2-Ethyl-5-isopropylpyrazine

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  • Identifiers

    CAS number
    38028-76-1

    Molecular formula
    C9H14N2

    SMILES
    CCC1=CN=C(C=N1)C(C)C

    Safety labels

  • Odor profile

    Fragrance
    Green 80.24%
    Nutty 74.68%
    Earthy 67.85%
    Roasted 60.88%
    Vegetable 54.43%
    Cocoa 49.6%
    Potato 48.83%
    Musty 48.51%
    Coffee 41.53%
    Hazelnut 40.72%

     

    Flavor
    Green 76.99%
    Earthy 55.87%
    Nutty 49.56%
    Pepper 46.01%
    Musty 40.29%
    Raw 40.1%
    Vegetable 39.93%
    Earth 35.83%
    Hazelnut 35.23%
    Herbal 34.93%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    4.62 (weak acid)

    Molecular weight
    150.22 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    197°C

    Flash point

    • 87.89 ˚C est.

  • Synonyms

    • 2-Ethyl-5-isopropylpyrazine
    • 38028-76-1
    • SCHEMBL11960353
    • DB-289040
    • PYRAZINE, 2-ETHYL-5-(1-METHYLETHYL)-
    • 38028-76-1

  • Applications

    2-Ethyl-5-isopropylpyrazine (CAS 38028-76-1) is a pyrazine derivative commonly used as an odorant and fragrance ingredient with multiple industrial applications. In perfumery, it serves as a note that enhances fragrance blends; in the flavor industry, it may be evaluated as a flavor/aroma compound contributing to meat- or nut-like notes; in cosmetics and personal care, it appears as a fragrance ingredient; in household cleaning products and air fresheners, it is used as a scent additive; in industrial manufacturing, it can be used as an intermediate or building block for the synthesis of other pyrazine-based chemicals.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 545.22
    methanol 643.37
    isopropanol 337.54
    water 1.55
    ethyl acetate 501.91
    n-propanol 407.56
    acetone 640.8
    n-butanol 512.73
    acetonitrile 592.36
    DMF 634.73
    toluene 435.24
    isobutanol 392.89
    1,4-dioxane 819.36
    methyl acetate 429.55
    THF 1020.26
    2-butanone 518.71
    n-pentanol 378.46
    sec-butanol 382.47
    n-hexane 163.39
    ethylene glycol 54.47
    NMP 650.17
    cyclohexane 307.2
    DMSO 441.67
    n-butyl acetate 928.34
    n-octanol 196.5
    chloroform 3004.56
    n-propyl acetate 401.38
    acetic acid 860.27
    dichloromethane 2257.16
    cyclohexanone 1062.64
    propylene glycol 82.33
    isopropyl acetate 308.7
    DMAc 500.08
    2-ethoxyethanol 320.85
    isopentanol 472.48
    n-heptane 107.85
    ethyl formate 568.88
    1,2-dichloroethane 1094.77
    n-hexanol 527.25
    2-methoxyethanol 518.73
    isobutyl acetate 279.2
    tetrachloromethane 603.19
    n-pentyl acetate 365.78
    transcutol 1013.75
    n-heptanol 237.32
    ethylbenzene 234.35
    MIBK 255.37
    2-propoxyethanol 513.39
    tert-butanol 411.44
    MTBE 462.7
    2-butoxyethanol 317.19
    propionic acid 390.57
    o-xylene 251.66
    formic acid 214.8
    diethyl ether 484.29
    m-xylene 250.93
    p-xylene 382.97
    chlorobenzene 847.12
    dimethyl carbonate 139.6
    n-octane 42.69
    formamide 274.73
    cyclopentanone 916.97
    2-pentanone 428.63
    anisole 327.34
    cyclopentyl methyl ether 491.34
    gamma-butyrolactone 968.55
    1-methoxy-2-propanol 300.42
    pyridine 1134.36
    3-pentanone 345.44
    furfural 1052.7
    n-dodecane 30.08
    diethylene glycol 244.38
    diisopropyl ether 151.63
    tert-amyl alcohol 437.87
    acetylacetone 414.47
    n-hexadecane 35.23
    acetophenone 328.91
    methyl propionate 292.23
    isopentyl acetate 717.42
    trichloroethylene 2370.48
    n-nonanol 176.79
    cyclohexanol 497.74
    benzyl alcohol 320.28
    2-ethylhexanol 379.93
    isooctanol 190.38
    dipropyl ether 365.14
    1,2-dichlorobenzene 717.83
    ethyl lactate 133.82
    propylene carbonate 725.84
    n-methylformamide 379.06
    2-pentanol 321.36
    n-pentane 121.04
    1-propoxy-2-propanol 391.93
    1-methoxy-2-propyl acetate 395.0
    2-(2-methoxypropoxy) propanol 237.16
    mesitylene 167.15
    ε-caprolactone 763.77
    p-cymene 198.77
    epichlorohydrin 1013.65
    1,1,1-trichloroethane 1223.3
    2-aminoethanol 138.93
    morpholine-4-carbaldehyde 604.43
    sulfolane 825.51
    2,2,4-trimethylpentane 70.49
    2-methyltetrahydrofuran 791.83
    n-hexyl acetate 430.16
    isooctane 43.77
    2-(2-butoxyethoxy)ethanol 326.85
    sec-butyl acetate 245.62
    tert-butyl acetate 286.57
    decalin 105.69
    glycerin 109.92
    diglyme 604.91
    acrylic acid 370.22
    isopropyl myristate 158.23
    n-butyric acid 765.47
    acetyl acetate 387.32
    di(2-ethylhexyl) phthalate 166.19
    ethyl propionate 271.05
    nitromethane 890.09
    1,2-diethoxyethane 544.72
    benzonitrile 723.39
    trioctyl phosphate 117.92
    1-bromopropane 717.71
    gamma-valerolactone 1019.1
    n-decanol 130.45
    triethyl phosphate 169.82
    4-methyl-2-pentanol 184.96
    propionitrile 527.33
    vinylene carbonate 713.09
    1,1,2-trichlorotrifluoroethane 658.46
    DMS 253.1
    cumene 174.83
    2-octanol 163.24
    2-hexanone 418.36
    octyl acetate 203.2
    limonene 290.45
    1,2-dimethoxyethane 681.98
    ethyl orthosilicate 182.6
    tributyl phosphate 161.46
    diacetone alcohol 260.9
    N,N-dimethylaniline 233.23
    acrylonitrile 575.29
    aniline 494.18
    1,3-propanediol 288.77
    bromobenzene 944.54
    dibromomethane 1570.65
    1,1,2,2-tetrachloroethane 1823.6
    2-methyl-cyclohexyl acetate 325.53
    tetrabutyl urea 184.64
    diisobutyl methanol 180.79
    2-phenylethanol 389.47
    styrene 323.0
    dioctyl adipate 218.49
    dimethyl sulfate 195.58
    ethyl butyrate 445.75
    methyl lactate 131.54
    butyl lactate 240.92
    diethyl carbonate 300.1
    propanediol butyl ether 223.65
    triethyl orthoformate 298.92
    p-tert-butyltoluene 175.81
    methyl 4-tert-butylbenzoate 242.57
    morpholine 835.69
    tert-butylamine 334.94
    n-dodecanol 104.19
    dimethoxymethane 330.99
    ethylene carbonate 596.98
    cyrene 223.82
    2-ethoxyethyl acetate 375.52
    2-ethylhexyl acetate 580.79
    1,2,4-trichlorobenzene 721.54
    4-methylpyridine 1037.28
    dibutyl ether 330.01
    2,6-dimethyl-4-heptanol 180.79
    DEF 499.16
    dimethyl isosorbide 443.04
    tetrachloroethylene 1389.71
    eugenol 249.15
    triacetin 268.88
    span 80 253.84
    1,4-butanediol 117.41
    1,1-dichloroethane 1134.7
    2-methyl-1-pentanol 387.3
    methyl formate 370.1
    2-methyl-1-butanol 460.7
    n-decane 51.26
    butyronitrile 706.21
    3,7-dimethyl-1-octanol 213.94
    1-chlorooctane 198.49
    1-chlorotetradecane 76.42
    n-nonane 52.36
    undecane 37.43
    tert-butylcyclohexane 86.8
    cyclooctane 84.15
    cyclopentanol 430.61
    tetrahydropyran 932.12
    tert-amyl methyl ether 331.43
    2,5,8-trioxanonane 364.1
    1-hexene 401.1
    2-isopropoxyethanol 230.94
    2,2,2-trifluoroethanol 238.47
    methyl butyrate 470.49

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction