2-Hydroxy-1-(2-methylphenyl)ethan-1-one

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  • Identifiers

    CAS number
    145070-48-0

    Molecular formula
    C9H10O2

    SMILES
    CC1=CC=CC=C1C(=O)CO

    Safety labels

  • Odor profile

    Fragrance
    Sweet 72.87%
    Floral 58.71%
    Honey 46.9%
    Powdery 43.71%
    Vanilla 43.51%
    Creamy 40.13%
    Almond 38.83%
    Hay 38.28%
    Balsamic 34.71%
    Phenolic 32.96%

     

    Flavor
    Sweet 65.72%
    Powdery 35.21%
    Balsam 33.76%
    Honey 30.65%
    Creamy 29.67%
    Phenolic 29.43%
    Fruity 29.26%
    Hawthorn 28.73%
    Balsamic 28.58%
    Faint 26.49%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    7.71 (neutral)

    Molecular weight
    150.17 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    244°C

    Flash point

    • 131.85 ˚C est.

  • Synonyms

    • 145070-48-0
    • 2-Hydroxy-1-(2-methylphenyl)ethan-1-one
    • DTXSID60612981
    • RefChem:261557
    • DTXCID50563736
    • 2-hydroxy-1-(o-tolyl)ethanone
    • 2-Hydroxy-2'-methylacetophenone
    • Ethanone, 2-hydroxy-1-(2-methylphenyl)-
    • MFCD16165840
    • 2-hydroxy-1-(2-methylphenyl)ethanone
    • 2-hydroxy-2-methylacetophenone
    • Hydroxy-2'-methylacetophenone
    • 5-methyl-2-hydroxyacetophenone
    • SCHEMBL2773397
    • SCHEMBL3704844
    • SCHEMBL27999261
    • SCHEMBL29639746
    • 2-hydroxy-1-(o-tolyl)-ethanone
    • AC4310
    • AKOS011305914
    • SY130976
    • 2-Hydroxy-2 inverted exclamation mark -methylacetophenone
    • 145070-48-0

  • Applications

    2-Hydroxy-1-(2-methylphenyl)ethan-1-one (CAS 145070-48-0) is primarily used as a chemical intermediate and fragrance-building block in industry; in perfumery it serves as a precursor to aroma compounds and as a functionalized alpha-hydroxy ketone scaffold for synthesizing more complex scents, while in cosmetics and personal care it may act as a fragrance component within formulations, subject to regulatory limits. It also finds use as an intermediate in pharmaceutical synthesis as a versatile building block and in industrial manufacturing as a starting material for derivatives used in polymers, coatings, and specialty inks. Additionally, it may be evaluated for use as a reactive intermediate in dye and polymer chemistry and as a precursor to protective or crosslinking agents.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 341.11
    methanol 416.33
    isopropanol 188.74
    water 15.15
    ethyl acetate 135.98
    n-propanol 232.3
    acetone 292.36
    n-butanol 157.35
    acetonitrile 337.78
    DMF 757.13
    toluene 68.23
    isobutanol 122.29
    1,4-dioxane 599.26
    methyl acetate 177.98
    THF 471.91
    2-butanone 187.66
    n-pentanol 112.68
    sec-butanol 119.26
    n-hexane 8.18
    ethylene glycol 279.6
    NMP 435.64
    cyclohexane 16.89
    DMSO 949.53
    n-butyl acetate 99.7
    n-octanol 90.85
    chloroform 405.21
    n-propyl acetate 96.78
    acetic acid 205.04
    dichloromethane 588.8
    cyclohexanone 278.7
    propylene glycol 120.04
    isopropyl acetate 70.71
    DMAc 296.92
    2-ethoxyethanol 245.99
    isopentanol 93.85
    n-heptane 18.18
    ethyl formate 182.14
    1,2-dichloroethane 402.43
    n-hexanol 148.15
    2-methoxyethanol 440.24
    isobutyl acetate 53.36
    tetrachloromethane 71.0
    n-pentyl acetate 71.88
    transcutol 341.4
    n-heptanol 88.72
    ethylbenzene 50.85
    MIBK 90.04
    2-propoxyethanol 259.17
    tert-butanol 185.43
    MTBE 94.63
    2-butoxyethanol 147.44
    propionic acid 173.48
    o-xylene 61.0
    formic acid 174.1
    diethyl ether 129.03
    m-xylene 63.73
    p-xylene 56.36
    chlorobenzene 122.46
    dimethyl carbonate 100.68
    n-octane 10.78
    formamide 355.61
    cyclopentanone 393.56
    2-pentanone 148.11
    anisole 127.65
    cyclopentyl methyl ether 146.96
    gamma-butyrolactone 490.59
    1-methoxy-2-propanol 247.99
    pyridine 243.24
    3-pentanone 105.79
    furfural 345.24
    n-dodecane 9.61
    diethylene glycol 300.16
    diisopropyl ether 33.07
    tert-amyl alcohol 113.73
    acetylacetone 176.01
    n-hexadecane 10.98
    acetophenone 111.73
    methyl propionate 142.2
    isopentyl acetate 80.69
    trichloroethylene 514.36
    n-nonanol 78.04
    cyclohexanol 109.64
    benzyl alcohol 111.66
    2-ethylhexanol 79.05
    isooctanol 68.58
    dipropyl ether 91.04
    1,2-dichlorobenzene 123.23
    ethyl lactate 82.36
    propylene carbonate 208.45
    n-methylformamide 454.96
    2-pentanol 78.01
    n-pentane 10.66
    1-propoxy-2-propanol 155.41
    1-methoxy-2-propyl acetate 115.27
    2-(2-methoxypropoxy) propanol 114.65
    mesitylene 45.48
    ε-caprolactone 207.87
    p-cymene 45.0
    epichlorohydrin 524.91
    1,1,1-trichloroethane 213.27
    2-aminoethanol 269.3
    morpholine-4-carbaldehyde 413.29
    sulfolane 581.14
    2,2,4-trimethylpentane 8.01
    2-methyltetrahydrofuran 233.71
    n-hexyl acetate 107.19
    isooctane 8.19
    2-(2-butoxyethoxy)ethanol 170.21
    sec-butyl acetate 51.17
    tert-butyl acetate 85.0
    decalin 12.72
    glycerin 203.44
    diglyme 333.74
    acrylic acid 174.59
    isopropyl myristate 51.21
    n-butyric acid 173.39
    acetyl acetate 84.77
    di(2-ethylhexyl) phthalate 50.67
    ethyl propionate 90.14
    nitromethane 457.23
    1,2-diethoxyethane 127.22
    benzonitrile 138.82
    trioctyl phosphate 47.02
    1-bromopropane 148.67
    gamma-valerolactone 428.38
    n-decanol 63.05
    triethyl phosphate 53.8
    4-methyl-2-pentanol 47.76
    propionitrile 203.13
    vinylene carbonate 206.42
    1,1,2-trichlorotrifluoroethane 263.32
    DMS 89.05
    cumene 40.47
    2-octanol 59.78
    2-hexanone 98.96
    octyl acetate 69.06
    limonene 60.76
    1,2-dimethoxyethane 331.82
    ethyl orthosilicate 49.03
    tributyl phosphate 46.79
    diacetone alcohol 147.82
    N,N-dimethylaniline 91.41
    acrylonitrile 294.33
    aniline 104.82
    1,3-propanediol 262.67
    bromobenzene 114.19
    dibromomethane 357.16
    1,1,2,2-tetrachloroethane 328.99
    2-methyl-cyclohexyl acetate 71.85
    tetrabutyl urea 71.56
    diisobutyl methanol 51.41
    2-phenylethanol 116.62
    styrene 61.02
    dioctyl adipate 70.86
    dimethyl sulfate 184.38
    ethyl butyrate 91.06
    methyl lactate 120.03
    butyl lactate 68.95
    diethyl carbonate 67.65
    propanediol butyl ether 119.92
    triethyl orthoformate 63.79
    p-tert-butyltoluene 42.53
    methyl 4-tert-butylbenzoate 118.55
    morpholine 479.33
    tert-butylamine 96.64
    n-dodecanol 50.16
    dimethoxymethane 314.44
    ethylene carbonate 170.1
    cyrene 130.06
    2-ethoxyethyl acetate 97.35
    2-ethylhexyl acetate 60.06
    1,2,4-trichlorobenzene 129.65
    4-methylpyridine 182.57
    dibutyl ether 70.08
    2,6-dimethyl-4-heptanol 51.41
    DEF 185.78
    dimethyl isosorbide 190.07
    tetrachloroethylene 238.93
    eugenol 123.23
    triacetin 98.34
    span 80 103.53
    1,4-butanediol 133.48
    1,1-dichloroethane 261.85
    2-methyl-1-pentanol 74.92
    methyl formate 350.89
    2-methyl-1-butanol 89.09
    n-decane 15.11
    butyronitrile 165.32
    3,7-dimethyl-1-octanol 66.17
    1-chlorooctane 60.99
    1-chlorotetradecane 25.67
    n-nonane 14.94
    undecane 11.89
    tert-butylcyclohexane 12.42
    cyclooctane 7.83
    cyclopentanol 154.5
    tetrahydropyran 279.76
    tert-amyl methyl ether 69.61
    2,5,8-trioxanonane 220.02
    1-hexene 35.81
    2-isopropoxyethanol 147.66
    2,2,2-trifluoroethanol 118.14
    methyl butyrate 124.24

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction