethoxyethanol 455.81
    isopentanol 112.04
    n-heptane 10.02
    ethyl formate 313.91
    1,2-dichloroethane 557.67
    n-hexanol 96.49
    2-methoxyethanol 743.08
    isobutyl acetate 115.77
    tetrachloromethane 62.36
    n-pentyl acetate 90.34
    transcutol 486.6
    n-heptanol 51.32
    ethylbenzene 38.84
    MIBK 153.66
    2-propoxyethanol 252.05
    tert-butanol 307.49
    MTBE 207.11
    2-butoxyethanol 136.73
    propionic acid 354.56
    o-xylene 38.91
    formic acid 355.55
    diethyl ether 309.87
    m-xylene 41.2
    p-xylene 49.08
    chlorobenzene 92.32
    dimethyl carbonate 223.44
    n-octane 5.68
    formamide 971.09
    cyclopentanone 780.83
    2-pentanone 308.64
    anisole 160.93
    cyclopentyl methyl ether 278.39
    gamma-butyrolactone 1137.5
    1-methoxy-2-propanol 337.12
    pyridine 298.75
    3-pentanone 224.63
    furfural 530.9
    n-dodecane 5.54
    diethylene glycol 283.11
    diisopropyl ether 56.19
    tert-amyl alcohol 196.25
    acetylacetone 370.98
    n-hexadecane 6.38
    acetophenone 149.89
    methyl propionate 408.94
    isopentyl acetate 121.25
    trichloroethylene 737.38
    n-nonanol 47.8
    cyclohexanol 125.21
    benzyl alcohol 114.17
    2-ethylhexanol 56.34
    isooctanol 43.79
    dipropyl ether 84.17
    1,2-dichlorobenzene 102.67
    ethyl lactate 114.46
    propylene carbonate 366.17
    n-methylformamide 803.82
    2-pentanol 100.42
    n-pentane 6.93
    1-propoxy-2-propanol 146.88
    1-methoxy-2-propyl acetate 171.02
    2-(2-methoxypropoxy) propanol 123.14
    mesitylene 33.17
    ε-caprolactone 360.38
    p-cymene 31.29
    epichlorohydrin 1179.7
    1,1,1-trichloroethane 318.67
    2-aminoethanol 302.75
    morpholine-4-carbaldehyde 492.98
    sulfolane 1060.84
    2,2,4-trimethylpentane 6.95
    2-methyltetrahydrofuran 575.19
    n-hexyl acetate 115.41
    isooctane 6.36
    2-(2-butoxyethoxy)ethanol 168.19
    sec-butyl acetate 135.06
    tert-butyl acetate 200.78
    decalin 9.76
    glycerin 217.5
    diglyme 383.51
    acrylic acid 320.9
    isopropyl myristate 49.76
    n-butyric acid 281.96
    acetyl acetate 217.03
    di(2-ethylhexyl) phthalate 42.01
    ethyl propionate 205.47
    nitromethane 1547.74
    1,2-diethoxyethane 170.13
    benzonitrile 135.37
    trioctyl phosphate 37.79
    1-bromopropane 157.96
    gamma-valerolactone 723.21
    n-decanol 37.98
    triethyl phosphate 70.17
    4-methyl-2-pentanol 54.07
    propionitrile 349.32
    vinylene carbonate 308.36
    1,1,2-trichlorotrifluoroethane 429.98
    DMS 151.88
    cumene 31.64
    2-octanol 39.17
    2-hexanone 206.72
    octyl acetate 62.16
    limonene 43.96
    1,2-dimethoxyethane 537.53
    ethyl orthosilicate 61.0
    tributyl phosphate 44.74
    diacetone alcohol 236.76
    N,N-dimethylaniline 85.29
    acrylonitrile 495.14
    aniline 97.38
    1,3-propanediol 380.16
    bromobenzene 83.18
    dibromomethane 324.15
    1,1,2,2-tetrachloroethane 409.3
    2-methyl-cyclohexyl acetate 88.69
    tetrabutyl urea 59.8
    diisobutyl methanol 41.12
    2-phenylethanol 96.65
    styrene 51.5
    dioctyl adipate 76.08
    dimethyl sulfate 368.71
    ethyl butyrate 131.36
    methyl lactate 159.52
    butyl lactate 66.27
    diethyl carbonate 98.54
    propanediol butyl ether 106.2
    triethyl orthoformate 82.2
    p-tert-butyltoluene 29.91
    methyl 4-tert-butylbenzoate 110.8
    morpholine 810.92
    tert-butylamine 108.5
    n-dodecanol 30.55
    dimethoxymethane 543.58
    ethylene carbonate 265.28
    cyrene 154.75
    2-ethoxyethyl acetate 156.79
    2-ethylhexyl acetate 89.33
    1,2,4-trichlorobenzene 127.32
    4-methylpyridine 188.67
    dibutyl ether 64.69
    2,6-dimethyl-4-heptanol 41.12
    DEF 279.25
    dimethyl isosorbide 235.3
    tetrachloroethylene 276.82
    eugenol 107.42
    triacetin 141.54
    span 80 86.53
    1,4-butanediol 131.87
    1,1-dichloroethane 339.68
    2-methyl-1-pentanol 82.8
    methyl formate 658.12
    2-methyl-1-butanol 104.35
    n-decane 8.54
    butyronitrile 226.18
    3,7-dimethyl-1-octanol 49.62
    1-chlorooctane 37.26
    1-chlorotetradecane 16.8
    n-nonane 7.9
    undecane 6.79
    tert-butylcyclohexane 9.66
    cyclooctane 5.21
    cyclopentanol 247.69
    tetrahydropyran 487.79
    tert-amyl methyl ether 138.3
    2,5,8-trioxanonane 230.93
    1-hexene 30.27
    2-isopropoxyethanol 226.23
    2,2,2-trifluoroethanol 264.46
    methyl butyrate 265.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction