2-Ethylhexyl p-hydroxybenzoate

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  • Identifiers

    CAS number
    5153-25-3

    Molecular formula
    C15H22O3

    SMILES
    CCCCC(CC)COC(=O)C1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Balsamic 53.24%
    Sweet 52.98%
    Floral 46.79%
    Fruity 45.74%
    Spicy 40.99%
    Herbal 39.52%
    Woody 28.48%
    Animal 25.55%
    Mint 25.07%
    Phenolic 24.85%

     

    Flavor
    Herbal 51.09%
    Woody 35.6%
    Balsam 28.92%
    Spicy 26.48%
    Warm 26.01%
    Oily 24.61%
    Mild 24.29%
    Floral 23.87%
    Bitter 22.98%
    Lovage 21.36%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.5

    pKa est.
    8.22 (weak base)

    Molecular weight
    250.33 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    366°C

    Flash point

    • 156.15 ˚C est.

  • Synonyms

    • 2-Ethylhexyl 4-hydroxybenzoate
    • 5153-25-3
    • 2-Ethylhexyl p-hydroxybenzoate
    • Benzoic acid, 4-hydroxy-, 2-ethylhexyl ester
    • 4-Hydroxybenzoic Acid 2-Ethylhexyl Ester
    • 2-Methylhexyl p-hydroxybenzoate
    • EINECS 225-925-9
    • 0XG05SSB3G
    • DTXSID4022525
    • AI3-03405
    • J151.186F
    • DTXCID802525
    • BENZOIC ACID, P-HYDROXY-, 2-ETHYLHEXYL ESTER
    • RefChem:471999
    • 225-925-9
    • 2-Ethylhexylparaben
    • 2-ethylhexyl-4-hydroxybenzoate
    • MFCD00016472
    • 2-Ethylhexyl4-hydroxybenzoate
    • CAS-5153-25-3
    • UNII-0XG05SSB3G
    • 2-ethylhexyl-p-hydroxybenzoate
    • p-Hydroxybenzoic acid 2-ethylhexyl ester
    • 4'-Hydroxybenzoic acid 2-ethylhexyl ester
    • SCHEMBL128529
    • CHEMBL3183756
    • CHEBI:34274
    • 2-Ethylhexyl 4-hydroxybenzoate #
    • 4-Hydroxybenzoic Acid Octyl Ester
    • Tox21_202354
    • Tox21_302793
    • AKOS015889418
    • FE68059
    • NCGC00249213-01
    • NCGC00256492-01
    • NCGC00259903-01
    • AS-60169
    • SY051915
    • CS-0213236
    • H0506
    • NS00020828
    • E78154
    • Q27115958
    • 5153-25-3

  • Applications

    2-Ethylhexyl p-hydroxybenzoate (CAS 5153-25-3) is primarily used as a preservative in cosmetics and personal care products to inhibit microbial growth and extend shelf life, such as in creams, lotions, shampoos, and deodorants. It is also used in pharmaceutical topical formulations as a preservative. In some household products, including cleaners and detergents, it may serve as a preservative/antimicrobial additive. In coatings, inks, and adhesives, it may be used as a preservative additive in water-based systems to improve microbiological stability. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 6511.59
    methanol 8093.55
    isopropanol 2897.72
    water 0.06
    ethyl acetate 5969.45
    n-propanol 4639.01
    acetone 6749.81
    n-butanol 3000.38
    acetonitrile 3741.66
    DMF 4593.31
    toluene 715.03
    isobutanol 2102.96
    1,4-dioxane 2897.12
    methyl acetate 3783.61
    THF 3550.57
    2-butanone 4593.12
    n-pentanol 1272.0
    sec-butanol 2405.76
    n-hexane 24.08
    ethylene glycol 149.12
    NMP 1809.59
    cyclohexane 54.1
    DMSO 4270.6
    n-butyl acetate 1638.75
    n-octanol 191.28
    chloroform 2585.38
    n-propyl acetate 1762.36
    acetic acid 1640.64
    dichloromethane 3499.2
    cyclohexanone 3225.84
    propylene glycol 440.64
    isopropyl acetate 2397.34
    DMAc 2489.85
    2-ethoxyethanol 1903.32
    isopentanol 1750.25
    n-heptane 8.86
    ethyl formate 1434.15
    1,2-dichloroethane 3398.61
    n-hexanol 833.43
    2-methoxyethanol 4328.83
    isobutyl acetate 798.01
    tetrachloromethane 169.14
    n-pentyl acetate 681.76
    transcutol 5426.35
    n-heptanol 242.18
    ethylbenzene 244.96
    MIBK 1379.23
    2-propoxyethanol 1778.4
    tert-butanol 2423.46
    MTBE 3215.93
    2-butoxyethanol 668.22
    propionic acid 1479.8
    o-xylene 309.0
    formic acid 360.48
    diethyl ether 4588.49
    m-xylene 386.42
    p-xylene 304.91
    chlorobenzene 970.29
    dimethyl carbonate 678.94
    n-octane 6.11
    formamide 1237.69
    cyclopentanone 3362.81
    2-pentanone 4056.78
    anisole 762.69
    cyclopentyl methyl ether 1842.41
    gamma-butyrolactone 3065.36
    1-methoxy-2-propanol 2721.41
    pyridine 2482.42
    3-pentanone 2076.21
    furfural 1670.61
    n-dodecane 7.35
    diethylene glycol 876.14
    diisopropyl ether 537.74
    tert-amyl alcohol 1799.66
    acetylacetone 2831.87
    n-hexadecane 9.08
    acetophenone 725.8
    methyl propionate 3211.47
    isopentyl acetate 1242.29
    trichloroethylene 4557.47
    n-nonanol 177.59
    cyclohexanol 1206.34
    benzyl alcohol 632.62
    2-ethylhexanol 339.55
    isooctanol 210.88
    dipropyl ether 447.52
    1,2-dichlorobenzene 676.19
    ethyl lactate 394.91
    propylene carbonate 1328.63
    n-methylformamide 2665.63
    2-pentanol 1567.96
    n-pentane 26.0
    1-propoxy-2-propanol 1103.66
    1-methoxy-2-propyl acetate 1350.51
    2-(2-methoxypropoxy) propanol 560.03
    mesitylene 195.56
    ε-caprolactone 2381.59
    p-cymene 112.2
    epichlorohydrin 4437.77
    1,1,1-trichloroethane 1636.48
    2-aminoethanol 863.59
    morpholine-4-carbaldehyde 1965.79
    sulfolane 2379.55
    2,2,4-trimethylpentane 28.55
    2-methyltetrahydrofuran 3262.42
    n-hexyl acetate 765.94
    isooctane 25.39
    2-(2-butoxyethoxy)ethanol 982.05
    sec-butyl acetate 1063.24
    tert-butyl acetate 1753.34
    decalin 33.11
    glycerin 412.41
    diglyme 1956.38
    acrylic acid 793.79
    isopropyl myristate 216.82
    n-butyric acid 2855.54
    acetyl acetate 1422.23
    di(2-ethylhexyl) phthalate 180.52
    ethyl propionate 1208.0
    nitromethane 4416.28
    1,2-diethoxyethane 1717.58
    benzonitrile 840.98
    trioctyl phosphate 129.45
    1-bromopropane 1560.97
    gamma-valerolactone 3747.26
    n-decanol 125.55
    triethyl phosphate 220.74
    4-methyl-2-pentanol 529.62
    propionitrile 2288.77
    vinylene carbonate 1112.06
    1,1,2-trichlorotrifluoroethane 1448.84
    DMS 687.35
    cumene 140.57
    2-octanol 164.2
    2-hexanone 1417.75
    octyl acetate 285.97
    limonene 193.0
    1,2-dimethoxyethane 2551.13
    ethyl orthosilicate 212.05
    tributyl phosphate 196.64
    diacetone alcohol 1542.57
    N,N-dimethylaniline 324.99
    acrylonitrile 2407.92
    aniline 982.53
    1,3-propanediol 1540.95
    bromobenzene 983.38
    dibromomethane 2048.89
    1,1,2,2-tetrachloroethane 3150.25
    2-methyl-cyclohexyl acetate 436.27
    tetrabutyl urea 224.18
    diisobutyl methanol 178.51
    2-phenylethanol 532.89
    styrene 384.63
    dioctyl adipate 321.85
    dimethyl sulfate 817.84
    ethyl butyrate 782.19
    methyl lactate 708.44
    butyl lactate 440.13
    diethyl carbonate 441.92
    propanediol butyl ether 563.67
    triethyl orthoformate 384.89
    p-tert-butyltoluene 111.69
    methyl 4-tert-butylbenzoate 420.12
    morpholine 5180.46
    tert-butylamine 1047.8
    n-dodecanol 87.89
    dimethoxymethane 3463.71
    ethylene carbonate 1026.01
    cyrene 433.01
    2-ethoxyethyl acetate 1134.47
    2-ethylhexyl acetate 798.09
    1,2,4-trichlorobenzene 794.27
    4-methylpyridine 2518.54
    dibutyl ether 379.61
    2,6-dimethyl-4-heptanol 178.51
    DEF 3366.99
    dimethyl isosorbide 849.75
    tetrachloroethylene 1539.8
    eugenol 409.38
    triacetin 628.48
    span 80 426.65
    1,4-butanediol 377.57
    1,1-dichloroethane 3152.03
    2-methyl-1-pentanol 879.03
    methyl formate 1264.55
    2-methyl-1-butanol 1674.54
    n-decane 12.16
    butyronitrile 2470.89
    3,7-dimethyl-1-octanol 252.52
    1-chlorooctane 122.43
    1-chlorotetradecane 40.77
    n-nonane 10.06
    undecane 9.22
    tert-butylcyclohexane 32.33
    cyclooctane 12.39
    cyclopentanol 1116.62
    tetrahydropyran 3862.47
    tert-amyl methyl ether 1450.04
    2,5,8-trioxanonane 1033.07
    1-hexene 306.11
    2-isopropoxyethanol 1102.69
    2,2,2-trifluoroethanol 315.43
    methyl butyrate 1859.8

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction