2-(Furan-2-yl)piperidine

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  • Identifiers

    CAS number
    97073-24-0

    Molecular formula
    C9H13NO

    SMILES
    C1CCNC(C1)C2=CC=CO2

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 49.06%
    Nutty 45.76%
    Animal 45.2%
    Roasted 44.18%
    Sweet 38.5%
    Earthy 35.29%
    Cheesy 34.63%
    Popcorn 32.78%
    Burnt 31.54%
    Musty 31.36%

     

    Flavor
    Bitter 58.35%
    Animal 35.88%
    Roasted 35.17%
    Sweet 33.14%
    Floral 28.01%
    Coffee 26.38%
    Alkaline 26.22%
    Amine 25.33%
    Cereal 24.28%
    Naphthalic 23.3%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    5.62 (weak acid)

    Molecular weight
    151.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    220°C

    Flash point

    • 87.94 ˚C est.

  • Synonyms

    • 2-(furan-2-yl)piperidine
    • 97073-24-0
    • 2-(2-Furanyl)piperidine
    • DTXSID00405814
    • RefChem:460995
    • DTXCID10356666
    • 860-608-4
    • 2-(2-furyl)piperidine
    • Piperidine, 2-(2-furanyl)-
    • MFCD02663560
    • (2R)-2-(2-furyl)piperidine
    • (2S)-2-(2-furyl)piperidine
    • 2-(2-Piperidinyl)furan
    • 2-(uran-2-yl)piperidine
    • SCHEMBL7015792
    • CHEMBL4560951
    • CHEBI:173410
    • MIJFUNGHFNXZGN-UHFFFAOYSA-N
    • XDA07324
    • BBL020695
    • STK893385
    • AKOS001476404
    • SB61783
    • CS-0259967
    • EN300-74369
    • N12707
    • Z1169540072
    • 97073-24-0

  • Applications

    2-(Furan-2-yl)piperidine, CAS 97073-24-0, is a chemical intermediate used in the synthesis of heterocyclic piperidine-furan derivatives and related compounds. Its main applications lie in the pharmaceutical and fine chemicals sectors, where it serves as a building block for drug-like precursors and potential active derivatives. In organic synthesis and medicinal chemistry research, it is commonly included in library generation to explore biological targets. In industrial manufacturing, it may be considered as a starting material for scalable routes to more complex piperidine-furan motifs. Given the basic character of the piperidine nitrogen, it participates in various amination and functionalization reactions, while its use is subject to local regulations and formulation safety considerations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 195.65
    methanol 286.01
    isopropanol 97.52
    water 2.3
    ethyl acetate 55.14
    n-propanol 130.64
    acetone 107.68
    n-butanol 104.02
    acetonitrile 87.57
    DMF 280.78
    toluene 47.69
    isobutanol 94.42
    1,4-dioxane 158.62
    methyl acetate 57.31
    THF 218.58
    2-butanone 76.04
    n-pentanol 86.42
    sec-butanol 76.57
    n-hexane 3.74
    ethylene glycol 92.03
    NMP 210.64
    cyclohexane 12.56
    DMSO 459.08
    n-butyl acetate 64.67
    n-octanol 54.09
    chloroform 502.76
    n-propyl acetate 48.11
    acetic acid 239.37
    dichloromethane 471.92
    cyclohexanone 160.1
    propylene glycol 98.21
    isopropyl acetate 35.83
    DMAc 175.07
    2-ethoxyethanol 127.1
    isopentanol 79.36
    n-heptane 7.52
    ethyl formate 89.8
    1,2-dichloroethane 182.13
    n-hexanol 91.23
    2-methoxyethanol 211.7
    isobutyl acetate 36.55
    tetrachloromethane 45.42
    n-pentyl acetate 43.38
    transcutol 348.77
    n-heptanol 50.5
    ethylbenzene 26.67
    MIBK 43.4
    2-propoxyethanol 141.96
    tert-butanol 78.4
    MTBE 35.18
    2-butoxyethanol 88.49
    propionic acid 134.5
    o-xylene 36.76
    formic acid 103.79
    diethyl ether 38.42
    m-xylene 36.6
    p-xylene 35.44
    chlorobenzene 123.04
    dimethyl carbonate 35.99
    n-octane 4.38
    formamide 117.6
    cyclopentanone 188.25
    2-pentanone 57.66
    anisole 62.14
    cyclopentyl methyl ether 75.59
    gamma-butyrolactone 215.53
    1-methoxy-2-propanol 146.17
    pyridine 217.42
    3-pentanone 43.09
    furfural 270.15
    n-dodecane 5.77
    diethylene glycol 153.67
    diisopropyl ether 13.48
    tert-amyl alcohol 60.64
    acetylacetone 74.21
    n-hexadecane 6.42
    acetophenone 73.11
    methyl propionate 58.34
    isopentyl acetate 54.36
    trichloroethylene 394.11
    n-nonanol 47.85
    cyclohexanol 87.18
    benzyl alcohol 92.56
    2-ethylhexanol 50.32
    isooctanol 40.92
    dipropyl ether 41.27
    1,2-dichlorobenzene 104.63
    ethyl lactate 51.97
    propylene carbonate 140.46
    n-methylformamide 160.6
    2-pentanol 49.88
    n-pentane 4.87
    1-propoxy-2-propanol 98.18
    1-methoxy-2-propyl acetate 68.45
    2-(2-methoxypropoxy) propanol 95.02
    mesitylene 24.33
    ε-caprolactone 119.55
    p-cymene 28.33
    epichlorohydrin 218.45
    1,1,1-trichloroethane 108.68
    2-aminoethanol 134.3
    morpholine-4-carbaldehyde 194.38
    sulfolane 283.18
    2,2,4-trimethylpentane 5.19
    2-methyltetrahydrofuran 112.01
    n-hexyl acetate 63.62
    isooctane 4.76
    2-(2-butoxyethoxy)ethanol 124.1
    sec-butyl acetate 30.13
    tert-butyl acetate 36.75
    decalin 8.49
    glycerin 145.85
    diglyme 196.65
    acrylic acid 149.55
    isopropyl myristate 32.06
    n-butyric acid 150.37
    acetyl acetate 48.33
    di(2-ethylhexyl) phthalate 49.01
    ethyl propionate 40.24
    nitromethane 216.02
    1,2-diethoxyethane 74.32
    benzonitrile 124.92
    trioctyl phosphate 34.17
    1-bromopropane 78.49
    gamma-valerolactone 213.43
    n-decanol 38.11
    triethyl phosphate 33.77
    4-methyl-2-pentanol 36.6
    propionitrile 87.19
    vinylene carbonate 147.78
    1,1,2-trichlorotrifluoroethane 192.76
    DMS 52.1
    cumene 24.89
    2-octanol 31.27
    2-hexanone 49.73
    octyl acetate 43.32
    limonene 37.1
    1,2-dimethoxyethane 136.06
    ethyl orthosilicate 31.03
    tributyl phosphate 36.65
    diacetone alcohol 62.75
    N,N-dimethylaniline 52.65
    acrylonitrile 140.81
    aniline 100.5
    1,3-propanediol 140.41
    bromobenzene 119.6
    dibromomethane 257.02
    1,1,2,2-tetrachloroethane 270.26
    2-methyl-cyclohexyl acetate 50.92
    tetrabutyl urea 52.32
    diisobutyl methanol 31.08
    2-phenylethanol 83.68
    styrene 37.65
    dioctyl adipate 54.38
    dimethyl sulfate 68.96
    ethyl butyrate 49.98
    methyl lactate 71.25
    butyl lactate 54.67
    diethyl carbonate 39.23
    propanediol butyl ether 101.91
    triethyl orthoformate 41.08
    p-tert-butyltoluene 25.83
    methyl 4-tert-butylbenzoate 78.26
    morpholine 164.7
    tert-butylamine 49.1
    n-dodecanol 31.99
    dimethoxymethane 111.84
    ethylene carbonate 108.42
    cyrene 100.03
    2-ethoxyethyl acetate 60.58
    2-ethylhexyl acetate 43.97
    1,2,4-trichlorobenzene 121.78
    4-methylpyridine 143.03
    dibutyl ether 38.31
    2,6-dimethyl-4-heptanol 31.08
    DEF 88.08
    dimethyl isosorbide 122.98
    tetrachloroethylene 194.6
    eugenol 84.57
    triacetin 76.67
    span 80 97.8
    1,4-butanediol 78.02
    1,1-dichloroethane 148.08
    2-methyl-1-pentanol 66.14
    methyl formate 112.67
    2-methyl-1-butanol 77.73
    n-decane 8.04
    butyronitrile 94.06
    3,7-dimethyl-1-octanol 48.79
    1-chlorooctane 31.17
    1-chlorotetradecane 16.3
    n-nonane 6.78
    undecane 6.62
    tert-butylcyclohexane 7.46
    cyclooctane 5.16
    cyclopentanol 116.74
    tetrahydropyran 111.72
    tert-amyl methyl ether 30.25
    2,5,8-trioxanonane 154.43
    1-hexene 18.44
    2-isopropoxyethanol 77.9
    2,2,2-trifluoroethanol 72.19
    methyl butyrate 60.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction