2-Ethyl-4-methyloxazole

Overview IFRA Request a quote

  • Identifiers

    CAS number
    24667-03-6

    Molecular formula
    C6H9NO

    SMILES
    CCC1=NC(=CO1)C

    Safety labels

  • Odor profile

    Fragrance
    Green 85.36%
    Nutty 63.18%
    Vegetable 58.53%
    Roasted 57.6%
    Earthy 50.82%
    Meaty 44.74%
    Cocoa 41.14%
    Musty 40.97%
    Burnt 39.78%
    Potato 35.07%

     

    Flavor
    Green 62.03%
    Nutty 54.49%
    Roasted 48.43%
    Vegetable 44.62%
    Earthy 43.14%
    Burnt 34.19%
    Coffee 33.66%
    Potato 30.18%
    Raw 26.94%
    Meaty 25.12%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    5.74 (weak acid)

    Molecular weight
    111.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    98°C

    Flash point

    • 32.75 ˚C est.

  • Synonyms

    • 2-ethyl-4-methyloxazole
    • 2-ethyl-4-methyl-1,3-oxazole
    • Oxazole, 2-ethyl-4-methyl
    • 24667-03-6
    • Oxazole, 2-ethyl-4-methyl-
    • SCHEMBL5537292
    • SCHEMBL7071890
    • SCHEMBL7908105
    • SCHEMBL8875301
    • CHEBI:179314
    • SRXOCFLMVTXDRQ-UHFFFAOYSA-N
    • DTXSID801313822
    • T78Y23G876
    • 24667-03-6

  • Applications

    2-Ethyl-4-methyloxazole (CAS 24667-03-6) is primarily used as an organic synthesis intermediate for oxazole-containing compounds. In pharmaceutical and agrochemical research, it is often used as a building block to access heterocyclic oxazole cores for downstream drug and crop-protection products. In chemical and materials industries, it may serve as a precursor for functional monomers or additives used in polymers and coatings. In fragrance and cosmetics, oxazole derivatives can be prepared as odor-active constituents or intermediates for fragrance materials. In electronics and photonics, oxazole scaffolds are explored as luminescent or charge-transport materials, and derivatives of this compound may be evaluated for such applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1146.99
    methanol 2432.85
    isopropanol 740.64
    water 47.61
    ethyl acetate 598.52
    n-propanol 872.6
    acetone 949.68
    n-butanol 809.79
    acetonitrile 790.72
    DMF 1725.61
    toluene 413.13
    isobutanol 756.38
    1,4-dioxane 1030.23
    methyl acetate 671.46
    THF 1208.39
    2-butanone 828.56
    n-pentanol 710.63
    sec-butanol 780.6
    n-hexane 208.7
    ethylene glycol 510.98
    NMP 1390.84
    cyclohexane 160.81
    DMSO 1469.02
    n-butyl acetate 491.36
    n-octanol 413.68
    chloroform 2066.22
    n-propyl acetate 462.35
    acetic acid 793.57
    dichloromethane 2463.55
    cyclohexanone 906.9
    propylene glycol 471.68
    isopropyl acetate 409.24
    DMAc 1431.56
    2-ethoxyethanol 1063.53
    isopentanol 706.71
    n-heptane 108.94
    ethyl formate 623.61
    1,2-dichloroethane 1219.0
    n-hexanol 548.44
    2-methoxyethanol 1471.31
    isobutyl acetate 324.82
    tetrachloromethane 524.38
    n-pentyl acetate 436.68
    transcutol 1492.31
    n-heptanol 343.59
    ethylbenzene 305.2
    MIBK 461.0
    2-propoxyethanol 925.7
    tert-butanol 805.55
    MTBE 796.74
    2-butoxyethanol 601.74
    propionic acid 624.71
    o-xylene 346.77
    formic acid 592.74
    diethyl ether 706.68
    m-xylene 329.47
    p-xylene 435.5
    chlorobenzene 688.66
    dimethyl carbonate 357.48
    n-octane 68.75
    formamide 579.84
    cyclopentanone 1105.37
    2-pentanone 641.38
    anisole 604.79
    cyclopentyl methyl ether 672.26
    gamma-butyrolactone 1151.53
    1-methoxy-2-propanol 985.6
    pyridine 830.64
    3-pentanone 569.91
    furfural 1265.35
    n-dodecane 65.13
    diethylene glycol 759.04
    diisopropyl ether 269.22
    tert-amyl alcohol 841.83
    acetylacetone 692.87
    n-hexadecane 70.78
    acetophenone 543.64
    methyl propionate 583.02
    isopentyl acetate 459.77
    trichloroethylene 1820.89
    n-nonanol 326.92
    cyclohexanol 578.25
    benzyl alcohol 548.75
    2-ethylhexanol 362.43
    isooctanol 299.68
    dipropyl ether 382.01
    1,2-dichlorobenzene 718.05
    ethyl lactate 299.2
    propylene carbonate 660.03
    n-methylformamide 924.69
    2-pentanol 535.39
    n-pentane 177.02
    1-propoxy-2-propanol 564.61
    1-methoxy-2-propyl acetate 439.47
    2-(2-methoxypropoxy) propanol 465.9
    mesitylene 238.08
    ε-caprolactone 796.56
    p-cymene 210.14
    epichlorohydrin 1340.32
    1,1,1-trichloroethane 1011.3
    2-aminoethanol 703.19
    morpholine-4-carbaldehyde 1261.28
    sulfolane 1469.06
    2,2,4-trimethylpentane 144.76
    2-methyltetrahydrofuran 972.63
    n-hexyl acetate 618.6
    isooctane 94.77
    2-(2-butoxyethoxy)ethanol 608.46
    sec-butyl acetate 328.3
    tert-butyl acetate 471.82
    decalin 139.88
    glycerin 642.89
    diglyme 1073.33
    acrylic acid 616.93
    isopropyl myristate 236.28
    n-butyric acid 742.22
    acetyl acetate 428.99
    di(2-ethylhexyl) phthalate 261.88
    ethyl propionate 445.77
    nitromethane 1129.17
    1,2-diethoxyethane 600.14
    benzonitrile 719.61
    trioctyl phosphate 195.16
    1-bromopropane 827.78
    gamma-valerolactone 1265.76
    n-decanol 239.6
    triethyl phosphate 217.95
    4-methyl-2-pentanol 344.6
    propionitrile 739.68
    vinylene carbonate 714.03
    1,1,2-trichlorotrifluoroethane 987.48
    DMS 441.97
    cumene 266.91
    2-octanol 295.08
    2-hexanone 533.53
    octyl acetate 300.82
    limonene 275.57
    1,2-dimethoxyethane 1433.27
    ethyl orthosilicate 220.77
    tributyl phosphate 251.9
    diacetone alcohol 496.94
    N,N-dimethylaniline 496.16
    acrylonitrile 917.29
    aniline 515.57
    1,3-propanediol 775.4
    bromobenzene 737.88
    dibromomethane 1551.29
    1,1,2,2-tetrachloroethane 1465.04
    2-methyl-cyclohexyl acetate 321.78
    tetrabutyl urea 313.91
    diisobutyl methanol 210.64
    2-phenylethanol 458.98
    styrene 381.65
    dioctyl adipate 309.59
    dimethyl sulfate 605.04
    ethyl butyrate 389.91
    methyl lactate 376.4
    butyl lactate 349.25
    diethyl carbonate 287.27
    propanediol butyl ether 581.78
    triethyl orthoformate 275.7
    p-tert-butyltoluene 203.61
    methyl 4-tert-butylbenzoate 474.89
    morpholine 994.87
    tert-butylamine 622.03
    n-dodecanol 187.69
    dimethoxymethane 1024.94
    ethylene carbonate 562.13
    cyrene 461.89
    2-ethoxyethyl acetate 484.1
    2-ethylhexyl acetate 372.88
    1,2,4-trichlorobenzene 782.29
    4-methylpyridine 957.44
    dibutyl ether 423.81
    2,6-dimethyl-4-heptanol 210.64
    DEF 914.21
    dimethyl isosorbide 655.79
    tetrachloroethylene 1098.28
    eugenol 508.55
    triacetin 455.67
    span 80 387.9
    1,4-butanediol 521.69
    1,1-dichloroethane 1093.88
    2-methyl-1-pentanol 675.49
    methyl formate 770.47
    2-methyl-1-butanol 782.67
    n-decane 95.1
    butyronitrile 843.76
    3,7-dimethyl-1-octanol 368.48
    1-chlorooctane 300.73
    1-chlorotetradecane 136.95
    n-nonane 99.46
    undecane 76.32
    tert-butylcyclohexane 156.63
    cyclooctane 75.94
    cyclopentanol 659.32
    tetrahydropyran 793.03
    tert-amyl methyl ether 687.48
    2,5,8-trioxanonane 709.36
    1-hexene 463.05
    2-isopropoxyethanol 664.28
    2,2,2-trifluoroethanol 369.54
    methyl butyrate 623.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction