2-Fluoroaniline

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  • Identifiers

    CAS number
    348-54-9

    Molecular formula
    C6H6FN

    SMILES
    C1=CC=C(C(=C1)N)F

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Burnt 36.37%
    Meaty 36.36%
    Phenolic 36.2%
    Animal 34.14%
    Smoky 31.35%
    Fishy 30.47%
    Cheesy 28.97%
    Sweet 28.21%
    Odorless 27.62%
    Ripe 26.72%

     

    Flavor
    Meaty 39.84%
    Sulfurous 37.89%
    Garlic 28.82%
    Onion 28.66%
    Phenolic 27.49%
    Egg 27.4%
    Fishy 27.34%
    Mild 26.83%
    Roasted 24.92%
    Sulfury 24.08%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.3

    pKa est.
    4.07 (weak acid)

    Molecular weight
    111.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Melting point expt.

    • -19.3 °F (USCG, 1999)
    • -34.6 °C

    Boiling point

    • 347 °F at 760 mmHg (USCG, 1999)
    • 175 °C

    Flash point

    • 74.79 ˚C est.
    • 140 °F (USCG, 1999)

  • Synonyms

    • 2-FLUOROANILINE
    • 348-54-9
    • o-Fluoroaniline
    • 1-Amino-2-fluorobenzene
    • Benzenamine, 2-fluoro-
    • 2-Fluorobenzenamine
    • 2-Fluoro-phenylamine
    • Aniline, o-fluoro-
    • 2-fluorophenylamine
    • o-aminofluorobenzene
    • Aniline, 2-fluoro-
    • CHEBI:27526
    • SE32ZK6617
    • EINECS 206-478-9
    • MFCD00007642
    • NSC 10299
    • NSC-10299
    • UNII-SE32ZK6617
    • AI3-52644
    • CHEMBL195328
    • DTXSID8059843
    • UN 2941
    • 2-fluoro-benzenamine
    • oFluoroaniline
    • 2fluoroaniline
    • 2-flouroaniline
    • Aniline, ofluoro
    • 2-fluoro aniline
    • 2-fluoro-aniline
    • 2Fluorobenzenamine
    • 2Fluorophenylamine
    • 1lgw
    • 2-Fluoroaniline-
    • Ortho-fluoroaniline
    • 2-fluorobenzeneamine
    • 1Amino2fluorobenzene
    • 2-fluorobenzenaminium
    • Benzenamine, 2fluoro
    • (2-fluorophenyl)amine
    • 1,2-fluorobenzenamine
    • (2-fluorophenyl)-amine
    • Aniline, ofluoro (8CI)
    • bmse000724
    • Aniline, o-fluoro-(8CI)
    • 2-Fluoroaniline, >=99%
    • SCHEMBL33295
    • BIDD:GT0093
    • DTXCID1038905
    • CS-M2715
    • NSC10299
    • STR00771
    • BDBM50167958
    • STK802386
    • AKOS000118879
    • CCG-302491
    • DB02403
    • FF15645
    • 1AN
    • o-Fluoroaniline; 1-Amino-2-fluorobenzene
    • PD008363
    • DB-028080
    • A6120
    • F0032
    • NS00041421
    • EN300-19550
    • AG-617/02198032
    • o-Fluoroaniline [UN2941] [Keep away from food]
    • Q27093404
    • F2190-0425
    • Z104474198
    • 206-478-9

  • Applications

    2-Fluoroaniline (CAS 348-54-9) is primarily used as an intermediate in the synthesis of dyes and pigments, including azo dyes and specialty pigments. It also serves as a precursor in pharmaceutical synthesis and in other complex organic compounds. In agriculture, it is considered a building block for certain agrochemical derivatives and crop protection intermediates. In polymers and plastics, 2-Fluoroaniline participates in the synthesis of specialty polymers or provides functional groups for resins and synthetic elastomers. In coatings and inks, it is used as a precursor to produce colorants and color systems for paints and printed inks with color stability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 57.02
    methanol 106.08
    isopropanol 33.97
    water 10.12
    ethyl acetate 17.48
    n-propanol 38.2
    acetone 33.1
    n-butanol 32.35
    acetonitrile 26.42
    DMF 56.94
    toluene 3.8
    isobutanol 26.86
    1,4-dioxane 55.58
    methyl acetate 29.96
    THF 76.11
    2-butanone 31.01
    n-pentanol 32.86
    sec-butanol 27.99
    n-hexane 1.82
    ethylene glycol 24.43
    NMP 64.52
    cyclohexane 0.84
    DMSO 116.09
    n-butyl acetate 26.08
    n-octanol 20.7
    chloroform 22.61
    n-propyl acetate 24.58
    acetic acid 88.11
    dichloromethane 24.54
    cyclohexanone 34.62
    propylene glycol 16.89
    isopropyl acetate 14.37
    DMAc 66.36
    2-ethoxyethanol 69.21
    isopentanol 31.87
    n-heptane 2.75
    ethyl formate 27.03
    1,2-dichloroethane 17.25
    n-hexanol 28.44
    2-methoxyethanol 77.52
    isobutyl acetate 14.37
    tetrachloromethane 5.38
    n-pentyl acetate 26.56
    transcutol 345.35
    n-heptanol 22.76
    ethylbenzene 3.88
    MIBK 24.24
    2-propoxyethanol 54.54
    tert-butanol 45.26
    MTBE 27.13
    2-butoxyethanol 55.22
    propionic acid 41.69
    o-xylene 5.65
    formic acid 98.99
    diethyl ether 19.91
    m-xylene 5.65
    p-xylene 5.99
    chlorobenzene 7.32
    dimethyl carbonate 9.67
    n-octane 1.41
    formamide 138.76
    cyclopentanone 47.11
    2-pentanone 22.37
    anisole 19.24
    cyclopentyl methyl ether 21.7
    gamma-butyrolactone 70.75
    1-methoxy-2-propanol 46.0
    pyridine 27.3
    3-pentanone 15.18
    furfural 80.42
    n-dodecane 1.23
    diethylene glycol 57.85
    diisopropyl ether 8.17
    tert-amyl alcohol 38.54
    acetylacetone 28.43
    n-hexadecane 1.3
    acetophenone 22.88
    methyl propionate 15.02
    isopentyl acetate 26.5
    trichloroethylene 33.62
    n-nonanol 19.01
    cyclohexanol 17.17
    benzyl alcohol 20.48
    2-ethylhexanol 19.12
    isooctanol 19.96
    dipropyl ether 17.42
    1,2-dichlorobenzene 9.59
    ethyl lactate 19.23
    propylene carbonate 35.68
    n-methylformamide 52.86
    2-pentanol 21.4
    n-pentane 1.9
    1-propoxy-2-propanol 41.11
    1-methoxy-2-propyl acetate 30.41
    2-(2-methoxypropoxy) propanol 63.1
    mesitylene 5.35
    ε-caprolactone 39.37
    p-cymene 7.53
    epichlorohydrin 64.01
    1,1,1-trichloroethane 12.29
    2-aminoethanol 41.82
    morpholine-4-carbaldehyde 85.73
    sulfolane 87.81
    2,2,4-trimethylpentane 2.2
    2-methyltetrahydrofuran 42.06
    n-hexyl acetate 33.49
    isooctane 2.11
    2-(2-butoxyethoxy)ethanol 89.2
    sec-butyl acetate 15.5
    tert-butyl acetate 25.87
    decalin 1.31
    glycerin 35.19
    diglyme 147.31
    acrylic acid 45.24
    isopropyl myristate 15.08
    n-butyric acid 39.52
    acetyl acetate 14.73
    di(2-ethylhexyl) phthalate 17.65
    ethyl propionate 15.12
    nitromethane 128.93
    1,2-diethoxyethane 66.19
    benzonitrile 17.99
    trioctyl phosphate 13.86
    1-bromopropane 8.34
    gamma-valerolactone 82.5
    n-decanol 14.4
    triethyl phosphate 14.91
    4-methyl-2-pentanol 18.75
    propionitrile 17.01
    vinylene carbonate 31.99
    1,1,2-trichlorotrifluoroethane 58.76
    DMS 24.16
    cumene 5.26
    2-octanol 15.68
    2-hexanone 27.88
    octyl acetate 19.33
    limonene 9.82
    1,2-dimethoxyethane 82.77
    ethyl orthosilicate 15.22
    tributyl phosphate 17.44
    diacetone alcohol 42.76
    N,N-dimethylaniline 15.61
    acrylonitrile 24.6
    aniline 12.7
    1,3-propanediol 48.46
    bromobenzene 4.82
    dibromomethane 13.78
    1,1,2,2-tetrachloroethane 25.25
    2-methyl-cyclohexyl acetate 22.99
    tetrabutyl urea 21.86
    diisobutyl methanol 15.85
    2-phenylethanol 23.71
    styrene 4.07
    dioctyl adipate 24.05
    dimethyl sulfate 21.07
    ethyl butyrate 21.88
    methyl lactate 19.54
    butyl lactate 28.72
    diethyl carbonate 15.61
    propanediol butyl ether 51.49
    triethyl orthoformate 19.54
    p-tert-butyltoluene 7.11
    methyl 4-tert-butylbenzoate 33.91
    morpholine 58.48
    tert-butylamine 24.97
    n-dodecanol 11.0
    dimethoxymethane 37.41
    ethylene carbonate 23.54
    cyrene 45.81
    2-ethoxyethyl acetate 46.96
    2-ethylhexyl acetate 19.25
    1,2,4-trichlorobenzene 13.25
    4-methylpyridine 21.45
    dibutyl ether 20.41
    2,6-dimethyl-4-heptanol 15.85
    DEF 28.92
    dimethyl isosorbide 78.02
    tetrachloroethylene 22.3
    eugenol 42.38
    triacetin 44.41
    span 80 42.99
    1,4-butanediol 28.58
    1,1-dichloroethane 11.32
    2-methyl-1-pentanol 31.99
    methyl formate 39.68
    2-methyl-1-butanol 27.51
    n-decane 1.94
    butyronitrile 19.72
    3,7-dimethyl-1-octanol 21.45
    1-chlorooctane 8.09
    1-chlorotetradecane 3.51
    n-nonane 1.7
    undecane 1.5
    tert-butylcyclohexane 2.04
    cyclooctane 0.58
    cyclopentanol 24.33
    tetrahydropyran 25.65
    tert-amyl methyl ether 21.75
    2,5,8-trioxanonane 108.98
    1-hexene 6.07
    2-isopropoxyethanol 46.65
    2,2,2-trifluoroethanol 43.7
    methyl butyrate 24.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction