2-Ethyl-5-methylthiazole

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  • Identifiers

    CAS number
    19961-53-6

    Molecular formula
    C6H9NS

    SMILES
    CCC1=NC=C(S1)C

    Safety labels

  • Odor profile

    Fragrance
    Green 81.98%
    Nutty 74.28%
    Roasted 63.34%
    Meaty 60.3%
    Vegetable 57.53%
    Sulfurous 54.03%
    Earthy 45.77%
    Cocoa 45.59%
    Coffee 41.33%
    Burnt 40.13%

     

    Flavor
    Green 75.8%
    Nutty 65.35%
    Vegetable 49.16%
    Roasted 46.4%
    Earthy 41.73%
    Tomato 31.5%
    Raw 30.86%
    Potato 29.68%
    Meaty 29.67%
    Coffee 29.3%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.08 (neutral)

    Molecular weight
    127.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    171°C

    Flash point

    • 47.04 ˚C est.

  • Synonyms

    • 2-Ethyl-5-methylthiazole
    • Thiazole, 2-ethyl-5-methyl-
    • 19961-53-6
    • 5-Methyl-2-ethylthiazole
    • DTXSID90334124
    • RefChem:260611
    • DTXCID00285214
    • YXWWUNNKMJZIOW-UHFFFAOYSA-N
    • 2-Ethyl-5-methyl-1,3-thiazole
    • 2-ethyl-5-methyl-thiazole
    • SCHEMBL127876
    • SCHEMBL127877
    • SCHEMBL1460715
    • SCHEMBL19057051
    • 2-Ethyl-5-methyl-1,3-thiazole #
    • 19961-53-6

  • Applications

    2-Ethyl-5-methylthiazole (CAS 19961-53-6) is predominantly used as an odorant and flavor ingredient, contributing savory or roasted notes in fragrance formulations and in food and beverage flavor systems; it may be used in perfumery, cosmetics and personal care, and household products as a fragrance component. It can also serve as an intermediate in organic synthesis, providing access to heterocyclic scaffolds for pharmaceuticals and agrochemicals; in industrial manufacturing it is often evaluated as a chemical building block for more complex compounds. The use is typically formulation- and regulation-dependent, and its applicability in a given domain depends on local regulations and compatibility with other ingredients.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 322.54
    methanol 435.76
    isopropanol 244.3
    water 4.57
    ethyl acetate 301.4
    n-propanol 265.95
    acetone 467.02
    n-butanol 293.3
    acetonitrile 254.44
    DMF 634.06
    toluene 304.45
    isobutanol 231.17
    1,4-dioxane 570.47
    methyl acetate 313.08
    THF 704.27
    2-butanone 414.09
    n-pentanol 250.84
    sec-butanol 251.89
    n-hexane 74.49
    ethylene glycol 111.94
    NMP 675.48
    cyclohexane 79.29
    DMSO 512.67
    n-butyl acetate 362.12
    n-octanol 214.25
    chloroform 1098.35
    n-propyl acetate 260.75
    acetic acid 258.06
    dichloromethane 926.22
    cyclohexanone 615.83
    propylene glycol 132.29
    isopropyl acetate 250.86
    DMAc 533.33
    2-ethoxyethanol 407.41
    isopentanol 270.53
    n-heptane 77.14
    ethyl formate 245.65
    1,2-dichloroethane 499.79
    n-hexanol 334.68
    2-methoxyethanol 533.89
    isobutyl acetate 229.15
    tetrachloromethane 328.22
    n-pentyl acetate 290.76
    transcutol 757.16
    n-heptanol 211.52
    ethylbenzene 192.53
    MIBK 299.19
    2-propoxyethanol 549.39
    tert-butanol 306.47
    MTBE 346.48
    2-butoxyethanol 361.52
    propionic acid 212.8
    o-xylene 234.71
    formic acid 106.21
    diethyl ether 318.88
    m-xylene 265.36
    p-xylene 256.57
    chlorobenzene 461.9
    dimethyl carbonate 181.42
    n-octane 45.62
    formamide 120.51
    cyclopentanone 646.18
    2-pentanone 373.71
    anisole 377.79
    cyclopentyl methyl ether 419.84
    gamma-butyrolactone 583.23
    1-methoxy-2-propanol 406.73
    pyridine 481.86
    3-pentanone 302.07
    furfural 736.48
    n-dodecane 42.64
    diethylene glycol 391.88
    diisopropyl ether 164.34
    tert-amyl alcohol 285.15
    acetylacetone 456.09
    n-hexadecane 47.71
    acetophenone 359.04
    methyl propionate 267.87
    isopentyl acetate 349.79
    trichloroethylene 982.95
    n-nonanol 191.45
    cyclohexanol 272.4
    benzyl alcohol 289.94
    2-ethylhexanol 237.81
    isooctanol 188.85
    dipropyl ether 257.01
    1,2-dichlorobenzene 451.42
    ethyl lactate 161.69
    propylene carbonate 379.62
    n-methylformamide 263.73
    2-pentanol 221.69
    n-pentane 69.98
    1-propoxy-2-propanol 375.01
    1-methoxy-2-propyl acetate 357.03
    2-(2-methoxypropoxy) propanol 305.17
    mesitylene 202.37
    ε-caprolactone 493.39
    p-cymene 173.22
    epichlorohydrin 663.32
    1,1,1-trichloroethane 639.08
    2-aminoethanol 170.22
    morpholine-4-carbaldehyde 732.42
    sulfolane 731.86
    2,2,4-trimethylpentane 65.94
    2-methyltetrahydrofuran 546.18
    n-hexyl acetate 370.13
    isooctane 58.69
    2-(2-butoxyethoxy)ethanol 374.28
    sec-butyl acetate 217.45
    tert-butyl acetate 313.88
    decalin 80.16
    glycerin 203.53
    diglyme 623.45
    acrylic acid 210.37
    isopropyl myristate 182.96
    n-butyric acid 314.12
    acetyl acetate 246.79
    di(2-ethylhexyl) phthalate 182.29
    ethyl propionate 225.29
    nitromethane 400.4
    1,2-diethoxyethane 381.79
    benzonitrile 425.03
    trioctyl phosphate 134.99
    1-bromopropane 351.45
    gamma-valerolactone 805.9
    n-decanol 150.18
    triethyl phosphate 160.72
    4-methyl-2-pentanol 168.62
    propionitrile 258.07
    vinylene carbonate 404.69
    1,1,2-trichlorotrifluoroethane 483.42
    DMS 278.36
    cumene 167.87
    2-octanol 173.08
    2-hexanone 327.2
    octyl acetate 214.54
    limonene 229.54
    1,2-dimethoxyethane 575.19
    ethyl orthosilicate 163.1
    tributyl phosphate 159.65
    diacetone alcohol 318.89
    N,N-dimethylaniline 297.87
    acrylonitrile 313.97
    aniline 311.38
    1,3-propanediol 270.46
    bromobenzene 504.2
    dibromomethane 621.62
    1,1,2,2-tetrachloroethane 767.61
    2-methyl-cyclohexyl acetate 258.21
    tetrabutyl urea 198.3
    diisobutyl methanol 159.86
    2-phenylethanol 333.03
    styrene 244.91
    dioctyl adipate 212.28
    dimethyl sulfate 298.79
    ethyl butyrate 256.3
    methyl lactate 185.1
    butyl lactate 220.68
    diethyl carbonate 185.16
    propanediol butyl ether 295.58
    triethyl orthoformate 206.46
    p-tert-butyltoluene 179.71
    methyl 4-tert-butylbenzoate 333.45
    morpholine 515.76
    tert-butylamine 219.22
    n-dodecanol 123.44
    dimethoxymethane 459.23
    ethylene carbonate 309.88
    cyrene 343.28
    2-ethoxyethyl acetate 342.51
    2-ethylhexyl acetate 306.1
    1,2,4-trichlorobenzene 519.43
    4-methylpyridine 582.45
    dibutyl ether 249.89
    2,6-dimethyl-4-heptanol 159.86
    DEF 411.01
    dimethyl isosorbide 504.78
    tetrachloroethylene 529.81
    eugenol 347.29
    triacetin 302.67
    span 80 279.7
    1,4-butanediol 154.15
    1,1-dichloroethane 547.58
    2-methyl-1-pentanol 261.91
    methyl formate 247.17
    2-methyl-1-butanol 262.3
    n-decane 63.15
    butyronitrile 322.44
    3,7-dimethyl-1-octanol 213.35
    1-chlorooctane 192.98
    1-chlorotetradecane 94.84
    n-nonane 63.44
    undecane 50.44
    tert-butylcyclohexane 93.22
    cyclooctane 50.51
    cyclopentanol 282.95
    tetrahydropyran 441.64
    tert-amyl methyl ether 306.14
    2,5,8-trioxanonane 450.06
    1-hexene 186.78
    2-isopropoxyethanol 309.19
    2,2,2-trifluoroethanol 144.71
    methyl butyrate 294.71

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction