2-Ethyl-4-methyl thiazole

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  • Identifiers

    CAS number
    15679-12-6

    Molecular formula
    C6H9NS

    SMILES
    CCC1=NC(=CS1)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Green 84.31%
    Nutty 70.88%
    Vegetable 66.66%
    Meaty 64.58%
    Sulfurous 60.83%
    Roasted 58.28%
    Cocoa 45.64%
    Earthy 42.34%
    Tomato 40.63%
    Coffee 40.38%

     

    Flavor
    Green 84.57%
    Nutty 68.8%
    Vegetable 50.47%
    Roasted 43.08%
    Earthy 40.36%
    Tomato 34.1%
    Raw 33.05%
    Hazelnut 26.74%
    Potato 26.61%
    Meaty 26.11%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    2.2

    pKa est.
    6.09 (neutral)

    Molecular weight
    127.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point

    • 161.00 to 162.00 °C. @ 760.00 mm Hg

    Flash point

    • 44.68 ˚C est.

    Solubility expt.

    • Slightly soluble in water; Soluble in fats
    • Miscible at room temperature (in ethanol)

  • Synonyms

    • 2-ETHYL-4-METHYLTHIAZOLE
    • 15679-12-6
    • 2-Ethyl-4-methyl thiazole
    • Thiazole, 2-ethyl-4-methyl-
    • 2-Ethyl-4-methyl-1,3-thiazole
    • FEMA No. 3680
    • LVC1ZV6X4U
    • EINECS 239-757-9
    • 4-Methyl-2-ethylthiazole
    • DTXSID6065923
    • 2-ETHYL-4-METHYL THIAZOLE [FHFI]
    • UNII-LVC1ZV6X4U
    • 2-ethyl-4-methyl-thiazole
    • MFCD00036621
    • SCHEMBL129956
    • DTXCID9035042
    • FEMA 3680
    • 2-Ethyl-4-methylthiazole, 98%
    • CHEBI:178615
    • AKOS015897435
    • CS-W013479
    • DS-6428
    • FE35754
    • 2-Ethyl-4-methylthiazole, >=98%, FG
    • BP-10598
    • DB-021040
    • E0456
    • NS00021700
    • D90521
    • EN300-1238590
    • Q27283206
    • InChI=1/C6H9NS/c1-3-6-7-5(2)4-8-6/h4H,3H2,1-2H
    • 239-757-9

  • Applications

    2-Ethyl-4-methylthiazole is a key natural flavor molecule with a characteristic roasted, coffee-nut aroma, and is therefore widely employed as a flavouring agent in foods (instant coffee, chocolate, biscuits, savory snacks, instant soups), beverages and e-liquids to add caramel-grilled nuances; it is also used as a GC-MS calibration standard, a tracer in Maillard reaction studies, a sensory reference compound, a gourmand note in fine fragrances, and a flavor simulator for premium animal feed and fishing bait formulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 223.5
    methanol 352.35
    isopropanol 163.28
    water 3.15
    ethyl acetate 228.11
    n-propanol 193.13
    acetone 365.71
    n-butanol 195.77
    acetonitrile 212.46
    DMF 664.64
    toluene 228.87
    isobutanol 156.19
    1,4-dioxane 516.69
    methyl acetate 239.71
    THF 642.69
    2-butanone 316.02
    n-pentanol 156.11
    sec-butanol 161.29
    n-hexane 55.6
    ethylene glycol 101.73
    NMP 772.42
    cyclohexane 64.88
    DMSO 611.24
    n-butyl acetate 206.91
    n-octanol 137.63
    chloroform 765.06
    n-propyl acetate 155.86
    acetic acid 186.1
    dichloromethane 720.47
    cyclohexanone 501.06
    propylene glycol 103.19
    isopropyl acetate 175.34
    DMAc 588.55
    2-ethoxyethanol 281.66
    isopentanol 167.88
    n-heptane 48.88
    ethyl formate 170.86
    1,2-dichloroethane 425.97
    n-hexanol 205.49
    2-methoxyethanol 443.95
    isobutyl acetate 135.91
    tetrachloromethane 206.65
    n-pentyl acetate 184.75
    transcutol 592.92
    n-heptanol 127.02
    ethylbenzene 124.98
    MIBK 207.67
    2-propoxyethanol 387.76
    tert-butanol 183.49
    MTBE 233.06
    2-butoxyethanol 227.02
    propionic acid 164.15
    o-xylene 166.33
    formic acid 80.89
    diethyl ether 241.32
    m-xylene 182.61
    p-xylene 163.34
    chlorobenzene 345.43
    dimethyl carbonate 150.89
    n-octane 28.16
    formamide 108.02
    cyclopentanone 591.88
    2-pentanone 279.96
    anisole 277.11
    cyclopentyl methyl ether 351.11
    gamma-butyrolactone 545.79
    1-methoxy-2-propanol 339.53
    pyridine 401.93
    3-pentanone 241.15
    furfural 595.32
    n-dodecane 27.76
    diethylene glycol 309.62
    diisopropyl ether 104.5
    tert-amyl alcohol 176.29
    acetylacetone 383.03
    n-hexadecane 31.35
    acetophenone 260.98
    methyl propionate 223.84
    isopentyl acetate 198.02
    trichloroethylene 737.8
    n-nonanol 123.83
    cyclohexanol 191.39
    benzyl alcohol 207.48
    2-ethylhexanol 142.69
    isooctanol 106.72
    dipropyl ether 172.49
    1,2-dichlorobenzene 342.5
    ethyl lactate 113.6
    propylene carbonate 274.57
    n-methylformamide 249.52
    2-pentanol 135.17
    n-pentane 48.71
    1-propoxy-2-propanol 257.27
    1-methoxy-2-propyl acetate 254.62
    2-(2-methoxypropoxy) propanol 226.68
    mesitylene 134.2
    ε-caprolactone 373.29
    p-cymene 110.49
    epichlorohydrin 571.19
    1,1,1-trichloroethane 448.68
    2-aminoethanol 142.93
    morpholine-4-carbaldehyde 706.83
    sulfolane 766.6
    2,2,4-trimethylpentane 37.32
    2-methyltetrahydrofuran 451.67
    n-hexyl acetate 255.96
    isooctane 31.33
    2-(2-butoxyethoxy)ethanol 278.59
    sec-butyl acetate 128.17
    tert-butyl acetate 215.61
    decalin 58.48
    glycerin 181.39
    diglyme 482.58
    acrylic acid 167.1
    isopropyl myristate 127.21
    n-butyric acid 212.63
    acetyl acetate 189.48
    di(2-ethylhexyl) phthalate 136.18
    ethyl propionate 155.22
    nitromethane 353.94
    1,2-diethoxyethane 260.84
    benzonitrile 307.33
    trioctyl phosphate 93.7
    1-bromopropane 267.27
    gamma-valerolactone 672.47
    n-decanol 95.87
    triethyl phosphate 111.63
    4-methyl-2-pentanol 101.57
    propionitrile 208.76
    vinylene carbonate 294.67
    1,1,2-trichlorotrifluoroethane 393.15
    DMS 231.6
    cumene 106.58
    2-octanol 101.71
    2-hexanone 206.28
    octyl acetate 155.43
    limonene 155.96
    1,2-dimethoxyethane 467.53
    ethyl orthosilicate 107.44
    tributyl phosphate 112.62
    diacetone alcohol 234.49
    N,N-dimethylaniline 217.62
    acrylonitrile 245.42
    aniline 244.2
    1,3-propanediol 196.92
    bromobenzene 379.86
    dibromomethane 479.63
    1,1,2,2-tetrachloroethane 597.5
    2-methyl-cyclohexyl acetate 173.66
    tetrabutyl urea 154.6
    diisobutyl methanol 92.48
    2-phenylethanol 227.99
    styrene 166.58
    dioctyl adipate 159.59
    dimethyl sulfate 295.47
    ethyl butyrate 160.66
    methyl lactate 159.3
    butyl lactate 141.55
    diethyl carbonate 119.55
    propanediol butyl ether 197.56
    triethyl orthoformate 128.97
    p-tert-butyltoluene 113.44
    methyl 4-tert-butylbenzoate 234.2
    morpholine 481.99
    tert-butylamine 130.57
    n-dodecanol 78.6
    dimethoxymethane 433.16
    ethylene carbonate 225.6
    cyrene 255.36
    2-ethoxyethyl acetate 249.02
    2-ethylhexyl acetate 175.42
    1,2,4-trichlorobenzene 408.89
    4-methylpyridine 453.71
    dibutyl ether 171.04
    2,6-dimethyl-4-heptanol 92.48
    DEF 342.17
    dimethyl isosorbide 400.44
    tetrachloroethylene 418.08
    eugenol 242.71
    triacetin 234.55
    span 80 216.83
    1,4-butanediol 105.27
    1,1-dichloroethane 404.52
    2-methyl-1-pentanol 157.6
    methyl formate 212.94
    2-methyl-1-butanol 169.02
    n-decane 39.19
    butyronitrile 216.13
    3,7-dimethyl-1-octanol 135.5
    1-chlorooctane 125.6
    1-chlorotetradecane 66.76
    n-nonane 38.88
    undecane 31.67
    tert-butylcyclohexane 59.41
    cyclooctane 35.43
    cyclopentanol 226.68
    tetrahydropyran 366.58
    tert-amyl methyl ether 207.39
    2,5,8-trioxanonane 368.14
    1-hexene 127.57
    2-isopropoxyethanol 204.85
    2,2,2-trifluoroethanol 99.44
    methyl butyrate 197.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction