2-Ethylcyclobutanol

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  • Identifiers

    CAS number
    35301-43-0

    Molecular formula
    C6H12O

    SMILES
    CCC1CCC1O

    Safety labels

  • Odor profile

    Fragrance
    Mint 50.64%
    Fermented 40.94%
    Solvent 40.68%
    Herbal 40.31%
    Oily 37.9%
    Musty 37.21%
    Floral 37.07%
    Camphoreous 35.94%
    Fruity 35.52%
    Alcoholic 34.92%

     

    Flavor
    Minty 41.55%
    Herbal 29.9%
    Sweet 26.85%
    Herb 24.08%
    Mentholic 22.19%
    Medicinal 21.87%
    Cauliflower 21.58%
    Beet 20.65%
    Soil 20.31%
    Caramel 20.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    8.27 (weak base)

    Molecular weight
    100.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Fast

    Boiling point est.
    155°C

    Flash point

    • 42.64 ˚C est.

  • Synonyms

    • 2-ETHYLCYCLOBUTANOL
    • 35301-43-0
    • Cyclobutanol, 2-ethyl-
    • RefChem:86956
    • JBHZDUFZWBLFID-UHFFFAOYSA-N
    • 2-ethylcyclobutan-1-ol
    • 2-ethyl cyclobutanol
    • SCHEMBL767106
    • SCHEMBL2287266
    • SCHEMBL2287269
    • SCHEMBL21436613
    • DTXSID00956735
    • DB-260998
    • EN300-1637009
    • 2-Ethylcyclobutanol

  • Applications

    2-Ethylcyclobutanol (CAS 35301-43-0) is primarily employed as an intermediate in organic synthesis, enabling downstream access to specialty chemicals. In fragrance and flavor development, it may function as an odorant precursor or fragrance-building block for exploratory formulations. In cosmetics and personal care, it is evaluated as a synthetic intermediate for innovative ingredients. In industrial manufacturing, it serves as a building block for polymers, resins, and coatings, where the hydroxyl group allows further functionalization. It can also be used as a solvent or co-solvent in specific synthetic or formulation processes, subject to regulatory constraints.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3447.84
    methanol 3739.02
    isopropanol 2234.11
    water 3.66
    ethyl acetate 993.42
    n-propanol 2195.27
    acetone 1234.5
    n-butanol 2039.07
    acetonitrile 1259.15
    DMF 582.58
    toluene 170.94
    isobutanol 1351.33
    1,4-dioxane 1808.14
    methyl acetate 760.68
    THF 2861.09
    2-butanone 849.92
    n-pentanol 1093.14
    sec-butanol 1283.52
    n-hexane 198.93
    ethylene glycol 331.95
    NMP 469.46
    cyclohexane 199.86
    DMSO 1127.72
    n-butyl acetate 1345.9
    n-octanol 380.35
    chloroform 1811.65
    n-propyl acetate 637.37
    acetic acid 1649.42
    dichloromethane 1236.49
    cyclohexanone 970.74
    propylene glycol 431.1
    isopropyl acetate 538.28
    DMAc 251.81
    2-ethoxyethanol 870.68
    isopentanol 1367.68
    n-heptane 187.58
    ethyl formate 708.65
    1,2-dichloroethane 745.99
    n-hexanol 1499.6
    2-methoxyethanol 1687.36
    isobutyl acetate 369.86
    tetrachloromethane 362.38
    n-pentyl acetate 444.4
    transcutol 2498.14
    n-heptanol 464.34
    ethylbenzene 81.93
    MIBK 477.59
    2-propoxyethanol 1628.16
    tert-butanol 1728.76
    MTBE 1104.91
    2-butoxyethanol 695.14
    propionic acid 1075.84
    o-xylene 93.7
    formic acid 585.9
    diethyl ether 1366.78
    m-xylene 133.06
    p-xylene 112.48
    chlorobenzene 322.73
    dimethyl carbonate 107.56
    n-octane 54.06
    formamide 606.13
    cyclopentanone 1093.98
    2-pentanone 834.56
    anisole 223.45
    cyclopentyl methyl ether 816.22
    gamma-butyrolactone 1202.9
    1-methoxy-2-propanol 1029.48
    pyridine 789.66
    3-pentanone 377.27
    furfural 791.59
    n-dodecane 35.58
    diethylene glycol 902.33
    diisopropyl ether 354.62
    tert-amyl alcohol 950.86
    acetylacetone 553.65
    n-hexadecane 38.19
    acetophenone 172.71
    methyl propionate 454.37
    isopentyl acetate 888.01
    trichloroethylene 1093.05
    n-nonanol 316.06
    cyclohexanol 859.33
    benzyl alcohol 221.08
    2-ethylhexanol 689.65
    isooctanol 347.1
    dipropyl ether 846.91
    1,2-dichlorobenzene 247.38
    ethyl lactate 173.98
    propylene carbonate 635.86
    n-methylformamide 758.93
    2-pentanol 1054.15
    n-pentane 222.02
    1-propoxy-2-propanol 1156.65
    1-methoxy-2-propyl acetate 630.3
    2-(2-methoxypropoxy) propanol 381.84
    mesitylene 91.19
    ε-caprolactone 822.46
    p-cymene 112.83
    epichlorohydrin 1290.68
    1,1,1-trichloroethane 735.64
    2-aminoethanol 892.51
    morpholine-4-carbaldehyde 625.51
    sulfolane 856.94
    2,2,4-trimethylpentane 75.8
    2-methyltetrahydrofuran 1682.57
    n-hexyl acetate 524.47
    isooctane 99.74
    2-(2-butoxyethoxy)ethanol 681.21
    sec-butyl acetate 330.6
    tert-butyl acetate 535.09
    decalin 61.86
    glycerin 477.53
    diglyme 1081.75
    acrylic acid 654.51
    isopropyl myristate 177.39
    n-butyric acid 1755.16
    acetyl acetate 380.98
    di(2-ethylhexyl) phthalate 137.8
    ethyl propionate 345.58
    nitromethane 1378.61
    1,2-diethoxyethane 1107.9
    benzonitrile 405.14
    trioctyl phosphate 126.5
    1-bromopropane 646.57
    gamma-valerolactone 1191.35
    n-decanol 225.71
    triethyl phosphate 136.95
    4-methyl-2-pentanol 518.18
    propionitrile 982.35
    vinylene carbonate 519.38
    1,1,2-trichlorotrifluoroethane 615.15
    DMS 216.7
    cumene 68.57
    2-octanol 264.11
    2-hexanone 643.55
    octyl acetate 221.26
    limonene 210.97
    1,2-dimethoxyethane 1127.7
    ethyl orthosilicate 160.06
    tributyl phosphate 160.65
    diacetone alcohol 530.06
    N,N-dimethylaniline 116.57
    acrylonitrile 825.25
    aniline 353.16
    1,3-propanediol 1322.92
    bromobenzene 279.54
    dibromomethane 929.49
    1,1,2,2-tetrachloroethane 808.48
    2-methyl-cyclohexyl acetate 298.74
    tetrabutyl urea 158.68
    diisobutyl methanol 335.95
    2-phenylethanol 387.1
    styrene 112.48
    dioctyl adipate 198.66
    dimethyl sulfate 130.83
    ethyl butyrate 587.82
    methyl lactate 206.76
    butyl lactate 300.08
    diethyl carbonate 280.97
    propanediol butyl ether 485.45
    triethyl orthoformate 340.64
    p-tert-butyltoluene 108.46
    methyl 4-tert-butylbenzoate 189.68
    morpholine 1963.93
    tert-butylamine 1296.21
    n-dodecanol 167.64
    dimethoxymethane 623.19
    ethylene carbonate 518.35
    cyrene 212.75
    2-ethoxyethyl acetate 504.86
    2-ethylhexyl acetate 618.22
    1,2,4-trichlorobenzene 260.18
    4-methylpyridine 620.65
    dibutyl ether 524.39
    2,6-dimethyl-4-heptanol 335.95
    DEF 509.87
    dimethyl isosorbide 501.65
    tetrachloroethylene 653.47
    eugenol 221.36
    triacetin 291.12
    span 80 384.27
    1,4-butanediol 389.95
    1,1-dichloroethane 932.51
    2-methyl-1-pentanol 704.12
    methyl formate 425.54
    2-methyl-1-butanol 1071.03
    n-decane 67.09
    butyronitrile 1321.96
    3,7-dimethyl-1-octanol 374.5
    1-chlorooctane 210.48
    1-chlorotetradecane 72.9
    n-nonane 69.02
    undecane 46.7
    tert-butylcyclohexane 73.56
    cyclooctane 62.34
    cyclopentanol 1023.81
    tetrahydropyran 1866.12
    tert-amyl methyl ether 524.84
    2,5,8-trioxanonane 608.06
    1-hexene 559.81
    2-isopropoxyethanol 552.32
    2,2,2-trifluoroethanol 335.45
    methyl butyrate 511.74

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction