2-(Furan-2-yl)-1,3-thiazolidine

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  • Identifiers

    CAS number
    51859-60-0

    Molecular formula
    C7H9NOS

    SMILES
    C1CSC(N1)C2=CC=CO2

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 59.83%
    Roasted 58.6%
    Nutty 56.71%
    Fishy 41.65%
    Cooked 36.6%
    Popcorn 36.05%
    Earthy 35.83%
    Sulfurous 35.29%
    Sweet 33.48%
    Burnt 32.17%

     

    Flavor
    Roasted 54.41%
    Bitter 42.88%
    Coffee 35.25%
    Meaty 33.7%
    Sulfury 27.49%
    Mushroom 26.87%
    Cooked 26.27%
    Fishy 25.43%
    Roast 24.77%
    Scallion 24.67%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.9

    pKa est.
    3.35 (weak acid)

    Molecular weight
    155.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Boiling point est.
    272°C

    Flash point

    • 104.57 ˚C est.

  • Synonyms

    • 51859-60-0
    • 2-(furan-2-yl)-1,3-thiazolidine
    • DTXSID70966184
    • RefChem:460982
    • DTXCID501393833
    • 874-388-2
    • 2-Furan-2-yl-thiazolidine
    • 2-(2-Furyl)thiazolidine
    • 2-(Furan-2-yl)thiazolidine
    • Thiazolidine, 2-(2-furanyl)-
    • Thiazolidine, 2-(2-furyl)-
    • 2-(2-Furyl)-1,3-thiazolidine
    • 2-(2-Furanyl)thiazolidine
    • BRN 0121422
    • 2-(2-furyl-) thiazolidine
    • Oprea1_326061
    • Oprea1_798702
    • 4-27-00-06297 (Beilstein Handbook Reference)
    • SCHEMBL1607474
    • SCHEMBL10898596
    • HXQNTXBXKKMEFR-UHFFFAOYSA-N
    • HMS1685O22
    • BCA85960
    • 2-(2-Furyl)-1,3-thiazolidine #
    • MFCD00222824
    • SBB027762
    • STL600135
    • AKOS000301117
    • AKOS017279293
    • CS-0231897
    • ST50249892
    • EN300-1257699
    • F0804-0862
    • 51859-60-0

  • Applications

    2-(Furan-2-yl)-1,3-thiazolidine (CAS 51859-60-0) is typically used as an intermediate and building block in organic synthesis, particularly for thiazolidine–furan–based heterocycles; it is commonly evaluated as a precursor in pharmaceutical and agrochemical research and can serve as a core scaffold for catalytic ligands and other functionalized heterocycles, while also supporting the development of functional materials and polymers in the chemical industry, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 136.37
    methanol 256.32
    isopropanol 76.73
    water 17.76
    ethyl acetate 58.27
    n-propanol 88.6
    acetone 196.46
    n-butanol 67.06
    acetonitrile 95.71
    DMF 445.92
    toluene 21.47
    isobutanol 65.58
    1,4-dioxane 150.54
    methyl acetate 73.21
    THF 255.47
    2-butanone 101.3
    n-pentanol 66.88
    sec-butanol 53.9
    n-hexane 1.39
    ethylene glycol 178.06
    NMP 368.62
    cyclohexane 2.48
    DMSO 865.64
    n-butyl acetate 51.48
    n-octanol 48.12
    chloroform 235.45
    n-propyl acetate 58.59
    acetic acid 276.93
    dichloromethane 231.79
    cyclohexanone 190.1
    propylene glycol 137.52
    isopropyl acetate 40.51
    DMAc 266.71
    2-ethoxyethanol 182.58
    isopentanol 59.0
    n-heptane 3.26
    ethyl formate 74.14
    1,2-dichloroethane 124.84
    n-hexanol 60.02
    2-methoxyethanol 289.44
    isobutyl acetate 45.8
    tetrachloromethane 23.41
    n-pentyl acetate 49.79
    transcutol 364.58
    n-heptanol 46.82
    ethylbenzene 12.6
    MIBK 59.14
    2-propoxyethanol 169.04
    tert-butanol 69.59
    MTBE 30.66
    2-butoxyethanol 114.32
    propionic acid 131.82
    o-xylene 18.55
    formic acid 248.72
    diethyl ether 23.26
    m-xylene 23.74
    p-xylene 19.4
    chlorobenzene 73.35
    dimethyl carbonate 53.42
    n-octane 2.14
    formamide 221.96
    cyclopentanone 302.63
    2-pentanone 82.2
    anisole 55.71
    cyclopentyl methyl ether 75.72
    gamma-butyrolactone 313.42
    1-methoxy-2-propanol 195.0
    pyridine 153.7
    3-pentanone 53.82
    furfural 350.48
    n-dodecane 3.01
    diethylene glycol 234.46
    diisopropyl ether 10.89
    tert-amyl alcohol 52.3
    acetylacetone 124.34
    n-hexadecane 3.39
    acetophenone 85.1
    methyl propionate 70.94
    isopentyl acetate 51.32
    trichloroethylene 304.3
    n-nonanol 42.15
    cyclohexanol 61.2
    benzyl alcohol 86.85
    2-ethylhexanol 37.84
    isooctanol 42.0
    dipropyl ether 27.89
    1,2-dichlorobenzene 75.92
    ethyl lactate 71.88
    propylene carbonate 144.97
    n-methylformamide 220.63
    2-pentanol 37.88
    n-pentane 1.55
    1-propoxy-2-propanol 105.27
    1-methoxy-2-propyl acetate 79.75
    2-(2-methoxypropoxy) propanol 106.03
    mesitylene 16.68
    ε-caprolactone 136.94
    p-cymene 18.35
    epichlorohydrin 289.14
    1,1,1-trichloroethane 77.89
    2-aminoethanol 173.03
    morpholine-4-carbaldehyde 328.89
    sulfolane 485.61
    2,2,4-trimethylpentane 2.7
    2-methyltetrahydrofuran 110.2
    n-hexyl acetate 65.56
    isooctane 2.75
    2-(2-butoxyethoxy)ethanol 140.22
    sec-butyl acetate 34.95
    tert-butyl acetate 47.66
    decalin 3.6
    glycerin 259.88
    diglyme 239.94
    acrylic acid 178.57
    isopropyl myristate 28.49
    n-butyric acid 125.54
    acetyl acetate 51.02
    di(2-ethylhexyl) phthalate 47.84
    ethyl propionate 43.2
    nitromethane 362.73
    1,2-diethoxyethane 61.36
    benzonitrile 104.17
    trioctyl phosphate 34.23
    1-bromopropane 37.52
    gamma-valerolactone 363.59
    n-decanol 32.6
    triethyl phosphate 33.03
    4-methyl-2-pentanol 32.24
    propionitrile 61.65
    vinylene carbonate 150.64
    1,1,2-trichlorotrifluoroethane 279.94
    DMS 61.46
    cumene 14.65
    2-octanol 31.27
    2-hexanone 66.44
    octyl acetate 39.1
    limonene 23.85
    1,2-dimethoxyethane 174.41
    ethyl orthosilicate 28.61
    tributyl phosphate 36.18
    diacetone alcohol 97.56
    N,N-dimethylaniline 49.73
    acrylonitrile 123.3
    aniline 66.97
    1,3-propanediol 148.97
    bromobenzene 63.3
    dibromomethane 113.13
    1,1,2,2-tetrachloroethane 208.57
    2-methyl-cyclohexyl acetate 50.09
    tetrabutyl urea 55.36
    diisobutyl methanol 25.37
    2-phenylethanol 75.39
    styrene 16.79
    dioctyl adipate 50.33
    dimethyl sulfate 131.49
    ethyl butyrate 42.52
    methyl lactate 106.68
    butyl lactate 64.77
    diethyl carbonate 31.96
    propanediol butyl ether 137.16
    triethyl orthoformate 36.09
    p-tert-butyltoluene 17.41
    methyl 4-tert-butylbenzoate 91.89
    morpholine 168.74
    tert-butylamine 30.37
    n-dodecanol 25.42
    dimethoxymethane 160.35
    ethylene carbonate 106.52
    cyrene 151.57
    2-ethoxyethyl acetate 75.51
    2-ethylhexyl acetate 39.65
    1,2,4-trichlorobenzene 96.3
    4-methylpyridine 110.89
    dibutyl ether 26.6
    2,6-dimethyl-4-heptanol 25.37
    DEF 104.74
    dimethyl isosorbide 148.59
    tetrachloroethylene 124.93
    eugenol 108.31
    triacetin 91.7
    span 80 101.74
    1,4-butanediol 107.34
    1,1-dichloroethane 88.78
    2-methyl-1-pentanol 56.43
    methyl formate 173.58
    2-methyl-1-butanol 55.37
    n-decane 4.15
    butyronitrile 58.42
    3,7-dimethyl-1-octanol 42.81
    1-chlorooctane 22.17
    1-chlorotetradecane 10.1
    n-nonane 3.45
    undecane 3.44
    tert-butylcyclohexane 3.87
    cyclooctane 1.52
    cyclopentanol 97.02
    tetrahydropyran 70.43
    tert-amyl methyl ether 27.66
    2,5,8-trioxanonane 177.53
    1-hexene 7.94
    2-isopropoxyethanol 115.63
    2,2,2-trifluoroethanol 129.41
    methyl butyrate 65.26

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction